{"id":"https://openalex.org/W185799671","doi":null,"title":"The role of the orbitofrontal cortex in reward related behavior in addiction and alcoholism in particular","display_name":"The role of the orbitofrontal cortex in reward related behavior in addiction and alcoholism in particular","publication_year":2009,"publication_date":"2009-12-21","ids":{"openalex":"https://openalex.org/W185799671","mag":"185799671"},"language":"en","primary_location":{"id":"pmh:oai:dspace.library.uu.nl:1874/37306","doi":null,"is_oa":true,"landing_page_url":"http://dspace.library.uu.nl:8080/handle/1874/37306","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Master thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://dspace.library.uu.nl:8080/handle/1874/37306","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049890386","display_name":"Rebecca M. E. Steketee","orcid":"https://orcid.org/0000-0003-2689-5490","observed_orcids":["https://orcid.org/0000-0003-2689-5490"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Rebecca M. E. Steketee","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2689-5490","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5049890386"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.6298999786376953,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.6298999786376953,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10042","display_name":"Neural and Behavioral Psychology Studies","score":0.36230000853538513,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10043","display_name":"Substance Abuse Treatment and Outcomes","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/orbitofrontal-cortex","display_name":"orbitofrontal cortex","score":1.0},{"id":"https://openalex.org/keywords/addiction","display_name":"addiction","score":0.8610000014305115},{"id":"https://openalex.org/keywords/alcoholism","display_name":"alcoholism","score":0.9990000128746033},{"id":"https://openalex.org/keywords/reward-learning","display_name":"reward learning","score":0.5569999814033508},{"id":"https://openalex.org/keywords/dopamine","display_name":"dopamine","score":0.734000027179718},{"id":"https://openalex.org/keywords/reward-valuation","display_name":"reward valuation","score":0.7409999966621399},{"id":"https://openalex.org/keywords/decision-making","display_name":"decision-making","score":0.6539999842643738},{"id":"https://openalex.org/keywords/genetic-predisposition-to-addiction","display_name":"genetic predisposition to addiction","score":0.765999972820282},{"id":"https://openalex.org/keywords/animal-models-of-addiction","display_name":"animal models of addiction","score":0.8809999823570251}],"concepts":[{"id":"https://openalex.org/C2776559556","wikidata":"https://www.wikidata.org/wiki/Q18717","display_name":"Orbitofrontal cortex","level":4,"score":0.79715895652771},{"id":"https://openalex.org/C48856860","wikidata":"https://www.wikidata.org/wiki/Q12029","display_name":"Addiction","level":2,"score":0.7958712577819824},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.6160882711410522},{"id":"https://openalex.org/C143661069","wikidata":"https://www.wikidata.org/wiki/Q670713","display_name":"Reward system","level":2,"score":0.4334881901741028},{"id":"https://openalex.org/C180747234","wikidata":"https://www.wikidata.org/wiki/Q23373","display_name":"Cognitive psychology","level":1,"score":0.40688616037368774},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3815217614173889},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.3365989327430725},{"id":"https://openalex.org/C2781195155","wikidata":"https://www.wikidata.org/wiki/Q18680","display_name":"Prefrontal cortex","level":3,"score":0.18855705857276917},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.0810900628566742}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:dspace.library.uu.nl:1874/37306","doi":null,"is_oa":true,"landing_page_url":"http://dspace.library.uu.nl:8080/handle/1874/37306","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Master thesis"},{"id":"mag:185799671","doi":null,"is_oa":false,"landing_page_url":"https://dspace.library.uu.nl/bitstream/handle/1874/37306/thesis_R.M.E.Steketee.pdf;sequence=2","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:dspace.library.uu.nl:1874/37306","doi":null,"is_oa":true,"landing_page_url":"http://dspace.library.uu.nl:8080/handle/1874/37306","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Master thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1581387623","https://openalex.org/W1918535853","https://openalex.org/W1972559070","https://openalex.org/W1983045607","https://openalex.org/W1985052963","https://openalex.org/W1985655629","https://openalex.org/W1990621985","https://openalex.org/W2001865657","https://openalex.org/W2003775449","https://openalex.org/W2005351217","https://openalex.org/W2013304652","https://openalex.org/W2017934537","https://openalex.org/W2022168505","https://openalex.org/W2028270191","https://openalex.org/W2032471892","https://openalex.org/W2038819711","https://openalex.org/W2044346852","https://openalex.org/W2058322016","https://openalex.org/W2062351163","https://openalex.org/W2076432816","https://openalex.org/W2078351862","https://openalex.org/W2090931660","https://openalex.org/W2099221443","https://openalex.org/W2107952769","https://openalex.org/W2110634897","https://openalex.org/W2111381283","https://openalex.org/W2117726420","https://openalex.org/W2117808207","https://openalex.org/W2123856966","https://openalex.org/W2125079958","https://openalex.org/W2133401211","https://openalex.org/W2147156351","https://openalex.org/W2154598652","https://openalex.org/W2157495188","https://openalex.org/W2163695767","https://openalex.org/W2165661567","https://openalex.org/W2221703765"],"related_works":["https://openalex.org/W2792872523","https://openalex.org/W2491224076","https://openalex.org/W2125079958","https://openalex.org/W1965591227","https://openalex.org/W1972559070","https://openalex.org/W2982459410","https://openalex.org/W3005943714","https://openalex.org/W2475909970","https://openalex.org/W3165440962","https://openalex.org/W3040753794"],"abstract_inverted_index":{"Addiction":[0],"can":[1],"be":[2,74],"conceptualized":[3],"as":[4,8,55,57,78,104,140,142],"a":[5],"learning":[6,21],"disorder":[7],"addicts":[9,79],"are":[10,138],"unable":[11],"to":[12,45,73,124,131],"regulate":[13],"behavior":[14,59],"associated":[15,25],"with":[16,26],"drug":[17],"reward.":[18],"Reward":[19],"related":[20],"has":[22],"traditionally":[23],"been":[24],"dopamine":[27,47],"transmission":[28],"in":[29,41,49,76,97,100,102,121],"subcortical":[30,50],"structures.":[31],"Recent":[32],"findings":[33],"indicate":[34],"however":[35],"that":[36],"the":[37,64,69,95,148],"orbitofrontal":[38],"cortex":[39],"(OFC)":[40],"particular":[42],"is":[43,71,109,114],"able":[44],"modulate":[46],"levels":[48],"structures,":[51],"regulating":[52],"reward":[53,81],"value":[54,65],"well":[56],"choice":[58],"by":[60],"providing":[61],"information":[62],"on":[63,145],"of":[66,94,107,117],"stimuli.":[67],"Therefore":[68],"OFC":[70,96],"thought":[72],"dysfunctional":[75],"addiction":[77,98,133,146],"overvalue":[80],"despite":[82],"long":[83],"term":[84],"negative":[85],"consequences.":[86],"This":[87],"review":[88],"discusses":[89],"structural":[90],"and":[91,99,134,147],"functional":[92],"abnormalities":[93],"alcoholism":[101],"particular,":[103],"problematic":[105,115],"consumption":[106,116],"alcohol":[108],"much":[110],"more":[111],"common":[112],"than":[113],"other":[118],"substances.":[119],"Furthermore,":[120],"an":[122],"attempt":[123],"elucidate":[125],"potential":[126],"causal":[127],"relations,":[128],"genetic":[129],"contributions":[130],"(alcohol)":[132],"its":[135],"predisposing":[136],"factors":[137],"discussed,":[139],"\\nwell":[141],"animal":[143],"studies":[144],"OFC.":[149]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2016-06-24T00:00:00"}