{"id":"https://openalex.org/W1853960255","doi":"https://doi.org/10.1017/s1092852900024056","title":"Long-Term Safety and Effectiveness of Lisdexamfetamine Dimesylate in Adults With Attention-Deficit/Hyperactivity Disorder","display_name":"Long-Term Safety and Effectiveness of Lisdexamfetamine Dimesylate in Adults With Attention-Deficit/Hyperactivity Disorder","publication_year":2009,"publication_date":"2009-10-01","ids":{"openalex":"https://openalex.org/W1853960255","doi":"https://doi.org/10.1017/s1092852900024056","mag":"1853960255","pmid":"https://pubmed.ncbi.nlm.nih.gov/20095369"},"language":"en","primary_location":{"id":"doi:10.1017/s1092852900024056","doi":"https://doi.org/10.1017/s1092852900024056","is_oa":false,"landing_page_url":"https://doi.org/10.1017/s1092852900024056","pdf_url":null,"source":{"id":"https://openalex.org/S4210237982","display_name":"CNS Spectrums","issn_l":"1092-8529","issn":["1092-8529","2165-6509"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CNS Spectrums","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048099033","display_name":"Richard H. Weisler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard Weisler","raw_affiliation_strings":["Department of Psychiatry, University of North Carolina, Chapel Hill, USA. RWeisler@aol.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of North Carolina, Chapel Hill, USA. RWeisler@aol.com","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066630164","display_name":"Joel L Young","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joel Young","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035939767","display_name":"Gregory W. Mattingly","orcid":"https://orcid.org/0000-0002-0234-6860","observed_orcids":["https://orcid.org/0000-0002-0234-6860"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Greg Mattingly","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101108686","display_name":"Joseph Gao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joseph Gao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039645834","display_name":"Liza A. Squires","orcid":"https://orcid.org/0009-0004-6886-0020","observed_orcids":["https://orcid.org/0009-0004-6886-0020"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Liza Squires","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010701317","display_name":"Lenard A. Adler","orcid":"https://orcid.org/0000-0002-9812-8234","observed_orcids":["https://orcid.org/0000-0002-9812-8234"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lenard Adler","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"304 Study Group","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"304 Study Group","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3550,"currency":"USD","value_usd":3550},"apc_paid":null,"fwci":4.4293,"has_fulltext":false,"cited_by_count":96,"citation_normalized_percentile":{"value":0.94651845,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"14","issue":"10","first_page":"573","last_page":"586"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10537","display_name":"Attention Deficit Hyperactivity Disorder","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10537","display_name":"Attention Deficit Hyperactivity Disorder","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12539","display_name":"Pharmacology and Obesity Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11953","display_name":"Neuroethics, Human Enhancement, Biomedical Innovations","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1211","display_name":"Philosophy"},"field":{"id":"https://openalex.org/fields/12","display_name":"Arts and Humanities"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lisdexamfetamine-dimesylate","display_name":"lisdexamfetamine dimesylate","score":0.9980000257492065},{"id":"https://openalex.org/keywords/adult-adhd","display_name":"adult ADHD","score":0.7360000014305115},{"id":"https://openalex.org/keywords/long-term-safety","display_name":"long-term safety","score":0.8650000095367432},{"id":"https://openalex.org/keywords/long-term-effectiveness","display_name":"long-term effectiveness","score":0.6930000185966492},{"id":"https://openalex.org/keywords/stimulant-medication","display_name":"stimulant medication","score":0.7300000190734863},{"id":"https://openalex.org/keywords/treatment-emergent-adverse-events","display_name":"treatment-emergent adverse events","score":0.8809999823570251},{"id":"https://openalex.org/keywords/adhd-rating-scale","display_name":"ADHD Rating Scale","score":0.6859999895095825},{"id":"https://openalex.org/keywords/dose-titration","display_name":"dose titration","score":0.574999988079071}],"concepts":[{"id":"https://openalex.org/C61797465","wikidata":"https://www.wikidata.org/wiki/Q1188986","display_name":"Term (time)","level":2,"score":0.5879946351051331},{"id":"https://openalex.org/C2780783007","wikidata":"https://www.wikidata.org/wiki/Q181923","display_name":"Attention deficit hyperactivity disorder","level":2,"score":0.5750497579574585},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4735778272151947},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.4690974950790405},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45094043016433716},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.33850324153900146},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.32497596740722656},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000069478","descriptor_name":"Lisdexamfetamine Dimesylate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000697","descriptor_name":"Central Nervous System Stimulants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000697","descriptor_name":"Central Nervous System Stimulants","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001289","descriptor_name":"Attention Deficit Disorder with Hyperactivity","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001289","descriptor_name":"Attention Deficit Disorder with Hyperactivity","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D003913","descriptor_name":"Dextroamphetamine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D003913","descriptor_name":"Dextroamphetamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003913","descriptor_name":"Dextroamphetamine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004562","descriptor_name":"Electrocardiography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011569","descriptor_name":"Psychiatric Status Rating Scales","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055986","descriptor_name":"Vital Signs","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1017/s1092852900024056","doi":"https://doi.org/10.1017/s1092852900024056","is_oa":false,"landing_page_url":"https://doi.org/10.1017/s1092852900024056","pdf_url":null,"source":{"id":"https://openalex.org/S4210237982","display_name":"CNS Spectrums","issn_l":"1092-8529","issn":["1092-8529","2165-6509"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CNS Spectrums","raw_type":"journal-article"},{"id":"pmid:20095369","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20095369","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CNS spectrums","raw_type":"Clinical Trial"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.632.3127","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.632.3127","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.cnsspectrums.com/userdocs/articleimages/176/1009cns_weisler.pdf","raw_type":"text"},{"id":"pmh:oai:digitalcommons.wustl.edu:open_access_pubs-4401","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.wustl.edu/open_access_pubs/3398","pdf_url":null,"source":{"id":"https://openalex.org/S4306400764","display_name":"Digital Commons@Becker (Washington University School of Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I204465549","host_organization_name":"Washington University in St. Louis","host_organization_lineage":["https://openalex.org/I204465549"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Open Access Publications","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W76668800","https://openalex.org/W182853122","https://openalex.org/W1666727496","https://openalex.org/W1970906132","https://openalex.org/W1979206088","https://openalex.org/W1989428478","https://openalex.org/W1992488678","https://openalex.org/W1999039388","https://openalex.org/W2006463161","https://openalex.org/W2008934160","https://openalex.org/W2009357282","https://openalex.org/W2012950683","https://openalex.org/W2013974594","https://openalex.org/W2016496786","https://openalex.org/W2023262882","https://openalex.org/W2034489605","https://openalex.org/W2042980378","https://openalex.org/W2047554178","https://openalex.org/W2048364865","https://openalex.org/W2056054149","https://openalex.org/W2058432412","https://openalex.org/W2062714266","https://openalex.org/W2064340252","https://openalex.org/W2082580890","https://openalex.org/W2091621243","https://openalex.org/W2121519528","https://openalex.org/W2129155589","https://openalex.org/W2129620184","https://openalex.org/W2151487996","https://openalex.org/W2159011576","https://openalex.org/W2159184227","https://openalex.org/W2159881136","https://openalex.org/W2164676183","https://openalex.org/W2169861403","https://openalex.org/W2171074660","https://openalex.org/W2171204232"],"related_works":["https://openalex.org/W76668800","https://openalex.org/W1985935801","https://openalex.org/W2996557655","https://openalex.org/W2182452737","https://openalex.org/W1996061461","https://openalex.org/W2127512142","https://openalex.org/W2146886967","https://openalex.org/W2131679908","https://openalex.org/W4406147901","https://openalex.org/W1979206088"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"evaluate":[2],"the":[3,13,76,81,96,161,172],"long-term":[4],"safety":[5,189],"and":[6,50,63,73,121,141,158,196],"effectiveness":[7,62,78,199],"of":[8,15,91],"lisdexamfetamine":[9],"dimesylate":[10],"(LDX)":[11],"in":[12,130,139,148,200],"treatment":[14],"adults":[16,29,201],"with":[17,30,192,202],"attention-deficit/hyperactivity":[18],"disorder":[19],"(ADHD).":[20],"METHODS:":[21],"Following":[22],"a":[23,188],"4-week,":[24],"placebo-controlled,":[25],"double-blind":[26],"trial,":[27],"349":[28],"ADHD":[31,82,203],"were":[32,105,126,144,153],"enrolled":[33],"into":[34],"an":[35],"open-label,":[36],"single-arm":[37],"study":[38,162],"for":[39,204],"up":[40,52,205],"to":[41,53,59,128,206],"12":[42,207],"months.":[43,208],"Treatment":[44],"was":[45,80,180],"initiated":[46],"at":[47,56,155,166],"30":[48],"mg/day":[49,55],"titrated":[51],"70":[54],"subsequent":[57],"visits":[58],"achieve":[60],"optimal":[61],"tolerability.":[64],"Safety":[65],"assessments":[66],"included":[67],"adverse":[68,102],"events":[69,103],"inquiries,":[70],"vital":[71],"signs,":[72],"electrocardiograms":[74],"while":[75],"primary":[77],"assessment":[79],"Rating":[83],"Scale":[84],"(ADHD-RS)":[85],"total":[86,90,151,178],"score.":[87],"RESULTS:":[88],"A":[89],"191":[92],"(54.7%)":[93],"subjects":[94],"completed":[95],"study.":[97],"The":[98],"most":[99],"common":[100],"treatment-emergent":[101],"(TEAEs)":[104],"upper":[106],"respiratory":[107],"tract":[108],"infection":[109],"(21.8%),":[110],"insomnia":[111],"(19.5%),":[112],"headache":[113],"(17.2%),":[114],"dry":[115],"mouth":[116],"(16.6%),":[117],"decreased":[118],"appetite":[119],"(14.3%),":[120],"irritability":[122],"(11.2%).":[123],"Most":[124],"TEAEs":[125],"mild":[127],"moderate":[129],"severity.":[131],"At":[132,170],"endpoint,":[133,171],"small":[134],"but":[135],"statistically":[136],"significant":[137],"increases":[138],"pulse":[140],"blood":[142],"pressure":[143],"noted.":[145],"Significant":[146],"improvements":[147],"mean":[149,173],"ADHD-RS":[150,177],"scores":[152],"observed":[154],"week":[156],"1":[157],"sustained":[159],"throughout":[160],"(P":[163,182],"<":[164,183],".0001":[165],"all":[167],"postbaseline":[168],"visits).":[169],"improvement":[174],"from":[175],"baseline":[176],"score":[179],"24.8":[181],".0001).":[184],"CONCLUSIONS:":[185],"LDX":[186],"demonstrated":[187],"profile":[190],"consistent":[191],"long-acting":[193],"stimulant":[194],"use":[195],"provided":[197],"continued":[198]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}