{"id":"https://openalex.org/W18532184","doi":null,"title":"Functional relationships between gene pairs in oral squamous cell carcinoma.","display_name":"Functional relationships between gene pairs in oral squamous cell carcinoma.","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W18532184","mag":"18532184","pmid":"https://pubmed.ncbi.nlm.nih.gov/14728197","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1479982"},"language":"en","primary_location":{"id":"pmid:14728197","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14728197","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AMIA ... Annual Symposium proceedings. AMIA Symposium","raw_type":"Journal Article"},"volume":null,"type":"conference-paper","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024500196","display_name":"Winston Patrick Kuo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Winston Patrick Kuo","raw_affiliation_strings":["Department of Oral Medicine, Harvard School of Dental Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Medicine, Harvard School of Dental Medicine","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021991186","display_name":"Eduardo M\u00e9ndez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eduardo Mendez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100741518","display_name":"Chu Chen","orcid":"https://orcid.org/0000-0003-2267-8050","observed_orcids":["https://orcid.org/0000-0003-2267-8050","https://orcid.org/0000-0002-8952-573X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chu Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017523930","display_name":"Mark Whipple","orcid":"https://orcid.org/0000-0003-1040-7528","observed_orcids":["https://orcid.org/0000-0003-1040-7528"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark E Whipple","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083387436","display_name":"Greg Farell","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Greg Farell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005496205","display_name":"Nicholas Agoff","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nicholas Agoff","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5022028438","display_name":"Peter J. Park","orcid":"https://orcid.org/0000-0001-9378-960X","observed_orcids":["https://orcid.org/0000-0001-9378-960X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter J Park","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.4044,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.88096487,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":null,"issue":null,"first_page":"371","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.875,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.875,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.121799997985363,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oral-squamous-cell-carcinoma","display_name":"oral squamous cell carcinoma","score":0.9369999766349792},{"id":"https://openalex.org/keywords/gene-pairs","display_name":"gene pairs","score":0.7310000061988831},{"id":"https://openalex.org/keywords/gene-co-expression","display_name":"gene co-expression","score":0.6079999804496765},{"id":"https://openalex.org/keywords/gene-expression-profiles","display_name":"gene expression profiles","score":0.5139999985694885},{"id":"https://openalex.org/keywords/microarray-data","display_name":"microarray data","score":0.6129999756813049},{"id":"https://openalex.org/keywords/disease-mechanisms","display_name":"disease mechanisms","score":0.5}],"concepts":[{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.7739516496658325},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.7632666826248169},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.6663055419921875},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6557197570800781},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6271414160728455},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.5926221609115601},{"id":"https://openalex.org/C3019992690","wikidata":"https://www.wikidata.org/wiki/Q92767510","display_name":"Basal cell","level":2,"score":0.5183066725730896},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5156003832817078},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.4933554232120514},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4831242263317108},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.33805686235427856},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.12647947669029236},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11496403813362122},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009062","descriptor_name":"Mouth Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018709","descriptor_name":"Statistics, Nonparametric","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:14728197","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14728197","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AMIA ... Annual Symposium proceedings. AMIA Symposium","raw_type":"Journal Article"},{"id":"mag:18532184","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14728197","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W1556472699","https://openalex.org/W1752488807","https://openalex.org/W1992452843","https://openalex.org/W1995342232","https://openalex.org/W2109363337","https://openalex.org/W2135187880","https://openalex.org/W2150926065","https://openalex.org/W2159203162"],"related_works":["https://openalex.org/W1985575688","https://openalex.org/W7151786443","https://openalex.org/W2597887158","https://openalex.org/W2794391482","https://openalex.org/W2107867141","https://openalex.org/W2884502789","https://openalex.org/W2361407211","https://openalex.org/W2134931522","https://openalex.org/W2982679498","https://openalex.org/W7099853017"],"abstract_inverted_index":{"We":[0,85],"developed":[1],"a":[2,82],"novel":[3],"method":[4,61],"for":[5,110],"the":[6,36,39,67,77,87],"discovery":[7],"of":[8,13,29,76,89],"functional":[9,78],"relationships":[10,79],"between":[11,38,69],"pairs":[12,28],"genes":[14,30,41],"based":[15],"on":[16,56],"gene":[17],"expression":[18],"profiles":[19],"generated":[20],"from":[21],"microarrays.":[22],"This":[23],"approach":[24,91],"examines":[25],"all":[26],"possible":[27],"and":[31],"identifies":[32],"those":[33],"in":[34,43,66],"which":[35],"relationship":[37],"two":[40],"changes":[42,65,72],"different":[44],"diseases":[45],"or":[46],"conditions.":[47],"In":[48],"contrast":[49],"to":[50,63,81,95],"previous":[51],"methods":[52],"that":[53],"have":[54],"focused":[55],"differentially":[57],"expressed":[58],"genes,":[59],"this":[60,90],"attempts":[62],"find":[64],"correlation":[68],"genes.":[70],"These":[71],"may":[73],"be":[74],"indicative":[75],"related":[80],"disease":[83],"mechanism.":[84],"demonstrate":[86],"utility":[88],"by":[92],"applying":[93],"it":[94],"an":[96],"oral":[97],"squamous":[98],"cell":[99],"carcinoma":[100],"(OSCC)":[101],"microarray":[102],"data":[103],"set.":[104],"Our":[105],"results":[106],"suggest":[107],"new":[108],"directions":[109],"future":[111],"experimental":[112],"investigations.":[113]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}