{"id":"https://openalex.org/W185319587","doi":"https://doi.org/10.1089/ars.2014.5873","title":"Abnormal Ca 2+ Cycling in Failing Ventricular Myocytes: Role of NOS1-Mediated Nitroso-Redox Balance","display_name":"Abnormal Ca 2+ Cycling in Failing Ventricular Myocytes: Role of NOS1-Mediated Nitroso-Redox Balance","publication_year":2014,"publication_date":"2014-05-07","ids":{"openalex":"https://openalex.org/W185319587","doi":"https://doi.org/10.1089/ars.2014.5873","mag":"185319587","pmid":"https://pubmed.ncbi.nlm.nih.gov/24801117","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4208612"},"language":"en","primary_location":{"id":"doi:10.1089/ars.2014.5873","doi":"https://doi.org/10.1089/ars.2014.5873","is_oa":false,"landing_page_url":"https://doi.org/10.1089/ars.2014.5873","pdf_url":null,"source":{"id":"https://openalex.org/S88052261","display_name":"Antioxidants and Redox Signaling","issn_l":"1523-0864","issn":["1523-0864","1557-7716"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxidants & Redox Signaling","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4208612","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040074839","display_name":"Mark T. Ziolo","orcid":"https://orcid.org/0000-0002-8810-2284","observed_orcids":["https://orcid.org/0000-0002-8810-2284"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mark T. Ziolo","raw_affiliation_strings":["The Ohio State University","Department of Physiology and Cell Biology, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State University","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"Department of Physiology and Cell Biology, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067892109","display_name":"Steven R. Houser","orcid":"https://orcid.org/0000-0001-6359-5425","observed_orcids":["https://orcid.org/0000-0001-6359-5425"]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven R. Houser","raw_affiliation_strings":["Temple University","Department of Physiology, Cardiovascular Research Center, Temple University, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Temple University","institution_ids":["https://openalex.org/I84392919"]},{"raw_affiliation_string":"Department of Physiology, Cardiovascular Research Center, Temple University, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I84392919"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5040074839"],"corresponding_institution_ids":["https://openalex.org/I52357470"],"apc_list":null,"apc_paid":null,"fwci":0.4316,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.36759514,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"21","issue":"14","first_page":"2044","last_page":"2059"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.7734000086784363,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.7734000086784363,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.06849999725818634,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.0674000009894371,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.9929999709129333},{"id":"https://openalex.org/keywords/calcium-handling","display_name":"calcium handling","score":0.6679999828338623},{"id":"https://openalex.org/keywords/ventricular-myocytes","display_name":"ventricular myocytes","score":0.9819999933242798},{"id":"https://openalex.org/keywords/nitric-oxide-synthase-1","display_name":"nitric oxide synthase 1","score":0.8579999804496765},{"id":"https://openalex.org/keywords/superoxide-radicals","display_name":"superoxide","score":0.6980000138282776},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8619999885559082},{"id":"https://openalex.org/keywords/redox-signaling","display_name":"redox signaling","score":0.9599999785423279},{"id":"https://openalex.org/keywords/antioxidant-therapy","display_name":"antioxidant therapy","score":0.531000018119812},{"id":"https://openalex.org/keywords/contractile-dysfunction","display_name":"contractile dysfunction","score":0.8339999914169312},{"id":"https://openalex.org/keywords/cardiac-remodeling","display_name":"cardiac remodeling","score":0.6759999990463257}],"concepts":[{"id":"https://openalex.org/C55904794","wikidata":"https://www.wikidata.org/wiki/Q82682","display_name":"Redox","level":2,"score":0.6662279367446899},{"id":"https://openalex.org/C2775932965","wikidata":"https://www.wikidata.org/wiki/Q57712202","display_name":"Nitroso","level":2,"score":0.6150973439216614},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5706177949905396},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.5546278357505798},{"id":"https://openalex.org/C541528975","wikidata":"https://www.wikidata.org/wiki/Q53121","display_name":"Cycling","level":2,"score":0.5344727635383606},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.49066412448883057},{"id":"https://openalex.org/C168031717","wikidata":"https://www.wikidata.org/wiki/Q1530280","display_name":"Balance (ability)","level":2,"score":0.45469632744789124},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.44332408905029297},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3239070177078247},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2474684715270996},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.11503130197525024},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.1120758056640625},{"id":"https://openalex.org/C155647269","wikidata":"https://www.wikidata.org/wiki/Q243455","display_name":"Medicinal chemistry","level":1,"score":0.08720630407333374},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C95457728","wikidata":"https://www.wikidata.org/wiki/Q309","display_name":"History","level":0,"score":0.0},{"id":"https://openalex.org/C166957645","wikidata":"https://www.wikidata.org/wiki/Q23498","display_name":"Archaeology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006352","descriptor_name":"Heart Ventricles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006352","descriptor_name":"Heart Ventricles","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009200","descriptor_name":"Myocardial Contraction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D052248","descriptor_name":"Nitric Oxide Synthase Type I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1089/ars.2014.5873","doi":"https://doi.org/10.1089/ars.2014.5873","is_oa":false,"landing_page_url":"https://doi.org/10.1089/ars.2014.5873","pdf_url":null,"source":{"id":"https://openalex.org/S88052261","display_name":"Antioxidants and Redox Signaling","issn_l":"1523-0864","issn":["1523-0864","1557-7716"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxidants & Redox Signaling","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3611918","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4208612","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4208612","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4208612","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxid Redox Signal","raw_type":"Text"},{"id":"pmid:24801117","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24801117","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxidants & redox signaling","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3611918","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4208612","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5600000023841858}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1154239676","display_name":"Calcium and Cardiac Regeneration after Myocardial Infarction","funder_award_id":"R01HL033921","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2365392527","display_name":"Nitric oxide signaling in healthy and diseased cardiac myocytes","funder_award_id":"K02HL094692","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4614689426","display_name":null,"funder_award_id":"HL-33921","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4827549421","display_name":null,"funder_award_id":"HL 094692","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6727582741","display_name":"Improving Cardiac Function After Myocardial Infarction","funder_award_id":"P01HL108806","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000161651","display_name":null,"funder_award_id":"HL33921","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":194,"referenced_works":["https://openalex.org/W193161323","https://openalex.org/W1414418298","https://openalex.org/W1430858901","https://openalex.org/W1488493608","https://openalex.org/W1492161308","https://openalex.org/W1497333599","https://openalex.org/W1502795332","https://openalex.org/W1505873700","https://openalex.org/W1530888481","https://openalex.org/W1563862298","https://openalex.org/W1678920698","https://openalex.org/W1730569001","https://openalex.org/W1747918402","https://openalex.org/W1826983063","https://openalex.org/W1837902822","https://openalex.org/W1946625793","https://openalex.org/W1953423403","https://openalex.org/W1964847650","https://openalex.org/W1967428301","https://openalex.org/W1969197079","https://openalex.org/W1969968096","https://openalex.org/W1973313311","https://openalex.org/W1974229149","https://openalex.org/W1974780945","https://openalex.org/W1975829062","https://openalex.org/W1976294480","https://openalex.org/W1977584503","https://openalex.org/W1978747078","https://openalex.org/W1980142263","https://openalex.org/W1981591574","https://openalex.org/W1986377133","https://openalex.org/W1989929553","https://openalex.org/W1990215202","https://openalex.org/W1990304386","https://openalex.org/W1992290425","https://openalex.org/W1993039541","https://openalex.org/W1994092760","https://openalex.org/W1995444906","https://openalex.org/W2000754365","https://openalex.org/W2000954596","https://openalex.org/W2001593050","https://openalex.org/W2003414258","https://openalex.org/W2004560046","https://openalex.org/W2004677075","https://openalex.org/W2004724154","https://openalex.org/W2005591501","https://openalex.org/W2007011272","https://openalex.org/W2007274732","https://openalex.org/W2007317026","https://openalex.org/W2009595653","https://openalex.org/W2009700086","https://openalex.org/W2011741149","https://openalex.org/W2013301331","https://openalex.org/W2014501709","https://openalex.org/W2014826453","https://openalex.org/W2014977126","https://openalex.org/W2015221597","https://openalex.org/W2017415739","https://openalex.org/W2019435811","https://openalex.org/W2020783425","https://openalex.org/W2021968322","https://openalex.org/W2022006673","https://openalex.org/W2023144609","https://openalex.org/W2023602943","https://openalex.org/W2024690999","https://openalex.org/W2025703404","https://openalex.org/W2026517131","https://openalex.org/W2026694431","https://openalex.org/W2027097035","https://openalex.org/W2027204345","https://openalex.org/W2030929060","https://openalex.org/W2034315036","https://openalex.org/W2037686934","https://openalex.org/W2037755911","https://openalex.org/W2037864697","https://openalex.org/W2038742469","https://openalex.org/W2038965219","https://openalex.org/W2039512686","https://openalex.org/W2040460879","https://openalex.org/W2040603631","https://openalex.org/W2041053875","https://openalex.org/W2041891844","https://openalex.org/W2042993494","https://openalex.org/W2043294986","https://openalex.org/W2044438496","https://openalex.org/W2044636253","https://openalex.org/W2045408001","https://openalex.org/W2047764172","https://openalex.org/W2048782251","https://openalex.org/W2050022795","https://openalex.org/W2050634155","https://openalex.org/W2050824263","https://openalex.org/W2050975011","https://openalex.org/W2051302531","https://openalex.org/W2051645126","https://openalex.org/W2053387749","https://openalex.org/W2054120564","https://openalex.org/W2055117340","https://openalex.org/W2058058175","https://openalex.org/W2059406577","https://openalex.org/W2061406590","https://openalex.org/W2062073230","https://openalex.org/W2064951152","https://openalex.org/W2065773243","https://openalex.org/W2068102085","https://openalex.org/W2068613600","https://openalex.org/W2069249788","https://openalex.org/W2069646480","https://openalex.org/W2070804621","https://openalex.org/W2072533343","https://openalex.org/W2075446232","https://openalex.org/W2075886742","https://openalex.org/W2077033733","https://openalex.org/W2081529440","https://openalex.org/W2081904592","https://openalex.org/W2082452850","https://openalex.org/W2082823804","https://openalex.org/W2085253569","https://openalex.org/W2086301758","https://openalex.org/W2086855768","https://openalex.org/W2089090200","https://openalex.org/W2089195576","https://openalex.org/W2090016088","https://openalex.org/W2090502913","https://openalex.org/W2091583229","https://openalex.org/W2094391023","https://openalex.org/W2095778449","https://openalex.org/W2096995613","https://openalex.org/W2098689751","https://openalex.org/W2098950302","https://openalex.org/W2099136646","https://openalex.org/W2100143490","https://openalex.org/W2100611216","https://openalex.org/W2101032933","https://openalex.org/W2107031860","https://openalex.org/W2109338235","https://openalex.org/W2109893157","https://openalex.org/W2112616547","https://openalex.org/W2114341210","https://openalex.org/W2115258969","https://openalex.org/W2115557889","https://openalex.org/W2116297568","https://openalex.org/W2116532275","https://openalex.org/W2121998234","https://openalex.org/W2123360435","https://openalex.org/W2124011330","https://openalex.org/W2125519662","https://openalex.org/W2126825653","https://openalex.org/W2127952198","https://openalex.org/W2128908058","https://openalex.org/W2129107858","https://openalex.org/W2132073262","https://openalex.org/W2133000747","https://openalex.org/W2133966054","https://openalex.org/W2134033040","https://openalex.org/W2135289666","https://openalex.org/W2138950473","https://openalex.org/W2139337253","https://openalex.org/W2139613162","https://openalex.org/W2140023412","https://openalex.org/W2140313980","https://openalex.org/W2141275308","https://openalex.org/W2141573806","https://openalex.org/W2141663828","https://openalex.org/W2142219196","https://openalex.org/W2143277924","https://openalex.org/W2144103385","https://openalex.org/W2145771828","https://openalex.org/W2146070419","https://openalex.org/W2146584509","https://openalex.org/W2147959747","https://openalex.org/W2148030708","https://openalex.org/W2149180473","https://openalex.org/W2150757211","https://openalex.org/W2151912878","https://openalex.org/W2153910284","https://openalex.org/W2154206971","https://openalex.org/W2155116390","https://openalex.org/W2157973908","https://openalex.org/W2159689950","https://openalex.org/W2160306365","https://openalex.org/W2161189845","https://openalex.org/W2164023695","https://openalex.org/W2164444293","https://openalex.org/W2167236268","https://openalex.org/W2167407855","https://openalex.org/W2169220342","https://openalex.org/W2171466485","https://openalex.org/W2238440277","https://openalex.org/W2316371152","https://openalex.org/W2399644778","https://openalex.org/W2467845479","https://openalex.org/W2792980560","https://openalex.org/W4247088117"],"related_works":["https://openalex.org/W2222150581","https://openalex.org/W2086848358","https://openalex.org/W2088358888","https://openalex.org/W2018010106","https://openalex.org/W2161895190","https://openalex.org/W2085111794","https://openalex.org/W2123360435","https://openalex.org/W2075416847","https://openalex.org/W7223102778","https://openalex.org/W3212197503"],"abstract_inverted_index":{"SIGNIFICANCE:":[0],"Heart":[1],"failure":[2],"(HF)":[3],"results":[4],"from":[5],"poor":[6,37],"heart":[7,38,152],"function":[8],"and":[9,66,136,150],"is":[10,92,117,129],"the":[11,24,27,36,49,55,63,113,125],"leading":[12],"cause":[13],"of":[14,20,26,35,62,109],"death":[15],"in":[16,71,86],"Western":[17],"society.":[18],"Abnormalities":[19],"Ca(2+)":[21,51],"handling":[22],"at":[23],"level":[25],"ventricular":[28],"myocyte":[29,148],"are":[30],"largely":[31],"responsible":[32],"for":[33,48],"much":[34,61],"function.":[39,153],"RECENT":[40],"ADVANCES:":[41],"Although":[42],"studies":[43],"have":[44,58],"unraveled":[45],"numerous":[46],"mechanisms":[47],"abnormal":[50],"handling,":[52],"investigations":[53],"over":[54],"past":[56],"decade":[57],"indicated":[59],"that":[60,69,139],"contractile":[64],"dysfunction":[65],"adverse":[67],"remodeling":[68],"occurs":[70],"HF":[72],"involves":[73],"oxidative":[74],"stress.":[75],"CRITICAL":[76],"ISSUES:":[77],"Regrettably,":[78],"antioxidant":[79],"therapy":[80],"has":[81],"been":[82],"an":[83],"immense":[84],"disappointment":[85],"clinical":[87],"trials.":[88],"Thus,":[89],"redox":[90,110],"signaling":[91,111],"being":[93],"reassessed":[94],"to":[95,100,146],"elucidate":[96],"why":[97],"antioxidants":[98],"failed":[99],"treat":[101],"HF.":[102],"FUTURE":[103],"DIRECTIONS:":[104],"A":[105],"recently":[106],"identified":[107],"aspect":[108],"(specifically":[112],"superoxide":[114],"anion":[115],"radical)":[116],"its":[118],"interaction":[119],"with":[120,134],"nitric":[121],"oxide,":[122],"known":[123],"as":[124],"nitroso-redox":[126,132],"balance.":[127],"There":[128],"a":[130],"large":[131],"imbalance":[133,142],"HF,":[135],"we":[137],"suggest":[138],"correcting":[140],"this":[141],"may":[143],"be":[144],"able":[145],"restore":[147],"contraction":[149],"improve":[151]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}