{"id":"https://openalex.org/W1852811226","doi":"https://doi.org/10.1128/mcb.19.10.7181","title":"C/EBP\u03b2 Modulates the Early Events of Keratinocyte Differentiation Involving Growth Arrest and Keratin 1 and Keratin 10 Expression","display_name":"C/EBP\u03b2 Modulates the Early Events of Keratinocyte Differentiation Involving Growth Arrest and Keratin 1 and Keratin 10 Expression","publication_year":1999,"publication_date":"1999-10-01","ids":{"openalex":"https://openalex.org/W1852811226","doi":"https://doi.org/10.1128/mcb.19.10.7181","mag":"1852811226","pmid":"https://pubmed.ncbi.nlm.nih.gov/10490653","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/84711"},"language":"en","primary_location":{"id":"doi:10.1128/mcb.19.10.7181","doi":"https://doi.org/10.1128/mcb.19.10.7181","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.19.10.7181","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC84711","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113540115","display_name":"Songyun Zhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Songyun Zhu","raw_affiliation_strings":["Molecular and Cellular Toxicology, Department of Toxicology, North Carolina State University","Molecular and Cellular Toxicology, Department of Toxicology, North Carolina State University, Raleigh, North Carolina 27695-7633, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular and Cellular Toxicology, Department of Toxicology, North Carolina State University","institution_ids":["https://openalex.org/I137902535"]},{"raw_affiliation_string":"Molecular and Cellular Toxicology, Department of Toxicology, North Carolina State University, Raleigh, North Carolina 27695-7633, USA","institution_ids":["https://openalex.org/I137902535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022354121","display_name":"Hye-Sun Oh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hye-Sun Oh","raw_affiliation_strings":["Molecular and Cellular Toxicology, Department of Toxicology, North Carolina State University","Molecular and Cellular Toxicology, Department of Toxicology, North Carolina State University, Raleigh, North Carolina 27695-7633,#N#1#N# and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular and Cellular Toxicology, Department of Toxicology, North Carolina State University","institution_ids":["https://openalex.org/I137902535"]},{"raw_affiliation_string":"Molecular and Cellular Toxicology, Department of Toxicology, North Carolina State University, Raleigh, North Carolina 27695-7633,#N#1#N# and","institution_ids":["https://openalex.org/I137902535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011767634","display_name":"Minsub Shim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Minsub Shim","raw_affiliation_strings":["Molecular and Cellular Toxicology, Department of Toxicology, North Carolina State University","Molecular and Cellular Toxicology, Department of Toxicology, North Carolina State University, Raleigh, North Carolina 27695-7633,#N#1#N# and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular and Cellular Toxicology, Department of Toxicology, North Carolina State University","institution_ids":["https://openalex.org/I137902535"]},{"raw_affiliation_string":"Molecular and Cellular Toxicology, Department of Toxicology, North Carolina State University, Raleigh, North Carolina 27695-7633,#N#1#N# and","institution_ids":["https://openalex.org/I137902535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070489823","display_name":"Esta Sterneck","orcid":"https://orcid.org/0000-0001-7716-8766","observed_orcids":["https://orcid.org/0000-0001-7716-8766"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Esta Sterneck","raw_affiliation_strings":["Eukaryotic Transcriptional Regulation Group, ABL-Basic Research Program, National Cancer Institute, Frederick Cancer Research and Development Center","#N#Eukaryotic Transcriptional Regulation Group, ABL-Basic Research Program, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland 21702-1201#N#2#N##N#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eukaryotic Transcriptional Regulation Group, ABL-Basic Research Program, National Cancer Institute, Frederick Cancer Research and Development Center","institution_ids":["https://openalex.org/I4210140884"]},{"raw_affiliation_string":"#N#Eukaryotic Transcriptional Regulation Group, ABL-Basic Research Program, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland 21702-1201#N#2#N##N#","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018475996","display_name":"Peter F. Johnson","orcid":"https://orcid.org/0000-0002-4145-4725","observed_orcids":["https://orcid.org/0000-0002-4145-4725"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter F. Johnson","raw_affiliation_strings":["Eukaryotic Transcriptional Regulation Group, ABL-Basic Research Program, National Cancer Institute, Frederick Cancer Research and Development Center","#N#Eukaryotic Transcriptional Regulation Group, ABL-Basic Research Program, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland 21702-1201#N#2#N##N#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eukaryotic Transcriptional Regulation Group, ABL-Basic Research Program, National Cancer Institute, Frederick Cancer Research and Development Center","institution_ids":["https://openalex.org/I4210140884"]},{"raw_affiliation_string":"#N#Eukaryotic Transcriptional Regulation Group, ABL-Basic Research Program, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland 21702-1201#N#2#N##N#","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087238768","display_name":"Robert C. Smart","orcid":"https://orcid.org/0000-0002-6767-6756","observed_orcids":["https://orcid.org/0000-0002-6767-6756"]},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robert C. Smart","raw_affiliation_strings":["Molecular and Cellular Toxicology, Department of Toxicology, North Carolina State University","Molecular and Cellular Toxicology, Department of Toxicology, North Carolina State University, Raleigh, North Carolina 27695-7633,#N#1#N# and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular and Cellular Toxicology, Department of Toxicology, North Carolina State University","institution_ids":["https://openalex.org/I137902535"]},{"raw_affiliation_string":"Molecular and Cellular Toxicology, Department of Toxicology, North Carolina State University, Raleigh, North Carolina 27695-7633,#N#1#N# and","institution_ids":["https://openalex.org/I137902535"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5087238768"],"corresponding_institution_ids":["https://openalex.org/I137902535"],"apc_list":null,"apc_paid":null,"fwci":1.2395,"has_fulltext":false,"cited_by_count":148,"citation_normalized_percentile":{"value":0.75125881,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"19","issue":"10","first_page":"7181","last_page":"7190"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11650","display_name":"Skin and Cellular Biology Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11650","display_name":"Skin and Cellular Biology Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11167","display_name":"Hair Growth and Disorders","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12355","display_name":"Genetic and rare skin diseases.","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/c-ebpbeta","display_name":"C/EBP\u03b2","score":0.9829999804496765},{"id":"https://openalex.org/keywords/keratinocyte-differentiation","display_name":"keratinocyte differentiation","score":0.9800000190734863},{"id":"https://openalex.org/keywords/epidermal-stratification","display_name":"epidermal stratification","score":0.8019999861717224},{"id":"https://openalex.org/keywords/growth-arrest","display_name":"growth arrest","score":0.7720000147819519},{"id":"https://openalex.org/keywords/keratin-1","display_name":"keratin 1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/keratin-10","display_name":"keratin 10","score":1.0},{"id":"https://openalex.org/keywords/epidermal-hyperplasia","display_name":"epidermal hyperplasia","score":0.9259999990463257},{"id":"https://openalex.org/keywords/involucrin","display_name":"involucrin","score":0.8330000042915344},{"id":"https://openalex.org/keywords/loricrin","display_name":"loricrin","score":0.9919999837875366},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.6349999904632568}],"concepts":[{"id":"https://openalex.org/C81241287","wikidata":"https://www.wikidata.org/wiki/Q189474","display_name":"Keratin","level":2,"score":0.887101411819458},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8512994050979614},{"id":"https://openalex.org/C2777074287","wikidata":"https://www.wikidata.org/wiki/Q1473931","display_name":"Keratinocyte","level":3,"score":0.7084150910377502},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.579306960105896},{"id":"https://openalex.org/C50548948","wikidata":"https://www.wikidata.org/wiki/Q14907896","display_name":"Keratin 8","level":3,"score":0.45169517397880554},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3356415033340454},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23221543431282043},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.1379690170288086}],"mesh":[{"descriptor_ui":"D000078404","descriptor_name":"Epidermal Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007633","descriptor_name":"Keratins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D008817","descriptor_name":"Mice, Mutant Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011498","descriptor_name":"Protein Precursors","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D015533","descriptor_name":"Transcriptional Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015603","descriptor_name":"Keratinocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022762","descriptor_name":"CCAAT-Enhancer-Binding Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053550","descriptor_name":"Keratin-10","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1128/mcb.19.10.7181","doi":"https://doi.org/10.1128/mcb.19.10.7181","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.19.10.7181","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:183501","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC84711","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:84711","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/84711","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Cell Biol","raw_type":"Text"},{"id":"pmid:10490653","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10490653","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and cellular biology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.419.8749","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.419.8749","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://service004.hpc.ncsu.edu/toxicology/faculty/smart/PDF's/Zhu 1999.pdf","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:183501","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC84711","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":60,"referenced_works":["https://openalex.org/W179818011","https://openalex.org/W215245711","https://openalex.org/W321874077","https://openalex.org/W1479725497","https://openalex.org/W1508935646","https://openalex.org/W1528349601","https://openalex.org/W1563613529","https://openalex.org/W1569152804","https://openalex.org/W1580811574","https://openalex.org/W1584008028","https://openalex.org/W1593187788","https://openalex.org/W1606298359","https://openalex.org/W1636221253","https://openalex.org/W1775749144","https://openalex.org/W1813392716","https://openalex.org/W1819840072","https://openalex.org/W1890532746","https://openalex.org/W1971533139","https://openalex.org/W1973869185","https://openalex.org/W1974725462","https://openalex.org/W1983585255","https://openalex.org/W1983683479","https://openalex.org/W1984240546","https://openalex.org/W1985103299","https://openalex.org/W1986184556","https://openalex.org/W1998183746","https://openalex.org/W2005019916","https://openalex.org/W2017359994","https://openalex.org/W2017515632","https://openalex.org/W2018576877","https://openalex.org/W2018748897","https://openalex.org/W2020575571","https://openalex.org/W2035388701","https://openalex.org/W2038085058","https://openalex.org/W2038269021","https://openalex.org/W2041460044","https://openalex.org/W2051665279","https://openalex.org/W2052165202","https://openalex.org/W2052218355","https://openalex.org/W2073638852","https://openalex.org/W2079431376","https://openalex.org/W2086689906","https://openalex.org/W2090784961","https://openalex.org/W2094830334","https://openalex.org/W2098974513","https://openalex.org/W2113187253","https://openalex.org/W2124753274","https://openalex.org/W2127174344","https://openalex.org/W2134098588","https://openalex.org/W2134352492","https://openalex.org/W2139440574","https://openalex.org/W2141728368","https://openalex.org/W2155549511","https://openalex.org/W2157438849","https://openalex.org/W2170005346","https://openalex.org/W2182302387","https://openalex.org/W2227731902","https://openalex.org/W2328687205","https://openalex.org/W2406317739","https://openalex.org/W2418691345"],"related_works":["https://openalex.org/W7097801944","https://openalex.org/W2007702182","https://openalex.org/W1964269036","https://openalex.org/W1508935646","https://openalex.org/W1971533139","https://openalex.org/W1997325504","https://openalex.org/W7097171094","https://openalex.org/W2149182758","https://openalex.org/W2057659096","https://openalex.org/W2046114655"],"abstract_inverted_index":{"The":[0,24],"epidermis":[1,37,141],"is":[2,54],"a":[3,67,73,106,126,146],"stratified":[4,222],"squamous":[5,223],"epithelium":[6],"composed":[7],"primarily":[8],"of":[9,26,48,62,94,115,132,139,142,153,159,174,201,221],"keratinocytes":[10,40,65,80,98,165,179,191,226],"that":[11,59,86,189,211],"become":[12],"postmitotic":[13],"and":[14,38,90,110,120,136,150,155,161,197,230,232],"undergo":[15],"sequential":[16],"changes":[17,103],"in":[18,72,76,96,195,217,225],"gene":[19],"expression":[20,25,93,131,152,200],"during":[21],"terminal":[22],"differentiation.":[23,91],"the":[27,46,51,130,140,218],"transcription":[28],"factor":[29],"CCAAT/enhancer":[30],"binding":[31],"protein":[32],"beta":[33],"(C/EBPbeta)":[34],"within":[35,50],"mouse":[36,63],"primary":[39,64,164],"has":[41],"recently":[42],"been":[43],"described;":[44],"however,":[45],"function":[47],"C/EBPbeta":[49,95,212],"epidermal":[52,148],"keratinocyte":[53],"unknown.":[55],"We":[56],"report":[57],"here":[58],"transient":[60],"transfection":[61],"with":[66,105],"C/EBP-responsive":[68],"promoter-reporter":[69],"construct":[70],"resulted":[71],"sevenfold":[74],"increase":[75],"luciferase":[77],"activity":[78],"when":[79],"were":[81,166],"switched":[82],"to":[83,169,183],"culture":[84,187],"conditions":[85],"induce":[87],"growth":[88,171,228],"arrest":[89,229],"Forced":[92],"BALB/MK2":[97],"inhibited":[99],"growth,":[100],"induced":[101,182],"morphological":[102],"consistent":[104],"more":[107],"differentiated":[108,176],"phenotype,":[109],"upregulated":[111],"two":[112],"early":[113,219],"markers":[114,203],"differentiation,":[116],"keratin":[117,121],"1":[118],"(K1)":[119],"10":[122],"(K10)":[123],"but":[124,157],"had":[125],"minimal":[127],"effect":[128],"on":[129],"late-stage":[133],"markers,":[134],"loricrin":[135],"involucrin.":[137],"Analysis":[138,173],"C/EBPbeta-deficient":[143,163,190],"mice":[144],"revealed":[145,188],"mild":[147],"hyperplasia":[149],"decreased":[151],"K1":[154,196,231],"K10":[156,233],"not":[158],"involucrin":[160],"loricrin.":[162],"partially":[167],"resistant":[168],"calcium-induced":[170],"arrest.":[172],"terminally":[175],"spontaneously":[177],"detached":[178],"or":[180],"those":[181],"differentiate":[184],"by":[185],"suspension":[186],"displayed":[192],"striking":[193],"decreases":[194],"K10,":[198],"while":[199],"later-stage":[202],"was":[204],"only":[205],"minimally":[206],"altered.":[207],"Our":[208],"results":[209],"demonstrate":[210],"plays":[213],"an":[214],"important":[215],"role":[216],"events":[220],"differentiation":[224],"involving":[227],"expression.":[234]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}