{"id":"https://openalex.org/W185242811","doi":null,"title":"The Molecular Mechanism of Aggression and Feeding Behaviour in Drosophila melanogaster","display_name":"The Molecular Mechanism of Aggression and Feeding Behaviour in Drosophila melanogaster","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W185242811","mag":"185242811"},"language":"en","primary_location":{"id":"pmh:oai:DiVA.org:uu-229124","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-229124","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-229124","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048339056","display_name":"Philip Goergen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Philip Goergen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5048339056"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aggression","display_name":"aggression","score":0.9049999713897705},{"id":"https://openalex.org/keywords/feeding-behaviour","display_name":"feeding behaviour","score":1.0},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.8429999947547913},{"id":"https://openalex.org/keywords/drosophila-melanogaster","display_name":"Drosophila melanogaster","score":0.949999988079071},{"id":"https://openalex.org/keywords/ap-2-transcription-factor","display_name":"AP2 transcription factor","score":0.824999988079071},{"id":"https://openalex.org/keywords/octopamine","display_name":"octopamine","score":0.8930000066757202},{"id":"https://openalex.org/keywords/octopaminergic-neurons","display_name":"octopaminergic neurons","score":0.8799999952316284},{"id":"https://openalex.org/keywords/rac2","display_name":"Rac2","score":0.6650000214576721},{"id":"https://openalex.org/keywords/small-gtpases","display_name":"small GTPases","score":0.7179999947547913},{"id":"https://openalex.org/keywords/insulin-signaling","display_name":"insulin signaling","score":0.6579999923706055},{"id":"https://openalex.org/keywords/insulin-producing-cells","display_name":"insulin-producing cells","score":0.9039999842643738},{"id":"https://openalex.org/keywords/protein-kinase-d","display_name":"protein kinase D","score":0.7820000052452087},{"id":"https://openalex.org/keywords/metabolic-homeostasis","display_name":"metabolic homeostasis","score":0.847000002861023},{"id":"https://openalex.org/keywords/courtship-behavior","display_name":"courtship behavior","score":0.9120000004768372}],"concepts":[{"id":"https://openalex.org/C2779448149","wikidata":"https://www.wikidata.org/wiki/Q191797","display_name":"Aggression","level":2,"score":0.7840536832809448},{"id":"https://openalex.org/C2780104201","wikidata":"https://www.wikidata.org/wiki/Q130888","display_name":"Drosophila melanogaster","level":3,"score":0.7330405116081238},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6477455496788025},{"id":"https://openalex.org/C2776453541","wikidata":"https://www.wikidata.org/wiki/Q376596","display_name":"Courtship","level":2,"score":0.6054275035858154},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5906076431274414},{"id":"https://openalex.org/C2776041557","wikidata":"https://www.wikidata.org/wiki/Q3715451","display_name":"Drosophila (subgenus)","level":3,"score":0.5778776407241821},{"id":"https://openalex.org/C514575182","wikidata":"https://www.wikidata.org/wiki/Q228395","display_name":"Mating","level":2,"score":0.5663048028945923},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.5379932522773743},{"id":"https://openalex.org/C74318829","wikidata":"https://www.wikidata.org/wiki/Q36458","display_name":"Multicellular organism","level":3,"score":0.5178230404853821},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4372691512107849},{"id":"https://openalex.org/C1337776","wikidata":"https://www.wikidata.org/wiki/Q1941955","display_name":"Facilitation","level":2,"score":0.4234501123428345},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4092819094657898},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.24533513188362122},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.21157553791999817},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.21008923649787903},{"id":"https://openalex.org/C90856448","wikidata":"https://www.wikidata.org/wiki/Q431","display_name":"Zoology","level":1,"score":0.17925891280174255},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.16515383124351501},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:DiVA.org:uu-229124","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-229124","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:185242811","doi":null,"is_oa":false,"landing_page_url":"http://uu.diva-portal.org/smash/get/diva2:735789/FULLTEXT01.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:DiVA.org:uu-229124","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-229124","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4043000042438507,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":150,"referenced_works":["https://openalex.org/W142036609","https://openalex.org/W1483765474","https://openalex.org/W1497506244","https://openalex.org/W1512875938","https://openalex.org/W1522183720","https://openalex.org/W1546792714","https://openalex.org/W1547754184","https://openalex.org/W1572982878","https://openalex.org/W1578580470","https://openalex.org/W1596198528","https://openalex.org/W1819496837","https://openalex.org/W1846385421","https://openalex.org/W1964343290","https://openalex.org/W1965495036","https://openalex.org/W1966530523","https://openalex.org/W1967119663","https://openalex.org/W1967843472","https://openalex.org/W1970889645","https://openalex.org/W1970980171","https://openalex.org/W1972432651","https://openalex.org/W1974072891","https://openalex.org/W1978281808","https://openalex.org/W1978637766","https://openalex.org/W1980403687","https://openalex.org/W1980892600","https://openalex.org/W1981158347","https://openalex.org/W1981542980","https://openalex.org/W1985178609","https://openalex.org/W1987830443","https://openalex.org/W1987942547","https://openalex.org/W1988845930","https://openalex.org/W1990484548","https://openalex.org/W1990775620","https://openalex.org/W1991836743","https://openalex.org/W1992496728","https://openalex.org/W1993827187","https://openalex.org/W1994639198","https://openalex.org/W1994970026","https://openalex.org/W1996001084","https://openalex.org/W1998038483","https://openalex.org/W1998387093","https://openalex.org/W1999409371","https://openalex.org/W2003810563","https://openalex.org/W2006045768","https://openalex.org/W2006641069","https://openalex.org/W2006885241","https://openalex.org/W2006923825","https://openalex.org/W2008408686","https://openalex.org/W2014137007","https://openalex.org/W2014605680","https://openalex.org/W2014887370","https://openalex.org/W2016821096","https://openalex.org/W2017882621","https://openalex.org/W2020291622","https://openalex.org/W2022185109","https://openalex.org/W2022984394","https://openalex.org/W2023765792","https://openalex.org/W2026790926","https://openalex.org/W2026997028","https://openalex.org/W2027387847","https://openalex.org/W2029021750","https://openalex.org/W2029787649","https://openalex.org/W2030439009","https://openalex.org/W2033242614","https://openalex.org/W2033949300","https://openalex.org/W2036952225","https://openalex.org/W2037415930","https://openalex.org/W2041499292","https://openalex.org/W2041729197","https://openalex.org/W2043760958","https://openalex.org/W2044981034","https://openalex.org/W2045467759","https://openalex.org/W2046570924","https://openalex.org/W2047978220","https://openalex.org/W2048479716","https://openalex.org/W2051980557","https://openalex.org/W2053326139","https://openalex.org/W2056695646","https://openalex.org/W2057197904","https://openalex.org/W2059735623","https://openalex.org/W2064385910","https://openalex.org/W2065505889","https://openalex.org/W2066612245","https://openalex.org/W2070211813","https://openalex.org/W2071280486","https://openalex.org/W2071804523","https://openalex.org/W2072031942","https://openalex.org/W2072558955","https://openalex.org/W2073787597","https://openalex.org/W2073958527","https://openalex.org/W2075736224","https://openalex.org/W2079027524","https://openalex.org/W2080865232","https://openalex.org/W2083850113","https://openalex.org/W2085529816","https://openalex.org/W2086660379","https://openalex.org/W2087654394","https://openalex.org/W2091770315","https://openalex.org/W2092886997","https://openalex.org/W2095887726","https://openalex.org/W2097660065","https://openalex.org/W2099786709","https://openalex.org/W2100992678","https://openalex.org/W2103238195","https://openalex.org/W2104315543","https://openalex.org/W2105062255","https://openalex.org/W2107900138","https://openalex.org/W2108751101","https://openalex.org/W2110643873","https://openalex.org/W2111544501","https://openalex.org/W2112450778","https://openalex.org/W2114096769","https://openalex.org/W2115286068","https://openalex.org/W2117604814","https://openalex.org/W2118296810","https://openalex.org/W2124124852","https://openalex.org/W2125140365","https://openalex.org/W2126717850","https://openalex.org/W2126738264","https://openalex.org/W2128648826","https://openalex.org/W2129150286","https://openalex.org/W2129815789","https://openalex.org/W2131838602","https://openalex.org/W2135539750","https://openalex.org/W2136572360","https://openalex.org/W2138409980","https://openalex.org/W2140170107","https://openalex.org/W2140675235","https://openalex.org/W2143258592","https://openalex.org/W2143808215","https://openalex.org/W2147311167","https://openalex.org/W2153863532","https://openalex.org/W2155783580","https://openalex.org/W2155808493","https://openalex.org/W2157765869","https://openalex.org/W2158673704","https://openalex.org/W2160114821","https://openalex.org/W2161201097","https://openalex.org/W2162653216","https://openalex.org/W2163910905","https://openalex.org/W2166208596","https://openalex.org/W2167664139","https://openalex.org/W2168132477","https://openalex.org/W2187975293","https://openalex.org/W2196158815","https://openalex.org/W2300948173","https://openalex.org/W2317539371","https://openalex.org/W2397905692","https://openalex.org/W2430143578","https://openalex.org/W7095824862"],"related_works":["https://openalex.org/W170758485","https://openalex.org/W2153863532","https://openalex.org/W2090320916","https://openalex.org/W2002176215","https://openalex.org/W2567428379","https://openalex.org/W2617447009","https://openalex.org/W2143808215","https://openalex.org/W2081478892","https://openalex.org/W7009969156","https://openalex.org/W1972440549"],"abstract_inverted_index":{"Obesity":[0],"is":[1,74,235],"a":[2,8,16,48,284,326,341],"complex":[3],"disorder":[4],"which":[5],"has":[6],"become":[7],"growing":[9],"health":[10],"concern.":[11],"Twin":[12],"studies":[13,29],"have":[14,30],"demonstrated":[15,141],"strong":[17],"genetic":[18,33,102],"component":[19],"to":[20,69,81,95,151,214,304,319],"the":[21,54,88,97,101,115,157,182,222,225,240,281,299],"development":[22],"of":[23,40,53,100,117,127,159,166,203,216,224,243,283,312],"obesity":[24],"and":[25,56,64,107,113,122,136,144,169,196,206,259,269,289,314,329,335,345],"genome":[26],"wide":[27],"association":[28],"identified":[31],"several":[32],"loci":[34,42],"associated":[35],"with":[36,306],"it.":[37],"However,":[38],"most":[39],"these":[41],"are":[43,66],"still":[44,75],"poorly":[45],"understood":[46,77],"in":[47,134,148,177,237,298,325,332,347],"functional":[49],"context.":[50],"Interestingly,":[51],"many":[52],"hormones":[55],"neurobiological":[57],"messengers":[58],"responsible":[59],"for":[60,162,239,343],"regulating":[61,104],"feeding":[62,137,200,262],"behaviour":[63,106,271],"metabolism":[65],"also":[67,198],"linked":[68],"controlling":[70,156],"aggression,":[71],"but":[72],"it":[73,172],"not":[76],"how":[78],"they":[79,265],"interact":[80,147],"maintain":[82],"metabolic":[83,108,244],"homeostasis.":[84,109],"In":[85,110],"this":[86],"thesis,":[87],"model":[89],"organism":[90],"Drosophila":[91,125,183,238],"melanogaster":[92],"was":[93,173],"employed":[94],"dissect":[96],"molecular":[98],"mechanisms":[99],"cascades":[103],"aggressive":[105],"paper":[111],"I":[112,140],"II,":[114],"role":[116],"transcription":[118],"factor":[119],"AP-2":[120],"(TfAP-2)":[121],"Tiwaz":[123],"Twz,":[124],"homologues":[126],"two":[128],"human":[129],"obesity-linked":[130,286],"genes":[131,160],"were":[132,253],"investigated":[133],"aggression":[135,154,180,268],"behaviour.":[138,263],"Paper":[139,191,218,274],"that":[142,175,194,221],"TfAP-2":[143,195],"Twz":[145,197],"genetically":[146],"octopaminergic":[149],"neurons":[150],"modulate":[152],"male":[153],"by":[155],"expression":[158,212,323],"necessary":[161],"octopamine":[163,176,204],"(fly":[164],"analogue":[165],"noradrenaline)":[167],"production":[168],"secretion.":[170,207],"Moreover,":[171,264],"revealed":[174,193],"turn":[178],"regulates":[179],"through":[181,201],"cholecystokinin":[184],"(CCK)":[185],"satiation":[186],"hormone":[187],"homologue":[188,282],"Drosulfakinin":[189],"(Dsk).":[190],"II":[192],"initiate":[199],"regulation":[202,242],"poduction":[205],"Octopamine":[208],"then":[209],"induces":[210],"Dsk":[211],"leading":[213],"inhibition":[215],"feeding.":[217],"III":[219],"established":[220],"activity":[223],"small":[226],"GTPase":[227],"Ras-related":[228],"C3":[229],"botulinum":[230],"toxin":[231],"substrate":[232],"2":[233],"(Rac2)":[234],"required":[236],"proper":[241],"homeostasis,":[245],"as":[246,248],"well":[247],"overt":[249],"behaviours.":[250],"Rac2":[251],"mutants":[252],"starvation":[254,308,327],"susceptible,":[255],"had":[256],"less":[257],"lipids":[258,313],"exhibited":[260],"disrupted":[261],"displayed":[266],"aberrant":[267],"courtship":[270],"towards":[272],"conspecifics.":[273],"IV":[275],"studied":[276],"Protein":[277],"kinase":[278,291],"D":[279],"(PKD),":[280],"third":[285],"gene":[287],"PRKD1,":[288],"another":[290],"Stretchin-Mlck":[292],"(Strn-Mlck).":[293],"Reducing":[294],"PKD":[295,344],"transcript":[296],"levels":[297,311],"insulin":[300,316,333,348],"producing":[301],"cells":[302],"led":[303],"flies":[305],"increased":[307],"susceptibility,":[309],"decreased":[310],"diminished":[315],"signalling":[317,334],"compared":[318],"controls.":[320],"Reduced":[321],"Strn-Mlck":[322,346],"resulted":[324],"phenotype":[328],"slight":[330],"reduction":[331],"lipid":[336],"content.":[337],"These":[338],"findings":[339],"imply":[340],"function":[342],"release.":[349]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
