{"id":"https://openalex.org/W1850895891","doi":null,"title":"Establishment of human cancer cell clones with different characteristics: a model for screening chemopreventive agents.","display_name":"Establishment of human cancer cell clones with different characteristics: a model for screening chemopreventive agents.","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W1850895891","mag":"1850895891","pmid":"https://pubmed.ncbi.nlm.nih.gov/17352209"},"language":"en","primary_location":{"id":"pmid:17352209","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17352209","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067787438","display_name":"Jeffrey H. Ware","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210143392","display_name":"University of Pennsylvania Health System","ror":"https://ror.org/04h81rw26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210143392"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey H Ware","raw_affiliation_strings":["Department of Radiation Oncology, Division of Oncology Research, University of Pennsylvania School of Medicine, 3620 Hamilton Walk, Philadelphia, PA 19104-6072, USA. jhware@mail.med.upenn.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Division of Oncology Research, University of Pennsylvania School of Medicine, 3620 Hamilton Walk, Philadelphia, PA 19104-6072, USA. jhware@mail.med.upenn.edu","institution_ids":["https://openalex.org/I4210143392","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030374831","display_name":"Zhaozong Zhou","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhaozong Zhou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100639935","display_name":"Jun Guan","orcid":"https://orcid.org/0000-0002-4088-8126","observed_orcids":["https://orcid.org/0000-0002-4088-8126"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jun Guan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075478892","display_name":"Ann R. Kennedy","orcid":"https://orcid.org/0000-0002-1602-2015","observed_orcids":["https://orcid.org/0000-0002-1602-2015"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ann R Kennedy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5051957313","display_name":"Levy Kopelovich","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Levy Kopelovich","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3528,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.64494849,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"27","issue":"1A","first_page":"1","last_page":"16"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clonal-selection","display_name":"clonal selection","score":0.8510000109672546},{"id":"https://openalex.org/keywords/limiting-dilution","display_name":"limiting dilution","score":0.8050000071525574},{"id":"https://openalex.org/keywords/chemoprevention","display_name":"chemoprevention","score":0.7630000114440918},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.7229999899864197},{"id":"https://openalex.org/keywords/breast-cancer-cell-lines","display_name":"breast cancer cell lines","score":0.6710000038146973},{"id":"https://openalex.org/keywords/prostate-cancer-cell-lines","display_name":"prostate cancer cell lines","score":0.996999979019165},{"id":"https://openalex.org/keywords/lung-cancer-cell-lines","display_name":"lung cancer cell lines","score":0.9990000128746033},{"id":"https://openalex.org/keywords/colon-cancer-cell-lines","display_name":"colon cancer cell lines","score":0.9950000047683716},{"id":"https://openalex.org/keywords/bladder-cancer-cell-lines","display_name":"bladder cancer cell lines","score":0.9990000128746033},{"id":"https://openalex.org/keywords/colony-formation","display_name":"colony formation","score":0.6029999852180481},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.5669999718666077},{"id":"https://openalex.org/keywords/plating-efficiency","display_name":"plating efficiency","score":0.6859999895095825},{"id":"https://openalex.org/keywords/soft-agar","display_name":"soft agar","score":0.6499999761581421}],"concepts":[{"id":"https://openalex.org/C2776438761","wikidata":"https://www.wikidata.org/wiki/Q5206280","display_name":"DU145","level":5,"score":0.8799039125442505},{"id":"https://openalex.org/C2776127477","wikidata":"https://www.wikidata.org/wiki/Q17093220","display_name":"Plating efficiency","level":3,"score":0.7286438345909119},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.706989586353302},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6288413405418396},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.6196816563606262},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.5043233633041382},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5001885890960693},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.47344303131103516},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.41571515798568726},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.40509751439094543},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.28199437260627747},{"id":"https://openalex.org/C2779723316","wikidata":"https://www.wikidata.org/wiki/Q6459234","display_name":"LNCaP","level":4,"score":0.07997003197669983}],"mesh":[{"descriptor_ui":"D001749","descriptor_name":"Urinary Bladder Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002999","descriptor_name":"Clone Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D016588","descriptor_name":"Anticarcinogenic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019073","descriptor_name":"HT29 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045325","descriptor_name":"HCT116 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:17352209","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17352209","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},{"id":"mag:1850895891","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17352209","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W50304346","https://openalex.org/W71698754","https://openalex.org/W1419228847","https://openalex.org/W1780914609","https://openalex.org/W1982946667","https://openalex.org/W1999812506","https://openalex.org/W2009444431","https://openalex.org/W2009857031","https://openalex.org/W2033031708","https://openalex.org/W2035244457","https://openalex.org/W2039074795","https://openalex.org/W2049165110","https://openalex.org/W2054814252","https://openalex.org/W2058223795","https://openalex.org/W2062206799","https://openalex.org/W2072928176","https://openalex.org/W2094613397","https://openalex.org/W2102838769","https://openalex.org/W2103885797","https://openalex.org/W2107204091","https://openalex.org/W2119531476","https://openalex.org/W2120427107","https://openalex.org/W2132415951","https://openalex.org/W2137330819","https://openalex.org/W2143476505","https://openalex.org/W2187430043","https://openalex.org/W2409252368","https://openalex.org/W2411893921","https://openalex.org/W2412361774","https://openalex.org/W2417212197","https://openalex.org/W2475137391"],"related_works":["https://openalex.org/W2404642451","https://openalex.org/W2000076223","https://openalex.org/W3196579971","https://openalex.org/W2136043430","https://openalex.org/W2084825435","https://openalex.org/W1959513513","https://openalex.org/W7095813168","https://openalex.org/W2080681997","https://openalex.org/W162136232","https://openalex.org/W1508260452"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,60],"present":[2],"study":[3,141],"was":[4],"undertaken":[5],"in":[6,65,79],"order":[7],"to":[8,127],"establish":[9],"phenotypically":[10],"different":[11,84],"cell":[12,70,85,94,123],"clones":[13,62,86,98,115],"from":[14,49,89,107,120],"10":[15],"parental":[16,53,91,105],"lines":[17,54],"of":[18,51,67,135,142],"human":[19,92,121],"breast":[20],"(MCF-7":[21],"and":[22,26,30,34,36,39,75,139],"T-47D),":[23],"prostate":[24],"(PC-3":[25],"DU145),":[27],"lung":[28],"(A549":[29],"A427),":[31],"colon":[32],"(HCT-116":[33],"HT-29)":[35],"bladder":[37],"(TCCSUP":[38],"T24)":[40],"cancer":[41,93,122,136],"cells.":[42],"MATERIALS":[43],"AND":[44],"METHODS:":[45],"Sublines":[46],"were":[47,63,87,110],"established":[48],"each":[50,90],"the":[52,56,104,133,140],"by":[55],"limiting":[57],"dilution":[58],"method.":[59],"derived":[61,88],"characterized":[64],"terms":[66],"plating":[68],"efficiency,":[69],"proliferation":[71],"rate,":[72],"saturation":[73],"density":[74],"colony":[76],"formation":[77],"efficiency":[78],"soft":[80],"agar.":[81],"RESULTS:":[82],"Phenotypically":[83,113],"line,":[95],"with":[96],"many":[97],"having":[99],"more":[100],"'normal'":[101],"characteristics":[102],"than":[103],"line":[106],"which":[108],"they":[109],"derived.":[111],"CONCLUSION:":[112],"normal":[114],"obtained":[116],"through":[117],"clonal":[118],"selection":[119],"populations":[124],"are":[125],"expected":[126],"be":[128],"a":[129],"useful":[130],"tool":[131],"for":[132],"screening":[134],"chemopreventive":[137],"agents":[138],"tumor":[143],"progression.":[144]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}