{"id":"https://openalex.org/W185085663","doi":null,"title":"Immunor\u00e9activit\u00e9 de l'apolipoprot\u00e9ine B humaine : variations exp\u00e9rimentales et physio-pathologiques","display_name":"Immunor\u00e9activit\u00e9 de l'apolipoprot\u00e9ine B humaine : variations exp\u00e9rimentales et physio-pathologiques","publication_year":1991,"publication_date":"1991-01-01","ids":{"openalex":"https://openalex.org/W185085663","mag":"185085663"},"language":"fr","primary_location":{"id":"pmh:hdl:10068/16952","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10068/16952","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077335209","display_name":"Hassan Gandjini","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Hassan Gandjini","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5077335209"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.548799991607666,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.548799991607666,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.2996000051498413,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.12399999797344208,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apolipoprotein-b","display_name":"apolipoprotein B","score":0.9670000076293945},{"id":"https://openalex.org/keywords/low-density-lipoprotein","display_name":"low-density lipoprotein","score":0.8370000123977661},{"id":"https://openalex.org/keywords/immunoreactivity","display_name":"immunoreactivity","score":0.8169999718666077},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.8659999966621399},{"id":"https://openalex.org/keywords/epitope-accessibility","display_name":"epitope accessibility","score":0.9279999732971191},{"id":"https://openalex.org/keywords/lipid-composition","display_name":"lipid composition","score":0.6240000128746033},{"id":"https://openalex.org/keywords/oxidized-ldl","display_name":"oxidized LDL","score":0.9430000185966492},{"id":"https://openalex.org/keywords/copper-mediated-oxidation","display_name":"copper-induced oxidation","score":0.765999972820282},{"id":"https://openalex.org/keywords/phospholipase-a2","display_name":"phospholipase A2","score":0.8659999966621399},{"id":"https://openalex.org/keywords/lipoxygenase","display_name":"lipoxygenase","score":0.996999979019165},{"id":"https://openalex.org/keywords/polyunsaturated-fatty-acids","display_name":"polyunsaturated fatty acids","score":0.8769999742507935},{"id":"https://openalex.org/keywords/cholesteryl-esters","display_name":"cholesterol esters","score":0.9700000286102295},{"id":"https://openalex.org/keywords/ldl-apheresis","display_name":"LDL apheresis","score":0.824999988079071},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.5659999847412109},{"id":"https://openalex.org/keywords/atherogenesis","display_name":"atherogenesis","score":0.36800000071525574}],"concepts":[{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.7407976388931274},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.707973062992096},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.4268333911895752},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21934747695922852},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.15309938788414001},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:hdl:10068/16952","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10068/16952","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},{"id":"mag:185085663","doi":null,"is_oa":false,"landing_page_url":"http://www.theses.fr/1991DIJOS034","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8560000061988831,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1991087899","https://openalex.org/W2184579097","https://openalex.org/W7100530327","https://openalex.org/W7097550930","https://openalex.org/W2466531391","https://openalex.org/W1512751283","https://openalex.org/W2408855463","https://openalex.org/W2013615486","https://openalex.org/W2114158744","https://openalex.org/W2070307201"],"abstract_inverted_index":{"L'etude":[0],"de":[1,5,20,36,43,45,47,50,56,81,118,127,137,142,147,156,174,181,189,202,206,212,260,275,283,294,312,315],"l'immunoreactivite":[2,157,168,234],"des":[3,27,74,94,108,114,149,158,164,222,235,245,264,287,290,296,299],"lipoproteines":[4],"faible":[6],"densite":[7],"(LDL)":[8],"a":[9,12,40,100,198,214,227,237],"ete":[10,101,215,228],"entreprise":[11],"l'aide":[13],"d'anticorps":[14],"monoclonaux":[15,69,76,304],"diriges":[16],"contre":[17],"differentes":[18,259],"parties":[19],"l'apolipoproteine":[21],"B":[22,183,317],"(apo":[23],"B).":[24],"Le":[25,210],"fractionnement":[26],"LDL":[28,80,105,109,150,223,236,256,288],"humaines":[29],"par":[30,34,66,153,267],"ultracentrifugation":[31],"zonale":[32],"et":[33,49,96,205,233],"chromatographie":[35],"filtration":[37],"sur":[38],"gel":[39],"montre":[41,229,279],"l'existence":[42],"sous-populations":[44,55],"particules":[46,250],"taille":[48,83],"composition":[51,98,144,232,285],"chimique":[52],"differentes.":[53],"Les":[54,249,273,302],"grande":[57],"taille,":[58],"plus":[59,161],"riches":[60],"en":[61,112,130,162],"lipides,":[62],"sont":[63],"mieux":[64],"reconnues":[65],"les":[67,79,104,160,219,255,281,310],"anticorps":[68,75,300,303],"anti-apo":[70],"B.":[71],"L'accessibilite":[72],"vis-a-vis":[73,298],"diminue":[77],"dans":[78,103,178,270],"petite":[82],"avec":[84],"la":[85,97,143,175,231,238,284,313],"diminution":[86,125,155],"du":[87,240],"rapport":[88],"lipide/proteine.":[89],"La":[90,194],"relation":[91],"entre":[92],"accessibilite":[93],"epitopes":[95,159,297],"lipidique":[99,145,286],"verifiee":[102],"oxydees.":[106],"L'incubation":[107],"in":[110,224,320],"vitro":[111,321],"presence":[113],"ions":[115],"Cu++":[116],"ou":[117],"l'association":[119],"phospholipase":[120],"A2+lipoxygenase,":[121],"est":[122,151,185,191],"suivie":[123],"d'une":[124],"importante":[126],"leur":[128],"teneur":[129],"acides":[131],"gras":[132],"polyinsatures":[133],"ainsi":[134],"qu'en":[135],"esters":[136],"cholesterol.":[138],"Ce":[139],"changement":[140],"important":[141],"lors":[146],"l'oxydation":[148,199],"suivi":[152],"une":[154,179],"contact":[163,188],"lipides.":[165],"A":[166],"l'inverse":[167],"d'un":[169,196],"epitope":[170,197],"situe":[171],"au":[172,187,292],"niveau":[173,293],"partie":[176,180],"N-terminale":[177],"l'apo":[182,316],"qui":[184],"moins":[186],"lipides":[190],"peu":[192],"alteree.":[193],"sensibilite":[195],"dependrait":[200],"donc":[201],"sa":[203],"localisation":[204],"son":[207],"environnement":[208],"lipidique.":[209],"modele":[211],"LDL-apherese":[213,252],"choisi":[216],"pour":[217],"approcher":[218],"changements":[220,291,311],"d'immunoreactivite":[221],"vivo.":[225,323],"Il":[226],"que":[230,280],"suite":[239],"traitement":[241],"apheretique":[242],"etaient":[243],"differents":[244],"lLDLavant":[246],"le":[247],"traitement.":[248],"apres":[251],"pourraient":[253,305],"etre":[254],"nouvellement":[257],"synthetisees":[258],"celles":[261],"ayant":[262],"subi":[263],"modifications":[265,282],"structurales":[266],"sejour":[268],"prolonge":[269],"l'espace":[271],"intravasculaire.":[272],"resultats":[274],"ce":[276],"travail":[277],"ont":[278],"entrainent":[289],"l'accessibilite":[295],"monoclonaux.":[301],"constituer":[306],"un":[307],"moyen":[308],"d'etudier":[309],"conformation":[314],"aussi":[318],"bien":[319],"qu'in":[322]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}