{"id":"https://openalex.org/W1850043500","doi":"https://doi.org/10.1684/bdc.2010.1088","title":"Bevacizumab plus oxaliplatine, acide folinique et 5-fluoro-uracile (Folfox7) en premi\u00e8re ligne de traitement des cancers colorectaux \u00e9volu\u00e9s et/ou m\u00e9tastatiques","display_name":"Bevacizumab plus oxaliplatine, acide folinique et 5-fluoro-uracile (Folfox7) en premi\u00e8re ligne de traitement des cancers colorectaux \u00e9volu\u00e9s et/ou m\u00e9tastatiques","publication_year":2010,"publication_date":"2010-04-01","ids":{"openalex":"https://openalex.org/W1850043500","doi":"https://doi.org/10.1684/bdc.2010.1088","mag":"1850043500","pmid":"https://pubmed.ncbi.nlm.nih.gov/20385517"},"language":"fr","primary_location":{"id":"doi:10.1684/bdc.2010.1088","doi":"https://doi.org/10.1684/bdc.2010.1088","is_oa":false,"landing_page_url":"https://doi.org/10.1684/bdc.2010.1088","pdf_url":null,"source":{"id":"https://openalex.org/S22998730","display_name":"Bulletin du Cancer","issn_l":"0007-4551","issn":["0007-4551","1769-6917"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bulletin du Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037735053","display_name":"Mohammed Oukkal","orcid":"https://orcid.org/0000-0002-4306-8377","observed_orcids":["https://orcid.org/0000-0002-4306-8377"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Oukkal","raw_affiliation_strings":["Service d'oncologie m\u00e9dicale, centre Pierre-et-Marie-Curie, Alger, Alg\u00e9rie"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service d'oncologie m\u00e9dicale, centre Pierre-et-Marie-Curie, Alger, Alg\u00e9rie","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040548892","display_name":"K. Djilat","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K. Djilat","raw_affiliation_strings":["Service d\u2019oncologie m\u00e9dicale, centre Pierre-et-Marie-Curie, Alger, Alg\u00e9rie"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service d\u2019oncologie m\u00e9dicale, centre Pierre-et-Marie-Curie, Alger, Alg\u00e9rie","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036659492","display_name":"R.M. Hadjam","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R.M. Hadjam","raw_affiliation_strings":["Service d\u2019oncologie m\u00e9dicale, centre Pierre-et-Marie-Curie, Alger, Alg\u00e9rie"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service d\u2019oncologie m\u00e9dicale, centre Pierre-et-Marie-Curie, Alger, Alg\u00e9rie","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018580879","display_name":"M.T. Mahgoun","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M.T. Mahgoun","raw_affiliation_strings":["Service d\u2019oncologie m\u00e9dicale, centre Pierre-et-Marie-Curie, Alger, Alg\u00e9rie"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service d\u2019oncologie m\u00e9dicale, centre Pierre-et-Marie-Curie, Alger, Alg\u00e9rie","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001294808","display_name":"K. Bentabak","orcid":"https://orcid.org/0000-0002-3793-673X","observed_orcids":["https://orcid.org/0000-0002-3793-673X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K. Bentabak","raw_affiliation_strings":["Service de chirurgie oncologique, centre Pierre-et-Marie-Curie, Alger, Alg\u00e9rie"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de chirurgie oncologique, centre Pierre-et-Marie-Curie, Alger, Alg\u00e9rie","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046082393","display_name":"Abdelaziz Graba","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Graba","raw_affiliation_strings":["Service de chirurgie oncologique, centre Pierre-et-Marie-Curie, Alger, Alg\u00e9rie"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de chirurgie oncologique, centre Pierre-et-Marie-Curie, Alger, Alg\u00e9rie","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029905814","display_name":"Nourredine Smail","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210154551","display_name":"Centre Hospitalo-Universitaire Bab El Oued","ror":"https://ror.org/05qf3bt68","country_code":"DZ","type":"healthcare","lineage":["https://openalex.org/I4210154551"]}],"countries":["DZ"],"is_corresponding":false,"raw_author_name":"N. Smail","raw_affiliation_strings":["Service d\u2019\u00e9pid\u00e9miologie et de pr\u00e9vention, CHU d\u2019Alger-Centre, Alger, Alg\u00e9rie"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service d\u2019\u00e9pid\u00e9miologie et de pr\u00e9vention, CHU d\u2019Alger-Centre, Alger, Alg\u00e9rie","institution_ids":["https://openalex.org/I4210154551"]}]},{"author_position":"middle","author":{"id":null,"display_name":"N. Ait Kaci","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N. Ait Kaci","raw_affiliation_strings":["Service d\u2019anatomie pathologique, centre Pierre-et-Marie-Curie, Alger, Alg\u00e9rie"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service d\u2019anatomie pathologique, centre Pierre-et-Marie-Curie, Alger, Alg\u00e9rie","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"R. Baba Ahmed","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210154551","display_name":"Centre Hospitalo-Universitaire Bab El Oued","ror":"https://ror.org/05qf3bt68","country_code":"DZ","type":"healthcare","lineage":["https://openalex.org/I4210154551"]}],"countries":["DZ"],"is_corresponding":false,"raw_author_name":"R. Baba Ahmed","raw_affiliation_strings":["Service d\u2019anatomie pathologique, h\u00f4pital Mohamed-Lamine-Debaghine, Bab-el-Oued, Alger, Alg\u00e9rie"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service d\u2019anatomie pathologique, h\u00f4pital Mohamed-Lamine-Debaghine, Bab-el-Oued, Alger, Alg\u00e9rie","institution_ids":["https://openalex.org/I4210154551"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063576946","display_name":"Kheira Bouzid","orcid":"https://orcid.org/0000-0001-8233-3308","observed_orcids":["https://orcid.org/0000-0001-8233-3308","https://orcid.org/0000-0003-4178-8773"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"K. Bouzid","raw_affiliation_strings":["Arome (Association de radioth\u00e9rapie et d\u2019oncologie de la M\u00e9diterran\u00e9e), www.aromecancer.org","Service d\u2019oncologie m\u00e9dicale, centre Pierre-et-Marie-Curie, Alger, Alg\u00e9rie"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arome (Association de radioth\u00e9rapie et d\u2019oncologie de la M\u00e9diterran\u00e9e), www.aromecancer.org","institution_ids":[]},{"raw_affiliation_string":"Service d\u2019oncologie m\u00e9dicale, centre Pierre-et-Marie-Curie, Alger, Alg\u00e9rie","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5063576946"],"corresponding_institution_ids":[],"apc_list":{"value":1790,"currency":"USD","value_usd":1790},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.11083459,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"97","issue":"4","first_page":"469","last_page":"474"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bevacizumab","display_name":"bevacizumab","score":0.9990000128746033},{"id":"https://openalex.org/keywords/oxaliplatin","display_name":"oxaliplatin","score":0.9150000214576721},{"id":"https://openalex.org/keywords/leucovorin","display_name":"leucovorin","score":0.8080000281333923},{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":0.9940000176429749},{"id":"https://openalex.org/keywords/metastatic-colorectal-cancer","display_name":"metastatic colorectal cancer","score":0.8820000290870667},{"id":"https://openalex.org/keywords/advanced-colorectal-cancer","display_name":"advanced colorectal cancer","score":0.9710000157356262},{"id":"https://openalex.org/keywords/first-line-chemotherapy","display_name":"first-line chemotherapy","score":0.9309999942779541},{"id":"https://openalex.org/keywords/vegf-expression","display_name":"VEGF expression","score":0.8069999814033508},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.7549999952316284},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.46000000834465027},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.9459999799728394},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.8769999742507935},{"id":"https://openalex.org/keywords/chemotherapy-toxicity","display_name":"chemotherapy toxicity","score":0.8330000042915344},{"id":"https://openalex.org/keywords/cetuximab","display_name":"cetuximab","score":0.8180000185966492},{"id":"https://openalex.org/keywords/panitumumab","display_name":"panitumumab","score":0.984000027179718},{"id":"https://openalex.org/keywords/egfr","display_name":"EGFR","score":0.640999972820282}],"concepts":[{"id":"https://openalex.org/C2777802072","wikidata":"https://www.wikidata.org/wiki/Q413299","display_name":"Bevacizumab","level":3,"score":0.8736075758934021},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8499864935874939},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.572234034538269},{"id":"https://openalex.org/C2779998722","wikidata":"https://www.wikidata.org/wiki/Q420296","display_name":"Cetuximab","level":4,"score":0.5719573497772217},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.5701605081558228},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5642368197441101},{"id":"https://openalex.org/C2780962732","wikidata":"https://www.wikidata.org/wiki/Q422327","display_name":"Oxaliplatin","level":4,"score":0.53414386510849},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5199888348579407},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4970236122608185},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.4121599495410919},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3363572359085083},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.06385034322738647}],"mesh":[{"descriptor_ui":"D000068258","descriptor_name":"Bevacizumab","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077150","descriptor_name":"Oxaliplatin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002955","descriptor_name":"Leucovorin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002955","descriptor_name":"Leucovorin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009944","descriptor_name":"Organoplatinum Compounds","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D009944","descriptor_name":"Organoplatinum Compounds","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D012004","descriptor_name":"Rectal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012004","descriptor_name":"Rectal Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012004","descriptor_name":"Rectal Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D012004","descriptor_name":"Rectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042442","descriptor_name":"Vascular Endothelial Growth Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1684/bdc.2010.1088","doi":"https://doi.org/10.1684/bdc.2010.1088","is_oa":false,"landing_page_url":"https://doi.org/10.1684/bdc.2010.1088","pdf_url":null,"source":{"id":"https://openalex.org/S22998730","display_name":"Bulletin du Cancer","issn_l":"0007-4551","issn":["0007-4551","1769-6917"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bulletin du Cancer","raw_type":"journal-article"},{"id":"pmid:20385517","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20385517","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bulletin du cancer","raw_type":"Evaluation Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W41292549","https://openalex.org/W2114682727","https://openalex.org/W2121368761","https://openalex.org/W2128447158","https://openalex.org/W2143743735","https://openalex.org/W2156575195","https://openalex.org/W2157019123","https://openalex.org/W2157769714","https://openalex.org/W2167805334"],"related_works":["https://openalex.org/W2020848815","https://openalex.org/W2168269586","https://openalex.org/W2624367735","https://openalex.org/W2006645158","https://openalex.org/W2267364018","https://openalex.org/W2039760828","https://openalex.org/W4237972197","https://openalex.org/W2160421592","https://openalex.org/W2077546410","https://openalex.org/W4384520842"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
