{"id":"https://openalex.org/W18497913","doi":"https://doi.org/10.1039/b800721g","title":"Microfluidic device for label-free measurement of platelet activation","display_name":"Microfluidic device for label-free measurement of platelet activation","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W18497913","doi":"https://doi.org/10.1039/b800721g","mag":"18497913","pmid":"https://pubmed.ncbi.nlm.nih.gov/18497913"},"language":"en","primary_location":{"id":"doi:10.1039/b800721g","doi":"https://doi.org/10.1039/b800721g","is_oa":false,"landing_page_url":"https://doi.org/10.1039/b800721g","pdf_url":null,"source":{"id":"https://openalex.org/S116836101","display_name":"Lab on a Chip","issn_l":"1473-0189","issn":["1473-0189","1473-0197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lab on a Chip","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"David W. Inglis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99043593","display_name":"Macquarie University","ror":"https://ror.org/01sf06y89","country_code":"AU","type":"education","lineage":["https://openalex.org/I99043593"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"David W. Inglis","raw_affiliation_strings":["Department of Physics, Macquarie University, Sydney, NSW 2109, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics, Macquarie University, Sydney, NSW 2109, Australia","institution_ids":["https://openalex.org/I99043593"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Keith J. Morton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keith J. Morton","raw_affiliation_strings":["Department of Electrical Engineering and the Princeton Institute for the Science and Technology of Materials (PRISM), Princeton University, Princeton, NJ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering and the Princeton Institute for the Science and Technology of Materials (PRISM), Princeton University, Princeton, NJ, USA","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"middle","author":{"id":null,"display_name":"John A. Davis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John A. Davis","raw_affiliation_strings":["Department of Electrical Engineering and the Princeton Institute for the Science and Technology of Materials (PRISM), Princeton University, Princeton, NJ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering and the Princeton Institute for the Science and Technology of Materials (PRISM), Princeton University, Princeton, NJ, USA","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Thomas. J. Zieziulewicz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1298060332","display_name":"New York State Department of Health","ror":"https://ror.org/04hf5kq57","country_code":"US","type":"government","lineage":["https://openalex.org/I1298060332"]},{"id":"https://openalex.org/I1339417872","display_name":"Wadsworth Center","ror":"https://ror.org/050kf9c55","country_code":"US","type":"facility","lineage":["https://openalex.org/I1298060332","https://openalex.org/I1339417872"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas. J. Zieziulewicz","raw_affiliation_strings":["Wadsworth Center, New York State Department of Health Albany, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wadsworth Center, New York State Department of Health Albany, NY, USA","institution_ids":["https://openalex.org/I1298060332","https://openalex.org/I1339417872"]}]},{"author_position":"middle","author":{"id":null,"display_name":"David A. Lawrence","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1298060332","display_name":"New York State Department of Health","ror":"https://ror.org/04hf5kq57","country_code":"US","type":"government","lineage":["https://openalex.org/I1298060332"]},{"id":"https://openalex.org/I1339417872","display_name":"Wadsworth Center","ror":"https://ror.org/050kf9c55","country_code":"US","type":"facility","lineage":["https://openalex.org/I1298060332","https://openalex.org/I1339417872"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David A. Lawrence","raw_affiliation_strings":["Wadsworth Center, New York State Department of Health Albany, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wadsworth Center, New York State Department of Health Albany, NY, USA","institution_ids":["https://openalex.org/I1298060332","https://openalex.org/I1339417872"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081117311","display_name":"Robert H. Austin","orcid":"https://orcid.org/0000-0002-4269-6793","observed_orcids":["https://orcid.org/0000-0002-4269-6793"]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert H. Austin","raw_affiliation_strings":["Department of Physics, Princeton University, Princeton, NJ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics, Princeton University, Princeton, NJ, USA","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074204707","display_name":"James C. Sturm","orcid":"https://orcid.org/0000-0002-0878-5266","observed_orcids":["https://orcid.org/0000-0002-0878-5266","https://orcid.org/0000-0003-0095-2143"]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James C. Sturm","raw_affiliation_strings":["Department of Electrical Engineering and the Princeton Institute for the Science and Technology of Materials (PRISM), Princeton University, Princeton, NJ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering and the Princeton Institute for the Science and Technology of Materials (PRISM), Princeton University, Princeton, NJ, USA","institution_ids":["https://openalex.org/I20089843"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.0985,"has_fulltext":false,"cited_by_count":84,"citation_normalized_percentile":{"value":0.90058218,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"8","issue":"6","first_page":"925","last_page":"925"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11255","display_name":"Microfluidic and Bio-sensing Technologies","score":0.948199987411499,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11255","display_name":"Microfluidic and Bio-sensing Technologies","score":0.948199987411499,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.03200000151991844,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/platelet-activation","display_name":"platelet activation","score":0.9959999918937683},{"id":"https://openalex.org/keywords/platelet-size","display_name":"platelet size","score":0.8790000081062317},{"id":"https://openalex.org/keywords/platelet-morphology","display_name":"platelet morphology","score":0.996999979019165},{"id":"https://openalex.org/keywords/whole-blood","display_name":"whole blood","score":0.5509999990463257},{"id":"https://openalex.org/keywords/thrombin","display_name":"thrombin","score":0.9210000038146973},{"id":"https://openalex.org/keywords/cold-exposure","display_name":"cold exposure","score":0.5519999861717224},{"id":"https://openalex.org/keywords/label-free-detection","display_name":"label-free detection","score":0.7120000123977661}],"concepts":[{"id":"https://openalex.org/C115343472","wikidata":"https://www.wikidata.org/wiki/Q7942","display_name":"Global warming","level":3,"score":0.6296393871307373},{"id":"https://openalex.org/C47768531","wikidata":"https://www.wikidata.org/wiki/Q1127188","display_name":"Development economics","level":1,"score":0.5375767350196838},{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.5202102065086365},{"id":"https://openalex.org/C2119116","wikidata":"https://www.wikidata.org/wiki/Q7181","display_name":"Globalization","level":2,"score":0.5110982060432434},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.47938254475593567},{"id":"https://openalex.org/C39853841","wikidata":"https://www.wikidata.org/wiki/Q161078","display_name":"Urbanization","level":2,"score":0.4710438549518585},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.4327372610569},{"id":"https://openalex.org/C138921699","wikidata":"https://www.wikidata.org/wiki/Q47555","display_name":"Political economy","level":1,"score":0.35668647289276123},{"id":"https://openalex.org/C132651083","wikidata":"https://www.wikidata.org/wiki/Q7942","display_name":"Climate change","level":2,"score":0.3421916961669922},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.2532346844673157},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.209649920463562},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17095816135406494},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.13570037484169006},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.12871551513671875},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.11798766255378723},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.08557644486427307}],"mesh":[{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004867","descriptor_name":"Equipment Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D010316","descriptor_name":"Particle Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010979","descriptor_name":"Platelet Function Tests","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D010979","descriptor_name":"Platelet Function Tests","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D013194","descriptor_name":"Staining and Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015539","descriptor_name":"Platelet Activation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018950","descriptor_name":"Lipopolysaccharide Receptors","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D018950","descriptor_name":"Lipopolysaccharide Receptors","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D046210","descriptor_name":"Microfluidic Analytical Techniques","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D046210","descriptor_name":"Microfluidic Analytical Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1039/b800721g","doi":"https://doi.org/10.1039/b800721g","is_oa":false,"landing_page_url":"https://doi.org/10.1039/b800721g","pdf_url":null,"source":{"id":"https://openalex.org/S116836101","display_name":"Lab on a Chip","issn_l":"1473-0189","issn":["1473-0189","1473-0197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lab on a Chip","raw_type":"journal-article"},{"id":"pmid:18497913","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18497913","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lab on a chip","raw_type":"Journal Article"},{"id":"mag:18497913","doi":null,"is_oa":false,"landing_page_url":"https://www.sciencedirect.com/science/article/pii/B978032326509600005X","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309292","display_name":"Princeton University","ror":"https://ror.org/00hx57361"},{"id":"https://openalex.org/F4320332180","display_name":"Defense Advanced Research Projects Agency","ror":"https://ror.org/02caytj08"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W136888697","https://openalex.org/W1972210545","https://openalex.org/W1972867200","https://openalex.org/W1975214851","https://openalex.org/W1977074515","https://openalex.org/W1984228084","https://openalex.org/W2015201449","https://openalex.org/W2042905651","https://openalex.org/W2049310908","https://openalex.org/W2060708823","https://openalex.org/W2071872424","https://openalex.org/W2077595268","https://openalex.org/W2084506323","https://openalex.org/W2086925927","https://openalex.org/W2089923129","https://openalex.org/W2102153483","https://openalex.org/W2103995851","https://openalex.org/W2143173770","https://openalex.org/W2169510890","https://openalex.org/W2261886880","https://openalex.org/W2316091952","https://openalex.org/W4243551237"],"related_works":["https://openalex.org/W7099097805","https://openalex.org/W2789027598","https://openalex.org/W4390924075","https://openalex.org/W4398242164","https://openalex.org/W2024195790","https://openalex.org/W7172012917","https://openalex.org/W6922763864","https://openalex.org/W2803578821","https://openalex.org/W4390232099","https://openalex.org/W2143517922"],"abstract_inverted_index":{"In":[0],"this":[1],"work":[2],"we":[3],"demonstrate":[4],"a":[5,39,89],"new":[6],"microfluidic":[7],"method":[8],"for":[9],"the":[10,34,47,56,59,68,98,109],"rapid":[11],"assessment":[12],"of":[13,61,73,91],"platelet":[14,49,74],"size":[15,28,75,83],"and":[16,58],"morphology":[17],"in":[18,38,82,112],"whole":[19],"blood.":[20],"The":[21],"device":[22,57],"continuously":[23],"fractionates":[24],"particles":[25],"according":[26],"to":[27,33,86],"by":[29],"displacing":[30],"them":[31],"perpendicularly":[32],"fluid":[35],"flow":[36],"direction":[37],"micro-fabricated":[40],"post":[41],"array.":[42,69],"Whole":[43],"blood,":[44],"labeled":[45],"with":[46],"fluorescent,":[48],"specific,":[50],"antibody":[51],"PE-anti-CD41,":[52],"was":[53],"run":[54],"through":[55],"positions":[60],"fluorescent":[62],"objects":[63],"noted":[64],"as":[65],"they":[66],"exited":[67],"From":[70],"this,":[71],"histograms":[72],"were":[76],"created":[77],"which":[78],"show":[79],"marked":[80],"increases":[81],"after":[84],"exposure":[85],"thrombin":[87],"or":[88],"temperature":[90],"4":[92],"degrees":[93],"C.":[94],"We":[95],"infer":[96],"that":[97,103],"well":[99],"known":[100],"morphological":[101],"changes":[102],"occur":[104],"during":[105],"activation":[106],"are":[107],"causing":[108],"observed":[110],"increase":[111],"size.":[113]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}