{"id":"https://openalex.org/W1848918783","doi":null,"title":"Comparative analysis of striatal FDOPA uptake in Parkinson's disease: ratio method versus graphical approach.","display_name":"Comparative analysis of striatal FDOPA uptake in Parkinson's disease: ratio method versus graphical approach.","publication_year":2002,"publication_date":"2002-10-01","ids":{"openalex":"https://openalex.org/W1848918783","mag":"1848918783","pmid":"https://pubmed.ncbi.nlm.nih.gov/12368370"},"language":"en","primary_location":{"id":"pmid:12368370","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12368370","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074164462","display_name":"VIJAY M. DHAWAN","orcid":"https://orcid.org/0000-0002-2418-5674","observed_orcids":["https://orcid.org/0000-0002-2418-5674"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vijay Dhawan","raw_affiliation_strings":["Center for Neuroscience, North Shore-Long Island Jewish Research Institute, Manhasset, New York 11030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Neuroscience, North Shore-Long Island Jewish Research Institute, Manhasset, New York 11030, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001118110","display_name":"Yilong Ma","orcid":"https://orcid.org/0000-0002-8383-6748","observed_orcids":["https://orcid.org/0000-0002-8383-6748"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yilong Ma","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068131453","display_name":"Vandhana Pillai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vandhana Pillai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091505277","display_name":"Phoebe G. Spetsieris","orcid":"https://orcid.org/0000-0001-7368-2354","observed_orcids":["https://orcid.org/0000-0001-7368-2354"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Phoebe Spetsieris","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025900057","display_name":"Thomas Chaly","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas Chaly","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054748099","display_name":"Abdelfatihe Belakhlef","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Abdelfatihe Belakhlef","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084460611","display_name":"Claude Margouleff","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Claude Margouleff","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5041539272","display_name":"David Eidelberg","orcid":"https://orcid.org/0000-0002-0854-864X","observed_orcids":["https://orcid.org/0000-0002-0854-864X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Eidelberg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.6911,"has_fulltext":false,"cited_by_count":85,"citation_normalized_percentile":{"value":0.92553191,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":92,"max":98},"biblio":{"volume":"43","issue":"10","first_page":"1324","last_page":"30"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.6596999764442444,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.6596999764442444,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.3091000020503998,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Deep Brain Stimulation and Movement Disorders","score":0.006599999964237213,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.984000027179718},{"id":"https://openalex.org/keywords/fdopa-pet","display_name":"FDOPA PET","score":0.972000002861023},{"id":"https://openalex.org/keywords/striatal-dopamine-uptake","display_name":"striatal dopamine uptake","score":0.921999990940094},{"id":"https://openalex.org/keywords/caudate-nucleus","display_name":"caudate nucleus","score":0.8199999928474426},{"id":"https://openalex.org/keywords/putamen","display_name":"putamen","score":1.0},{"id":"https://openalex.org/keywords/disease-severity","display_name":"disease severity","score":0.6729999780654907},{"id":"https://openalex.org/keywords/time-activity-curves","display_name":"time-activity curves","score":0.6309999823570251},{"id":"https://openalex.org/keywords/dynamic-pet","display_name":"dynamic PET","score":0.382999986410141}],"concepts":[{"id":"https://openalex.org/C2779714222","wikidata":"https://www.wikidata.org/wiki/Q550934","display_name":"Putamen","level":2,"score":0.8508092164993286},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.6358853578567505},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.6318427920341492},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.522632360458374},{"id":"https://openalex.org/C2780062018","wikidata":"https://www.wikidata.org/wiki/Q1319792","display_name":"Striatum","level":3,"score":0.44692039489746094},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4308001399040222},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41104209423065186},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.33820733428001404},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30197542905807495},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.28880369663238525},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.14055243134498596}],"mesh":[{"descriptor_ui":"D003342","descriptor_name":"Corpus Striatum","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005462","descriptor_name":"Fluorine Radioisotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010135","descriptor_name":"p-Fluorophenylalanine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D014055","descriptor_name":"Tomography, Emission-Computed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:12368370","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12368370","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.488.3583","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.488.3583","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jnm.snmjournals.org/content/43/10/1324.full.pdf","raw_type":"text"},{"id":"mag:1848918783","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12368370","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1410492949","display_name":"PET IN PARKINSONISM: A MULTICENTER COLLABORATIVE STUDY","funder_award_id":"R01NS035069","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G4344833753","display_name":"Mechanisms of dopamine neuron degeneration","funder_award_id":"P50NS038370","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W201588874","https://openalex.org/W1562359367","https://openalex.org/W1983721061","https://openalex.org/W1987226185","https://openalex.org/W2041849296","https://openalex.org/W2051228374","https://openalex.org/W2062168538","https://openalex.org/W2076548939","https://openalex.org/W2077049128","https://openalex.org/W2092078486","https://openalex.org/W2143426269","https://openalex.org/W2156177559","https://openalex.org/W2188391608","https://openalex.org/W2270880334","https://openalex.org/W2396351959","https://openalex.org/W2411790861"],"related_works":["https://openalex.org/W1972960190","https://openalex.org/W2143426269","https://openalex.org/W2071556500","https://openalex.org/W4220994836","https://openalex.org/W2151929064","https://openalex.org/W2905038249","https://openalex.org/W2182130533","https://openalex.org/W2396351959","https://openalex.org/W3165563365","https://openalex.org/W7100233375"],"abstract_inverted_index":{"UNLABELLED:":[0],"Striatal-to-occipital":[1],"ratio":[2],"(SOR)":[3],"and":[4,42,61,73,109,127,131,156,183,199,217,254],"influx":[5,43],"constant":[6,44],"K(i)(occ)":[7,132,157,246],"are":[8,186],"commonly":[9],"used":[10],"as":[11,243,245],"analytic":[12],"parameters":[13,214],"in":[14,26,46,54,162,166,189,196,247,255],"L-3,4-dihydroxy-6-(18)F-fluorophenylalanine":[15],"(FDOPA)":[16],"PET":[17,96],"studies.":[18],"Both":[19,154,213],"have":[20],"been":[21],"shown":[22],"to":[23,90],"be":[24],"useful":[25],"discriminating":[27],"Parkinson's":[28,221],"disease":[29,260],"(PD)":[30],"patients":[31,59,250],"from":[32,88,140,149,234,251],"healthy":[33,75,252],"subjects.":[34],"We":[35],"evaluated":[36],"the":[37,47,150,167,172,197,207,210],"relative":[38],"performance":[39],"of":[40,50,120,123,209,259],"SOR":[41,130,155,175,194,232],"(K(i)(occ))":[45],"clinical":[48,257],"assessment":[49],"nigrostriatal":[51],"dopaminergic":[52],"function":[53,148],"PD.":[55],"METHODS:":[56],"Twenty-one":[57],"parkinsonian":[58],"(Hoehn":[60],"Yahr":[62],"scale":[63],"I-IV;":[64],"mean":[65],"age":[66],"+/-":[67,70,80],"SD,":[68],"56":[69],"9.2":[71],"y)":[72,82],"11":[74],"subjects":[76,253],"(mean":[77],"age,":[78],"60":[79],"16":[81],"underwent":[83],"3-dimensional":[84],"dynamic":[85],"FDOPA":[86],"scanning":[87,211],"0":[89],"100":[91],"min.":[92],"After":[93],"spatial":[94],"realignment,":[95],"images":[97],"at":[98,142,239],"each":[99,135],"frame":[100],"were":[101,113,137],"integrated":[102],"by":[103],"summing":[104],"4":[105],"central":[106],"striatal":[107,126,163],"slices,":[108],"time-activity":[110],"curves":[111],"(TACs)":[112],"generated":[114],"after":[115],"placing":[116],"a":[117,235],"standard":[118],"set":[119],"elliptic":[121],"regions":[122],"interest":[124],"over":[125],"occipital":[128,151],"structures.":[129],"values":[133,176,195],"for":[134,178],"subject":[136],"then":[138],"computed":[139],"TACs":[141],"different":[143],"times":[144],"using":[145],"an":[146],"input":[147],"cortex.":[152],"RESULTS:":[153],"showed":[158],"significant":[159],"bilateral":[160],"decreases":[161],"dopamine":[164],"uptake":[165],"PD":[168,249],"group":[169,190],"compared":[170],"with":[171,203,219],"control":[173],"group.":[174],"estimated":[177],"10-min":[179,237],"frames":[180],"between":[181],"65":[182],"95":[184,240],"min":[185,241],"statistically":[187],"equivalent":[188],"discrimination.":[191],"In":[192],"addition,":[193],"caudate":[198],"putamen":[200],"correlated":[201,215],"strongly":[202],"K(i)(occ),":[204],"especially":[205],"toward":[206],"end":[208],"epoch.":[212],"significantly":[216],"comparably":[218],"Unified":[220],"Disease":[222],"Rating":[223],"Scale":[224],"motor":[225],"scores.":[226],"CONCLUSION:":[227],"These":[228],"results":[229],"suggest":[230],"that":[231],"determined":[233],"single":[236],"scan":[238],"is":[242],"accurate":[244],"separating":[248],"predicting":[256],"measures":[258],"severity.":[261]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
