{"id":"https://openalex.org/W1848434933","doi":null,"title":"Conversion from radiologically isolated syndrome to multiple sclerosis.","display_name":"Conversion from radiologically isolated syndrome to multiple sclerosis.","publication_year":2014,"publication_date":"2014-11-01","ids":{"openalex":"https://openalex.org/W1848434933","mag":"1848434933","pmid":"https://pubmed.ncbi.nlm.nih.gov/25538833","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4274544"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:3240558","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4274544","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4274544","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001360175","display_name":"Masoud Etemadifar","orcid":"https://orcid.org/0000-0002-0066-3782","observed_orcids":["https://orcid.org/0000-0002-0066-3782","https://orcid.org/0000-0003-3318-7513"]},"institutions":[{"id":"https://openalex.org/I114982161","display_name":"Isfahan University of Medical Sciences","ror":"https://ror.org/04waqzz56","country_code":"IR","type":"education","lineage":["https://openalex.org/I114982161"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Masoud Etemadifar","raw_affiliation_strings":["Isfahan Multiple Sclerosis Society, Isfahan University of Medical Sciences, Isfahan, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Isfahan Multiple Sclerosis Society, Isfahan University of Medical Sciences, Isfahan, Iran","institution_ids":["https://openalex.org/I114982161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025579242","display_name":"Mohsen Janghorbani","orcid":"https://orcid.org/0000-0003-3024-3380","observed_orcids":["https://orcid.org/0000-0003-3024-3380"]},"institutions":[{"id":"https://openalex.org/I114982161","display_name":"Isfahan University of Medical Sciences","ror":"https://ror.org/04waqzz56","country_code":"IR","type":"education","lineage":["https://openalex.org/I114982161"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Mohsen Janghorbani","raw_affiliation_strings":["Department of Epidemiology and Biostatistics, School of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology and Biostatistics, School of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran","institution_ids":["https://openalex.org/I114982161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002435969","display_name":"Mohammad Mehdi Koushki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114982161","display_name":"Isfahan University of Medical Sciences","ror":"https://ror.org/04waqzz56","country_code":"IR","type":"education","lineage":["https://openalex.org/I114982161"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Mohammad Mehdi Koushki","raw_affiliation_strings":["Isfahan Multiple Sclerosis Society, Isfahan University of Medical Sciences, Isfahan, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Isfahan Multiple Sclerosis Society, Isfahan University of Medical Sciences, Isfahan, Iran","institution_ids":["https://openalex.org/I114982161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024060142","display_name":"Fatemeh Etemadifar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114982161","display_name":"Isfahan University of Medical Sciences","ror":"https://ror.org/04waqzz56","country_code":"IR","type":"education","lineage":["https://openalex.org/I114982161"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Fatemeh Etemadifar","raw_affiliation_strings":["Isfahan Multiple Sclerosis Society, Isfahan University of Medical Sciences, Isfahan, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Isfahan Multiple Sclerosis Society, Isfahan University of Medical Sciences, Isfahan, Iran","institution_ids":["https://openalex.org/I114982161"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083131758","display_name":"Mahboobeh Fereidan-Esfahani","orcid":"https://orcid.org/0000-0003-1777-841X","observed_orcids":["https://orcid.org/0000-0003-1777-841X"]},"institutions":[{"id":"https://openalex.org/I114982161","display_name":"Isfahan University of Medical Sciences","ror":"https://ror.org/04waqzz56","country_code":"IR","type":"education","lineage":["https://openalex.org/I114982161"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Mahboobeh Fereidan Esfahani","raw_affiliation_strings":["Isfahan Multiple Sclerosis Society, Isfahan University of Medical Sciences, Isfahan, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Isfahan Multiple Sclerosis Society, Isfahan University of Medical Sciences, Isfahan, Iran","institution_ids":["https://openalex.org/I114982161"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I114982161"],"apc_list":null,"apc_paid":null,"fwci":0.6335,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.67871084,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"5","issue":"11","first_page":"1379","last_page":"86"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11827","display_name":"Polyomavirus and related diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11735","display_name":"Peripheral Neuropathies and Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/radiologically-isolated-syndrome","display_name":"radiologically isolated syndrome","score":0.9990000128746033},{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.8130000233650208},{"id":"https://openalex.org/keywords/conversion-rate","display_name":"conversion rate","score":0.8320000171661377},{"id":"https://openalex.org/keywords/contrast-enhancing-lesions","display_name":"contrast-enhancing lesions","score":0.8679999709129333},{"id":"https://openalex.org/keywords/brain-mri","display_name":"brain MRI","score":0.7860000133514404},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.46399998664855957},{"id":"https://openalex.org/keywords/young-adults","display_name":"young adults","score":0.527999997138977}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9314248561859131},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.7356683015823364},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.7278420925140381},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.6419926881790161},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.5718488097190857},{"id":"https://openalex.org/C2781028063","wikidata":"https://www.wikidata.org/wiki/Q338802","display_name":"Clinically isolated syndrome","level":3,"score":0.5058107376098633},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4096277952194214},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.2929416596889496},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:3240558","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4274544","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:25538833","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25538833","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of preventive medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4274544","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4274544/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Prev Med","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:a9f8487a4ace4708b14589fc3ac9dc90","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/a9f8487a4ace4708b14589fc3ac9dc90","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Preventive Medicine, Vol 5, Iss 11, Pp 1379-1386 (2014)","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3240558","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4274544","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1488216947","https://openalex.org/W1966515383","https://openalex.org/W1967085009","https://openalex.org/W1981468808","https://openalex.org/W1986748577","https://openalex.org/W1997325103","https://openalex.org/W2030113529","https://openalex.org/W2056544619","https://openalex.org/W2061642892","https://openalex.org/W2063158442","https://openalex.org/W2069886565","https://openalex.org/W2102945024","https://openalex.org/W2122545833","https://openalex.org/W2122894564","https://openalex.org/W2124811944","https://openalex.org/W2141185335","https://openalex.org/W2142577589","https://openalex.org/W2160313677","https://openalex.org/W2162472598","https://openalex.org/W2246548868","https://openalex.org/W2406505937","https://openalex.org/W4234850775"],"related_works":["https://openalex.org/W2083804344","https://openalex.org/W4394598848","https://openalex.org/W3191803398","https://openalex.org/W3080099619","https://openalex.org/W2971797637","https://openalex.org/W2142215446","https://openalex.org/W3046369811","https://openalex.org/W6948343935","https://openalex.org/W2576602336","https://openalex.org/W4280605182"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,60,77,102,171],"aim":[2],"of":[3,31,57,64,90,125,132,161],"this":[4,203],"study":[5,198],"was":[6,66,110,139],"to":[7,17,107,166,176,201],"estimate":[8,160],"the":[9,55,83,136,158],"conversion":[10,103,162,172],"rate":[11,104,163],"from":[12,48,105,164,174],"radiologically":[13],"isolated":[14],"syndrome":[15],"(RIS)":[16],"definite":[18,58,78,100,108,167,177],"multiple":[19],"sclerosis":[20],"(MS).":[21],"METHODS:":[22],"During":[23],"a":[24,49],"mean":[25,61],"(standard":[26],"deviation":[27],"[SD])":[28],"follow-up":[29,186],"period":[30],"17.4":[32],"(5.4)":[33],"(range":[34],"8-29)":[35],"months,":[36],"25":[37,91],"subjects":[38],"with":[39,97,143],"RIS":[40,106,165,175],"and":[41,184,187],"without":[42],"neurological":[43],"symptom":[44,95],"aged":[45],"22-45":[46],"year":[47],"single-center":[50],"have":[51],"been":[52],"examined":[53],"for":[54,99,192],"occurrence":[56],"MS.":[59,101],"(SD)":[62],"age":[63],"participants":[65,181],"35.1":[67],"(6.2)":[68],"years":[69],"at":[70],"first":[71,159],"brain":[72],"magnetic":[73],"resonance":[74],"imaging":[75],"(MRI).":[76],"MS":[79,109,144,168,178],"were":[80],"assessed":[81],"using":[82],"revised":[84],"McDonald's":[85],"criteria":[86,98],"(2010).":[87],"RESULTS:":[88],"Six":[89],"patients":[92],"developed":[93],"clinical":[94],"consistent":[96],"1.5":[111],"(95%":[112],"confidence":[113],"interval":[114],"[CI]":[115],"0.54,":[116],"3.17)":[117],"per":[118],"100":[119],"person-months":[120,124],"based":[121],"on":[122,135],"480":[123],"follow-up.":[126],"Multivariate":[127],"analysis":[128],"revealed":[129],"that":[130],"presence":[131],"contrast-enhancing":[133],"lesions":[134],"initial":[137],"MRI":[138],"marginally":[140],"significantly":[141],"associated":[142],"(hazard":[145],"ratio":[146],"1.83,":[147],"95%":[148],"CI":[149],"0.98,":[150],"3.45,":[151],"P":[152],"=":[153],"0.060).":[154],"CONCLUSIONS:":[155],"This":[156],"is":[157,199],"in":[169,179,205],"Iran.":[170],"rates":[173],"these":[180,193],"are":[182,190],"high":[183],"intensive":[185],"intervention":[188],"strategies":[189],"recommended":[191],"high-risk":[194],"individuals.":[195],"A":[196],"larger":[197],"warranted":[200],"assess":[202],"risk":[204],"greater":[206],"detail.":[207]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}