{"id":"https://openalex.org/W184807856","doi":null,"title":"Periodontal microorganisms, obesity, chronic inflammation, and type 1 diabetes","display_name":"Periodontal microorganisms, obesity, chronic inflammation, and type 1 diabetes","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W184807856","mag":"184807856"},"language":"en","primary_location":{"id":"pmh:oai:scholarcommons.sc.edu:etd-3947","doi":null,"is_oa":true,"landing_page_url":"https://scholarcommons.sc.edu/etd/2941","pdf_url":"https://scholarcommons.sc.edu/etd/2941","source":{"id":"https://openalex.org/S4306401386","display_name":"Scholar Commons (University of South Carolina)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I155781252","host_organization_name":"University of South Carolina","host_organization_lineage":["https://openalex.org/I155781252"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Theses and Dissertations","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://scholarcommons.sc.edu/etd/2941","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022406160","display_name":"Georges Joseph Nahhas","orcid":"https://orcid.org/0000-0001-8909-2228","observed_orcids":["https://orcid.org/0000-0001-8909-2228"]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Georges J. Nahhas","raw_affiliation_strings":["University of South Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of South Carolina","institution_ids":["https://openalex.org/I155781252"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5022406160"],"corresponding_institution_ids":["https://openalex.org/I155781252"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.9049999713897705},{"id":"https://openalex.org/keywords/oral-bacteria","display_name":"oral bacteria","score":0.5230000019073486},{"id":"https://openalex.org/keywords/subgingival-plaque","display_name":"subgingival plaque","score":0.9760000109672546},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.8299999833106995},{"id":"https://openalex.org/keywords/chronic-inflammation","display_name":"chronic inflammation","score":0.7860000133514404},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.9890000224113464},{"id":"https://openalex.org/keywords/adiponectin","display_name":"adiponectin","score":1.0},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.9549999833106995},{"id":"https://openalex.org/keywords/adolescents","display_name":"adolescents","score":0.4519999921321869},{"id":"https://openalex.org/keywords/glycemic-control","display_name":"glycemic control","score":0.746999979019165},{"id":"https://openalex.org/keywords/hba1c","display_name":"HbA1c","score":0.8259999752044678},{"id":"https://openalex.org/keywords/oral-hygiene","display_name":"oral hygiene","score":0.48899999260902405},{"id":"https://openalex.org/keywords/gingival-status","display_name":"gingival status","score":0.6150000095367432}],"concepts":[{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6385388374328613},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6219425797462463},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.5636770129203796},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5621187686920166},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.5445303320884705},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3108990788459778},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.22654476761817932}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:scholarcommons.sc.edu:etd-3947","doi":null,"is_oa":true,"landing_page_url":"https://scholarcommons.sc.edu/etd/2941","pdf_url":"https://scholarcommons.sc.edu/etd/2941","source":{"id":"https://openalex.org/S4306401386","display_name":"Scholar Commons (University of South Carolina)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I155781252","host_organization_name":"University of South Carolina","host_organization_lineage":["https://openalex.org/I155781252"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Theses and Dissertations","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.858.8322","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.858.8322","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://scholarcommons.sc.edu/cgi/viewcontent.cgi?article%3D3947%26context%3Detd","raw_type":"text"},{"id":"mag:184807856","doi":null,"is_oa":false,"landing_page_url":"https://scholarcommons.sc.edu/cgi/viewcontent.cgi?article=3947&context=etd","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:scholarcommons.sc.edu:etd-3947","doi":null,"is_oa":true,"landing_page_url":"https://scholarcommons.sc.edu/etd/2941","pdf_url":"https://scholarcommons.sc.edu/etd/2941","source":{"id":"https://openalex.org/S4306401386","display_name":"Scholar Commons (University of South Carolina)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I155781252","host_organization_name":"University of South Carolina","host_organization_lineage":["https://openalex.org/I155781252"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Theses and Dissertations","raw_type":"text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W184807856.pdf","grobid_xml":"https://content.openalex.org/works/W184807856.grobid-xml"},"referenced_works_count":153,"referenced_works":["https://openalex.org/W33911032","https://openalex.org/W65822152","https://openalex.org/W86050754","https://openalex.org/W104371847","https://openalex.org/W1489920188","https://openalex.org/W1564321763","https://openalex.org/W1606088617","https://openalex.org/W1965486382","https://openalex.org/W1969587274","https://openalex.org/W1973897031","https://openalex.org/W1974033843","https://openalex.org/W1976248362","https://openalex.org/W1980028051","https://openalex.org/W1980275970","https://openalex.org/W1981211060","https://openalex.org/W1984033049","https://openalex.org/W1984961321","https://openalex.org/W1986160442","https://openalex.org/W1987531445","https://openalex.org/W1987590777","https://openalex.org/W1988519907","https://openalex.org/W1988683038","https://openalex.org/W1988870963","https://openalex.org/W1990974422","https://openalex.org/W1994080141","https://openalex.org/W1994464447","https://openalex.org/W1996346597","https://openalex.org/W1996602846","https://openalex.org/W1996742164","https://openalex.org/W1997072139","https://openalex.org/W1998221258","https://openalex.org/W1998356843","https://openalex.org/W1998614770","https://openalex.org/W2000252039","https://openalex.org/W2001018972","https://openalex.org/W2003194282","https://openalex.org/W2004290014","https://openalex.org/W2006182928","https://openalex.org/W2009170813","https://openalex.org/W2009590767","https://openalex.org/W2009707556","https://openalex.org/W2010149962","https://openalex.org/W2012490955","https://openalex.org/W2013917284","https://openalex.org/W2014296405","https://openalex.org/W2019094601","https://openalex.org/W2019847468","https://openalex.org/W2020837921","https://openalex.org/W2021720963","https://openalex.org/W2021792184","https://openalex.org/W2025732533","https://openalex.org/W2031207391","https://openalex.org/W2031469679","https://openalex.org/W2031719417","https://openalex.org/W2033431538","https://openalex.org/W2037666663","https://openalex.org/W2038252558","https://openalex.org/W2038869287","https://openalex.org/W2038891617","https://openalex.org/W2040554957","https://openalex.org/W2040750127","https://openalex.org/W2040874707","https://openalex.org/W2042327633","https://openalex.org/W2044527758","https://openalex.org/W2045264957","https://openalex.org/W2046223572","https://openalex.org/W2047283836","https://openalex.org/W2052802407","https://openalex.org/W2055294433","https://openalex.org/W2057428444","https://openalex.org/W2059117703","https://openalex.org/W2059133726","https://openalex.org/W2062573090","https://openalex.org/W2066616037","https://openalex.org/W2067612926","https://openalex.org/W2068587775","https://openalex.org/W2070105940","https://openalex.org/W2073195943","https://openalex.org/W2073332363","https://openalex.org/W2074185541","https://openalex.org/W2076728075","https://openalex.org/W2077113219","https://openalex.org/W2077591662","https://openalex.org/W2081206953","https://openalex.org/W2082776571","https://openalex.org/W2083185572","https://openalex.org/W2083909147","https://openalex.org/W2087484128","https://openalex.org/W2089135366","https://openalex.org/W2095774121","https://openalex.org/W2095797295","https://openalex.org/W2095935768","https://openalex.org/W2100884884","https://openalex.org/W2102751207","https://openalex.org/W2103445279","https://openalex.org/W2104918369","https://openalex.org/W2105136110","https://openalex.org/W2105797187","https://openalex.org/W2107832644","https://openalex.org/W2109056023","https://openalex.org/W2109694442","https://openalex.org/W2110235509","https://openalex.org/W2111420514","https://openalex.org/W2113835734","https://openalex.org/W2116241217","https://openalex.org/W2119217669","https://openalex.org/W2121530178","https://openalex.org/W2122199148","https://openalex.org/W2123039389","https://openalex.org/W2123421680","https://openalex.org/W2128168531","https://openalex.org/W2128832840","https://openalex.org/W2129316761","https://openalex.org/W2129330535","https://openalex.org/W2130495917","https://openalex.org/W2131270395","https://openalex.org/W2131536322","https://openalex.org/W2133549697","https://openalex.org/W2133707909","https://openalex.org/W2133814459","https://openalex.org/W2134241357","https://openalex.org/W2134327953","https://openalex.org/W2134724351","https://openalex.org/W2135202112","https://openalex.org/W2136252190","https://openalex.org/W2137265735","https://openalex.org/W2137620994","https://openalex.org/W2138004915","https://openalex.org/W2143980582","https://openalex.org/W2144610619","https://openalex.org/W2145256793","https://openalex.org/W2145609732","https://openalex.org/W2145717531","https://openalex.org/W2145966983","https://openalex.org/W2149266012","https://openalex.org/W2151487987","https://openalex.org/W2152377123","https://openalex.org/W2153951707","https://openalex.org/W2154279165","https://openalex.org/W2157107389","https://openalex.org/W2158024433","https://openalex.org/W2160645541","https://openalex.org/W2162926032","https://openalex.org/W2166449272","https://openalex.org/W2166466209","https://openalex.org/W2270024543","https://openalex.org/W2314938170","https://openalex.org/W2414866153","https://openalex.org/W2424682954","https://openalex.org/W2470404765","https://openalex.org/W2567809950","https://openalex.org/W4240575119","https://openalex.org/W4321258693"],"related_works":["https://openalex.org/W2186407003","https://openalex.org/W2948147868","https://openalex.org/W65822152","https://openalex.org/W1980028051","https://openalex.org/W2951262851","https://openalex.org/W2082776571","https://openalex.org/W7202294629","https://openalex.org/W4406927175","https://openalex.org/W2606543902","https://openalex.org/W2973114984"],"abstract_inverted_index":{"Periodontal":[0],"disease":[1],"is":[2,20],"a":[3,192,254],"low-grade":[4],"chronic":[5,26],"inflammation":[6],"in":[7,35,52,106,194,232,263],"the":[8,11,102,151,174,195,233,264,276,373,381],"tissues":[9],"surrounding":[10],"teeth":[12,185,250],"caused":[13],"by":[14],"multiple,":[15],"mostly":[16],"gram-negative":[17],"pathogens.":[18],"It":[19],"associated":[21,308],"with":[22,54,82,143,216,309,327,337],"diabetes,":[23,59],"obesity,":[24],"and":[25,55,60,73,86,94,121,132,203,213,217,245,280,298,311,328,334,363,376],"inflammation.":[27],"The":[28,318],"specific":[29],"roles":[30],"that":[31],"periodontal":[32,45,305,367],"microorganism":[33],"play":[34],"these":[36],"conditions":[37],"are":[38],"not":[39,258,285],"well-studied.":[40],"Hereby,":[41],"we":[42],"explored":[43],"how":[44,61],"bacteria":[46],"from":[47,79,113],"sub":[48,114],"gingival":[49],"plaque":[50],"clustered":[51],"youth":[53,81,326,336],"without":[56,88,218,329],"type":[57,83,144,219,228,330,338,356],"1":[58,84,145,220,229,331,339,357],"such":[62],"patterns":[63],"related":[64],"to":[65,134,349,372,380],"body-mass-index":[66],"percentile":[67],"(BMI":[68],"percentile),":[69],"C-reactive":[70],"protein":[71],"(CRP)":[72],"adiponectin.":[74,281],"Cross-sectional":[75],"data":[76],"were":[77,91,116,130,161,167,201,238,269,284,307],"collected":[78],"105":[80],"diabetes":[85,176,221,230,340,358],"71":[87],"diabetes.":[89,332],"Participants":[90,160],"between":[92],"12":[93],"19":[95],"years":[96],"of":[97,110,127,153,156,227,236,267,278,304,321,352,366],"age":[98,351],"receiving":[99],"care":[100],"at":[101,150,251,260],"Barbara":[103],"Davis":[104],"Center":[105],"Colorado,":[107,154],"2009-2011.":[108],"Counts":[109],"41":[111],"oral-bacteria":[112],"gingival-plaque":[115],"obtained":[117],"using":[118,123],"DNA-DNA":[119],"hybridization,":[120],"grouped":[122],"cluster-analysis.":[124],"Standardized-mean":[125],"counts":[126],"each":[128],"organism":[129],"computed":[131],"summed":[133],"get":[135],"microbial-scores":[136],"per":[137],"cluster.":[138,384],"A":[139],"subset":[140],"(n=101,":[141],"54":[142],"diabetes)":[146],"underwent":[147],"dental":[148],"examinations":[149],"University":[152],"School":[155],"Dental":[157],"Medicine":[158],"clinic.":[159],"15-years":[162],"old":[163],"on":[164],"average;":[165],"51%":[166],"female;":[168],"73%":[169],"non-Hispanic":[170],"white;":[171],"37%":[172],"overweight;":[173],"average":[175],"duration":[177],"was":[178,273,323,370,378],"8":[179],"years.":[180],"About":[181],"48%":[182],"brushed":[183,248],"their":[184,249],"twice/day;":[186],"12%":[187],"flossed":[188],"once/day;":[189],"47%":[190],"visited":[191],"dentist":[193],"past":[196],"6":[197],"months.":[198],"Bacterial":[199],"clusters":[200,296],"identified":[202],"named":[204],"after":[205,313],"Socransky\u2019s":[206],"color-coded":[207],"complexes":[208],"as":[209],"\u2018blue-other\u2019,":[210],"\u2018orange-blue\u2019,":[211],"\u2018orange-red\u2019,":[212],"\u2018yellow-other\u2019.":[214],"Individuals":[215],"had":[222,241,291,341],"similar":[223,274,324,342],"microbial":[224],"composition.":[225],"Cases":[226],"ranking":[231],"highest":[234,265],"tertile":[235,266],"CRP":[237,279,310,369],"older,":[239],"female,":[240],"higher":[242],"Hemoglobin-A1c":[243],"(HbA1c)":[244],"glucose":[246],"levels,":[247],"least":[252],"twice":[253],"day":[255],"but":[256],"did":[257],"floss":[259],"all.":[261],"Those":[262],"adiponectin":[268,312,377],"similar.":[270],"Gingival":[271],"condition":[272],"across":[275],"tertiles":[277],"Cluster":[282],"scores":[283,294],"significantly":[286],"different;":[287],"however,":[288],"overweight":[289,335],"participants":[290],"qualitatively":[292],"lower":[293],"for":[295,315],"2":[297],"3":[299],"than":[300],"normal":[301],"participants.":[302],"Clusters":[303],"microorganisms":[306,322],"accounting":[314],"potential":[316],"confounders.":[317],"oral":[319],"composition":[320],"among":[325],"Normal":[333],"profiles":[343],"too.":[344],"This":[345],"may":[346],"be":[347],"due":[348],"young":[350],"participants,":[353],"relatively":[354],"short":[355],"duration,":[359],"regular":[360],"medical":[361],"care,":[362],"low":[364],"level":[365],"disease.":[368],"positively-related":[371],"\u2018orange-blue\u2019":[374],"cluster":[375],"negatively-related":[379],"\u2018Blue-Other":[382],"\u2019":[383]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
