{"id":"https://openalex.org/W1846166808","doi":null,"title":"Elucidating The Regulatory Mechanisms Of The Mammalian Target Of Rapamycin Complex 1 (Mtorc1) In Protein Homeostasis","display_name":"Elucidating The Regulatory Mechanisms Of The Mammalian Target Of Rapamycin Complex 1 (Mtorc1) In Protein Homeostasis","publication_year":2013,"publication_date":"2013-08-19","ids":{"openalex":"https://openalex.org/W1846166808","mag":"1846166808"},"language":"en","primary_location":{"id":"pmh:oai:ecommons.cornell.edu:1813/34159","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1813/34159","pdf_url":"https://hdl.handle.net/1813/34159","source":{"id":"https://openalex.org/S4306400757","display_name":"eCommons (Cornell University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"dissertation or thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hdl.handle.net/1813/34159","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004778421","display_name":"Crystal S. Conn","orcid":"https://orcid.org/0000-0003-3209-0445","observed_orcids":["https://orcid.org/0000-0003-3209-0445"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Crystal S. Conn","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3209-0445","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5004778421"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mtorc1","display_name":"mTORC1","score":0.8510000109672546},{"id":"https://openalex.org/keywords/proteostasis","display_name":"proteostasis","score":0.871999979019165},{"id":"https://openalex.org/keywords/protein-synthesis","display_name":"protein synthesis","score":0.6919999718666077},{"id":"https://openalex.org/keywords/mrna-translation","display_name":"mRNA translation","score":0.8889999985694885},{"id":"https://openalex.org/keywords/cap-dependent-translation","display_name":"cap-dependent translation","score":0.7480000257492065},{"id":"https://openalex.org/keywords/cap-independent-translation","display_name":"cap-independent translation","score":0.9369999766349792},{"id":"https://openalex.org/keywords/internal-ribosome-entry-site","display_name":"internal ribosome entry site","score":0.7870000004768372},{"id":"https://openalex.org/keywords/hsp70","display_name":"HSP70","score":0.9330000281333923},{"id":"https://openalex.org/keywords/5-untranslated-region","display_name":"5' untranslated region","score":0.7879999876022339},{"id":"https://openalex.org/keywords/heat-shock-response","display_name":"heat shock response","score":0.6800000071525574},{"id":"https://openalex.org/keywords/stress-tolerance","display_name":"stress tolerance","score":0.6620000004768372},{"id":"https://openalex.org/keywords/ribosomal-protein-s6-kinase","display_name":"S6K","score":0.7519999742507935},{"id":"https://openalex.org/keywords/translation-fidelity","display_name":"translation fidelity","score":0.8970000147819519},{"id":"https://openalex.org/keywords/protein-quality-control","display_name":"protein quality control","score":0.5529999732971191},{"id":"https://openalex.org/keywords/proteasome","display_name":"proteasome","score":0.4740000069141388},{"id":"https://openalex.org/keywords/ubiquitin","display_name":"ubiquitin","score":0.47099998593330383},{"id":"https://openalex.org/keywords/protein-degradation","display_name":"protein degradation","score":0.3630000054836273},{"id":"https://openalex.org/keywords/mtorc1-hyperactivation","display_name":"mTORC1 hyperactivation","score":0.609000027179718},{"id":"https://openalex.org/keywords/lifespan","display_name":"lifespan","score":0.4410000145435333},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.4259999990463257},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.8600000143051147},{"id":"https://openalex.org/keywords/age-related-diseases","display_name":"age-related diseases","score":0.7289999723434448}],"concepts":[{"id":"https://openalex.org/C98490376","wikidata":"https://www.wikidata.org/wiki/Q14876060","display_name":"mTORC1","level":4,"score":0.8734002113342285},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.518629252910614},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.48364269733428955},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.40484195947647095},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40294790267944336},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.31830036640167236},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.16847679018974304}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:ecommons.cornell.edu:1813/34159","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1813/34159","pdf_url":"https://hdl.handle.net/1813/34159","source":{"id":"https://openalex.org/S4306400757","display_name":"eCommons (Cornell University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"dissertation or thesis"},{"id":"mag:1846166808","doi":null,"is_oa":false,"landing_page_url":"https://ecommons.cornell.edu/bitstream/1813/34159/1/csc235.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:ecommons.cornell.edu:1813/34159","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1813/34159","pdf_url":"https://hdl.handle.net/1813/34159","source":{"id":"https://openalex.org/S4306400757","display_name":"eCommons (Cornell University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"dissertation or thesis"},"sustainable_development_goals":[{"score":0.766700029373169,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1846166808.pdf","grobid_xml":"https://content.openalex.org/works/W1846166808.grobid-xml"},"referenced_works_count":172,"referenced_works":["https://openalex.org/W284175395","https://openalex.org/W820273407","https://openalex.org/W1597525592","https://openalex.org/W1782287000","https://openalex.org/W1901983160","https://openalex.org/W1902818137","https://openalex.org/W1964221844","https://openalex.org/W1966082815","https://openalex.org/W1967138582","https://openalex.org/W1968892625","https://openalex.org/W1970027651","https://openalex.org/W1971108880","https://openalex.org/W1973785682","https://openalex.org/W1973856122","https://openalex.org/W1980939920","https://openalex.org/W1982789056","https://openalex.org/W1983698019","https://openalex.org/W1985641201","https://openalex.org/W1985754630","https://openalex.org/W1986720579","https://openalex.org/W1987535942","https://openalex.org/W1988330295","https://openalex.org/W1989964807","https://openalex.org/W1991204394","https://openalex.org/W1993431258","https://openalex.org/W1993750625","https://openalex.org/W1995430236","https://openalex.org/W1996799677","https://openalex.org/W1999999605","https://openalex.org/W2000731858","https://openalex.org/W2000789682","https://openalex.org/W2001259221","https://openalex.org/W2002226709","https://openalex.org/W2002741326","https://openalex.org/W2004543547","https://openalex.org/W2005583424","https://openalex.org/W2006559495","https://openalex.org/W2007006796","https://openalex.org/W2008100923","https://openalex.org/W2008239768","https://openalex.org/W2008410413","https://openalex.org/W2009971361","https://openalex.org/W2011282245","https://openalex.org/W2013057225","https://openalex.org/W2014892893","https://openalex.org/W2018553282","https://openalex.org/W2020209656","https://openalex.org/W2020401706","https://openalex.org/W2023012828","https://openalex.org/W2023431124","https://openalex.org/W2023563008","https://openalex.org/W2024069519","https://openalex.org/W2025176940","https://openalex.org/W2025569664","https://openalex.org/W2026784725","https://openalex.org/W2027785297","https://openalex.org/W2029220273","https://openalex.org/W2033774852","https://openalex.org/W2034404031","https://openalex.org/W2034764834","https://openalex.org/W2034872394","https://openalex.org/W2036755369","https://openalex.org/W2037313242","https://openalex.org/W2037786814","https://openalex.org/W2038169765","https://openalex.org/W2038440449","https://openalex.org/W2039196160","https://openalex.org/W2041308494","https://openalex.org/W2041811289","https://openalex.org/W2043704121","https://openalex.org/W2045440227","https://openalex.org/W2048376025","https://openalex.org/W2048731469","https://openalex.org/W2049883153","https://openalex.org/W2050068554","https://openalex.org/W2050416589","https://openalex.org/W2050980183","https://openalex.org/W2051648135","https://openalex.org/W2057583443","https://openalex.org/W2058268504","https://openalex.org/W2060905299","https://openalex.org/W2063513058","https://openalex.org/W2065049493","https://openalex.org/W2065642231","https://openalex.org/W2065887259","https://openalex.org/W2066659565","https://openalex.org/W2071056869","https://openalex.org/W2071193766","https://openalex.org/W2071847586","https://openalex.org/W2073701988","https://openalex.org/W2074037083","https://openalex.org/W2075839343","https://openalex.org/W2076159058","https://openalex.org/W2076495609","https://openalex.org/W2077612844","https://openalex.org/W2078010704","https://openalex.org/W2078589754","https://openalex.org/W2078765043","https://openalex.org/W2079517684","https://openalex.org/W2080451230","https://openalex.org/W2081221632","https://openalex.org/W2085522899","https://openalex.org/W2085628457","https://openalex.org/W2085717111","https://openalex.org/W2086338749","https://openalex.org/W2086691574","https://openalex.org/W2087527859","https://openalex.org/W2087689873","https://openalex.org/W2092954099","https://openalex.org/W2093707058","https://openalex.org/W2094148055","https://openalex.org/W2094478098","https://openalex.org/W2094487239","https://openalex.org/W2094853437","https://openalex.org/W2096009990","https://openalex.org/W2096405334","https://openalex.org/W2097000222","https://openalex.org/W2097774036","https://openalex.org/W2098912234","https://openalex.org/W2099646709","https://openalex.org/W2100680605","https://openalex.org/W2101083009","https://openalex.org/W2101220920","https://openalex.org/W2102220689","https://openalex.org/W2103446696","https://openalex.org/W2104052951","https://openalex.org/W2104493977","https://openalex.org/W2104504238","https://openalex.org/W2104944283","https://openalex.org/W2111607026","https://openalex.org/W2114040881","https://openalex.org/W2114189030","https://openalex.org/W2115568781","https://openalex.org/W2115820946","https://openalex.org/W2116058717","https://openalex.org/W2120067067","https://openalex.org/W2120934046","https://openalex.org/W2122611378","https://openalex.org/W2123996523","https://openalex.org/W2124565600","https://openalex.org/W2125666085","https://openalex.org/W2127063807","https://openalex.org/W2127646238","https://openalex.org/W2128264254","https://openalex.org/W2128551987","https://openalex.org/W2130623329","https://openalex.org/W2136272779","https://openalex.org/W2136676465","https://openalex.org/W2137275982","https://openalex.org/W2137417707","https://openalex.org/W2138138136","https://openalex.org/W2139448195","https://openalex.org/W2141444248","https://openalex.org/W2142374550","https://openalex.org/W2145760315","https://openalex.org/W2146415848","https://openalex.org/W2147501289","https://openalex.org/W2148573587","https://openalex.org/W2152600551","https://openalex.org/W2153574614","https://openalex.org/W2153607816","https://openalex.org/W2156777696","https://openalex.org/W2157497892","https://openalex.org/W2158389310","https://openalex.org/W2164462432","https://openalex.org/W2166415858","https://openalex.org/W2170138349","https://openalex.org/W2170604221","https://openalex.org/W2171660629","https://openalex.org/W2186049180","https://openalex.org/W2468654678","https://openalex.org/W7098362075"],"related_works":["https://openalex.org/W1590405048","https://openalex.org/W2157504723","https://openalex.org/W2608431390","https://openalex.org/W4284899241","https://openalex.org/W2104493977","https://openalex.org/W177277007","https://openalex.org/W2123996523","https://openalex.org/W186589885","https://openalex.org/W2993777255","https://openalex.org/W2335506759"],"abstract_inverted_index":{"The":[0,39],"proper":[1,398],"balance":[2],"between":[3,245,384],"protein":[4,36,43,193,209,257,275,305,312,371,385],"synthesis,":[5,194],"maturation,":[6],"and":[7,16,71,83,102,121,150,163,180,198,248,274,290,307,387,401,435],"degradation":[8],"is":[9,22,45,119,188],"crucial":[10],"for":[11,64,95,127,190],"an":[12,96,242,254,281,285,309,443],"organism":[13,97,282],"to":[14,24,34,77,99,130,169,173,236,265,280,284,358,410],"survive":[15],"prosper.":[17],"Each":[18],"of":[19,31,42,52,89,140,216,229,301,317,394,423,432,439,445],"these":[20,114],"processes":[21,80],"coupled":[23],"the":[25,49,65,109,128,138,144,206,225,249,299,315,340,359,392,424,430,437],"cellular":[26],"environment":[27],"through":[28,48,218,330],"a":[29,61,124,213,261,269,381,420],"multitude":[30],"signaling":[32,91,187,223,247,273,326,351,396,428],"events":[33,111,416],"maintain":[35,266],"homeostasis":[37],"(proteostasis).":[38],"costly":[40],"process":[41],"synthesis":[44,258,276,306],"partially":[46,363],"regulated":[47],"mammalian":[50],"target":[51,333],"rapamycin":[53,368],"in":[54,75,177,256,271,287,311,349,397],"complex":[55],"1":[56],"(mTORC1).":[57],"mTORC1":[58,90,118,142,164,171,186,222,246,272,302,325,365,388,412,418,427],"acts":[59],"as":[60,419],"metabolic":[62],"hub":[63],"cell":[66,129,154,233,237,399],"monitoring":[67],"energy":[68],"levels,":[69],"nutrients,":[70],"amino":[72],"acid":[73],"availability":[74],"order":[76],"increase":[78,255,286,310,348],"anabolic":[79],"including":[81],"initiation":[82],"elongation":[84,354],"during":[85],"mRNA":[86,178,200,376],"translation.":[87,201,377],"Deregulation":[88],"can":[92,259,277],"be":[93,278],"catastrophic":[94],"leading":[98,235,283,357],"cancer,":[100],"obesity,":[101],"age-related":[103,433],"illness.":[104],"This":[105],"work":[106],"focuses":[107],"on":[108,143,304,339],"molecular":[110,415],"that":[112,185,205,323],"promote":[113],"disease":[115],"states":[116],"when":[117],"hyperactivated,":[120],"further":[122,297],"investigates":[123],"potential":[125,447],"mechanism":[126,215,295],"cope":[131],"with":[132,335,367],"this":[133,294],"dys-homeostasis.":[134],"Here,":[135],"I":[136,166,183,203,296,321],"investigated":[137,298],"impact":[139],"hyperactive":[141,324],"proteostasis":[145,425],"network":[146,342],"by":[147,373],"inducing":[148],"cytosolic":[149],"proteotoxic":[151],"stress":[152,250,288],"within":[153],"cultures.":[155],"Utilizing":[156],"fibroblast":[157],"knockouts,":[158],"lentiviral":[159],"knockdowns,":[160],"plasmid":[161],"transfections,":[162],"inhibitors,":[165],"was":[167],"able":[168],"manipulate":[170,411],"activity":[172,303,366,413,441],"elucidate":[174,293],"its":[175,219,331,440],"role":[176,393],"translation":[179,217,228,328],"overall":[181],"proteostasis.":[182,267],"discovered":[184,308],"necessary":[189,264],"global":[191],"cap-dependent":[192],"but":[195],"attenuated":[196],"cap-independent":[197,214],"IRES":[199],"Moreover,":[202],"demonstrated":[204,322],"heat":[207],"shock":[208],"70":[210],"(Hsp70)":[211],"utilized":[212],"5'UTR.":[220],"Hyperactive":[221],"prevented":[224],"stress-induced":[226],"preferential":[227],"HSP70,":[230],"which":[231,390],"inhibited":[232],"recovery":[234],"death.":[238],"These":[239],"results":[240,379,408],"uncovered":[241],"intimate":[243],"connection":[244,383],"response,":[251],"highlighting":[252,417],"how":[253],"imbalance":[260],"translational":[262],"switch":[263],"Correspondingly,":[268],"decrease":[270],"beneficial":[279],"resistance":[289],"lifespan.":[291],"To":[292],"effects":[300,438],"quantity":[313],"altered":[314],"quality":[316,372,386],"newly":[318],"synthesized":[319],"polypeptides.":[320],"decreased":[327],"fidelity":[329],"downstream":[332,446],"S6K,":[334],"no":[336],"apparent":[337],"influence":[338],"chaperone":[341],"or":[343],"ubiquitin":[344],"proteasome":[345],"system.":[346],"An":[347],"S6K":[350],"promoted":[352],"faster":[353],"rates,":[355],"potentially":[356],"observed":[360],"mistranslation.":[361],"Furthermore,":[362],"inhibiting":[364],"treatment":[369],"restored":[370],"slowing":[374],"down":[375],"My":[378],"reveal":[380],"mechanistic":[382],"activity,":[389],"strengthen":[391],"nutrient":[395],"growth":[400],"healthy":[402],"aging.":[403],"Collectively,":[404],"my":[405],"ex":[406],"vivo":[407],"used":[409],"uncover":[414],"key":[421],"component":[422],"network.":[426],"favors":[429],"development":[431],"pathologies":[434],"investigating":[436],"provides":[442],"array":[444],"drug":[448],"targets.":[449]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}