{"id":"https://openalex.org/W1845962002","doi":"https://doi.org/10.1042/bj3110431","title":"Synthesis and mass-spectrometric characterization of human serum albumins modified by covalent binding of two non-steroidal anti-inflammatory drugs: tolmetin and zomepirac","display_name":"Synthesis and mass-spectrometric characterization of human serum albumins modified by covalent binding of two non-steroidal anti-inflammatory drugs: tolmetin and zomepirac","publication_year":1995,"publication_date":"1995-10-15","ids":{"openalex":"https://openalex.org/W1845962002","doi":"https://doi.org/10.1042/bj3110431","mag":"1845962002","pmid":"https://pubmed.ncbi.nlm.nih.gov/7487878","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1136018"},"language":"en","primary_location":{"id":"doi:10.1042/bj3110431","doi":"https://doi.org/10.1042/bj3110431","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj3110431","pdf_url":"https://portlandpress.com/biochemj/article-pdf/311/2/431/728503/bj3110431.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://portlandpress.com/biochemj/article-pdf/311/2/431/728503/bj3110431.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090661455","display_name":"Parnian Zia\u2010Amirhosseini","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Zia-Amirhosseini","raw_affiliation_strings":["Departments of San Francisco, CA 94143 0446, U.S.A","Pharmacy and San Francisco, CA 94143 0446, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of San Francisco, CA 94143 0446, U.S.A","institution_ids":[]},{"raw_affiliation_string":"Pharmacy and San Francisco, CA 94143 0446, U.S.A","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041417579","display_name":"A Ding","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Ding","raw_affiliation_strings":["Departments of San Francisco, CA 94143 0446, U.S.A","Pharmaceutical Chemistry and the San Francisco, CA 94143 0446, U.S.A","Pharmacy and San Francisco, CA 94143 0446, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of San Francisco, CA 94143 0446, U.S.A","institution_ids":[]},{"raw_affiliation_string":"Pharmaceutical Chemistry and the San Francisco, CA 94143 0446, U.S.A","institution_ids":[]},{"raw_affiliation_string":"Pharmacy and San Francisco, CA 94143 0446, U.S.A","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068865174","display_name":"Alma L. Burlingame","orcid":"https://orcid.org/0000-0002-8403-7307","observed_orcids":["https://orcid.org/0000-0002-8403-7307"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A L Burlingame","raw_affiliation_strings":["Departments of San Francisco, CA 94143 0446, U.S.A","Pharmaceutical Chemistry and the San Francisco, CA 94143 0446, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of San Francisco, CA 94143 0446, U.S.A","institution_ids":[]},{"raw_affiliation_string":"Pharmaceutical Chemistry and the San Francisco, CA 94143 0446, U.S.A","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015647281","display_name":"Antony F. McDonagh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A F McDonagh","raw_affiliation_strings":["Departments of San Francisco, CA 94143 0446, U.S.A","Liver Center, University of California at San Francisco, San Francisco, CA 94143 0446, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of San Francisco, CA 94143 0446, U.S.A","institution_ids":[]},{"raw_affiliation_string":"Liver Center, University of California at San Francisco, San Francisco, CA 94143 0446, U.S.A","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075960682","display_name":"Leslie Z. Benet","orcid":"https://orcid.org/0000-0002-9678-2371","observed_orcids":["https://orcid.org/0000-0002-9678-2371"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Z Benet","raw_affiliation_strings":["Departments of San Francisco, CA 94143 0446, U.S.A","Pharmacy and San Francisco, CA 94143 0446, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of San Francisco, CA 94143 0446, U.S.A","institution_ids":[]},{"raw_affiliation_string":"Pharmacy and San Francisco, CA 94143 0446, U.S.A","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.123,"has_fulltext":true,"cited_by_count":26,"citation_normalized_percentile":{"value":0.3713498,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"311","issue":"2","first_page":"431","last_page":"435"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-serum-albumin","display_name":"human serum albumin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tolmetin","display_name":"tolmetin","score":0.8989999890327454},{"id":"https://openalex.org/keywords/zomepirac","display_name":"zomepirac","score":1.0},{"id":"https://openalex.org/keywords/nonsteroidal-anti-inflammatory-drugs","display_name":"nonsteroidal anti-inflammatory drugs","score":0.9200000166893005},{"id":"https://openalex.org/keywords/covalent-drug-binding","display_name":"covalent drug binding","score":0.7139999866485596},{"id":"https://openalex.org/keywords/acyl-glucuronides","display_name":"acyl glucuronides","score":0.9190000295639038},{"id":"https://openalex.org/keywords/active-esters","display_name":"activated esters","score":0.7129999995231628},{"id":"https://openalex.org/keywords/edc-coupling","display_name":"EDC coupling","score":0.6349999904632568},{"id":"https://openalex.org/keywords/tryptic-peptide-mapping","display_name":"tryptic peptide mapping","score":0.6150000095367432},{"id":"https://openalex.org/keywords/tandem-mass-spectrometry","display_name":"tandem mass spectrometry","score":0.9520000219345093},{"id":"https://openalex.org/keywords/lysine-binding-site","display_name":"lysine binding site","score":0.7409999966621399}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8201953172683716},{"id":"https://openalex.org/C2778597219","wikidata":"https://www.wikidata.org/wiki/Q11721976","display_name":"Human serum albumin","level":2,"score":0.7898108959197998},{"id":"https://openalex.org/C2776016237","wikidata":"https://www.wikidata.org/wiki/Q178430","display_name":"Lysine","level":3,"score":0.6904116868972778},{"id":"https://openalex.org/C180577832","wikidata":"https://www.wikidata.org/wiki/Q127920","display_name":"Covalent bond","level":2,"score":0.6340676546096802},{"id":"https://openalex.org/C2776125364","wikidata":"https://www.wikidata.org/wiki/Q169219","display_name":"Albumin","level":2,"score":0.5834330320358276},{"id":"https://openalex.org/C165616093","wikidata":"https://www.wikidata.org/wiki/Q424232","display_name":"Serum albumin","level":2,"score":0.5619339942932129},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.482297420501709},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4773064851760864},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4037833511829376},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.3279070258140564},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.21630609035491943},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0632483959197998},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012709","descriptor_name":"Serum Albumin","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D012709","descriptor_name":"Serum Albumin","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D012709","descriptor_name":"Serum Albumin","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D012709","descriptor_name":"Serum Albumin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012709","descriptor_name":"Serum Albumin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012709","descriptor_name":"Serum Albumin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012709","descriptor_name":"Serum Albumin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012709","descriptor_name":"Serum Albumin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012709","descriptor_name":"Serum Albumin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014046","descriptor_name":"Tolmetin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D014046","descriptor_name":"Tolmetin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D014046","descriptor_name":"Tolmetin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D014046","descriptor_name":"Tolmetin","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D014046","descriptor_name":"Tolmetin","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D014046","descriptor_name":"Tolmetin","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D014046","descriptor_name":"Tolmetin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014046","descriptor_name":"Tolmetin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014046","descriptor_name":"Tolmetin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014046","descriptor_name":"Tolmetin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014046","descriptor_name":"Tolmetin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014046","descriptor_name":"Tolmetin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1042/bj3110431","doi":"https://doi.org/10.1042/bj3110431","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj3110431","pdf_url":"https://portlandpress.com/biochemj/article-pdf/311/2/431/728503/bj3110431.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1136018","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1136018","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochem J","raw_type":"Text"},{"id":"pmid:7487878","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7487878","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Biochemical journal","raw_type":"Comparative Study"}],"best_oa_location":{"id":"doi:10.1042/bj3110431","doi":"https://doi.org/10.1042/bj3110431","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj3110431","pdf_url":"https://portlandpress.com/biochemj/article-pdf/311/2/431/728503/bj3110431.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1698368382","display_name":"ACYLCOA FORMATION--COVALENT BINDING, PHARMACOKINETICS","funder_award_id":"5r01gm036633-15","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G258049824","display_name":null,"funder_award_id":"RR 01614","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G3290696142","display_name":null,"funder_award_id":"GM-36633","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5334010142","display_name":"Bio-Organic Biomedical Mass Spectrometry Resource","funder_award_id":"5p41rr001614-29","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5715790255","display_name":"Bilirubin and Photobilirubin: Metabolism &Exretion","funder_award_id":"R01DK026307","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G616142304","display_name":null,"funder_award_id":"DK26307","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1845962002.pdf","grobid_xml":"https://content.openalex.org/works/W1845962002.grobid-xml"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W359627332","https://openalex.org/W1499495082","https://openalex.org/W1858639498","https://openalex.org/W1870948423","https://openalex.org/W1969866655","https://openalex.org/W1982585026","https://openalex.org/W1983769447","https://openalex.org/W2014239314","https://openalex.org/W2049071218","https://openalex.org/W2058022391","https://openalex.org/W2066664962","https://openalex.org/W2088584868","https://openalex.org/W2091561757","https://openalex.org/W2094754630","https://openalex.org/W2119341715","https://openalex.org/W2134379070","https://openalex.org/W2290390269","https://openalex.org/W6606642502"],"related_works":["https://openalex.org/W1858639498","https://openalex.org/W2336259172","https://openalex.org/W1986966205","https://openalex.org/W2028558993","https://openalex.org/W3033997186","https://openalex.org/W2521598904","https://openalex.org/W13856662","https://openalex.org/W2134379070","https://openalex.org/W7099496441","https://openalex.org/W2179715993"],"abstract_inverted_index":{"Human":[0],"serum":[1,39],"albumins":[2],"modified":[3,84],"by":[4,49,65],"covalently":[5,55],"bound":[6,56],"tolmetin":[7],"or":[8],"zomepirac":[9],"were":[10,28,47,63,72,86],"synthesized":[11],"as":[12],"models":[13],"for":[14,88],"similar":[15],"products":[16,46],"formed":[17],"in":[18],"vivo":[19],"from":[20],"acyl":[21],"glucuronides.":[22],"Activated":[23],"esters":[24],"of":[25,43],"both":[26,44,75],"drugs":[27],"prepared":[29],"with":[30,37],"1-ethyl-3-(3-dimethylaminopropyl)-carbodi-imide,":[31],"and":[32,58,80,96,98],"then":[33],"allowed":[34],"to":[35,51,74],"react":[36],"human":[38],"albumin.":[40],"Tryptic":[41],"digests":[42],"protein":[45],"analysed":[48],"HPLC":[50],"identify":[52],"peptides":[53],"containing":[54],"drugs,":[57],"binding":[59,70],"sites":[60,71],"on":[61],"albumin":[62],"identified":[64,87],"high-performance":[66],"tandem":[67],"MS.":[68],"Three":[69,82],"common":[73],"products,":[76],"i.e.":[77,92],"lysine-195,":[78],"-199":[79],"-351.":[81],"further":[83],"residues":[85],"the":[89],"tolmetin-albumin":[90],"product,":[91],"aspartic":[93],"acid":[94],"1,":[95],"lysine-524":[97],"-536.":[99]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}
