{"id":"https://openalex.org/W1845228396","doi":null,"title":"alpha6beta1-Integrin, a major cell surface carrier of beta1-6-branched oligosaccharides, mediates migration of EJ-ras-transformed fibroblasts on laminin-1 independently of its glycosylation state.","display_name":"alpha6beta1-Integrin, a major cell surface carrier of beta1-6-branched oligosaccharides, mediates migration of EJ-ras-transformed fibroblasts on laminin-1 independently of its glycosylation state.","publication_year":1996,"publication_date":"1996-04-01","ids":{"openalex":"https://openalex.org/W1845228396","mag":"1845228396","pmid":"https://pubmed.ncbi.nlm.nih.gov/8603420"},"language":"en","primary_location":{"id":"pmid:8603420","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8603420","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://repositorio.unifesp.br/11600/43246","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009905050","display_name":"Miriam Galvonas Jasiulionis","orcid":"https://orcid.org/0000-0002-4135-0440","observed_orcids":["https://orcid.org/0000-0002-4135-0440"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M G Jasiulionis","raw_affiliation_strings":["Ludwig Institute for Cancer Research, Sao Paulo, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ludwig Institute for Cancer Research, Sao Paulo, Brasil","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083692113","display_name":"Roger J. Chammas","orcid":"https://orcid.org/0000-0003-0342-8726","observed_orcids":["https://orcid.org/0000-0003-0342-8726"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Chammas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052725457","display_name":"Armando Morais Ventura","orcid":"https://orcid.org/0000-0001-9987-4880","observed_orcids":["https://orcid.org/0000-0001-9987-4880"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A M Ventura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074953319","display_name":"Luiz Rodolpho Travassos","orcid":"https://orcid.org/0000-0002-7692-2795","observed_orcids":["https://orcid.org/0000-0002-7692-2795"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L R Travassos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5090411219","display_name":"Helena Brentani","orcid":"https://orcid.org/0000-0001-5192-4682","observed_orcids":["https://orcid.org/0000-0001-5192-4682"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R R Brentani","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8657,"has_fulltext":true,"cited_by_count":40,"citation_normalized_percentile":{"value":0.71375,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"56","issue":"7","first_page":"1682","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.02160000056028366,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10835","display_name":"Carbohydrate Chemistry and Synthesis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/integrin-alpha6beta1","display_name":"alpha6beta1 integrin","score":0.9369999766349792},{"id":"https://openalex.org/keywords/beta1-integrin","display_name":"beta1 integrin","score":0.8259999752044678},{"id":"https://openalex.org/keywords/laminin-1","display_name":"laminin-1","score":0.8330000042915344},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.8270000219345093},{"id":"https://openalex.org/keywords/malignant-transformation","display_name":"malignant transformation","score":0.8370000123977661},{"id":"https://openalex.org/keywords/cell-surface-glycosylation","display_name":"cell surface glycosylation","score":0.7260000109672546},{"id":"https://openalex.org/keywords/leukoagglutinins","display_name":"leukoagglutinins","score":0.7770000100135803},{"id":"https://openalex.org/keywords/n-acetylglucosaminyltransferase-v","display_name":"N-acetylglucosaminyltransferase V","score":0.9739999771118164},{"id":"https://openalex.org/keywords/integrin-alpha6","display_name":"CD49f","score":0.6499999761581421},{"id":"https://openalex.org/keywords/cell-aggregation","display_name":"cell aggregation","score":0.6340000033378601},{"id":"https://openalex.org/keywords/c-jun","display_name":"c-Jun","score":0.8550000190734863},{"id":"https://openalex.org/keywords/nih-3t3-cells","display_name":"NIH3T3 cells","score":0.8840000033378601}],"concepts":[{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.8207495212554932},{"id":"https://openalex.org/C2779814568","wikidata":"https://www.wikidata.org/wiki/Q58345","display_name":"Laminin","level":3,"score":0.7837567329406738},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5313884019851685},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.5035902857780457},{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.46118810772895813},{"id":"https://openalex.org/C86492073","wikidata":"https://www.wikidata.org/wiki/Q413766","display_name":"Fibronectin","level":3,"score":0.4458438456058502},{"id":"https://openalex.org/C2777313579","wikidata":"https://www.wikidata.org/wiki/Q898365","display_name":"Glycosylation","level":2,"score":0.43314674496650696},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4184810519218445},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41059935092926025},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.38103288412094116},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3556470274925232},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26014435291290283}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002461","descriptor_name":"Cell Line, Transformed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006031","descriptor_name":"Glycosylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007797","descriptor_name":"Laminin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009844","descriptor_name":"Oligosaccharides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010835","descriptor_name":"Phytohemagglutinins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011905","descriptor_name":"Genes, ras","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016023","descriptor_name":"Integrins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016475","descriptor_name":"3T3 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019012","descriptor_name":"Integrin beta1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D039121","descriptor_name":"Integrin alpha6beta1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmid:8603420","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8603420","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:americanae.aecid.es:3193172","doi":null,"is_oa":true,"landing_page_url":"http://repositorio.unifesp.br/11600/43246","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da UNIFESP","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:repositorio.unifesp.br:11600/43246","doi":null,"is_oa":true,"landing_page_url":"http://cancerres.aacrjournals.org/content/56/7/1682","pdf_url":"http://cancerres.aacrjournals.org/content/56/7/1682","source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"instacron:UNIFESP","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:1845228396","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8603420","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:americanae.aecid.es:3193172","doi":null,"is_oa":true,"landing_page_url":"http://repositorio.unifesp.br/11600/43246","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da UNIFESP","raw_type":"info:eu-repo/semantics/publishedVersion"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1845228396.pdf","grobid_xml":"https://content.openalex.org/works/W1845228396.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2515667669","https://openalex.org/W2402861189","https://openalex.org/W3161833430","https://openalex.org/W2123255093","https://openalex.org/W2227831008","https://openalex.org/W1994115546","https://openalex.org/W2058560110","https://openalex.org/W2075606600","https://openalex.org/W1989247542","https://openalex.org/W1568242898"],"abstract_inverted_index":{"EJ-ras":[0],"oncogene-induced":[1],"malignant":[2],"transformation":[3],"is":[4,107,116],"characterized":[5],"by":[6,39,62],"a":[7,28,35,94],"series":[8],"of":[9,71,84,100,104,112,140,160],"changes":[10],"in":[11,76,91,118,166,182],"cell":[12,56,145,157],"surface":[13,57,158],"carbohydrates":[14],"and":[15,17,51,200],"cell-cell":[16],"cell-matrix":[18],"interactions.":[19],"Here,":[20],"we":[21],"show":[22,133],"that":[23,134],"EJ-ras-transformed":[24,77,92,173],"NIH-3T3":[25],"fibroblasts":[26,174],"acquired":[27],"migratory":[29,168],"phenotype":[30,36],"on":[31,54,109,143,190],"laminin-1":[32],"surfaces.":[33],"Such":[34],"was":[37,73,89,151],"accompanied":[38],"overexpression":[40,99],"of:":[41],"(a)":[42],"functional":[43,164],"alpha6beta1,":[44],"but":[45],"not":[46,152,180,193,202],"other":[47],"laminin":[48],"binding":[49],"beta1-integrins;":[50],"(b)":[52],"glycoconjugates":[53],"the":[55,98,101,110,137,144,156,167],"bearing":[58],"large":[59],"oligosaccharides":[60,106,142],"recognized":[61],"leukoagglutinin":[63],"from":[64],"Phaseolus":[65],"vulgaris":[66],"(L-PHA).":[67],"The":[68],"internal":[69],"pool":[70],"pre-beta1-integrins":[72],"differently":[74],"regulated":[75],"cells":[78,120],"compared":[79],"with":[80,97],"nontransfected":[81],"fibroblasts.":[82],"Conversion":[83],"pre-beta1-":[85],"into":[86],"mature":[87],"beta1-integrins":[88,135,161,196],"faster":[90],"cells,":[93],"process":[95],"associated":[96],"alpha6-chain.":[102],"Overexpression":[103],"L-PHA-reactive":[105,141,198],"dependent":[108],"activity":[111,165],"N-acetylglucosaminyltransferase":[113],"V,":[114],"which":[115,185],"increased":[117],"transformed":[119],"[J.":[121],"W.":[122],"Dennis":[123],"et":[124],"al.,":[125],"Science":[126],"(Washington":[127],"DC),":[128],"236:":[129],"582-585,":[130],"1987].":[131],"We":[132],"were":[136,179,186],"major":[138],"carriers":[139],"surface.":[146],"This":[147],"glycosylation":[148],"pattern,":[149],"however,":[150],"necessary":[153],"for":[154],"either":[155,195],"expression":[159],"or":[162,197],"their":[163],"response":[169],"to":[170,188],"laminin-1.":[171],"Moreover,":[172],"aggregated":[175],"spontaneously.":[176],"These":[177],"effects":[178],"observed":[181],"c-jun-transfected":[183],"fibroblasts,":[184],"unable":[187],"migrate":[189],"laminin,":[191],"did":[192,201],"overexpress":[194],"oligosaccharides,":[199],"self-aggregate.":[203]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}
