{"id":"https://openalex.org/W18436705","doi":null,"title":"Establishment and characterization of two divergent cell lines derived from a human chromophobe renal cell carcinoma.","display_name":"Establishment and characterization of two divergent cell lines derived from a human chromophobe renal cell carcinoma.","publication_year":1995,"publication_date":"1995-04-01","ids":{"openalex":"https://openalex.org/W18436705","mag":"18436705","pmid":"https://pubmed.ncbi.nlm.nih.gov/7717462","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1869263"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:1533422","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1869263","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1869263","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110026032","display_name":"Claus\u2010Dieter Gerharz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089242","display_name":"D\u00fcsseldorf University Hospital","ror":"https://ror.org/006k2kk72","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210089242"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"C D Gerharz","raw_affiliation_strings":["Institute of Pathology, University Hospital of D\u00fcsseldorf, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, University Hospital of D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I4210089242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111857145","display_name":"R. Moll","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Moll","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047130116","display_name":"S St\u00f6rkel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S St\u00f6rkel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113725776","display_name":"U. Ramp","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"U Ramp","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109150459","display_name":"Barbara Hildebrandt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B Hildebrandt","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032700516","display_name":"Gabriele Molsberger","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Molsberger","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113445445","display_name":"P. Koldovsk\u00fd","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Koldovsky","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111866616","display_name":"Helmut Erich Gabbert","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H E Gabbert","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.9788,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.85404015,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"146","issue":"4","first_page":"953","last_page":"62"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12140","display_name":"Renal and related cancers","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11054","display_name":"Adrenal and Paraganglionic Tumors","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chromophobe-renal-cell-carcinoma","display_name":"chromophobe renal cell carcinoma","score":1.0},{"id":"https://openalex.org/keywords/cell-line-establishment","display_name":"cell line establishment","score":0.781000018119812},{"id":"https://openalex.org/keywords/intercalated-cells","display_name":"intercalated cells","score":0.8299999833106995},{"id":"https://openalex.org/keywords/collecting-duct","display_name":"collecting duct","score":0.7910000085830688},{"id":"https://openalex.org/keywords/cytokeratin","display_name":"cytokeratin","score":0.9789999723434448},{"id":"https://openalex.org/keywords/vimentin","display_name":"vimentin","score":0.8149999976158142},{"id":"https://openalex.org/keywords/coated-vesicles","display_name":"coated vesicles","score":0.9309999942779541},{"id":"https://openalex.org/keywords/hyperdiploidy","display_name":"hyperdiploidy","score":0.8169999718666077},{"id":"https://openalex.org/keywords/telomeric-associations","display_name":"telomeric associations","score":0.796999990940094},{"id":"https://openalex.org/keywords/chromosomal-abnormalities","display_name":"chromosomal abnormalities","score":0.7620000243186951},{"id":"https://openalex.org/keywords/tumor-xenografts","display_name":"tumor xenografts","score":0.5640000104904175},{"id":"https://openalex.org/keywords/population-doubling-time","display_name":"population doubling time","score":0.6840000152587891}],"concepts":[{"id":"https://openalex.org/C78795084","wikidata":"https://www.wikidata.org/wiki/Q5113900","display_name":"Chromophobe cell","level":4,"score":0.8494775891304016},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7072645425796509},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.6675029397010803},{"id":"https://openalex.org/C147447768","wikidata":"https://www.wikidata.org/wiki/Q411624","display_name":"Vimentin","level":3,"score":0.476081520318985},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.43938273191452026},{"id":"https://openalex.org/C2777430276","wikidata":"https://www.wikidata.org/wiki/Q3882418","display_name":"Renal oncocytoma","level":4,"score":0.436451256275177},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.4307926893234253},{"id":"https://openalex.org/C35866371","wikidata":"https://www.wikidata.org/wiki/Q6005502","display_name":"Immunocytochemistry","level":2,"score":0.42794737219810486},{"id":"https://openalex.org/C2781278892","wikidata":"https://www.wikidata.org/wiki/Q18556340","display_name":"Clear cell renal cell carcinoma","level":3,"score":0.4266619384288788},{"id":"https://openalex.org/C2777472916","wikidata":"https://www.wikidata.org/wiki/Q1164529","display_name":"Renal cell carcinoma","level":2,"score":0.3699303865432739},{"id":"https://openalex.org/C2778560582","wikidata":"https://www.wikidata.org/wiki/Q18347894","display_name":"Clear cell","level":3,"score":0.3678905963897705},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3318987786769867},{"id":"https://openalex.org/C2780674462","wikidata":"https://www.wikidata.org/wiki/Q1760202","display_name":"Oncocytoma","level":3,"score":0.27752578258514404},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13541674613952637},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.11664432287216187},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.11527490615844727},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.09669536352157593},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.05857032537460327}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007124","descriptor_name":"Immunoenzyme Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007621","descriptor_name":"Karyotyping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015180","descriptor_name":"Electrophoresis, Gel, Two-Dimensional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:1533422","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1869263","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:1869263","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1869263","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},{"id":"pmid:7717462","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7717462","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of pathology","raw_type":"Journal Article"},{"id":"mag:18436705","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7717462","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:1533422","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1869263","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8560000061988831,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.5600000023841858,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W34522353","https://openalex.org/W181147267","https://openalex.org/W254064965","https://openalex.org/W1508153485","https://openalex.org/W1561739127","https://openalex.org/W1939179218","https://openalex.org/W1965297768","https://openalex.org/W1977379434","https://openalex.org/W1986343884","https://openalex.org/W2007782538","https://openalex.org/W2009571697","https://openalex.org/W2017412286","https://openalex.org/W2023479492","https://openalex.org/W2023484466","https://openalex.org/W2031148752","https://openalex.org/W2033318513","https://openalex.org/W2049415840","https://openalex.org/W2050635307","https://openalex.org/W2068593305","https://openalex.org/W2070985748","https://openalex.org/W2074213404","https://openalex.org/W2086578727","https://openalex.org/W2089837140","https://openalex.org/W2111486924","https://openalex.org/W2116397048","https://openalex.org/W2126146582","https://openalex.org/W2145929767","https://openalex.org/W2145959805","https://openalex.org/W2170128339","https://openalex.org/W2197572211","https://openalex.org/W2314789569","https://openalex.org/W2407982617","https://openalex.org/W2409395259","https://openalex.org/W2409772813","https://openalex.org/W2414469329","https://openalex.org/W2464949621"],"related_works":["https://openalex.org/W2002563641","https://openalex.org/W254064965","https://openalex.org/W2003387831","https://openalex.org/W2415646594","https://openalex.org/W2017412286","https://openalex.org/W2434392225","https://openalex.org/W72330261","https://openalex.org/W2440985662","https://openalex.org/W2023562999","https://openalex.org/W2007782538"],"abstract_inverted_index":{"The":[0],"chromophobe":[1,65,98,202],"renal":[2,10,32,44,99,203],"cell":[3,17,33,45,61,88,100,168,190,204],"carcinoma":[4,46],"is":[5],"a":[6,25,150],"distinct":[7],"type":[8,67],"of":[9,18,31,43,63,84,143],"cancer":[11],"presumably":[12],"derived":[13,94],"from":[14,40,95,201],"the":[15,19,64,74,79,96,144,178],"intercalated":[16,145],"collecting":[20],"duct":[21],"system":[22],"and":[23,55,82,92,107,111,120],"exhibiting":[24],"better":[26],"prognosis":[27],"than":[28,160],"other":[29,41],"types":[30,42],"carcinoma.":[34,101],"Chromophobe":[35],"carcinomas":[36,205],"can":[37],"be":[38,140],"separated":[39],"by":[47],"their":[48],"characteristic":[49,141],"cytomorphology,":[50],"ultrastructural":[51],"appearance,":[52],"cytoskeletal":[53],"architecture,":[54],"cytogenetic":[56],"aberrations.":[57],"As":[58],"no":[59],"permanent":[60,87],"line":[62],"tumor":[66],"has":[68],"previously":[69],"been":[70],"described,":[71],"we":[72],"are":[73,137],"first":[75],"to":[76,139,171],"report":[77],"on":[78],"successful":[80],"establishment":[81],"characterization":[83],"two":[85],"divergent":[86],"lines,":[89],"ie,":[90],"chrompho-A":[91,110,161],"chrompho-B,":[93],"same":[97],"With":[102],"immunocytochemistry,":[103],"two-dimensional":[104],"gel":[105],"electrophoresis,":[106],"Western":[108],"blot,":[109],"chrompho-B":[112],"exclusively":[113],"exhibited":[114,149],"cytokeratins":[115],"(Nos.":[116],"7,":[117],"8,":[118],"18,":[119],"19)":[121],"but":[122],"not":[123],"vimentin.":[124],"Ultrastructural":[125],"studies":[126],"revealed":[127,184],"numerous":[128],"cytoplasmic":[129],"microvesicles":[130],"as":[131,133,195,197],"well":[132,196],"coated":[134],"vesicles":[135],"that":[136],"known":[138,200],"features":[142],"cell.":[146],"Chrompho-B":[147],"cells":[148,162],"shorter":[151],"mean":[152],"population":[153],"doubling":[154],"time":[155],"(tD":[156,163],"=":[157,164],"43":[158],"hours)":[159],"51":[165],"hours).":[166],"Both":[167],"lines":[169,191],"failed":[170],"produce":[172],"tumors":[173],"in":[174,188,206],"nude":[175],"mice":[176],"with":[177,192],"subrenal":[179],"capsule":[180],"assay.":[181],"Cytogenetic":[182],"analyses":[183],"hyperdiploid":[185],"chromosome":[186],"numbers":[187],"both":[189],"telomeric":[193],"associations":[194],"numeric":[198],"aberrations":[199],"vivo.":[207]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
