{"id":"https://openalex.org/W1843636445","doi":"https://doi.org/10.1096/fasebj.28.1_supplement.892.27","title":"EGF/RhoGDI\u03b1/Rac1 pathway modulates ENaC activity and contributes to the development of salt\u2010sensitive hypertension (892.27)","display_name":"EGF/RhoGDI\u03b1/Rac1 pathway modulates ENaC activity and contributes to the development of salt\u2010sensitive hypertension (892.27)","publication_year":2014,"publication_date":"2014-04-01","ids":{"openalex":"https://openalex.org/W1843636445","doi":"https://doi.org/10.1096/fasebj.28.1_supplement.892.27","mag":"1843636445"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.28.1_supplement.892.27","doi":"https://doi.org/10.1096/fasebj.28.1_supplement.892.27","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.28.1_supplement.892.27","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-2","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046663769","display_name":"Tengis S. Pavlov","orcid":"https://orcid.org/0000-0002-6481-0390","observed_orcids":["https://orcid.org/0000-0002-6481-0390"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tengis Pavlov","raw_affiliation_strings":["Physiology Medical College of Wisconsin MIlwaukee WI United States","1Physiology Medical College of Wisconsin Milwaukee WI United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physiology Medical College of Wisconsin MIlwaukee WI United States","institution_ids":["https://openalex.org/I204308271"]},{"raw_affiliation_string":"1Physiology Medical College of Wisconsin Milwaukee WI United States","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103102416","display_name":"Vladislav Levchenko","orcid":"https://orcid.org/0000-0003-0771-8034","observed_orcids":["https://orcid.org/0000-0003-0771-8034"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vladislav Levchenko","raw_affiliation_strings":["Physiology Medical College of Wisconsin MIlwaukee WI United States","1Physiology Medical College of Wisconsin Milwaukee WI United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physiology Medical College of Wisconsin MIlwaukee WI United States","institution_ids":["https://openalex.org/I204308271"]},{"raw_affiliation_string":"1Physiology Medical College of Wisconsin Milwaukee WI United States","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002899728","display_name":"Daria V. Ilatovskaya","orcid":"https://orcid.org/0000-0003-4832-4170","observed_orcids":["https://orcid.org/0000-0003-4832-4170"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daria Ilatovskaya","raw_affiliation_strings":["Physiology Medical College of Wisconsin MIlwaukee WI United States","1Physiology Medical College of Wisconsin Milwaukee WI United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physiology Medical College of Wisconsin MIlwaukee WI United States","institution_ids":["https://openalex.org/I204308271"]},{"raw_affiliation_string":"1Physiology Medical College of Wisconsin Milwaukee WI United States","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023839040","display_name":"Oleg Palygin","orcid":"https://orcid.org/0000-0002-3680-5527","observed_orcids":["https://orcid.org/0000-0002-3680-5527"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Oleg Palygin","raw_affiliation_strings":["Physiology Medical College of Wisconsin MIlwaukee WI United States","1Physiology Medical College of Wisconsin Milwaukee WI United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physiology Medical College of Wisconsin MIlwaukee WI United States","institution_ids":["https://openalex.org/I204308271"]},{"raw_affiliation_string":"1Physiology Medical College of Wisconsin Milwaukee WI United States","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005174825","display_name":"Alexander Staruschenko","orcid":"https://orcid.org/0000-0002-5190-8356","observed_orcids":["https://orcid.org/0000-0002-5190-8356"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander Staruschenko","raw_affiliation_strings":["Physiology Medical College of Wisconsin MIlwaukee WI United States","1Physiology Medical College of Wisconsin Milwaukee WI United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physiology Medical College of Wisconsin MIlwaukee WI United States","institution_ids":["https://openalex.org/I204308271"]},{"raw_affiliation_string":"1Physiology Medical College of Wisconsin Milwaukee WI United States","institution_ids":["https://openalex.org/I204308271"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I204308271"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.05704309,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"28","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.7919999957084656,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.7919999957084656,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.10440000146627426,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.0357000008225441,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/enac","display_name":"epithelial sodium channel","score":0.9670000076293945},{"id":"https://openalex.org/keywords/epidermal-growth-factor","display_name":"epidermal growth factor","score":0.8809999823570251},{"id":"https://openalex.org/keywords/rhogdialpha","display_name":"RhoGDI\u03b1","score":0.9480000138282776},{"id":"https://openalex.org/keywords/rac1","display_name":"Rac1","score":0.9739999771118164},{"id":"https://openalex.org/keywords/salt-sensitive-hypertension","display_name":"salt-sensitive hypertension","score":0.8700000047683716},{"id":"https://openalex.org/keywords/high-salt-diet","display_name":"high-salt diet","score":0.8080000281333923},{"id":"https://openalex.org/keywords/dahl-salt-sensitive-rats","display_name":"Dahl salt-sensitive rats","score":0.8220000267028809},{"id":"https://openalex.org/keywords/sodium-reabsorption","display_name":"sodium reabsorption","score":0.8050000071525574},{"id":"https://openalex.org/keywords/distal-nephron","display_name":"distal nephron","score":0.7950000166893005},{"id":"https://openalex.org/keywords/principal-cells","display_name":"principal cells","score":0.6880000233650208},{"id":"https://openalex.org/keywords/rho-gtpases","display_name":"Rho GTPases","score":0.6980000138282776},{"id":"https://openalex.org/keywords/egf-signaling","display_name":"EGF signaling","score":0.4909999966621399}],"concepts":[{"id":"https://openalex.org/C6507245","wikidata":"https://www.wikidata.org/wiki/Q424948","display_name":"Epithelial sodium channel","level":3,"score":0.9145743250846863},{"id":"https://openalex.org/C2779717556","wikidata":"https://www.wikidata.org/wiki/Q15325735","display_name":"RAC1","level":3,"score":0.7871007323265076},{"id":"https://openalex.org/C56906281","wikidata":"https://www.wikidata.org/wiki/Q4391435","display_name":"Reabsorption","level":3,"score":0.6358643770217896},{"id":"https://openalex.org/C2776362946","wikidata":"https://www.wikidata.org/wiki/Q424374","display_name":"Epidermal growth factor","level":3,"score":0.6180474758148193},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5402933955192566},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5354378819465637},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5280647873878479},{"id":"https://openalex.org/C2778525890","wikidata":"https://www.wikidata.org/wiki/Q184564","display_name":"Aldosterone","level":2,"score":0.526491105556488},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5057132244110107},{"id":"https://openalex.org/C57476199","wikidata":"https://www.wikidata.org/wiki/Q7312501","display_name":"Renal sodium reabsorption","level":4,"score":0.4633766710758209},{"id":"https://openalex.org/C2780298669","wikidata":"https://www.wikidata.org/wiki/Q415071","display_name":"Small GTPase","level":3,"score":0.44868409633636475},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.4484423100948334},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.44619327783584595},{"id":"https://openalex.org/C174459258","wikidata":"https://www.wikidata.org/wiki/Q6980232","display_name":"Natriuresis","level":3,"score":0.42131954431533813},{"id":"https://openalex.org/C207332259","wikidata":"https://www.wikidata.org/wiki/Q769143","display_name":"GTPase","level":2,"score":0.418265700340271},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.3697354793548584},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3135324716567993},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.30720067024230957},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16402706503868103},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.134515643119812},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.28.1_supplement.892.27","doi":"https://doi.org/10.1096/fasebj.28.1_supplement.892.27","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.28.1_supplement.892.27","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-2","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4225399884","https://openalex.org/W4200590042","https://openalex.org/W2369280051","https://openalex.org/W3201692742","https://openalex.org/W2050405860","https://openalex.org/W2085322842","https://openalex.org/W1975896187","https://openalex.org/W2496004474","https://openalex.org/W2060903392","https://openalex.org/W1509217985"],"abstract_inverted_index":{"Epithelial":[0],"sodium":[1,5,18],"channel":[2],"(ENaC)":[3],"performs":[4],"reabsorption":[6,19],"in":[7,41,53,65,76,87,107,146],"the":[8,23,35,60,147,164],"aldosterone":[9],"sensitive":[10],"distal":[11],"nephron.":[12],"Amongst":[13],"other":[14],"hormonal":[15],"agents,":[16],"ENaC\u2010mediated":[17,115],"is":[20,51],"regulated":[21],"by":[22,80,174],"members":[24,37],"of":[25,62,71,78,92,101,122,166],"epidermal":[26],"growth":[27],"factor":[28],"(EGF)":[29],"family;":[30],"specifically,":[31],"chronic":[32],"treatment":[33],"with":[34],"EGF\u2010family":[36],"downregulates":[38],"ENaC":[39,55,79,123,157],"activity":[40,56,124,158],"vitro":[42],".":[43],"We":[44,140],"have":[45],"recently":[46],"shown":[47],"that":[48,83,131,142],"EGF":[49,126,144],"deficiency":[50,106,145],"involved":[52,75],"improper":[54],"and":[57,118,161],"contributes":[58,162],"to":[59,125,163],"development":[61,165],"salt\u2010induced":[63,167],"hypertension":[64],"Dahl":[66],"salt\u2010sensitive":[67],"(SS)":[68],"rats.":[69],"Investigation":[70],"signaling":[72],"pathways":[73],"potentially":[74],"regulation":[77],"EGF,":[81],"revealed":[82,130],"high":[84,152],"salt":[85,153],"diet":[86,154],"SS":[88,148],"rats":[89,149],"decreases":[90],"abundance":[91],"Rho":[93],"GDP\u2010dissociation":[94],"inhibitor":[95],"1(RhoGDI\u03b1),":[96],"a":[97,151],"well":[98],"characterized":[99],"modulator":[100],"Rho\u2010family":[102],"small":[103,138],"GTPases.":[104],"RhoGDI\u03b1":[105],"cultured":[108],"mCCD":[109],"cl1":[110],"principal":[111],"cell":[112],"line":[113],"increases":[114],"current":[116],"formation":[117],"causes":[119],"enhanced":[120],"response":[121],"treatment.":[127],"Further":[128],"experiments":[129],"these":[132],"effects":[133],"are":[134],"mediated":[135],"via":[136,159],"Rac1":[137],"GTPase.":[139],"conclude":[141],"renal":[143],"on":[150],"provokes":[155],"excessive":[156],"RhoGDI\u03b1/Rac1pathway":[160],"hypertension.":[168],"Grant":[169],"Funding":[170],"Source":[171],":":[172],"Supported":[173],"AHA,":[175],"NHLBI":[176]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2025-10-10T00:00:00"}
