{"id":"https://openalex.org/W1843329329","doi":"https://doi.org/10.1152/ajpgi.1987.253.4.g517","title":"Intracellular transport of pancreatic zymogens during caerulein supramaximal stimulation","display_name":"Intracellular transport of pancreatic zymogens during caerulein supramaximal stimulation","publication_year":1987,"publication_date":"1987-10-01","ids":{"openalex":"https://openalex.org/W1843329329","doi":"https://doi.org/10.1152/ajpgi.1987.253.4.g517","mag":"1843329329","pmid":"https://pubmed.ncbi.nlm.nih.gov/3661711"},"language":"en","primary_location":{"id":"doi:10.1152/ajpgi.1987.253.4.g517","doi":"https://doi.org/10.1152/ajpgi.1987.253.4.g517","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpgi.1987.253.4.g517","pdf_url":null,"source":{"id":"https://openalex.org/S34136372","display_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","issn_l":"0193-1857","issn":["0193-1857","1522-1547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"I. Saito","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"I. Saito","raw_affiliation_strings":["Deparment of Pharmacology, Consiglio Nationale delle Ricerche Centerof Cytopharmacology, University of Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Deparment of Pharmacology, Consiglio Nationale delle Ricerche Centerof Cytopharmacology, University of Milan, Italy","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111626093","display_name":"S. Hashimoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"S. Hashimoto","raw_affiliation_strings":["Deparment of Pharmacology, Consiglio Nationale delle Ricerche Centerof Cytopharmacology, University of Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Deparment of Pharmacology, Consiglio Nationale delle Ricerche Centerof Cytopharmacology, University of Milan, Italy","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090882752","display_name":"A. Saluja","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A. Saluja","raw_affiliation_strings":["Deparment of Pharmacology, Consiglio Nationale delle Ricerche Centerof Cytopharmacology, University of Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Deparment of Pharmacology, Consiglio Nationale delle Ricerche Centerof Cytopharmacology, University of Milan, Italy","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089990723","display_name":"Michael L. Steer","orcid":"https://orcid.org/0000-0002-5365-8215","observed_orcids":["https://orcid.org/0000-0002-5365-8215"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M. L. Steer","raw_affiliation_strings":["Deparment of Pharmacology, Consiglio Nationale delle Ricerche Centerof Cytopharmacology, University of Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Deparment of Pharmacology, Consiglio Nationale delle Ricerche Centerof Cytopharmacology, University of Milan, Italy","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010982287","display_name":"Jacopo Meldolesi","orcid":"https://orcid.org/0000-0003-4022-1281","observed_orcids":["https://orcid.org/0000-0003-4022-1281"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"J. Meldolesi","raw_affiliation_strings":["Deparment of Pharmacology, Consiglio Nationale delle Ricerche Centerof Cytopharmacology, University of Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Deparment of Pharmacology, Consiglio Nationale delle Ricerche Centerof Cytopharmacology, University of Milan, Italy","institution_ids":["https://openalex.org/I189158943"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I189158943"],"apc_list":null,"apc_paid":null,"fwci":1.5271,"has_fulltext":false,"cited_by_count":73,"citation_normalized_percentile":{"value":0.82022472,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"253","issue":"4","first_page":"G517","last_page":"G526"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.6786999702453613,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.6786999702453613,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.30399999022483826,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.007600000128149986,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/caerulein","display_name":"caerulein","score":0.8360000252723694},{"id":"https://openalex.org/keywords/supramaximal-stimulation","display_name":"supramaximal stimulation","score":0.8460000157356262},{"id":"https://openalex.org/keywords/edematous-pancreatitis","display_name":"edematous pancreatitis","score":0.8029999732971191},{"id":"https://openalex.org/keywords/acinar-cells","display_name":"acinar cells","score":0.7680000066757202},{"id":"https://openalex.org/keywords/zymogen-granules","display_name":"zymogen granules","score":0.8420000076293945},{"id":"https://openalex.org/keywords/condensing-vacuoles","display_name":"condensing vacuoles","score":0.8289999961853027},{"id":"https://openalex.org/keywords/crinophagy","display_name":"crinophagy","score":0.8980000019073486},{"id":"https://openalex.org/keywords/lysosomal-enzymes","display_name":"lysosomal enzymes","score":0.8080000281333923},{"id":"https://openalex.org/keywords/cathepsin-d","display_name":"cathepsin D","score":0.9959999918937683},{"id":"https://openalex.org/keywords/intracellular-transport","display_name":"intracellular transport","score":0.7099999785423279},{"id":"https://openalex.org/keywords/golgi-apparatus","display_name":"Golgi apparatus","score":0.6970000267028809},{"id":"https://openalex.org/keywords/exocytosis","display_name":"exocytosis","score":0.7080000042915344},{"id":"https://openalex.org/keywords/vacuole-fusion","display_name":"vacuole fusion","score":0.6470000147819519}],"concepts":[{"id":"https://openalex.org/C102568950","wikidata":"https://www.wikidata.org/wiki/Q127702","display_name":"Vacuole","level":3,"score":0.8014944791793823},{"id":"https://openalex.org/C2776731452","wikidata":"https://www.wikidata.org/wiki/Q5065299","display_name":"Ceruletide","level":4,"score":0.7957441806793213},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6095713376998901},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5983225107192993},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.5562491416931152},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5408317446708679},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5071368217468262},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.469562292098999},{"id":"https://openalex.org/C119062480","wikidata":"https://www.wikidata.org/wiki/Q83181","display_name":"Golgi apparatus","level":3,"score":0.4481451213359833},{"id":"https://openalex.org/C2991930265","wikidata":"https://www.wikidata.org/wiki/Q5062943","display_name":"Acinar cell","level":3,"score":0.43917039036750793},{"id":"https://openalex.org/C2777593968","wikidata":"https://www.wikidata.org/wiki/Q60315441","display_name":"Cholecystokinin","level":3,"score":0.43043211102485657},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33490484952926636},{"id":"https://openalex.org/C2778764654","wikidata":"https://www.wikidata.org/wiki/Q9618","display_name":"Pancreas","level":2,"score":0.3226545751094818},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.25890418887138367},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10239166021347046},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.09212693572044373},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001345","descriptor_name":"Autoradiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002108","descriptor_name":"Ceruletide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002402","descriptor_name":"Cathepsin D","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004721","descriptor_name":"Endoplasmic Reticulum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004792","descriptor_name":"Enzyme Precursors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006056","descriptor_name":"Golgi Apparatus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D010195","descriptor_name":"Pancreatitis","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D010195","descriptor_name":"Pancreatitis","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D010649","descriptor_name":"Phenylalanine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajpgi.1987.253.4.g517","doi":"https://doi.org/10.1152/ajpgi.1987.253.4.g517","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpgi.1987.253.4.g517","pdf_url":null,"source":{"id":"https://openalex.org/S34136372","display_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","issn_l":"0193-1857","issn":["0193-1857","1522-1547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","raw_type":"journal-article"},{"id":"pmid:3661711","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3661711","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6641771780","display_name":"ACUTE PANCREATITIS","funder_award_id":"5r01am031396-03","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8897400802","display_name":"STIMULUS-SECRETION COUPLING IN THE EXOCRINE PANCREAS","funder_award_id":"5r01am031914-03","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1786647014","https://openalex.org/W2404571891","https://openalex.org/W1987949125","https://openalex.org/W158969769","https://openalex.org/W1987589308","https://openalex.org/W2091155804","https://openalex.org/W2287728217","https://openalex.org/W2101748226","https://openalex.org/W1965408883","https://openalex.org/W1982491871"],"abstract_inverted_index":{"Rats":[0,121],"infused":[1,123],"with":[2,124,244,261],"a":[3,17,136,268],"dose":[4,37],"of":[5,13,20,35,38,49,57,62,109,115,138,185,201,209,228,235,242],"the":[6,47,105,113,146,161,165,183,199,207,210,221,229,247,278],"secretagogue":[7,286],"caerulein":[8,39,125,155],"that":[9,14,33,277,282,289],"is":[10],"in":[11,53],"excess":[12],"which":[15,154],"stimulates":[16],"maximal":[18],"rate":[19],"pancreatic":[21],"digestive":[22,63,216,238,292],"enzyme":[23],"secretion":[24],"develop":[25],"acute":[26],"edematous":[27],"pancreatitis.":[28],"We":[29],"have":[30],"previously":[31],"noted":[32],"infusion":[34,156],"this":[36],"(5":[40,126],"micrograms":[41,127],".":[42,44,128,130],"kg-1":[43,129],"h-1)":[45,131],"induces":[46],"appearance":[48],"large":[50,211,263,279],"heterogeneous":[51,280],"vacuoles":[52,187,204,212,243,266,281],"acinar":[54],"cell,":[55],"blockade":[56],"exocytosis,":[58],"and":[59,79,111,119,140,205,237,288,294,307],"intracellular":[60],"accumulation":[61,200],"zymogens":[64,217,293],"[O.":[65],"Watanabe":[66],"et":[67,82],"al.":[68,83],"Am.":[69,84],"J.":[70,85],"Physiol.":[71,75,86,90],"246":[72],"(Gastrointest.":[73,88],"Liver":[74,89],"9):":[76],"G457-G467,":[77],"1984":[78],"A.":[80],"Saluja":[81],"249":[87],"12):":[91],"G702-G710,":[92],"1985].":[93],"The":[94,226],"current":[95],"studies":[96,275],"were":[97,122,256],"performed":[98],"to":[99,149,164,193,198,206,259,271],"further":[100],"elucidate":[101],"these":[102,262,274],"phenomena":[103],"at":[104,142,299],"electron":[106],"microscopic":[107],"level":[108],"resolution":[110],"employed":[112],"techniques":[114],"pulse":[116,137,251],"labeling,":[117,252],"radioautography,":[118],"immunolocalization.":[120],"for":[132],"1":[133],"h,":[134],"given":[135],"[3H]phenylalanine,":[139],"killed":[141],"selected":[143],"times":[144,249],"during":[145,153,284],"subsequent":[147],"5-":[148],"180-min":[150],"postpulse":[151],"period":[152],"was":[157,168,179,191],"continued.":[158],"Transport":[159],"from":[160],"endoplasmic":[162],"reticulum":[163],"Golgi":[166],"cisternae":[167],"not":[169],"altered":[170],"by":[171,267,298],"supramaximal":[172,285],"stimulation,":[173],"but":[174],"transport":[175],"through":[176],"post-Golgi":[177],"elements":[178],"altered.":[180],"In":[181],"particular,":[182],"maturation":[184,306],"condensing":[186,304],"into":[188],"zymogen":[189,254],"granules":[190,255],"found":[192,258],"be":[194,232],"impaired.":[195],"This":[196],"led":[197],"partially":[202],"condensed":[203],"development":[208],"containing":[213],"newly":[214],"synthesized":[215],"as":[218,220],"well":[219],"lysosomal":[222,236,295],"hydrolase":[223],"cathepsin":[224,264],"D.":[225],"source":[227],"latter":[230],"could":[231],"impaired":[233,303],"sorting":[234],"enzymes":[239],"and/or":[240],"fusion":[241],"lysosomes.":[245],"At":[246],"later":[248],"after":[250],"mature":[253],"also":[257],"fuse":[260],"D-containing":[265],"process":[269],"analogous":[270],"crinophagy.":[272,308],"Thus":[273],"indicate":[276],"appear":[283],"stimulation":[287],"contain":[290],"admixed":[291],"hydrolases":[296],"arise":[297],"least":[300],"two":[301],"mechanisms,":[302],"vacuole":[305]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}