{"id":"https://openalex.org/W1842979957","doi":"https://doi.org/10.1128/jvi.02149-15","title":"Early Vertebrate Evolution of the Host Restriction Factor Tetherin","display_name":"Early Vertebrate Evolution of the Host Restriction Factor Tetherin","publication_year":2015,"publication_date":"2015-09-24","ids":{"openalex":"https://openalex.org/W1842979957","doi":"https://doi.org/10.1128/jvi.02149-15","mag":"1842979957","pmid":"https://pubmed.ncbi.nlm.nih.gov/26401043","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4645306"},"language":"en","primary_location":{"id":"doi:10.1128/jvi.02149-15","doi":"https://doi.org/10.1128/jvi.02149-15","is_oa":true,"landing_page_url":"https://doi.org/10.1128/jvi.02149-15","pdf_url":"https://jvi.asm.org/content/jvi/89/23/12154.full.pdf","source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://jvi.asm.org/content/jvi/89/23/12154.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065725634","display_name":"Elena Heusinger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Elena Heusinger","raw_affiliation_strings":["Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany","institution_ids":["https://openalex.org/I4210155144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079615728","display_name":"Silvia F. Kluge","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Silvia F. Kluge","raw_affiliation_strings":["Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany","institution_ids":["https://openalex.org/I4210155144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075006919","display_name":"Frank Kirchhoff","orcid":"https://orcid.org/0000-0002-7052-2360","observed_orcids":["https://orcid.org/0000-0002-7052-2360"]},"institutions":[{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Frank Kirchhoff","raw_affiliation_strings":["Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany","institution_ids":["https://openalex.org/I4210155144"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041471505","display_name":"Daniel Sauter","orcid":"https://orcid.org/0000-0001-7665-0040","observed_orcids":["https://orcid.org/0000-0001-7665-0040"]},"institutions":[{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Daniel Sauter","raw_affiliation_strings":["Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany","institution_ids":["https://openalex.org/I4210155144"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210155144"],"apc_list":null,"apc_paid":null,"fwci":1.4857,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.80227137,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"89","issue":"23","first_page":"12154","last_page":"12165"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tetherin","display_name":"tetherin","score":0.9580000042915344},{"id":"https://openalex.org/keywords/restriction-factors","display_name":"host restriction factors","score":0.7429999709129333},{"id":"https://openalex.org/keywords/antiviral-immunity","display_name":"antiviral immunity","score":0.6859999895095825},{"id":"https://openalex.org/keywords/vertebrate-evolution","display_name":"vertebrate evolution","score":0.8240000009536743},{"id":"https://openalex.org/keywords/glycosylphosphatidylinositol-anchor","display_name":"glycosylphosphatidylinositol anchor","score":0.9210000038146973},{"id":"https://openalex.org/keywords/transmembrane-domain","display_name":"transmembrane domain","score":0.9580000042915344},{"id":"https://openalex.org/keywords/dictyostelium-discoideum","display_name":"Dictyostelium discoideum","score":0.9089999794960022},{"id":"https://openalex.org/keywords/convergent-evolution","display_name":"convergent evolution","score":0.6840000152587891},{"id":"https://openalex.org/keywords/cell-intrinsic-immunity","display_name":"cell-intrinsic immunity","score":0.7649999856948853},{"id":"https://openalex.org/keywords/viral-evolution","display_name":"viral evolution","score":0.3409999907016754},{"id":"https://openalex.org/keywords/reptiles","display_name":"reptiles","score":0.9959999918937683},{"id":"https://openalex.org/keywords/birds","display_name":"birds","score":0.9980000257492065},{"id":"https://openalex.org/keywords/mammals","display_name":"mammals","score":0.41499999165534973}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9427269697189331},{"id":"https://openalex.org/C2776855506","wikidata":"https://www.wikidata.org/wiki/Q21100505","display_name":"Tetherin","level":4,"score":0.921986997127533},{"id":"https://openalex.org/C2778961482","wikidata":"https://www.wikidata.org/wiki/Q25241","display_name":"Vertebrate","level":3,"score":0.7917147874832153},{"id":"https://openalex.org/C126831891","wikidata":"https://www.wikidata.org/wiki/Q221673","display_name":"Host (biology)","level":2,"score":0.588129997253418},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.5081400871276855},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4675772488117218},{"id":"https://openalex.org/C2777627835","wikidata":"https://www.wikidata.org/wiki/Q16963978","display_name":"Host factor","level":3,"score":0.43067502975463867},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19028308987617493},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.1321706771850586},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.1257169246673584}],"mesh":[{"descriptor_ui":"D000074010","descriptor_name":"Bone Marrow Stromal Antigen 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003412","descriptor_name":"Cricetulus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008840","descriptor_name":"Microfilament Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016466","descriptor_name":"CHO Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057074","descriptor_name":"Virus Release","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D057074","descriptor_name":"Virus Release","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058851","descriptor_name":"GPI-Linked Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D058851","descriptor_name":"GPI-Linked Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1128/jvi.02149-15","doi":"https://doi.org/10.1128/jvi.02149-15","is_oa":true,"landing_page_url":"https://doi.org/10.1128/jvi.02149-15","pdf_url":"https://jvi.asm.org/content/jvi/89/23/12154.full.pdf","source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4645306","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4645306","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"},{"id":"pmid:26401043","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26401043","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of virology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1128/jvi.02149-15","doi":"https://doi.org/10.1128/jvi.02149-15","is_oa":true,"landing_page_url":"https://doi.org/10.1128/jvi.02149-15","pdf_url":"https://jvi.asm.org/content/jvi/89/23/12154.full.pdf","source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W1842979957.pdf"},"referenced_works_count":74,"referenced_works":["https://openalex.org/W293525958","https://openalex.org/W1482575531","https://openalex.org/W1514154332","https://openalex.org/W1644854647","https://openalex.org/W1815414038","https://openalex.org/W1898326375","https://openalex.org/W1964567249","https://openalex.org/W1965048581","https://openalex.org/W1966060871","https://openalex.org/W1969964540","https://openalex.org/W1975456388","https://openalex.org/W1984751884","https://openalex.org/W1987219992","https://openalex.org/W1989887938","https://openalex.org/W1992975997","https://openalex.org/W1993029406","https://openalex.org/W1994503091","https://openalex.org/W2000665020","https://openalex.org/W2001375348","https://openalex.org/W2010458160","https://openalex.org/W2012761046","https://openalex.org/W2013279274","https://openalex.org/W2020258831","https://openalex.org/W2021889176","https://openalex.org/W2022044318","https://openalex.org/W2024875935","https://openalex.org/W2026237846","https://openalex.org/W2027844128","https://openalex.org/W2032204627","https://openalex.org/W2036161664","https://openalex.org/W2039337517","https://openalex.org/W2043090465","https://openalex.org/W2045000874","https://openalex.org/W2045089827","https://openalex.org/W2047452261","https://openalex.org/W2049593811","https://openalex.org/W2051871530","https://openalex.org/W2061041720","https://openalex.org/W2064526258","https://openalex.org/W2064632057","https://openalex.org/W2066335893","https://openalex.org/W2069554621","https://openalex.org/W2082314789","https://openalex.org/W2084671891","https://openalex.org/W2085015448","https://openalex.org/W2095620108","https://openalex.org/W2097928174","https://openalex.org/W2105134519","https://openalex.org/W2107024954","https://openalex.org/W2113371722","https://openalex.org/W2119837484","https://openalex.org/W2122883276","https://openalex.org/W2127485186","https://openalex.org/W2129581022","https://openalex.org/W2132278469","https://openalex.org/W2134463805","https://openalex.org/W2137696284","https://openalex.org/W2139376543","https://openalex.org/W2147282728","https://openalex.org/W2147579012","https://openalex.org/W2148731561","https://openalex.org/W2155575747","https://openalex.org/W2158179662","https://openalex.org/W2159265075","https://openalex.org/W2162691916","https://openalex.org/W2164439474","https://openalex.org/W2165918134","https://openalex.org/W2167406239","https://openalex.org/W2168606329","https://openalex.org/W2169244146","https://openalex.org/W2170908011","https://openalex.org/W2180585235","https://openalex.org/W2787027105","https://openalex.org/W2992633330"],"related_works":["https://openalex.org/W2361152365","https://openalex.org/W2026237846","https://openalex.org/W2107841204","https://openalex.org/W4386757805","https://openalex.org/W2474576471","https://openalex.org/W2406736308","https://openalex.org/W2023664577","https://openalex.org/W1992423640","https://openalex.org/W2064632057","https://openalex.org/W7095847719"],"abstract_inverted_index":{"UNLABELLED:":[0],"Tetherin":[1],"is":[2,46,148,212,240],"an":[3,19,23,30,174,338,376],"interferon-inducible":[4],"restriction":[5,236,276,310,379],"factor":[6,311,380],"targeting":[7],"a":[8,35,81,170,178,258,293,343],"broad":[9,294],"range":[10,295],"of":[11,41,59,80,84,104,127,162,221,237,244,257,260,268,274,282,296,308,337,368],"enveloped":[12,297],"viruses.":[13],"Its":[14],"antiviral":[15,140,222,314],"activity":[16,141,223,315],"depends":[17],"on":[18],"unusual":[20,335],"topology":[21,228],"comprising":[22],"N-terminal":[24,175,339],"transmembrane":[25,340],"domain":[26,341],"(TMD)":[27],"followed":[28],"by":[29,68],"extracellular":[31],"coiled-coil":[32],"region":[33],"and":[34,72,87,107,118,137,177,191,211,303,312,342,357,359,381,393],"C-terminal":[36,179,344],"glycosylphosphatidylinositol":[37,345],"(GPI)":[38],"anchor.":[39,181,346],"One":[40,273],"the":[42,52,56,60,78,101,125,143,156,163,226,241,255,269,280,305,333,366,387],"two":[43],"membrane":[44,58],"anchors":[45],"inserted":[47],"into":[48,386],"assembling":[49],"virions,":[50],"while":[51],"other":[53],"remains":[54],"in":[55,115,354],"plasma":[57],"infected":[61,288],"cell.":[62],"Thus,":[63,130],"tetherin":[64,76,110,122,131,203,291,332,350,363,374],"entraps":[65],"budding":[66],"viruses":[67,252,392],"physically":[69],"bridging":[70],"viral":[71,270],"cellular":[73,327],"membranes.":[74],"Although":[75,146,290],"restricts":[77],"release":[79,126,239,281,367],"large":[82],"variety":[83,259],"diverse":[85,321],"human":[86],"animal":[88],"viruses,":[89,298],"only":[90,149],"mammalian":[91],"orthologs":[92,111,154,351],"have":[93],"been":[94],"described":[95],"to":[96,193],"date.":[97],"Here,":[98,318],"we":[99,319],"examined":[100,320],"evolutionary":[102,306],"origin":[103,307],"this":[105,309],"protein":[106],"demonstrate":[108,201,360],"that":[109,202,235,264,329,349,361],"are":[112,352],"also":[113,168],"found":[114,353],"fish,":[116,355],"reptiles,":[117,356],"birds.":[119],"Notably,":[120],"alligator":[121,362],"efficiently":[123,364],"blocks":[124],"retroviral":[128,369],"particles.":[129,370],"emerged":[132,204],"early":[133,219],"during":[134],"vertebrate":[135,322],"evolution":[136,190,220,256],"acquired":[138],"its":[139,313],"before":[142],"mammal/reptile":[144],"divergence.":[145],"there":[147],"limited":[150],"sequence":[151,232],"homology,":[152],"all":[153],"share":[155,330],"typical":[157],"topology.":[158],"Two":[159],"unrelated":[160],"proteins":[161,184,328],"slime":[164],"mold":[165],"Dictyostelium":[166],"discoideum":[167],"adopt":[169],"tetherin-like":[171],"configuration":[172],"with":[173,225,251,331],"TMD":[176],"GPI":[180],"However,":[182],"these":[183,275],"showed":[185],"no":[186],"evidence":[187],"for":[188,324],"convergent":[189],"failed":[192],"inhibit":[194,265],"virion":[195],"release.":[196],"In":[197],"summary,":[198],"our":[199],"findings":[200,372],"at":[205],"least":[206],"450":[207],"million":[208],"years":[209],"ago":[210],"more":[213],"widespread":[214],"than":[215],"previously":[216],"anticipated.":[217],"The":[218,247],"together":[224],"high":[227],"conservation":[229],"but":[230],"low":[231],"homology":[233],"suggests":[234],"virus":[238],"primary":[242],"function":[243],"tetherin.":[245],"IMPORTANCE:":[246],"continuous":[248,388],"arms":[249,389],"race":[250,390],"has":[253],"driven":[254],"cell-intrinsic":[261],"immunity":[262],"factors":[263],"different":[266],"steps":[267],"replication":[271],"cycle.":[272],"factors,":[277],"tetherin,":[278],"inhibits":[279,365],"newly":[283],"formed":[284],"progeny":[285],"virions":[286],"from":[287],"cells.":[289],"targets":[292],"including":[299],"retro-,":[300],"filo-,":[301],"herpes-,":[302],"arenaviruses,":[304],"remained":[316],"obscure.":[317],"genomes":[323],"genes":[325],"encoding":[326],"highly":[334],"combination":[336],"We":[347],"show":[348],"birds":[358],"Our":[371],"identify":[373],"as":[375],"evolutionarily":[377],"ancient":[378],"provide":[382],"new":[383],"important":[384],"insights":[385],"between":[391],"their":[394],"hosts.":[395]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}