{"id":"https://openalex.org/W1840988451","doi":null,"title":"Molecular pathogenesis of liver fibrosis.","display_name":"Molecular pathogenesis of liver fibrosis.","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W1840988451","mag":"1840988451","pmid":"https://pubmed.ncbi.nlm.nih.gov/19768189","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2744540"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2744540","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2744540","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trans Am Clin Climatol Assoc","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2744540","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015535660","display_name":"David A. Brenner","orcid":"https://orcid.org/0000-0003-2573-525X","observed_orcids":["https://orcid.org/0000-0003-2573-525X"]},"institutions":[{"id":"https://openalex.org/I2800935791","display_name":"UC San Diego Health System","ror":"https://ror.org/01kbfgm16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David A Brenner","raw_affiliation_strings":["1318 Biomedical Sciences Building, UC San Diego Health Sciences, 9500 Gilman Drive, La Jolla, CA 92093-0602, USA. dbrenner@ucsd.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1318 Biomedical Sciences Building, UC San Diego Health Sciences, 9500 Gilman Drive, La Jolla, CA 92093-0602, USA. dbrenner@ucsd.edu","institution_ids":["https://openalex.org/I2800935791","https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5015535660"],"corresponding_institution_ids":["https://openalex.org/I2800935791","https://openalex.org/I36258959"],"apc_list":null,"apc_paid":null,"fwci":12.2305,"has_fulltext":false,"cited_by_count":223,"citation_normalized_percentile":{"value":0.98922441,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":100},"biblio":{"volume":"120","issue":null,"first_page":"361","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.9380000233650208},{"id":"https://openalex.org/keywords/myofibroblasts","display_name":"myofibroblasts","score":0.8629999756813049},{"id":"https://openalex.org/keywords/hepatic-stellate-cells","display_name":"hepatic stellate cells","score":0.9900000095367432},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9490000009536743},{"id":"https://openalex.org/keywords/bone-marrow-derived-cells","display_name":"bone marrow-derived cells","score":0.7519999742507935},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9710000157356262},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.9940000176429749},{"id":"https://openalex.org/keywords/hepatocyte-death","display_name":"hepatocyte death","score":0.9789999723434448},{"id":"https://openalex.org/keywords/chronic-inflammation","display_name":"chronic inflammation","score":0.9520000219345093},{"id":"https://openalex.org/keywords/fibrosis-reversal","display_name":"fibrosis reversal","score":0.828000009059906},{"id":"https://openalex.org/keywords/chronic-liver-disease","display_name":"chronic liver disease","score":0.921999990940094}],"concepts":[{"id":"https://openalex.org/C207865475","wikidata":"https://www.wikidata.org/wiki/Q1467330","display_name":"Myofibroblast","level":3,"score":0.9197911024093628},{"id":"https://openalex.org/C176891718","wikidata":"https://www.wikidata.org/wiki/Q1997459","display_name":"Hepatic stellate cell","level":2,"score":0.8267204165458679},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.6998583078384399},{"id":"https://openalex.org/C2993667909","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Hepatic fibrosis","level":3,"score":0.6345220804214478},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5521711111068726},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5432208776473999},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.5342041254043579},{"id":"https://openalex.org/C2776200302","wikidata":"https://www.wikidata.org/wiki/Q827450","display_name":"Hepatocyte","level":3,"score":0.44715237617492676},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42180532217025757},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3176060616970062},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2810794413089752},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018836","descriptor_name":"Inflammation Mediators","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055166","descriptor_name":"Hepatic Stellate Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D055166","descriptor_name":"Hepatic Stellate Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:2744540","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2744540","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trans Am Clin Climatol Assoc","raw_type":"Text"},{"id":"pmid:19768189","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19768189","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transactions of the American Clinical and Climatological Association","raw_type":"Journal Article"},{"id":"mag:1840988451","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19768189","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2744540","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2744540","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trans Am Clin Climatol Assoc","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":5,"referenced_works":["https://openalex.org/W1995201433","https://openalex.org/W2040804852","https://openalex.org/W2115583388","https://openalex.org/W2126232334","https://openalex.org/W2170528610"],"related_works":["https://openalex.org/W2065348863","https://openalex.org/W4386969702","https://openalex.org/W2107036592","https://openalex.org/W2358008917","https://openalex.org/W2142988890","https://openalex.org/W4400775597","https://openalex.org/W3095484986","https://openalex.org/W2114628121","https://openalex.org/W1553544778","https://openalex.org/W4366769872"],"abstract_inverted_index":{"Hepatic":[0,63],"fibrosis":[1,17,56,64,85],"is":[2,65],"the":[3,21,82,88,91],"final":[4],"common":[5,60],"pathway":[6],"for":[7,15],"most":[8],"chronic":[9,79],"liver":[10],"diseases.":[11],"The":[12,24],"cell":[13],"responsible":[14],"hepatic":[16,31,55],"appears":[18],"to":[19,35],"be":[20,27],"activated":[22,92],"myofibroblast.":[23,93],"myofibroblast":[25],"may":[26],"derived":[28,39],"from":[29,40],"quiescent":[30],"stellate":[32],"cells,":[33],"epithelial":[34],"mesenhymal":[36],"transition,":[37],"or":[38],"bone":[41],"marrow":[42],"precursors.":[43],"Studies":[44],"in":[45,51],"primary":[46],"cultures":[47],"of":[48,54,84,90],"myofibroblasts":[49],"and":[50,78],"mouse":[52],"models":[53],"have":[57],"revealed":[58],"several":[59],"pathophysiological":[61],"mechanisms.":[62],"strongly":[66],"associated":[67],"with":[68],"oxidative":[69],"stress,":[70],"increased":[71],"transforming":[72],"growth":[73],"factor":[74],"beta,":[75],"hepatocyte":[76],"death,":[77],"inflammation.":[80],"Finally,":[81],"reversal":[83],"depends":[86],"upon":[87],"elimination":[89]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":14},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":21},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":17},{"year":2014,"cited_by_count":21},{"year":2013,"cited_by_count":22},{"year":2012,"cited_by_count":30}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}