{"id":"https://openalex.org/W1840509092","doi":"https://doi.org/10.3892/or.2015.4221","title":"Promoting roles of the secreted frizzled-related protein 2 as a Wnt agonist in lung cancer cells","display_name":"Promoting roles of the secreted frizzled-related protein 2 as a Wnt agonist in lung cancer cells","publication_year":2015,"publication_date":"2015-08-21","ids":{"openalex":"https://openalex.org/W1840509092","doi":"https://doi.org/10.3892/or.2015.4221","mag":"1840509092","pmid":"https://pubmed.ncbi.nlm.nih.gov/26323494","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4583535"},"language":"en","primary_location":{"id":"doi:10.3892/or.2015.4221","doi":"https://doi.org/10.3892/or.2015.4221","is_oa":true,"landing_page_url":"https://doi.org/10.3892/or.2015.4221","pdf_url":"http://www.spandidos-publications.com/10.3892/or.2015.4221/download","source":{"id":"https://openalex.org/S124357017","display_name":"Oncology Reports","issn_l":"1021-335X","issn":["1021-335X","1791-2431"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.spandidos-publications.com/10.3892/or.2015.4221/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032589347","display_name":"Xiao Xiao-min","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106933","display_name":"Kingmed Diagnostics","ror":"https://ror.org/02d0gmv36","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210106933"]},{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"XIAOMIN XIAO","raw_affiliation_strings":["KingMed Diagnostics and KingMed School of Laboratory Medicine, Guangzhou Medical University, Guangzhou, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KingMed Diagnostics and KingMed School of Laboratory Medicine, Guangzhou Medical University, Guangzhou, P.R. China","institution_ids":["https://openalex.org/I4210106933","https://openalex.org/I92039509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059555330","display_name":"Xiao Yingying","orcid":"https://orcid.org/0009-0004-0226-2175","observed_orcids":["https://orcid.org/0009-0004-0226-2175"]},"institutions":[{"id":"https://openalex.org/I4210106933","display_name":"Kingmed Diagnostics","ror":"https://ror.org/02d0gmv36","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210106933"]},{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"YINGYING XIAO","raw_affiliation_strings":["KingMed Diagnostics and KingMed School of Laboratory Medicine, Guangzhou Medical University, Guangzhou, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KingMed Diagnostics and KingMed School of Laboratory Medicine, Guangzhou Medical University, Guangzhou, P.R. China","institution_ids":["https://openalex.org/I4210106933","https://openalex.org/I92039509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100507069","display_name":"Ruiling Wen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106933","display_name":"Kingmed Diagnostics","ror":"https://ror.org/02d0gmv36","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210106933"]},{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"RUILING WEN","raw_affiliation_strings":["KingMed Diagnostics and KingMed School of Laboratory Medicine, Guangzhou Medical University, Guangzhou, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KingMed Diagnostics and KingMed School of Laboratory Medicine, Guangzhou Medical University, Guangzhou, P.R. China","institution_ids":["https://openalex.org/I4210106933","https://openalex.org/I92039509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101721287","display_name":"Yuhua Zhang","orcid":"https://orcid.org/0000-0002-9870-2865","observed_orcids":["https://orcid.org/0000-0002-9870-2865"]},"institutions":[{"id":"https://openalex.org/I4210106933","display_name":"Kingmed Diagnostics","ror":"https://ror.org/02d0gmv36","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210106933"]},{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"YUHUA ZHANG","raw_affiliation_strings":["KingMed Diagnostics and KingMed School of Laboratory Medicine, Guangzhou Medical University, Guangzhou, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KingMed Diagnostics and KingMed School of Laboratory Medicine, Guangzhou Medical University, Guangzhou, P.R. China","institution_ids":["https://openalex.org/I4210106933","https://openalex.org/I92039509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100348756","display_name":"Xiaoxia Li","orcid":"https://orcid.org/0000-0002-4872-9525","observed_orcids":["https://orcid.org/0000-0002-4872-9525"]},"institutions":[{"id":"https://openalex.org/I4210106933","display_name":"Kingmed Diagnostics","ror":"https://ror.org/02d0gmv36","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210106933"]},{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"XIAOXIA LI","raw_affiliation_strings":["KingMed Diagnostics and KingMed School of Laboratory Medicine, Guangzhou Medical University, Guangzhou, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KingMed Diagnostics and KingMed School of Laboratory Medicine, Guangzhou Medical University, Guangzhou, P.R. China","institution_ids":["https://openalex.org/I4210106933","https://openalex.org/I92039509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101841154","display_name":"Haoli Wang","orcid":"https://orcid.org/0009-0004-2981-8647","observed_orcids":["https://orcid.org/0009-0004-2981-8647"]},"institutions":[{"id":"https://openalex.org/I4210106933","display_name":"Kingmed Diagnostics","ror":"https://ror.org/02d0gmv36","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210106933"]},{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"HAOLI WANG","raw_affiliation_strings":["KingMed Diagnostics and KingMed School of Laboratory Medicine, Guangzhou Medical University, Guangzhou, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KingMed Diagnostics and KingMed School of Laboratory Medicine, Guangzhou Medical University, Guangzhou, P.R. China","institution_ids":["https://openalex.org/I4210106933","https://openalex.org/I92039509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100991474","display_name":"Jianqiong Huang","orcid":"https://orcid.org/0000-0003-1048-9164","observed_orcids":["https://orcid.org/0000-0003-1048-9164"]},"institutions":[{"id":"https://openalex.org/I4210106933","display_name":"Kingmed Diagnostics","ror":"https://ror.org/02d0gmv36","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210106933"]},{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"JIANQIONG HUANG","raw_affiliation_strings":["KingMed Diagnostics and KingMed School of Laboratory Medicine, Guangzhou Medical University, Guangzhou, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KingMed Diagnostics and KingMed School of Laboratory Medicine, Guangzhou Medical University, Guangzhou, P.R. China","institution_ids":["https://openalex.org/I4210106933","https://openalex.org/I92039509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101867177","display_name":"Jiahua Liu","orcid":"https://orcid.org/0009-0007-6889-2657","observed_orcids":["https://orcid.org/0009-0007-6889-2657","https://orcid.org/0009-0009-5357-0350"]},"institutions":[{"id":"https://openalex.org/I4210106933","display_name":"Kingmed Diagnostics","ror":"https://ror.org/02d0gmv36","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210106933"]},{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"JIAHUA LIU","raw_affiliation_strings":["KingMed Diagnostics and KingMed School of Laboratory Medicine, Guangzhou Medical University, Guangzhou, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KingMed Diagnostics and KingMed School of Laboratory Medicine, Guangzhou Medical University, Guangzhou, P.R. China","institution_ids":["https://openalex.org/I4210106933","https://openalex.org/I92039509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065491634","display_name":"TIANDI LONG","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106933","display_name":"Kingmed Diagnostics","ror":"https://ror.org/02d0gmv36","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210106933"]},{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"TIANDI LONG","raw_affiliation_strings":["KingMed Diagnostics and KingMed School of Laboratory Medicine, Guangzhou Medical University, Guangzhou, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KingMed Diagnostics and KingMed School of Laboratory Medicine, Guangzhou Medical University, Guangzhou, P.R. China","institution_ids":["https://openalex.org/I4210106933","https://openalex.org/I92039509"]}]},{"author_position":"last","author":{"id":null,"display_name":"JUN TANG","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106933","display_name":"Kingmed Diagnostics","ror":"https://ror.org/02d0gmv36","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210106933"]},{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"JUN TANG","raw_affiliation_strings":["KingMed Diagnostics and KingMed School of Laboratory Medicine, Guangzhou Medical University, Guangzhou, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KingMed Diagnostics and KingMed School of Laboratory Medicine, Guangzhou Medical University, Guangzhou, P.R. China","institution_ids":["https://openalex.org/I4210106933","https://openalex.org/I92039509"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210106933","https://openalex.org/I92039509"],"apc_list":null,"apc_paid":null,"fwci":0.9203,"has_fulltext":true,"cited_by_count":24,"citation_normalized_percentile":{"value":0.71410569,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"34","issue":"5","first_page":"2259","last_page":"2266"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12009","display_name":"Hedgehog Signaling Pathway Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sfrp2","display_name":"SFRP2","score":0.9890000224113464},{"id":"https://openalex.org/keywords/wnt-signaling","display_name":"Wnt signaling","score":0.7480000257492065},{"id":"https://openalex.org/keywords/wnt-agonist","display_name":"Wnt agonist","score":0.8690000176429749},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.9819999933242798},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.8949999809265137},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.859000027179718},{"id":"https://openalex.org/keywords/cell-invasion","display_name":"cell invasion","score":0.906000018119812},{"id":"https://openalex.org/keywords/g1-cell-cycle-arrest","display_name":"G1 cell cycle arrest","score":0.8500000238418579},{"id":"https://openalex.org/keywords/beta-catenin","display_name":"\u03b2-catenin","score":0.9319999814033508},{"id":"https://openalex.org/keywords/ccnd1","display_name":"CCND1","score":0.9390000104904175},{"id":"https://openalex.org/keywords/cdk4","display_name":"CDK4","score":0.9900000095367432},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.8709999918937683}],"concepts":[{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.8569631576538086},{"id":"https://openalex.org/C107300179","wikidata":"https://www.wikidata.org/wiki/Q41797887","display_name":"Frizzled","level":4,"score":0.6772695779800415},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6365691423416138},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6070502400398254},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.5803806185722351},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.539333701133728},{"id":"https://openalex.org/C81729549","wikidata":"https://www.wikidata.org/wiki/Q4649475","display_name":"A549 cell","level":3,"score":0.5350314974784851},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5198608040809631},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.5197581648826599},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.505188524723053},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5021333694458008},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.45587557554244995},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.4267328679561615},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4161815345287323},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.33983874320983887},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3160601854324341},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2846534848213196},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.2743920087814331},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20619088411331177},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20042774081230164},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.04770088195800781},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000094742","descriptor_name":"Secreted Frizzled-Related Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051153","descriptor_name":"Wnt Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D060449","descriptor_name":"Wnt Signaling Pathway","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.3892/or.2015.4221","doi":"https://doi.org/10.3892/or.2015.4221","is_oa":true,"landing_page_url":"https://doi.org/10.3892/or.2015.4221","pdf_url":"http://www.spandidos-publications.com/10.3892/or.2015.4221/download","source":{"id":"https://openalex.org/S124357017","display_name":"Oncology Reports","issn_l":"1021-335X","issn":["1021-335X","1791-2431"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4583535","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4583535","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncol Rep","raw_type":"Text"},{"id":"pmid:26323494","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26323494","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology reports","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3892/or.2015.4221","doi":"https://doi.org/10.3892/or.2015.4221","is_oa":true,"landing_page_url":"https://doi.org/10.3892/or.2015.4221","pdf_url":"http://www.spandidos-publications.com/10.3892/or.2015.4221/download","source":{"id":"https://openalex.org/S124357017","display_name":"Oncology Reports","issn_l":"1021-335X","issn":["1021-335X","1791-2431"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2050633149","display_name":null,"funder_award_id":"B147048","funder_id":"https://openalex.org/F4320311429","funder_display_name":"Guangzhou Medical University"}],"funders":[{"id":"https://openalex.org/F4320311429","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1840509092.pdf","grobid_xml":"https://content.openalex.org/works/W1840509092.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W1970635495","https://openalex.org/W1975160239","https://openalex.org/W1975306683","https://openalex.org/W1992127683","https://openalex.org/W2004419844","https://openalex.org/W2008031660","https://openalex.org/W2015974087","https://openalex.org/W2017135231","https://openalex.org/W2023186669","https://openalex.org/W2023192965","https://openalex.org/W2033420737","https://openalex.org/W2057096351","https://openalex.org/W2064945386","https://openalex.org/W2069533006","https://openalex.org/W2078861077","https://openalex.org/W2079819294","https://openalex.org/W2090704433","https://openalex.org/W2103143075","https://openalex.org/W2107503169","https://openalex.org/W2107648723","https://openalex.org/W2108296770","https://openalex.org/W2129444165","https://openalex.org/W2136868885","https://openalex.org/W2138022504","https://openalex.org/W2138410291","https://openalex.org/W2332316926","https://openalex.org/W4232719563","https://openalex.org/W6836478811"],"related_works":["https://openalex.org/W2569472791","https://openalex.org/W2623220562","https://openalex.org/W2006555393","https://openalex.org/W3096377085","https://openalex.org/W2165600416","https://openalex.org/W2429065637","https://openalex.org/W2006917333","https://openalex.org/W2090704433","https://openalex.org/W3171783192","https://openalex.org/W3029940240"],"abstract_inverted_index":{"The":[0,125],"secreted":[1],"frizzled-related":[2],"protein":[3,229],"2":[4],"(SFRP2)":[5],"plays":[6],"a":[7,200,226,236],"pivotal":[8],"role":[9],"in":[10,30,83,143,190,203],"the":[11,43,46,55,80,87,100,111,138,141,144,156,171,188,208],"Wnt":[12,158,201,222],"pathway,":[13,223],"however,":[14],"it":[15,186],"functions":[16],"as":[17,199,235],"an":[18,21,219],"agonist":[19,202,220],"or":[20],"antagonist":[22],"is":[23,216],"still":[24],"controversial.":[25],"We":[26,108],"profiled":[27],"SFRP2":[28,73,98,135,149,172,197,215,234],"expression":[29,179],"several":[31],"lung":[32,104,151,204,231,241],"cancer":[33,105,152,205,227,242],"cell":[34,76,88,106,112,153],"lines,":[35],"and":[36,40,45,58,63,78,94,116,122,130,137],"found":[37,71],"that":[38,72,97,148,196,214],"A549":[39,62,175],"95-D":[41,64,81,132,191],"exhibited":[42],"lowest":[44],"highest":[47],"level":[48],"of":[49,86,92,102,114,165,180,210,221],"SFRP2,":[50],"respectively.":[51,66],"Then":[52],"we":[53,70],"employed":[54],"SFRP2-overexpressing":[56],"plasmid":[57],"siRNA":[59],"to":[60],"transfect":[61],"cells,":[65],"Through":[67],"MTT":[68],"assays,":[69],"knockdown":[74],"inhibited":[75],"proliferation,":[77],"halted":[79],"cells":[82,133,176],"G1":[84],"phase":[85],"cycle":[89],"by":[90,167],"downregulation":[91],"CCND1":[93],"CDK4,":[95],"indicating":[96,233],"has":[99],"ability":[101],"promoting":[103,228],"proliferation.":[107],"further":[109],"checked":[110],"properties":[113],"migration":[115],"invasion,":[117],"using":[118],"wound":[119],"scratch":[120],"assay":[121],"Transwell":[123],"assays.":[124],"data":[126],"showed":[127],"decreased":[128],"migrated":[129],"invasive":[131],"after":[134],"knockdown,":[136],"observations":[139],"were":[140],"opposite":[142,189],"overexpressing":[145,173],"model,":[146,174],"implying":[147],"promoted":[150],"invasion.":[154],"Moreover,":[155],"canonical":[157],"pathway":[159],"was":[160,187],"also":[161,225],"studied":[162],"through":[163],"detection":[164],"\u03b2-catenin":[166,181],"western":[168],"blotting.":[169],"In":[170],"presented":[177],"stronger":[178],"compared":[182],"with":[183],"controls,":[184],"while":[185],"cells.":[192,206],"These":[193],"results":[194],"suggested":[195],"serves":[198],"Together,":[207],"findings":[209],"this":[211],"study":[212],"implied":[213],"not":[217],"only":[218],"but":[224],"for":[230,240],"cancer,":[232],"promising":[237],"therapeutic":[238],"target":[239],"treatment.":[243]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}