{"id":"https://openalex.org/W183996337","doi":null,"title":"Targeted therapy in advanced urothelial carcinoma.","display_name":"Targeted therapy in advanced urothelial carcinoma.","publication_year":2013,"publication_date":"2013-03-01","ids":{"openalex":"https://openalex.org/W183996337","mag":"183996337","pmid":"https://pubmed.ncbi.nlm.nih.gov/23687793"},"language":"en","primary_location":{"id":"pmid:23687793","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23687793","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology (Williston Park, N.Y.)","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074985724","display_name":"Brandon P. Verdoorn","orcid":"https://orcid.org/0000-0003-4289-2740","observed_orcids":["https://orcid.org/0000-0003-4289-2740"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brandon P Verdoorn","raw_affiliation_strings":["Division of Medical Oncology, Department of Medicine, University of Colorado School of Medicine, Denver, Colorado, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology, Department of Medicine, University of Colorado School of Medicine, Denver, Colorado, USA","institution_ids":["https://openalex.org/I51713134","https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044287083","display_name":"Elizabeth Riley Kessler","orcid":"https://orcid.org/0000-0001-7285-867X","observed_orcids":["https://orcid.org/0000-0001-7285-867X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elizabeth R Kessler","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5088312939","display_name":"Thomas W. Flaig","orcid":"https://orcid.org/0000-0001-6145-9040","observed_orcids":["https://orcid.org/0000-0001-6145-9040"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas W Flaig","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.5934,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.81372793,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"27","issue":"3","first_page":"219","last_page":"26"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/urothelial-carcinoma","display_name":"urothelial carcinoma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.7950000166893005},{"id":"https://openalex.org/keywords/advanced-disease","display_name":"advanced disease","score":0.6520000100135803},{"id":"https://openalex.org/keywords/egfr","display_name":"EGFR","score":0.8209999799728394},{"id":"https://openalex.org/keywords/vegfr","display_name":"VEGFR","score":0.996999979019165},{"id":"https://openalex.org/keywords/her2-neu","display_name":"HER2/neu","score":0.9929999709129333},{"id":"https://openalex.org/keywords/igf-1-receptor","display_name":"IGF-1 receptor","score":0.9950000047683716},{"id":"https://openalex.org/keywords/molecular-pathways","display_name":"molecular pathways","score":0.8610000014305115},{"id":"https://openalex.org/keywords/clinical-trials","display_name":"clinical trials","score":0.3880000114440918},{"id":"https://openalex.org/keywords/bladder-cancer","display_name":"bladder cancer","score":0.6179999709129333}],"concepts":[{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.7288668751716614},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7232061624526978},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.5834856629371643},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.550206184387207},{"id":"https://openalex.org/C144174609","wikidata":"https://www.wikidata.org/wiki/Q14901457","display_name":"Insulin-like growth factor 1 receptor","level":4,"score":0.5443347096443176},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.46197545528411865},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4616066515445709},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.45649850368499756},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.44284921884536743},{"id":"https://openalex.org/C26375932","wikidata":"https://www.wikidata.org/wiki/Q118226","display_name":"Growth factor receptor","level":3,"score":0.4117697477340698},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4026843309402466},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.3620534837245941},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.36147284507751465},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3569675087928772},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2959974408149719},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.23143300414085388},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14704641699790955}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001749","descriptor_name":"Urinary Bladder Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002295","descriptor_name":"Carcinoma, Transitional Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:23687793","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23687793","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology (Williston Park, N.Y.)","raw_type":"Journal Article"},{"id":"mag:183996337","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23687793","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9907000064849854}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W1483015025","https://openalex.org/W1554602088","https://openalex.org/W1672915283","https://openalex.org/W1965127349","https://openalex.org/W1971605007","https://openalex.org/W1972486056","https://openalex.org/W1991064094","https://openalex.org/W1991206511","https://openalex.org/W2002566146","https://openalex.org/W2008585163","https://openalex.org/W2027611776","https://openalex.org/W2033248824","https://openalex.org/W2041383926","https://openalex.org/W2042906712","https://openalex.org/W2046052085","https://openalex.org/W2072440407","https://openalex.org/W2073987572","https://openalex.org/W2080615855","https://openalex.org/W2090705049","https://openalex.org/W2094952890","https://openalex.org/W2098028863","https://openalex.org/W2101562875","https://openalex.org/W2104584442","https://openalex.org/W2104845282","https://openalex.org/W2113425527","https://openalex.org/W2114699723","https://openalex.org/W2123213003","https://openalex.org/W2126055089","https://openalex.org/W2129739125","https://openalex.org/W2139567146","https://openalex.org/W2141065197","https://openalex.org/W2141398932","https://openalex.org/W2142173484","https://openalex.org/W2147609992","https://openalex.org/W2151488185","https://openalex.org/W2152194109","https://openalex.org/W2152393440","https://openalex.org/W2154673624","https://openalex.org/W2156845957","https://openalex.org/W2165948908","https://openalex.org/W2170517479","https://openalex.org/W2182514684","https://openalex.org/W2249487864","https://openalex.org/W2254098818","https://openalex.org/W2265447285","https://openalex.org/W2286614396","https://openalex.org/W2524775076","https://openalex.org/W2560072137","https://openalex.org/W2591295891"],"related_works":["https://openalex.org/W4308336309","https://openalex.org/W2319592043","https://openalex.org/W4404601414","https://openalex.org/W4399897565","https://openalex.org/W2068548371","https://openalex.org/W3176330349","https://openalex.org/W7116692415","https://openalex.org/W2075162207","https://openalex.org/W2020972159","https://openalex.org/W2921949700"],"abstract_inverted_index":{"Urothelial":[0],"carcinoma":[1],"(UC)":[2],"is":[3],"a":[4],"common":[5],"and":[6,69,101,140],"deadly":[7],"cancer":[8,152],"in":[9,28,36,65],"the":[10,21,31,42,55,60,66,82,122,128,138,162,165],"United":[11],"States.":[12],"While":[13],"molecularly":[14],"targeted":[15,34,113],"therapies":[16,114],"have":[17,73],"been":[18],"integrated":[19],"into":[20],"standard-of-care":[22],"management":[23,43],"of":[24,33,44,62,119,124,134,142,164],"other":[25],"solid":[26],"tumors":[27],"recent":[29],"years,":[30],"use":[32],"therapy":[35],"UC":[37],"has":[38,50],"lagged":[39],"behind.":[40],"Accordingly,":[41],"advanced":[45,125],"disease,":[46],"along":[47],"with":[48],"outcomes,":[49],"remained":[51],"largely":[52],"unchanged":[53],"for":[54,121],"past":[56],"2":[57,99],"decades.":[58],"Despite":[59],"lack":[61],"new":[63,143],"agents":[64,144],"clinic,":[67],"preclinical":[68],"early":[70],"clinical":[71],"studies":[72],"demonstrated":[74],"that":[75],"numerous":[76],"potentially\"targetable\"":[77],"molecular":[78],"pathways":[79,118],"exist,":[80],"including":[81],"epidermal":[83,95],"growth":[84,90,96,103],"factor":[85,91,97,104],"receptor":[86,92,98,106],"(EGFR),":[87],"vascular":[88],"endothelial":[89],"(VEGFR),":[93],"human":[94],"(HER2/neu),":[100],"insulin-like":[102],"1":[105],"(IGF1R)":[107],"pathways.":[108],"This":[109],"review":[110],"focuses":[111],"on":[112],"related":[115],"to":[116,130,150,155],"these":[117,135,157],"interest":[120],"treatment":[123],"UC,":[126],"describing":[127],"evidence":[129],"support":[131,163],"further":[132],"investigation":[133],"approaches.":[136],"Notably,":[137],"identification":[139],"validation":[141],"will":[145,160],"only":[146],"occur":[147],"through":[148],"accrual":[149],"urothelial":[151],"trials":[153],"designed":[154],"answer":[156],"questions,":[158],"which":[159],"require":[161],"entire":[166],"urologic":[167],"community.":[168]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
