{"id":"https://openalex.org/W1837979596","doi":"https://doi.org/10.1113/jphysiol.2006.118091","title":"A spoonful of sugar helps the KV channel activity go down","display_name":"A spoonful of sugar helps the KV channel activity go down","publication_year":2006,"publication_date":"2006-08-04","ids":{"openalex":"https://openalex.org/W1837979596","doi":"https://doi.org/10.1113/jphysiol.2006.118091","mag":"1837979596","pmid":"https://pubmed.ncbi.nlm.nih.gov/16887870","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1995689"},"language":"en","primary_location":{"id":"doi:10.1113/jphysiol.2006.118091","doi":"https://doi.org/10.1113/jphysiol.2006.118091","is_oa":false,"landing_page_url":"https://doi.org/10.1113/jphysiol.2006.118091","pdf_url":null,"source":{"id":"https://openalex.org/S2090548","display_name":"The Journal of Physiology","issn_l":"0022-3751","issn":["0022-3751","1469-7793"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1995689","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078948939","display_name":"Stephen V. Straub","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen V. Straub","raw_affiliation_strings":["Department of Pharmacology, University of Vermont, Burlington, VT 05405, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Vermont, Burlington, VT 05405, USA","institution_ids":["https://openalex.org/I111236770"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048090770","display_name":"Mark T. Nelson","orcid":"https://orcid.org/0000-0002-6608-8784","observed_orcids":["https://orcid.org/0000-0002-6608-8784"]},"institutions":[{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark T. Nelson","raw_affiliation_strings":["Department of Pharmacology, University of Vermont, Burlington, VT 05405, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Vermont, Burlington, VT 05405, USA","institution_ids":["https://openalex.org/I111236770"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I111236770"],"apc_list":{"value":5400,"currency":"USD","value_usd":5400},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.07808957,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"575","issue":"3","first_page":"691","last_page":"691"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/voltage-gated-potassium-channels","display_name":"voltage-gated potassium channels","score":0.7319999933242798},{"id":"https://openalex.org/keywords/kv1-5","display_name":"Kv1.5","score":0.8659999966621399},{"id":"https://openalex.org/keywords/kv1-2","display_name":"Kv1.2","score":0.5120000243186951},{"id":"https://openalex.org/keywords/kv1-3","display_name":"Kv1.3 potassium channel","score":0.5849999785423279},{"id":"https://openalex.org/keywords/kv1-4","display_name":"Kv1.4","score":0.609000027179718},{"id":"https://openalex.org/keywords/kv1-6","display_name":"Kv1.6","score":0.6700000166893005},{"id":"https://openalex.org/keywords/kv2-1","display_name":"Kv2.1","score":0.6079999804496765},{"id":"https://openalex.org/keywords/kv2-2","display_name":"Kv2.2","score":0.8289999961853027},{"id":"https://openalex.org/keywords/kv3-1","display_name":"Kv3.1","score":0.7310000061988831},{"id":"https://openalex.org/keywords/kv3-4","display_name":"Kv3.4","score":0.8820000290870667},{"id":"https://openalex.org/keywords/kv4-1","display_name":"Kv4.1","score":0.8379999995231628},{"id":"https://openalex.org/keywords/kv4-2","display_name":"Kv4.2","score":0.9490000009536743},{"id":"https://openalex.org/keywords/kv4-3","display_name":"Kv4.3","score":0.9580000042915344}],"concepts":[{"id":"https://openalex.org/C4141045","wikidata":"https://www.wikidata.org/wiki/Q83183","display_name":"Depolarization","level":2,"score":0.6778250336647034},{"id":"https://openalex.org/C2779395532","wikidata":"https://www.wikidata.org/wiki/Q7916469","display_name":"Vascular smooth muscle","level":3,"score":0.6133632063865662},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.6039575934410095},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5771867632865906},{"id":"https://openalex.org/C83743174","wikidata":"https://www.wikidata.org/wiki/Q423778","display_name":"Potassium channel","level":2,"score":0.5665909647941589},{"id":"https://openalex.org/C181911157","wikidata":"https://www.wikidata.org/wiki/Q389844","display_name":"Membrane potential","level":2,"score":0.48358577489852905},{"id":"https://openalex.org/C163415756","wikidata":"https://www.wikidata.org/wiki/Q126473","display_name":"Contraction (grammar)","level":2,"score":0.46334677934646606},{"id":"https://openalex.org/C149614440","wikidata":"https://www.wikidata.org/wiki/Q5018801","display_name":"Calcium-activated potassium channel","level":3,"score":0.42194581031799316},{"id":"https://openalex.org/C94924445","wikidata":"https://www.wikidata.org/wiki/Q841456","display_name":"Inward-rectifier potassium ion channel","level":4,"score":0.41607147455215454},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33807137608528137},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.30746909976005554},{"id":"https://openalex.org/C50254741","wikidata":"https://www.wikidata.org/wiki/Q62536","display_name":"Ion channel","level":3,"score":0.29121720790863037},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2480400800704956},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21866613626480103},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1567576825618744},{"id":"https://openalex.org/C2992686903","wikidata":"https://www.wikidata.org/wiki/Q208453","display_name":"Smooth muscle","level":2,"score":0.1125364601612091},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08992692828178406}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015640","descriptor_name":"Ion Channel Gating","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051666","descriptor_name":"Kv1.5 Potassium Channel","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D051666","descriptor_name":"Kv1.5 Potassium Channel","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1113/jphysiol.2006.118091","doi":"https://doi.org/10.1113/jphysiol.2006.118091","is_oa":false,"landing_page_url":"https://doi.org/10.1113/jphysiol.2006.118091","pdf_url":null,"source":{"id":"https://openalex.org/S2090548","display_name":"The Journal of Physiology","issn_l":"0022-3751","issn":["0022-3751","1469-7793"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1995689","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1995689","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Physiol","raw_type":"Text"},{"id":"pmid:16887870","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16887870","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of physiology","raw_type":"Comment"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/82534821-11b5-4281-a0c6-1407894455f9","doi":null,"is_oa":false,"landing_page_url":"https://research.manchester.ac.uk/en/publications/82534821-11b5-4281-a0c6-1407894455f9","pdf_url":null,"source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Straub, S V & Nelson, M T 2006, 'A spoonful of sugar helps the KV channel activity go down', Journal of Physiology, vol. 575, no. 3, pp. 691. https://doi.org/10.1113/jphysiol.2006.118091","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1995689","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1995689","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Physiol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.428600013256073,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W1753089048","https://openalex.org/W1972617290","https://openalex.org/W2052061197","https://openalex.org/W2079255926","https://openalex.org/W2110563613","https://openalex.org/W2159579272","https://openalex.org/W2215025934","https://openalex.org/W2299508194"],"related_works":["https://openalex.org/W2468863259","https://openalex.org/W2766583932","https://openalex.org/W2921827250","https://openalex.org/W2772637478","https://openalex.org/W1913443320","https://openalex.org/W4231339955","https://openalex.org/W2761340202","https://openalex.org/W2016652093","https://openalex.org/W2756814063","https://openalex.org/W2060974177"],"abstract_inverted_index":{"Modulation":[0,169],"of":[1,22,34,44,53,120,137,146,170,179,193,210,267,301,323,326,380,388,409,427,434,451,479,489,519,532,542,551,575,620,657,708,725,776,781,784,792,816],"vascular":[2,19,45,58,151,318,501,552,560,567,590,709,714,763,793],"smooth":[3,78],"muscle":[4,79],"cell":[5,382,496],"(SMC)":[6],"potassium":[7,139],"(K+)":[8],"channel":[9,172,181,231,241,258,307,340,384,491,498,521,534,643,752,786],"function":[10,794],"has":[11],"a":[12,51,311,335,359,378,402,504,545,616,629,661],"profound":[13,623],"influence":[14],"on":[15,364,436,528,548,611],"SMC":[16,35,121,148,314,557,747],"contractility":[17,558],"and":[18,38,74,85,100,109,150,185,195,222,293,316,373,386,441,476,493,559,569,582,601,622,649,703,745,749,765,811],"function.":[20],"Depolarization":[21],"SMCs":[23,46,345,389,480,502,591,648],"activates":[24],"L-type":[25],"voltage-dependent":[26,138],"Ca2+":[27,31],"channels":[28,55,141,554],"resulting":[29],"in":[30,200,213,224,234,280,342,351,377,500,503,625,666,685,762,788],"influx,":[32],"elevation":[33],"cytosolic":[36],"Ca2+,":[37],"contraction.":[39],"The":[40,135,324,507,573,768],"membrane":[41],"potential":[42],"(Vm)":[43],"is":[47,142,176,346,362,414,483,525,563,633,679,754],"tightly":[48],"controlled":[49],"by":[50,57,68,349,735,742,756],"complement":[52],"K+":[54,87,93,98,103],"expressed":[56],"SMCs,":[59,710,736],"whose":[60],"activity":[61,136,173,259,341,644,672,753,787],"serves":[62,303],"to":[63,114,128,204,218,226,245,282,304,310,416,481,485,555,565,596,606,712,728,759,772,823],"counteract":[64],"depolarizing":[65],"influences":[66],"induced":[67,517,530],"constricting":[69],"stimuli":[70],"including":[71],"intravascular":[72,227],"pressure":[73,228],"vasoactive":[75,283],"substances.":[76],"Vascular":[77],"can":[80,174,260,277,464],"express":[81],"large":[82],"conductance,":[83],"voltage-":[84],"calcium-sensitive":[86],"(BK)":[88],"channels,":[89,95,99,105],"strong":[90],"inward":[91],"rectifier":[92],"(Kir)":[94],"ATP-sensitive":[96],"(KATP)":[97],"voltage":[101],"dependent":[102,363],"(KV)":[104,140],"which":[106,276,338,361,562],"are":[107,733,740],"activated":[108,279],"modulated":[110,348],"through":[111,177,264,337],"different":[112],"mechanisms":[113],"allow":[115],"for":[116,334,471],"the":[117,124,147,208,235,265,355,407,432,444,474,487,549,626,655,667,706,779,789,817],"fine":[118],"tuning":[119],"Vm":[122],"throughout":[123],"physiological":[125,357,540,790],"range":[126],"(\u221260":[127],"\u221240":[129],"mV)":[130],"(Nelson":[131],"&":[132,154,158,796,800],"Quayle,":[133],"1995).":[134],"an":[143,593,773,813],"important":[144],"determinant":[145],"Vm,":[149,315],"tone":[152,764],"(Knot":[153,795],"Nelson,":[155,797],"1995;":[156,798],"Cox":[157,799],"Rusch,":[159,801],"2002;":[160,802],"Cole":[161,184,803],"et":[162,166,188,254,290,297,329,458,577,804,808],"al.":[163,167,189,255,291,298,330,459,578,805,809],"2005;":[164,806],"Plane":[165,807],"2005).":[168],"KV":[171,180,230,240,257,306,339,383,437,490,497,520,553,642,748,785],"occur":[175],"alteration":[178],"expression":[182,209,232,242],"levels.":[183],"colleagues":[186],"(Chen":[187],"2006)":[190],"utilized":[191,470],"overexpression":[192],"wild-type":[194],"dominant":[196],"negative":[197],"KV1.5":[198],"subunits":[199,212],"middle":[201],"cerebral":[202,251,651,686],"arteries":[203,217],"demonstrate":[205],"that":[206,461,511,539,589,693],"decreasing":[207],"KV1":[211],"this":[214,321,418,429,515],"system":[215],"causes":[216],"be":[219,262,278,619,664,724],"more":[220,312],"depolarized":[221,313],"constricted":[223],"response":[225,281],"Increasing":[229],"results":[233,376],"opposite":[236],"effect.":[237],"Reduced":[238],"arterial":[239],"likely":[243,564],"contributes":[244],"certain":[246],"pathological":[247],"conditions":[248],"such":[249,270,285],"as":[250,271,286,399,598],"vasospasm":[252],"(Ishiguro":[253],"2006).":[256],"also":[261],"regulated":[263],"action":[266],"various":[268],"kinases":[269],"protein":[272],"kinase":[273],"C":[274],"(PKC),":[275],"substances":[284],"angiotensin":[287],"II":[288],"(Clement-Chomienne":[289],"1996)":[292],"endothelin-1":[294],"(ET-1)":[295],"(Shimoda":[296],"1998).":[299],"Activation":[300],"PKC":[302,365,397,403],"reduce":[305,494],"currents,":[308,522],"leading":[309,711],"increased":[317,675,713],"tone.":[319],"In":[320,719],"issue":[322],"Journal":[325],"Physiology,":[327],"Rainbow":[328,457,576],"(2006)":[331],"provide":[332],"evidence":[333,777],"mechanism":[336,617,662],"mesenteric":[343,392],"artery":[344],"rapidly":[347],"variations":[350],"glucose":[352,369,410,435,452,463,513,543,631,696,731],"concentration":[353,370],"within":[354,390,448],"normal":[356],"range,":[358],"process":[360],"activity.":[366],"Specifically,":[367],"increasing":[368,654],"between":[371,473],"0":[372],"10":[374],"mm":[375],"decrease":[379,570],"whole":[381,495],"current":[385,508,769],"depolarization":[387],"intact":[391],"arteries.":[393],"This":[394],"effect":[395,408,446,527],"requires":[396],"activity,":[398],"preincubation":[400],"with":[401,443,466,699],"inhibitory":[404],"peptide":[405],"blocks":[406],"elevation.":[411],"Glucose":[412],"metabolism":[413],"necessary":[415],"induce":[417,760],"effect,":[419],"since":[420],"non-metabolizable":[421],"mono-":[422],"or":[423],"disaccharides":[424],"were":[425,439],"incapable":[426],"producing":[428],"response.":[430],"Interestingly,":[431],"effects":[433],"currents":[438,499],"rapid":[440],"reversible,":[442],"complete":[445],"occurring":[447],"200":[449],"s":[450],"application.":[453],"Perhaps":[454],"most":[455],"significantly,":[456],"show":[460],"elevated":[462,512,695,743],"interfere":[465],"endo-genous":[467],"signalling":[468,738],"pathways":[469],"communication":[472],"endothelium":[475],"SMCs.":[477],"Exposure":[478],"ET-1":[482,516,529],"known":[484],"increase":[486,566],"rate":[488],"inactivation":[492],"PKC-dependent":[505],"manner.":[506],"study":[509,574,770],"illustrates":[510],"prevents":[514],"suppression":[518,531],"but":[523],"interestingly":[524],"without":[526],"KATP":[533],"current.":[535],"These":[536,635],"findings":[537,587,636,691],"suggest":[538,637],"levels":[541,697,732],"have":[544],"significant":[546,581],"impact":[547],"ability":[550,595],"regulate":[556],"tone,":[561],"resistance":[568,715],"tissue":[571,608],"perfusion.":[572],"raises":[579],"several":[580],"interesting":[583],"points.":[584],"First,":[585],"these":[586,690],"imply":[588,692],"possess":[592],"intrinsic":[594],"act":[597],"metabolic":[599,613,677,821],"sensors,":[600],"alter":[602,705],"their":[603],"contractile":[604],"state":[605,822],"modulate":[607],"perfusion":[609],"based":[610],"local":[612],"requirements.":[614],"Such":[615,660],"would":[618,645,701],"obvious":[621],"importance":[624,727],"brain,":[627],"where":[628],"constant":[630],"supply":[632],"essential.":[634],"that,":[638],"under":[639],"hypoglycaemic":[640],"conditions,":[641],"increase,":[646],"hyperpolarizing":[647],"dilating":[650],"vessels,":[652],"thus":[653],"delivery":[656],"energetic":[658],"substrates.":[659],"could":[663],"involved":[665],"hyperaemic":[668],"response,":[669],"whereby":[670],"neuronal":[671,676],"(and":[673],"presumably":[674],"demand)":[678],"translated":[680],"into":[681],"spatially":[682],"localized":[683],"increases":[684],"blood":[687,766,824],"flow.":[688,767,825],"Furthermore,":[689],"abnormally":[694],"associated":[698],"diabetes":[700],"directly":[702],"persistently":[704],"excitability":[707],"and,":[716],"potentially,":[717],"hypertension.":[718],"future":[720],"studies,":[721],"it":[722],"will":[723],"fundamental":[726],"discern":[729],"how":[730,746],"decoded":[734],"what":[737],"cascades":[739],"affected":[741,755],"glucose,":[744],"other":[750],"ion":[751],"endogenous":[757],"factors":[758],"changes":[761],"adds":[771],"emerging":[774],"body":[775],"expounding":[778],"significance":[780],"dynamic":[782],"regulation":[783],"control":[791],"2005),":[810],"provides":[812],"elegant":[814],"example":[815],"processes":[818],"linking":[819],"cellular":[820]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
