{"id":"https://openalex.org/W183770710","doi":"https://doi.org/10.1089/jmf.2013.2913","title":"Diferuloylputrescine, a Predominant Phenolic Amide in Corn Bran, Potently Induces Apoptosis in Human Leukemia U937 Cells","display_name":"Diferuloylputrescine, a Predominant Phenolic Amide in Corn Bran, Potently Induces Apoptosis in Human Leukemia U937 Cells","publication_year":2014,"publication_date":"2014-05-01","ids":{"openalex":"https://openalex.org/W183770710","doi":"https://doi.org/10.1089/jmf.2013.2913","mag":"183770710","pmid":"https://pubmed.ncbi.nlm.nih.gov/24827745"},"language":"en","primary_location":{"id":"doi:10.1089/jmf.2013.2913","doi":"https://doi.org/10.1089/jmf.2013.2913","is_oa":false,"landing_page_url":"https://doi.org/10.1089/jmf.2013.2913","pdf_url":null,"source":{"id":"https://openalex.org/S78718175","display_name":"Journal of Medicinal Food","issn_l":"1096-620X","issn":["1096-620X","1557-7600"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","kci-registered","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Food","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.liebertpub.com/doi/abs/10.1089/jmf.2013.2913","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033669747","display_name":"Eun Ok Kim","orcid":"https://orcid.org/0000-0002-0590-2076","observed_orcids":["https://orcid.org/0000-0002-0590-2076"]},"institutions":[{"id":"https://openalex.org/I39705031","display_name":"Daegu Catholic University","ror":"https://ror.org/04fxknd68","country_code":"KR","type":"education","lineage":["https://openalex.org/I39705031"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Eun-Ok Kim","raw_affiliation_strings":["Department of Food Science and Nutrition, Catholic University of Daegu, Gyeongsan, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Science and Nutrition, Catholic University of Daegu, Gyeongsan, Korea","institution_ids":["https://openalex.org/I39705031"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080645017","display_name":"Taeg\u2010Kyu Kwon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52010207","display_name":"Keimyung University","ror":"https://ror.org/00tjv0s33","country_code":"KR","type":"education","lineage":["https://openalex.org/I52010207"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Taeg-Kyu Kwon","raw_affiliation_strings":["Department of Immunology, School of Medicine, Keimyung University, Daegu, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, School of Medicine, Keimyung University, Daegu, Korea","institution_ids":["https://openalex.org/I52010207"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050916746","display_name":"Sang\u2010Won Choi","orcid":"https://orcid.org/0000-0002-1603-0576","observed_orcids":["https://orcid.org/0000-0002-1603-0576"]},"institutions":[{"id":"https://openalex.org/I39705031","display_name":"Daegu Catholic University","ror":"https://ror.org/04fxknd68","country_code":"KR","type":"education","lineage":["https://openalex.org/I39705031"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Sang-Won Choi","raw_affiliation_strings":["Department of Food Science and Nutrition, Catholic University of Daegu, Gyeongsan, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Science and Nutrition, Catholic University of Daegu, Gyeongsan, Korea","institution_ids":["https://openalex.org/I39705031"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5050916746"],"corresponding_institution_ids":["https://openalex.org/I39705031"],"apc_list":null,"apc_paid":null,"fwci":0.6359,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.62859948,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"17","issue":"5","first_page":"519","last_page":"526"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.3463999927043915,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.3463999927043915,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.2992999851703644,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11973","display_name":"Plant chemical constituents analysis","score":0.14169999957084656,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hydroxycinnamic-acid-derivatives","display_name":"hydroxycinnamic acid derivatives","score":0.9100000262260437},{"id":"https://openalex.org/keywords/corn-bran","display_name":"corn bran","score":0.8799999952316284},{"id":"https://openalex.org/keywords/maize","display_name":"maize","score":0.8199999928474426},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6949999928474426},{"id":"https://openalex.org/keywords/u937-cells","display_name":"U937 cells","score":0.8970000147819519},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.8370000123977661},{"id":"https://openalex.org/keywords/cytochrome-c-release","display_name":"cytochrome c release","score":0.8519999980926514},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.8920000195503235},{"id":"https://openalex.org/keywords/xiap","display_name":"XIAP","score":0.9319999814033508},{"id":"https://openalex.org/keywords/ciap2","display_name":"cIAP2","score":0.9110000133514404},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.9959999918937683},{"id":"https://openalex.org/keywords/mcl-1","display_name":"Mcl-1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/dna-fragmentation","display_name":"DNA fragmentation","score":0.6790000200271606},{"id":"https://openalex.org/keywords/antileukemic-agents","display_name":"antileukemic agents","score":0.8050000071525574}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.8317570686340332},{"id":"https://openalex.org/C33195913","wikidata":"https://www.wikidata.org/wiki/Q20970121","display_name":"XIAP","level":5,"score":0.775481104850769},{"id":"https://openalex.org/C108634530","wikidata":"https://www.wikidata.org/wiki/Q7863610","display_name":"U937 cell","level":3,"score":0.5667497515678406},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5626707673072815},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.5290725827217102},{"id":"https://openalex.org/C2776873940","wikidata":"https://www.wikidata.org/wiki/Q188672","display_name":"Bran","level":3,"score":0.48532646894454956},{"id":"https://openalex.org/C2780213334","wikidata":"https://www.wikidata.org/wiki/Q417362","display_name":"Ferulic acid","level":2,"score":0.4622736871242523},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.44333869218826294},{"id":"https://openalex.org/C98424977","wikidata":"https://www.wikidata.org/wiki/Q25805","display_name":"Caspase","level":4,"score":0.3933827579021454},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.38548219203948975},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.32924574613571167},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32064032554626465},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.22596478462219238},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.12827461957931519},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C206139338","wikidata":"https://www.wikidata.org/wiki/Q192355","display_name":"Raw material","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003313","descriptor_name":"Zea mays","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D003373","descriptor_name":"Coumaric Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011700","descriptor_name":"Putrescine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D011700","descriptor_name":"Putrescine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012639","descriptor_name":"Seeds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020298","descriptor_name":"U937 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045304","descriptor_name":"Cytochromes c","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D053148","descriptor_name":"Caspase 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053938","descriptor_name":"DNA Fragmentation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1089/jmf.2013.2913","doi":"https://doi.org/10.1089/jmf.2013.2913","is_oa":false,"landing_page_url":"https://doi.org/10.1089/jmf.2013.2913","pdf_url":null,"source":{"id":"https://openalex.org/S78718175","display_name":"Journal of Medicinal Food","issn_l":"1096-620X","issn":["1096-620X","1557-7600"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","kci-registered","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Food","raw_type":"journal-article"},{"id":"pmid:24827745","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24827745","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medicinal food","raw_type":"Journal Article"},{"id":"pmh:oai:kumel.medlib.dsmc.or.kr:2015.oak/34165","doi":null,"is_oa":true,"landing_page_url":"https://www.liebertpub.com/doi/abs/10.1089/jmf.2013.2913","pdf_url":null,"source":{"id":"https://openalex.org/S4377196386","display_name":"KUMeL Repository (Keimyung University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I52010207","host_organization_name":"Keimyung University","host_organization_lineage":["https://openalex.org/I52010207"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:kumel.medlib.dsmc.or.kr:2015.oak/34165","doi":null,"is_oa":true,"landing_page_url":"https://www.liebertpub.com/doi/abs/10.1089/jmf.2013.2913","pdf_url":null,"source":{"id":"https://openalex.org/S4377196386","display_name":"KUMeL Repository (Keimyung University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I52010207","host_organization_name":"Keimyung University","host_organization_lineage":["https://openalex.org/I52010207"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321189","display_name":"Catholic University of Daegu","ror":"https://ror.org/04fxknd68"},{"id":"https://openalex.org/F4320321343","display_name":"Daegu University","ror":"https://ror.org/01zqccq48"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1483201954","https://openalex.org/W1745634660","https://openalex.org/W1965746568","https://openalex.org/W1967568801","https://openalex.org/W1970546664","https://openalex.org/W1978764552","https://openalex.org/W1984866351","https://openalex.org/W1985300899","https://openalex.org/W1989927530","https://openalex.org/W1990899921","https://openalex.org/W1991865867","https://openalex.org/W1994475416","https://openalex.org/W2005013074","https://openalex.org/W2010298858","https://openalex.org/W2015365417","https://openalex.org/W2034219543","https://openalex.org/W2039867146","https://openalex.org/W2051707874","https://openalex.org/W2054526986","https://openalex.org/W2067711550","https://openalex.org/W2071280387","https://openalex.org/W2076961963","https://openalex.org/W2093615237","https://openalex.org/W2093816621","https://openalex.org/W2096685256","https://openalex.org/W2097786201","https://openalex.org/W2106410559","https://openalex.org/W2110317278","https://openalex.org/W2143757024","https://openalex.org/W2479077703"],"related_works":["https://openalex.org/W1996820667","https://openalex.org/W2017675726","https://openalex.org/W2364138792","https://openalex.org/W2344323124","https://openalex.org/W3167733139","https://openalex.org/W2094775744","https://openalex.org/W2062864061","https://openalex.org/W2105988986","https://openalex.org/W2739703664","https://openalex.org/W2047122771"],"abstract_inverted_index":{"The":[0,81],"purpose":[1],"of":[2,55,69,96,103,128,152],"this":[3],"study":[4],"was":[5,84,117],"to":[6],"investigate":[7],"how":[8],"proliferation":[9],"and":[10,38,53,78,108,111,137],"apoptosis":[11,56,83,116],"in":[12,25,57,91,121],"human":[13],"leukemia":[14,122],"U937":[15,59],"cells":[16],"are":[17],"affected":[18],"by":[19],"four":[20,43],"hydroxycinnamic":[21],"acid":[22],"derivatives":[23],"(HCADs)":[24],"corn":[26],"(Zea":[27],"mays":[28],"L.)":[29],"bran:":[30],"p-coumaric":[31],"(CA),":[32],"ferulic":[33],"acids":[34],"(FA),":[35],"dicoumaroylputrescine":[36],"(DCP),":[37],"diferuloylputrescine":[39],"(DFP).":[40],"Of":[41],"the":[42,49,58,92,101,114],"HCADs,":[44],"DFP":[45,63,144],"dose":[46],"dependently":[47],"exerted":[48],"strongest":[50],"cytotoxic":[51],"effect":[52],"induction":[54],"cells.":[60],"In":[61],"addition,":[62],"induced":[64],"distinct":[65],"morphological":[66],"changes":[67],"characteristic":[68],"cellular":[70],"apoptosis,":[71],"such":[72,132],"as":[73,124,133,148],"chromatin":[74],"condensation,":[75],"apoptotic":[76],"bodies,":[77],"DNA":[79],"fragmentations.":[80],"DFP-induced":[82,115],"also":[85],"associated":[86],"with":[87,94,100,126],"released":[88],"cytochrome":[89],"c":[90],"cytosol":[93],"activation":[95],"caspase":[97],"3,":[98],"together":[99],"downregulation":[102],"anti-apoptotic":[104],"proteins,":[105],"including":[106],"XIAP":[107],"cIAP2,":[109],"Bcl-2,":[110],"Mcl-1.":[112],"Finally,":[113],"a":[118,149],"cell-specific":[119],"response":[120],"cells,":[123,131],"compared":[125],"those":[127],"other":[129],"cancer":[130],"Caki,":[134],"HT29,":[135],"SK-Hep1,":[136],"MDA-MB231.":[138],"Thus,":[139],"these":[140],"results":[141],"suggest":[142],"that":[143],"may":[145],"be":[146],"useful":[147],"potential":[150],"source":[151],"natural":[153],"antileukemic":[154],"agents.":[155]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}