{"id":"https://openalex.org/W1837535271","doi":"https://doi.org/10.1111/j.1365-2303.2011.00853.x","title":"Immunochemistry for oestrogen receptor, progesterone receptor and HER2 on cell blocks in primary breast carcinoma","display_name":"Immunochemistry for oestrogen receptor, progesterone receptor and HER2 on cell blocks in primary breast carcinoma","publication_year":2011,"publication_date":"2011-03-06","ids":{"openalex":"https://openalex.org/W1837535271","doi":"https://doi.org/10.1111/j.1365-2303.2011.00853.x","mag":"1837535271","pmid":"https://pubmed.ncbi.nlm.nih.gov/21375607"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2303.2011.00853.x","doi":"https://doi.org/10.1111/j.1365-2303.2011.00853.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2303.2011.00853.x","pdf_url":null,"source":{"id":"https://openalex.org/S86895130","display_name":"Cytopathology","issn_l":"0956-5507","issn":["0956-5507","1365-2303"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cytopathology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100597461","display_name":"K. Kumar S","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K. Kumar S","raw_affiliation_strings":["Department of Cytology and Gynecological Pathology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cytology and Gynecological Pathology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040516726","display_name":"Nalini Gupta","orcid":"https://orcid.org/0000-0003-3385-1955","observed_orcids":["https://orcid.org/0000-0003-3385-1955"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"N. Gupta","raw_affiliation_strings":["Department of Cytology and Gynecological Pathology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cytology and Gynecological Pathology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109896284","display_name":"Arvind Rajwanshi","orcid":"https://orcid.org/0000-0003-2877-7818","observed_orcids":["https://orcid.org/0000-0003-2877-7818"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Rajwanshi","raw_affiliation_strings":["Department of Cytology and Gynecological Pathology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cytology and Gynecological Pathology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071257048","display_name":"Kamaldeep Joshi","orcid":"https://orcid.org/0000-0002-3238-0234","observed_orcids":["https://orcid.org/0000-0002-3238-0234"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K. Joshi","raw_affiliation_strings":["Department of Histopathology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Histopathology","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045154697","display_name":"Gurpreet Singh","orcid":"https://orcid.org/0000-0001-8128-2078","observed_orcids":["https://orcid.org/0000-0001-8128-2078"]},"institutions":[{"id":"https://openalex.org/I45294948","display_name":"Post Graduate Institute of Medical Education and Research","ror":"https://ror.org/009nfym65","country_code":"IN","type":"education","lineage":["https://openalex.org/I45294948"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"G. Singh","raw_affiliation_strings":["Department of General Surgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India","institution_ids":["https://openalex.org/I45294948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5040516726"],"corresponding_institution_ids":[],"apc_list":{"value":3900,"currency":"USD","value_usd":3900},"apc_paid":null,"fwci":0.5438,"has_fulltext":false,"cited_by_count":43,"citation_normalized_percentile":{"value":0.66574382,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"23","issue":"3","first_page":"181","last_page":"186"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.86080002784729,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.86080002784729,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11134","display_name":"Breast Lesions and Carcinomas","score":0.125900000333786,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.007799999788403511,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oestrogen-receptor","display_name":"oestrogen receptor","score":0.8289999961853027},{"id":"https://openalex.org/keywords/progesterone-receptor","display_name":"progesterone receptor","score":1.0},{"id":"https://openalex.org/keywords/her2","display_name":"HER2","score":0.9850000143051147},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.7789999842643738},{"id":"https://openalex.org/keywords/cell-block","display_name":"cell block","score":0.9210000038146973},{"id":"https://openalex.org/keywords/fine-needle-aspiration-cytology","display_name":"fine needle aspiration cytology","score":0.9679999947547913},{"id":"https://openalex.org/keywords/immunohistochemistry","display_name":"immunohistochemistry","score":0.8270000219345093},{"id":"https://openalex.org/keywords/hormone-receptor-status","display_name":"hormone receptor status","score":0.8560000061988831},{"id":"https://openalex.org/keywords/her2-overexpression","display_name":"HER2 overexpression","score":0.8220000267028809},{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.800000011920929},{"id":"https://openalex.org/keywords/luminal-a-and-b-subtypes","display_name":"luminal A and B subtypes","score":0.6449999809265137}],"concepts":[{"id":"https://openalex.org/C2780659158","wikidata":"https://www.wikidata.org/wiki/Q2466273","display_name":"Immunochemistry","level":3,"score":0.8380579948425293},{"id":"https://openalex.org/C2910080358","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Oestrogen receptor","level":4,"score":0.6949849724769592},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6754828691482544},{"id":"https://openalex.org/C98717036","wikidata":"https://www.wikidata.org/wiki/Q14872994","display_name":"Progesterone receptor","level":5,"score":0.6687232851982117},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5384359955787659},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4290359318256378},{"id":"https://openalex.org/C3018521938","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast carcinoma","level":4,"score":0.4212121069431305},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3605334758758545},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.32381972670555115},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.2524747848510742},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.2230904996395111},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.1911347508430481},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1326068937778473},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.11905911564826965}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005188","descriptor_name":"False Negative Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011980","descriptor_name":"Receptors, Progesterone","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1365-2303.2011.00853.x","doi":"https://doi.org/10.1111/j.1365-2303.2011.00853.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2303.2011.00853.x","pdf_url":null,"source":{"id":"https://openalex.org/S86895130","display_name":"Cytopathology","issn_l":"0956-5507","issn":["0956-5507","1365-2303"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cytopathology","raw_type":"journal-article"},{"id":"pmid:21375607","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21375607","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cytopathology : official journal of the British Society for Clinical Cytology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W171037026","https://openalex.org/W1543231979","https://openalex.org/W1892496998","https://openalex.org/W1989663680","https://openalex.org/W1995224853","https://openalex.org/W1995877317","https://openalex.org/W1997540242","https://openalex.org/W2000413123","https://openalex.org/W2017238868","https://openalex.org/W2063722536","https://openalex.org/W2071521600","https://openalex.org/W2072120990","https://openalex.org/W2072645355","https://openalex.org/W2083372836","https://openalex.org/W2097255042","https://openalex.org/W2105789619","https://openalex.org/W2127362596","https://openalex.org/W2130900820","https://openalex.org/W2139188444","https://openalex.org/W2145257123","https://openalex.org/W2164400719","https://openalex.org/W2164681813","https://openalex.org/W2172064294","https://openalex.org/W2231000545","https://openalex.org/W2282906902","https://openalex.org/W2288404678","https://openalex.org/W2288763477","https://openalex.org/W2338576551","https://openalex.org/W2396581554","https://openalex.org/W2404819829","https://openalex.org/W2413280320"],"related_works":["https://openalex.org/W3011645990","https://openalex.org/W1559112018","https://openalex.org/W2981355191","https://openalex.org/W2100038149","https://openalex.org/W2804835720","https://openalex.org/W2947792428","https://openalex.org/W171037026","https://openalex.org/W2029704305","https://openalex.org/W2437556100","https://openalex.org/W2039621200"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Steroid":[1],"receptors":[2],"and":[3,30,48,54,78,85,99,134,143,146,162,174,187,230,233,249,269,295],"human":[4],"epidermal":[5],"growth":[6],"receptor":[7,50,267],"2":[8],"(HER2)":[9],"have":[10,290],"been":[11],"used":[12,33],"for":[13,34,75,97,122,171,221,253,281],"predicting":[14],"response":[15],"to":[16,42,104,289],"treatment":[17],"in":[18,68,112,196,236,247,255,262,274],"breast":[19,65,94,279],"cancers.":[20],"Fine":[21],"needle":[22],"aspiration":[23],"cytology":[24],"can":[25,31],"provide":[26],"highly":[27,287],"cellular":[28],"material":[29],"be":[32,210],"such":[35],"analysis.":[36],"The":[37,124,218],"present":[38],"study":[39],"was":[40,80,101,119,245],"undertaken":[41],"assess":[43],"the":[44,105,138,163,242,263],"reliability":[45],"of":[46,90,116,140,176,265,276,298],"oestrogen":[47],"progesterone":[49],"(ER,":[51],"PR)":[52],"status":[53,145,268],"HER2":[55,79,144,175,237,254,270],"as":[56,128],"demonstrated":[57],"by":[58,271],"immunochemistry":[59],"(IHC)":[60],"on":[61,82,137,148,159,213,239],"cell":[62,83,149,160,198,214,240,293],"blocks":[63,84,150,161,199,259,294],"from":[64],"carcinoma":[66],"cases,":[67],"comparison":[69],"with":[70,152],"histological":[71,153],"sections.":[72,154],"METHODS:":[73],"IHC":[74],"ER,":[76,141,172],"PR":[77,100,142,173,204],"performed":[81],"their":[86,299],"corresponding":[87,164],"tissue":[88],"sections":[89],"50":[91],"primary":[92],"pre-chemotherapy":[93],"carcinomas.":[95],"Positivity":[96],"ER":[98,202],"scored":[102],"according":[103],"Allred":[106],"scoring":[107],"system.":[108],"Strong":[109],"membranous":[110],"positivity":[111],"more":[113],"than":[114],"30%":[115],"tumour":[117,165],"cells":[118],"considered":[120],"positive":[121],"HER2.":[123],"tumours":[125],"were":[126,200],"classified":[127,212],"luminal":[129,131],"A,":[130],"B,":[132],"HER2-over-expressing":[133],"triple":[135],"negative":[136,252],"basis":[139],"results":[147],"compared":[151],"RESULTS:":[155],"Correlation":[156],"between":[157],"immunostaining":[158,216],"tissues":[166],"revealed":[167],"a":[168],"concordance":[169],"rate":[170],"90%":[177,188],"[Correlation":[178],"coefficient":[179],"(r)":[180],"=":[181,185,190],"0.79],":[182],"94%":[183],"(r":[184,189],"0.86)":[186],"0.76),":[191],"respectively.":[192],"Including":[193],"five":[194],"cases":[195,207,224,275],"which":[197],"either":[201],"or":[203],"positive,":[205],"43/50":[206],"(86.0%)":[208],"could":[209],"correctly":[211],"block":[215],"alone.":[217],"main":[219],"reasons":[220],"seven":[222],"discordant":[223],"included":[225],"technical":[226],"errors":[227],"(sampling":[228],"error":[229,235],"staining":[231],"error)":[232],"interpretational":[234],"evaluation":[238],"blocks;":[241],"core":[243],"biopsy":[244],"inadequate":[246],"one,":[248],"apparently":[250],"false":[251],"another.":[256],"CONCLUSION:":[257],"Cell":[258],"are":[260],"useful":[261],"assessment":[264],"hormone":[266],"IHC,":[272],"especially":[273],"locally":[277],"advanced":[278],"cancer":[280],"planning":[282],"neoadjuvant":[283],"chemotherapy.":[284],"It":[285],"is":[286],"recommended":[288],"good":[291],"quality":[292,296],"control":[297],"interpretation.":[300]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}