{"id":"https://openalex.org/W1836878243","doi":"https://doi.org/10.1128/jvi.71.12.9075-9086.1997","title":"The roles of the human immunodeficiency virus type 1 Pol protein and the primer binding site in the placement of primer tRNA(3Lys) onto viral genomic RNA","display_name":"The roles of the human immunodeficiency virus type 1 Pol protein and the primer binding site in the placement of primer tRNA(3Lys) onto viral genomic RNA","publication_year":1997,"publication_date":"1997-12-01","ids":{"openalex":"https://openalex.org/W1836878243","doi":"https://doi.org/10.1128/jvi.71.12.9075-9086.1997","mag":"1836878243","pmid":"https://pubmed.ncbi.nlm.nih.gov/9371564","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/230208"},"language":"en","primary_location":{"id":"doi:10.1128/jvi.71.12.9075-9086.1997","doi":"https://doi.org/10.1128/jvi.71.12.9075-9086.1997","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.71.12.9075-9086.1997","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC230208","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044530218","display_name":"Chen Liang","orcid":"https://orcid.org/0000-0002-1552-2077","observed_orcids":["https://orcid.org/0000-0002-1552-2077"]},"institutions":[{"id":"https://openalex.org/I2801824472","display_name":"Jewish General Hospital","ror":"https://ror.org/056jjra10","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801824472","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405256057","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4405267356","display_name":"Lady Davis Institute for Medical Research","ror":"https://ror.org/02c1np254","country_code":"CA","type":"education","lineage":["https://openalex.org/I2801824472","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405256057","https://openalex.org/I4405267356","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"C Liang","raw_affiliation_strings":["McGill University AIDS Centre, Lady Davis Institute-Jewish General Hospital, Montreal, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"McGill University AIDS Centre, Lady Davis Institute-Jewish General Hospital, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I2801824472","https://openalex.org/I4405267356","https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034031384","display_name":"Libin Rong","orcid":"https://orcid.org/0000-0002-1464-6078","observed_orcids":["https://orcid.org/0000-0002-1464-6078"]},"institutions":[{"id":"https://openalex.org/I2801824472","display_name":"Jewish General Hospital","ror":"https://ror.org/056jjra10","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801824472","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405256057","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4405267356","display_name":"Lady Davis Institute for Medical Research","ror":"https://ror.org/02c1np254","country_code":"CA","type":"education","lineage":["https://openalex.org/I2801824472","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405256057","https://openalex.org/I4405267356","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"L Rong","raw_affiliation_strings":["McGill University AIDS Centre, Lady Davis Institute-Jewish General Hospital, Montreal, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"McGill University AIDS Centre, Lady Davis Institute-Jewish General Hospital, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I2801824472","https://openalex.org/I4405267356","https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":null,"display_name":"N Morin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801824472","display_name":"Jewish General Hospital","ror":"https://ror.org/056jjra10","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801824472","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405256057","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4405267356","display_name":"Lady Davis Institute for Medical Research","ror":"https://ror.org/02c1np254","country_code":"CA","type":"education","lineage":["https://openalex.org/I2801824472","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405256057","https://openalex.org/I4405267356","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"N Morin","raw_affiliation_strings":["McGill University AIDS Centre, Lady Davis Institute-Jewish General Hospital, Montreal, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"McGill University AIDS Centre, Lady Davis Institute-Jewish General Hospital, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I2801824472","https://openalex.org/I4405267356","https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088113725","display_name":"Elana Cherry","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801824472","display_name":"Jewish General Hospital","ror":"https://ror.org/056jjra10","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801824472","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405256057","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4405267356","display_name":"Lady Davis Institute for Medical Research","ror":"https://ror.org/02c1np254","country_code":"CA","type":"education","lineage":["https://openalex.org/I2801824472","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405256057","https://openalex.org/I4405267356","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"E Cherry","raw_affiliation_strings":["McGill University AIDS Centre, Lady Davis Institute-Jewish General Hospital, Montreal, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"McGill University AIDS Centre, Lady Davis Institute-Jewish General Hospital, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I2801824472","https://openalex.org/I4405267356","https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101457875","display_name":"Yue Huang","orcid":"https://orcid.org/0009-0006-9557-450X","observed_orcids":["https://orcid.org/0009-0006-9557-450X"]},"institutions":[{"id":"https://openalex.org/I2801824472","display_name":"Jewish General Hospital","ror":"https://ror.org/056jjra10","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801824472","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405256057","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4405267356","display_name":"Lady Davis Institute for Medical Research","ror":"https://ror.org/02c1np254","country_code":"CA","type":"education","lineage":["https://openalex.org/I2801824472","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405256057","https://openalex.org/I4405267356","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Y Huang","raw_affiliation_strings":["McGill University AIDS Centre, Lady Davis Institute-Jewish General Hospital, Montreal, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"McGill University AIDS Centre, Lady Davis Institute-Jewish General Hospital, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I2801824472","https://openalex.org/I4405267356","https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111920057","display_name":"Lawrence Kleiman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801824472","display_name":"Jewish General Hospital","ror":"https://ror.org/056jjra10","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801824472","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405256057","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4405267356","display_name":"Lady Davis Institute for Medical Research","ror":"https://ror.org/02c1np254","country_code":"CA","type":"education","lineage":["https://openalex.org/I2801824472","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405256057","https://openalex.org/I4405267356","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"L Kleiman","raw_affiliation_strings":["McGill University AIDS Centre, Lady Davis Institute-Jewish General Hospital, Montreal, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"McGill University AIDS Centre, Lady Davis Institute-Jewish General Hospital, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I2801824472","https://openalex.org/I4405267356","https://openalex.org/I5023651"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029881635","display_name":"Mark A. Wainberg","orcid":"https://orcid.org/0000-0002-0272-1317","observed_orcids":["https://orcid.org/0000-0002-0272-1317"]},"institutions":[{"id":"https://openalex.org/I2801824472","display_name":"Jewish General Hospital","ror":"https://ror.org/056jjra10","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801824472","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405256057","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4405267356","display_name":"Lady Davis Institute for Medical Research","ror":"https://ror.org/02c1np254","country_code":"CA","type":"education","lineage":["https://openalex.org/I2801824472","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405256057","https://openalex.org/I4405267356","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"M A Wainberg","raw_affiliation_strings":["McGill University AIDS Centre, Lady Davis Institute-Jewish General Hospital, Montreal, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"McGill University AIDS Centre, Lady Davis Institute-Jewish General Hospital, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I2801824472","https://openalex.org/I4405267356","https://openalex.org/I5023651"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.225,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.4465827,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"71","issue":"12","first_page":"9075","last_page":"9086"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.6455000042915344,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.6455000042915344,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.290800005197525,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.04500000178813934,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1-reverse-transcription","display_name":"HIV-1 reverse transcription","score":0.8840000033378601},{"id":"https://openalex.org/keywords/primer-binding-site","display_name":"primer binding site","score":0.8460000157356262},{"id":"https://openalex.org/keywords/reverse-transcriptase","display_name":"reverse transcriptase","score":0.7960000038146973},{"id":"https://openalex.org/keywords/proteolytic-activity","display_name":"proteolytic activity","score":0.49399998784065247},{"id":"https://openalex.org/keywords/translational-frameshifting","display_name":"translational frameshifting","score":0.765999972820282},{"id":"https://openalex.org/keywords/viral-rna-genome","display_name":"viral RNA genome","score":0.492000013589859}],"concepts":[{"id":"https://openalex.org/C2776294106","wikidata":"https://www.wikidata.org/wiki/Q7243406","display_name":"Primer binding site","level":5,"score":0.8789538145065308},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.834399938583374},{"id":"https://openalex.org/C153957851","wikidata":"https://www.wikidata.org/wiki/Q201448","display_name":"Transfer RNA","level":4,"score":0.6199239492416382},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.5906442999839783},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.5742007493972778},{"id":"https://openalex.org/C156719811","wikidata":"https://www.wikidata.org/wiki/Q28774","display_name":"Reverse transcriptase","level":4,"score":0.5663626194000244},{"id":"https://openalex.org/C2777563447","wikidata":"https://www.wikidata.org/wiki/Q7243397","display_name":"Primer (cosmetics)","level":2,"score":0.55742347240448},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4735747277736664},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.44385606050491333},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.4379822015762329},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.42196837067604065},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3628878593444824},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002461","descriptor_name":"Cell Line, Transformed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011498","descriptor_name":"Protein Precursors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012346","descriptor_name":"RNA, Transfer, Amino Acyl","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015683","descriptor_name":"Gene Products, gag","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015684","descriptor_name":"Gene Products, pol","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015684","descriptor_name":"Gene Products, pol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016679","descriptor_name":"Genome, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017384","descriptor_name":"Sequence Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019556","descriptor_name":"COS Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054301","descriptor_name":"gag Gene Products, Human Immunodeficiency Virus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054302","descriptor_name":"pol Gene Products, Human Immunodeficiency Virus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054303","descriptor_name":"HIV Reverse Transcriptase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054303","descriptor_name":"HIV Reverse Transcriptase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1128/jvi.71.12.9075-9086.1997","doi":"https://doi.org/10.1128/jvi.71.12.9075-9086.1997","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.71.12.9075-9086.1997","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:237257","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC230208","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:230208","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/230208","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"},{"id":"pmid:9371564","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9371564","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of virology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.965.5630","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.965.5630","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jvi.asm.org/content/71/12/9075.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:237257","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC230208","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4000000059604645}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W64672568","https://openalex.org/W135792834","https://openalex.org/W201050536","https://openalex.org/W287296146","https://openalex.org/W1504782024","https://openalex.org/W1505853139","https://openalex.org/W1584664639","https://openalex.org/W1616088578","https://openalex.org/W1834412424","https://openalex.org/W1834993052","https://openalex.org/W1898538816","https://openalex.org/W1941217386","https://openalex.org/W1947454506","https://openalex.org/W1969349514","https://openalex.org/W1972673208","https://openalex.org/W1981500779","https://openalex.org/W2000284725","https://openalex.org/W2008457983","https://openalex.org/W2013241878","https://openalex.org/W2014359186","https://openalex.org/W2016844359","https://openalex.org/W2019333227","https://openalex.org/W2022929361","https://openalex.org/W2032737565","https://openalex.org/W2034458000","https://openalex.org/W2037777548","https://openalex.org/W2048647241","https://openalex.org/W2056273722","https://openalex.org/W2062660070","https://openalex.org/W2072822306","https://openalex.org/W2089471930","https://openalex.org/W2096627686","https://openalex.org/W2108112802","https://openalex.org/W2116193414","https://openalex.org/W2118954412","https://openalex.org/W2126911149","https://openalex.org/W2156516278"],"related_works":["https://openalex.org/W7096181973","https://openalex.org/W1878363965","https://openalex.org/W1505598199","https://openalex.org/W2116193414","https://openalex.org/W1504782024","https://openalex.org/W2124389515","https://openalex.org/W2125447905","https://openalex.org/W7034009602","https://openalex.org/W2101335809","https://openalex.org/W7161998294"],"abstract_inverted_index":{"Factors":[0],"that":[1,27,94,98,134,147,166,173,191,275,388],"modulate":[2],"the":[3,9,31,38,45,52,57,76,83,95,117,130,150,159,174,189,202,209,221,231,242,256,282,290,293,299,314,318,332,356,370,390,394,400,403],"placement":[4,175,300,359],"of":[5,24,47,56,88,119,132,162,176,185,204,211,233,241,281,284,292,301,306,317,335,358,389,396,402],"primer":[6,96,177,294,342],"tRNA(3Lys)":[7,32,97,115,133,178,190,234,244,302,336,343],"onto":[8,101,137,179,346],"viral":[10,102,138,180,347],"RNA":[11,104,139,182,349],"genome":[12],"in":[13,44,51,79,107,116,140,149,196,220,230,267,298,369,411],"human":[14],"immunodeficiency":[15],"virus":[16,122,261,364,371],"type":[17],"1":[18],"(HIV-1)":[19],"were":[20,35,353],"investigated":[21,289],"through":[22,214,303],"analysis":[23],"reverse-transcribed":[25],"products":[26],"are":[28],"extended":[29,125,249],"from":[30],"primer.":[33],"Mutations":[34],"introduced":[36],"into":[37],"HIV-1":[39],"pol":[40],"gene":[41],"to":[42,201,247,255,264,366,399,419],"result":[43],"appearance":[46],"a":[48,156,215,228,239,265,304,417,420],"stop":[49],"codon":[50],"open":[53],"reading":[54],"frame":[55],"reverse":[58],"transcriptase":[59],"(RT)":[60],"gene.":[61],"These":[62],"constructs,":[63],"BH10-RT1":[64],"and":[65,309,323,330],"BH10-RT2,":[66],"yielded":[67],"viruses":[68,142,328,380],"with":[69,259,271,361,372,387,393],"truncated":[70],"Pol":[71],"proteins.":[72],"Alternatively,":[73],"we":[74,92],"altered":[75],"sequences":[77],"involved":[78],"frameshifting":[80],"by":[81,126,250,416],"generating":[82],"construct":[84],"BH10-FS.":[85],"With":[86],"each":[87],"these":[89,378],"mutated":[90,141,327,379],"viruses,":[91],"found":[93,172,246,258],"was":[99,105,135,143,183,192,194,245,337,344,414],"placed":[100,136,148,193,243,345],"genomic":[103,181,348],"present":[106,195],"an":[108,197,409],"unextended":[109,198],"state.":[110],"In":[111,207,236,326],"contrast,":[112,208],"as":[113,350],"expected,":[114],"case":[118],"wild-type":[120,151,260,362,391,421],"BH10":[121,363],"had":[123],"been":[124],"2":[127,251],"bases.":[128],"Furthermore,":[129],"amount":[131],"significantly":[144],"less":[145,341],"than":[146],"virus.":[152],"We":[153,171,287],"also":[154,288],"generated":[155],"mutant":[157],"within":[158],"polymerase-active":[160],"site":[161,223,296],"RT":[163,168,205,268],"(D185H)":[164],"(Asp-->His)":[165],"eliminated":[167],"polymerase":[169],"activity.":[170,206,286],"independent":[184],"enzyme":[186],"function;":[187],"however,":[188],"state":[199],"due":[200,263],"loss":[203,283],"elimination":[210],"protease":[212,285],"activity":[213,269],"D25A":[216],"(Asp-->Ala)":[217],"point":[218],"mutation":[219],"protease-active":[222],"(construct":[224],"BH10-PR)":[225],"did":[226],"cause":[227],"drop":[229],"efficiency":[232],"placement.":[235],"this":[237],"situation,":[238],"proportion":[240],"be":[248,278],"bases,":[252],"although":[253],"not":[254,277],"extent":[257,395],"(BH10),":[262],"decrease":[266],"associated":[270],"unprocessed":[272],"Gag-Pol":[273],"protein":[274],"could":[276],"cleaved":[279],"because":[280],"role":[291],"binding":[295],"(PBS)":[297],"series":[305],"2-,":[307],"4-,":[308],"8-nucleotide":[310],"(nt)":[311],"deletions":[312],"at":[313],"3'":[315],"end":[316],"PBS,":[319],"i.e.,":[320],"BH10-PBS2,":[321],"BH10-PBS4,":[322,331],"BH10-PBS8,":[324],"respectively.":[325],"BH10-PBS2":[329],"2-base-extended":[333],"form":[334],"still":[338],"detected.":[339],"However,":[340,405],"more":[351],"nucleotides":[352],"deleted":[354,375],"until":[355],"percentage":[357],"seen":[360],"dropped":[365],"only":[367],"4%":[368],"8":[373],"nt":[374],"(BH10-PBS8).":[376],"Consistently,":[377],"possessed":[381],"decreased":[382],"initial":[383],"replication":[384,412],"capacity":[385],"compared":[386],"virus,":[392],"incapacity":[397],"corresponding":[398],"size":[401],"deletion.":[404],"after":[406],"several":[407],"days,":[408],"increase":[410],"potential":[413],"accompanied":[415],"reversion":[418],"PBS.":[422]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}