{"id":"https://openalex.org/W1835913342","doi":null,"title":"Construcci\u00f3n de una genoteca en \"Phage Display\" para la selecci\u00f3n de efectores inmunes de Drosophila melanogaster","display_name":"Construcci\u00f3n de una genoteca en \"Phage Display\" para la selecci\u00f3n de efectores inmunes de Drosophila melanogaster","publication_year":2011,"publication_date":"2011-06-01","ids":{"openalex":"https://openalex.org/W1835913342","mag":"1835913342"},"language":"es","primary_location":{"id":"pmh:oai:repositorio.unican.es:10902/528","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10902/528","pdf_url":null,"source":{"id":"https://openalex.org/S4306400398","display_name":"UCrea (University of Cantabria)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I13134134","host_organization_name":"Universidad de Cantabria","host_organization_lineage":["https://openalex.org/I13134134"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/masterThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023702740","display_name":"Gamboa Ram\u00edrez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gamboa Ram\u00edrez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5013963546","display_name":"Kevin Eder","orcid":"https://orcid.org/0000-0002-1876-3503","observed_orcids":["https://orcid.org/0000-0002-1876-3503"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kevin Eder","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1876-3503","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11403","display_name":"Invertebrate Immune Response Mechanisms","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11403","display_name":"Invertebrate Immune Response Mechanisms","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.005799999926239252,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phage-display","display_name":"phage display","score":0.9300000071525574},{"id":"https://openalex.org/keywords/drosophila-melanogaster","display_name":"Drosophila melanogaster","score":0.968999981880188},{"id":"https://openalex.org/keywords/innate-immune-response","display_name":"innate immune response","score":0.6439999938011169},{"id":"https://openalex.org/keywords/toll-signaling-pathway","display_name":"Toll pathway","score":0.7549999952316284},{"id":"https://openalex.org/keywords/imd-pathway","display_name":"Imd pathway","score":0.9829999804496765},{"id":"https://openalex.org/keywords/biopanning","display_name":"biopanning","score":0.6679999828338623},{"id":"https://openalex.org/keywords/pathogen-receptors","display_name":"pathogen receptors","score":0.6359999775886536}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4967256188392639},{"id":"https://openalex.org/C142362112","wikidata":"https://www.wikidata.org/wiki/Q735","display_name":"Art","level":0,"score":0.4352208971977234},{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.37494248151779175},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3254571259021759}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:repositorio.unican.es:10902/528","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10902/528","pdf_url":null,"source":{"id":"https://openalex.org/S4306400398","display_name":"UCrea (University of Cantabria)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I13134134","host_organization_name":"Universidad de Cantabria","host_organization_lineage":["https://openalex.org/I13134134"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/masterThesis"},{"id":"mag:1835913342","doi":null,"is_oa":false,"landing_page_url":"https://repositorio.unican.es/xmlui/handle/10902/528","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2499337746","https://openalex.org/W7100269765","https://openalex.org/W4237082553","https://openalex.org/W2990750653","https://openalex.org/W7098302266","https://openalex.org/W2142189691","https://openalex.org/W7101026779","https://openalex.org/W632425996","https://openalex.org/W7098218384","https://openalex.org/W6911474949"],"abstract_inverted_index":{"La":[0,54,220],"t\u00e9cnica":[1],"de":[2,13,19,25,31,43,56,65,67,77,81,93,128,145,153,168,170,183,200,206,209,217,229,233,239,244,248,289,298,305,315,317,323,331],"phage":[3,57,119,154,273],"display":[4,58,120,155,274],"es":[5,24],"una":[6,82,105,111,122,158,165,321],"poderosa":[7],"herramienta":[8,23],"que":[9,45,71,84,131,174,249],"permite":[10],"la":[11,17,38,41,50,129,161,179,184,196,251,270,295,299,303,306,348,359],"expresi\u00f3n":[12,271],"prote\u00ednas":[14,33,87,169,207,344],"heterologas":[15,345],"en":[16,49,91,125,137,160,178,192,242,255,272,282,291,320,347,356],"c\u00e1pside":[18,349],"un":[20,75,97,108,115],"bacteri\u00f3fago.":[21],"Esta":[22,188],"utilidad":[26],"para":[27,47,62,156,195,202,260,266,335],"el":[28,63,118,126,151,278,283,292,311],"an\u00e1lisis":[29],"funcional":[30],"dichas":[32],"al":[34,327],"permitir":[35,269],"aislar":[36],"tanto":[37],"prote\u00edna":[39,296,360],"como":[40],"secuencia":[42],"DNA":[44],"codifica":[46],"ella":[48],"misma":[51],"particula":[52],"v\u00ecrica.":[53],"tecnolog\u00eda":[55],"ha":[59,148,223,276,309],"sido":[60,149],"utilizada":[61],"estudio":[64],"genotecas":[66],"p\u00e9ptidos":[68],"y":[69,205,262,313,339],"anticuerpos":[70],"presentan":[72],"afinidad":[73,95],"por":[74,96],"ligando":[76,98,103],"inter\u00e9s.":[78],"A":[79],"partir":[80,228],"genoteca":[83,159,189,221],"contiene":[85],"diversas":[86,246],"se":[88,132,190,222,275,285,308,353],"seleccionen":[89],"polipeptidos":[90],"funci\u00f3n":[92,243],"su":[94,337],"especifico,":[99],"pudiendo":[100],"ser":[101],"este":[102,146],"desde":[104],"mol\u00e9culasimple,":[106],"hasta":[107],"complejo":[109],"multimolecular,":[110],"celula":[112],"o":[113,141,181],"incluso":[114],"tejido.":[116],"Adem\u00e1s":[117],"tiene":[121],"gran":[123,166],"versatilidad":[124],"momento":[127],"selecci\u00f3n,":[130],"puede":[133],"llevar":[134],"a":[135,225,227,236],"cabo":[136,226],"procesos":[138],"in":[139],"vitro":[140],"in.vivo.":[142],"El":[143],"objetivo":[144],"trabajo":[147],"utilizar":[150],"principio":[152],"construir":[157],"cual":[162,284],"estuviera":[163],"representada":[164],"cantidad":[167],"D.":[171,218,256],"melanogaster,":[172],"principalmente":[173],"pudieran":[175],"estar":[176],"involucradas":[177],"regulaci\u00f3n":[180],"desarrollo":[182],"respuesta":[185,252],"inmune":[186],"innata.":[187],"empleara":[191],"trabajos":[193],"posteriores":[194],"selecci\u00f3n":[197],"mediante":[198],"biopanning":[199],"receptores":[201],"pat\u00f3genos":[203],"concreto":[204],"capaces":[208],"interaccionar":[210],"con":[211,358],"otros":[212],"componentes":[213],"del":[214,350],"sistema":[215],"inmunitario":[216],"melanogaster.":[219],"llevado":[224],"RNA":[230],"mensajero":[231],"obtenido":[232],"moscas":[234],"sometidas":[235],"distintos":[237],"tipos":[238],"reto":[240],"inmunol\u00f3gico,":[241],"las":[245,343],"v\u00edas":[247],"activan":[250],"inmunes":[253],"inata":[254],"melanogaster":[257],"(via":[258],"Toll":[259],"Gram+":[261],"hongos,":[263],"via":[264],"Imd":[265],"Gram-).":[267],"Para":[268,301],"empleado":[277],"vector":[279],"T7Select":[280],"10-3b,":[281],"ligan":[286],"los":[287],"insertos":[288,316],"cDNA":[290,318],"extremo":[293],"3\u00b4de":[294],"10-3b":[297],"c\u00e1pside.":[300],"estudiar":[302],"representatividad":[304],"genoteca,":[307],"caracterizado":[310],"tama\u00f1o":[312],"numero":[314],"contenidos":[319],"muestra":[322],"72":[324],"clones":[325],"seleccionados":[326],"azar.":[328],"Un":[329],"grupo":[330],"ellos":[332],"fueron":[333],"subclonados":[334],"facilitar":[336],"secuenciaci\u00f3n,":[338],"poder":[340],"determinar":[341],"si":[342],"expresadas":[346],"bacteri\u00f3fago":[351],"T7":[352],"encontraban":[354],"fusionadas":[355],"fase":[357],"10-3b.":[361]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}