{"id":"https://openalex.org/W183565686","doi":null,"title":"An update on the impact of Staphylococcus aureus enterotoxins in chronic sinusitis with nasal polyposis.","display_name":"An update on the impact of Staphylococcus aureus enterotoxins in chronic sinusitis with nasal polyposis.","publication_year":2005,"publication_date":"2005-09-01","ids":{"openalex":"https://openalex.org/W183565686","mag":"183565686","pmid":"https://pubmed.ncbi.nlm.nih.gov/16218508"},"language":"en","primary_location":{"id":"pmid:16218508","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16218508","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rhinology","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025354476","display_name":"N. Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801227569","display_name":"Ghent University Hospital","ror":"https://ror.org/00xmkp704","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801227569"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"N Zhang","raw_affiliation_strings":["ENT-Department, University Hospital Ghent, Upper Airway Research Laboratory, Ghent, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ENT-Department, University Hospital Ghent, Upper Airway Research Laboratory, Ghent, Belgium","institution_ids":["https://openalex.org/I2801227569"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090361830","display_name":"Philippe Gevaert","orcid":"https://orcid.org/0000-0002-1629-8468","observed_orcids":["https://orcid.org/0000-0002-1629-8468"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Gevaert","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041919909","display_name":"Thibaut Van Zele","orcid":"https://orcid.org/0000-0002-6031-4293","observed_orcids":["https://orcid.org/0000-0002-6031-4293"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T van Zele","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080048104","display_name":"Claudina Angela Perez-Novo","orcid":"https://orcid.org/0000-0003-4562-4346","observed_orcids":["https://orcid.org/0000-0003-4562-4346"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Perez-Novo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075982512","display_name":"Joke Patou","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Patou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080249904","display_name":"Gabri\u00eble Holtappels","orcid":"https://orcid.org/0000-0002-1111-2011","observed_orcids":["https://orcid.org/0000-0002-1111-2011"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Holtappels","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111475531","display_name":"Paul Van Cauwenberge","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P van Cauwenberge","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5055677585","display_name":"Claus Bachert","orcid":"https://orcid.org/0000-0003-4742-1665","observed_orcids":["https://orcid.org/0000-0003-4742-1665"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Bachert","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":10.8592,"has_fulltext":false,"cited_by_count":126,"citation_normalized_percentile":{"value":0.98681948,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"43","issue":"3","first_page":"162","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10984","display_name":"Sinusitis and nasal conditions","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10984","display_name":"Sinusitis and nasal conditions","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/staphylococcus-aureus","display_name":"Staphylococcus aureus","score":0.9919999837875366},{"id":"https://openalex.org/keywords/bacterial-enterotoxins","display_name":"bacterial enterotoxins","score":0.871999979019165},{"id":"https://openalex.org/keywords/chronic-rhinosinusitis","display_name":"chronic rhinosinusitis","score":0.8029999732971191},{"id":"https://openalex.org/keywords/nasal-polyps","display_name":"nasal polyps","score":0.9409999847412109},{"id":"https://openalex.org/keywords/superantigens","display_name":"superantigens","score":0.9440000057220459},{"id":"https://openalex.org/keywords/ige-antibodies","display_name":"IgE antibodies","score":0.6809999942779541},{"id":"https://openalex.org/keywords/eosinophilic-inflammation","display_name":"eosinophilic inflammation","score":0.9940000176429749},{"id":"https://openalex.org/keywords/aspirin-hypersensitivity","display_name":"aspirin intolerance","score":0.6800000071525574},{"id":"https://openalex.org/keywords/lower-airway-disease","display_name":"lower airway disease","score":0.7120000123977661},{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.6769999861717224},{"id":"https://openalex.org/keywords/acute-exacerbation-of-copd","display_name":"COPD exacerbations","score":0.9210000038146973}],"concepts":[{"id":"https://openalex.org/C36333154","wikidata":"https://www.wikidata.org/wiki/Q772950","display_name":"Superantigen","level":4,"score":0.9015752077102661},{"id":"https://openalex.org/C2781390199","wikidata":"https://www.wikidata.org/wiki/Q8055111","display_name":"Nasal polyps","level":2,"score":0.815725564956665},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.7705413103103638},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7491601705551147},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.6263487339019775},{"id":"https://openalex.org/C141105273","wikidata":"https://www.wikidata.org/wiki/Q79455","display_name":"Immunoglobulin E","level":3,"score":0.6210476756095886},{"id":"https://openalex.org/C2779758542","wikidata":"https://www.wikidata.org/wiki/Q2106364","display_name":"Eosinophilic","level":2,"score":0.5208771228790283},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5204484462738037},{"id":"https://openalex.org/C66999527","wikidata":"https://www.wikidata.org/wiki/Q421978","display_name":"Enterotoxin","level":4,"score":0.515798807144165},{"id":"https://openalex.org/C207480886","wikidata":"https://www.wikidata.org/wiki/Q42982","display_name":"Allergy","level":2,"score":0.4886322617530823},{"id":"https://openalex.org/C2777768476","wikidata":"https://www.wikidata.org/wiki/Q183344","display_name":"Sinusitis","level":2,"score":0.4560648202896118},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.43586260080337524},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.41230645775794983},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16277745366096497},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.1559455394744873},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.15139034390449524},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004768","descriptor_name":"Enterotoxins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009298","descriptor_name":"Nasal Polyps","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D009298","descriptor_name":"Nasal Polyps","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D012852","descriptor_name":"Sinusitis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D012852","descriptor_name":"Sinusitis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:16218508","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16218508","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rhinology","raw_type":"Journal Article"},{"id":"pmh:oai:archive.ugent.be:431795","doi":null,"is_oa":false,"landing_page_url":"https://biblio.ugent.be/publication/431795","pdf_url":null,"source":{"id":"https://openalex.org/S4306400478","display_name":"Ghent University Academic Bibliography (Ghent University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I32597200","host_organization_name":"Ghent University","host_organization_lineage":["https://openalex.org/I32597200"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 0300-0729","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:183565686","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16218508","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2291667181","https://openalex.org/W2034497007","https://openalex.org/W2332441166","https://openalex.org/W2156959293","https://openalex.org/W7062274723","https://openalex.org/W2006122901","https://openalex.org/W2731708623","https://openalex.org/W2564425493","https://openalex.org/W4220818658","https://openalex.org/W125286863"],"abstract_inverted_index":{"Nasal":[0],"polyps":[1],"in":[2,102,159,170,182,193,196,220,236],"adults,":[3],"characterized":[4],"by":[5,206],"abundant":[6],"eosinophils,":[7],"local":[8,132],"overproduction":[9],"of":[10,26,144,147,173,189,212,231,256,280],"immunoglobulin":[11],"E,":[12],"and":[13,61,85,116,151,184,200,217,244,254,259,269],"often":[14],"associated":[15,177],"with":[16,49,178],"asthma,":[17],"have":[18],"been":[19,204],"appreciated":[20],"as":[21,59,67,69,241],"an":[22,229],"eosinophilic":[23,74,149],"inflammation,":[24,150],"potentially":[25,86],"allergic":[27],"origin,":[28],"but":[29,45],"unrelated":[30],"to":[31,82,87,131,141,155,165,215,228,275],"a":[32,63,70,142,179,249],"bacterial":[33],"impact.":[34],"Evidence":[35],"accumulates,":[36],"however,":[37],"that":[38],"Staphylococcus":[39],"aureus":[40,78,191,233],"colonizes":[41],"chronic":[42],"rhinosinusitis":[43],"with,":[44],"not":[46],"without":[47],"polyps,":[48],"significantly":[50],"increased":[51],"prevalence.":[52],"The":[53,135,186],"germs":[54],"release":[55,88],"enterotoxins,":[56,121],"which":[57],"act":[58],"superantigens":[60,89],"induce":[62],"topical":[64],"multiclonal":[65],"IgE-formation":[66],"well":[68],"severe,":[71],"possibly":[72],"steroid-insensitive":[73],"inflammation.":[75],"Recently,":[76],"S.":[77,190,232],"could":[79],"be":[80,109,123,153,168],"demonstrated":[81],"reside":[83],"intraepithelially,":[84],"into":[90],"the":[91,95,103,126,145,148,171,198,210,257,277,281],"tissue":[92],"from":[93],"within":[94,125],"epithelial":[96],"cells.":[97],"An":[98],"immune":[99,137],"defect,":[100],"either":[101],"innate":[104],"or":[105],"adaptive":[106],"immunity,":[107],"might":[108],"responsible":[110],"for":[111,252],"this":[112],"phenomenon.":[113],"Follicle-like":[114],"structures":[115],"lymphocyte":[117],"accumulations,":[118],"specifically":[119],"binding":[120],"can":[122,167],"found":[124,169],"polyp":[127,160,175,194,222],"tissues,":[128,176],"giving":[129],"rise":[130],"IgE":[133,163,213],"formation.":[134],"superantigen-induced":[136],"response":[138],"also":[139,226,273],"leads":[140],"modulation":[143],"severity":[146],"may":[152],"linked":[154],"lower":[156,237],"airway":[157,238],"co-morbidity":[158],"patients.":[161],"Interestingly,":[162],"antibodies":[164,214],"enterotoxins":[166,192,216,235],"majority":[172],"aspirin-sensitive":[174],"substantial":[180],"increase":[181],"ECP":[183],"IL-5.":[185],"possible":[187],"role":[188],"disease":[195],"Europe,":[197],"US":[199],"Asia":[201],"has":[202],"meanwhile":[203],"supported":[205],"several":[207],"studies,":[208],"demonstrating":[209],"presence":[211],"inflammatory":[218],"consequences":[219],"nasal":[221],"tissue.":[223],"First":[224],"studies":[225],"point":[227],"involvement":[230],"derived":[234],"disease,":[239],"such":[240],"severe":[242],"asthma":[243],"exacerbated":[245],"COPD,":[246],"clearly":[247],"suggesting":[248],"clinical":[250,278],"need":[251,270],"diagnosis":[253],"treatment":[255],"germ":[258],"its":[260],"related":[261],"effects.":[262],"Therapeutic":[263],"approaches":[264],"are":[265],"so":[266],"far":[267],"empirical,":[268],"further":[271],"study,":[272],"serving":[274],"proof":[276],"relevance":[279],"concept.":[282]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":12}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
