{"id":"https://openalex.org/W183460740","doi":null,"title":"Development of novel LOXL1 genotyping method and evaluation of LOXL1, APOE and MTHFR polymorphisms in exfoliation syndrome/glaucoma in a Greek population.","display_name":"Development of novel LOXL1 genotyping method and evaluation of LOXL1, APOE and MTHFR polymorphisms in exfoliation syndrome/glaucoma in a Greek population.","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W183460740","mag":"183460740","pmid":"https://pubmed.ncbi.nlm.nih.gov/23687437","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3654845"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3654845","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3654845/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3654845/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Vis","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3654845/pdf/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088201067","display_name":"Dimitrios Chiras","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141877","display_name":"University Hospital of Ioannina","ror":"https://ror.org/03zww1h73","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210141877"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Dimitrios Chiras","raw_affiliation_strings":["Department of Ophthalmology, University Hospital of Ioannina, Ioannina, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, University Hospital of Ioannina, Ioannina, Greece","institution_ids":["https://openalex.org/I4210141877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089070652","display_name":"Konstantina Tzika","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Konstantina Tzika","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073440175","display_name":"Haris Kokotas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Haris Kokotas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079744565","display_name":"Samantha C. Oliveira","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Samantha C Oliveira","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004639478","display_name":"Maria Grigoriadou","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maria Grigoriadou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013473990","display_name":"Anastasia Kastania","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anastasia Kastania","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053604079","display_name":"Kleanthi Dima","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kleanthi Dima","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113468363","display_name":"Maria I. Stefaniotou","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maria Stefaniotou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111528033","display_name":"Miltiadis B. Aspiotis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Miltiadis Aspiotis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001726668","display_name":"Michael Bjorn Petersen","orcid":"https://orcid.org/0000-0003-0316-8207","observed_orcids":["https://orcid.org/0000-0003-0316-8207"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael B Petersen","raw_affiliation_strings":["Det Sundhedsvidenskabelige Fakultet"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Det Sundhedsvidenskabelige Fakultet","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031768538","display_name":"Christos \u039aroupis","orcid":"https://orcid.org/0000-0002-5876-2599","observed_orcids":["https://orcid.org/0000-0002-5876-2599","https://orcid.org/0000-0002-5162-1304"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christos Kroupis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5038851855","display_name":"George Kitsos","orcid":"https://orcid.org/0000-0001-8041-5190","observed_orcids":["https://orcid.org/0000-0001-8041-5190"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"George Kitsos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.6075,"has_fulltext":true,"cited_by_count":23,"citation_normalized_percentile":{"value":0.87420467,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"19","issue":null,"first_page":"1006","last_page":"16"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10563","display_name":"Corneal surgery and disorders","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12989","display_name":"Ocular Disorders and Treatments","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pseudoexfoliation-syndrome","display_name":"pseudoexfoliation syndrome","score":0.8989999890327454},{"id":"https://openalex.org/keywords/pseudoexfoliation-glaucoma","display_name":"pseudoexfoliation glaucoma","score":1.0},{"id":"https://openalex.org/keywords/loxl1","display_name":"LOXL1","score":0.9919999837875366},{"id":"https://openalex.org/keywords/apolipoprotein-e","display_name":"apolipoprotein E","score":0.6949999928474426},{"id":"https://openalex.org/keywords/mthfr","display_name":"MTHFR","score":0.8130000233650208},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.8349999785423279},{"id":"https://openalex.org/keywords/genetic-risk-factors","display_name":"genetic risk factors","score":0.7710000276565552},{"id":"https://openalex.org/keywords/primary-open-angle-glaucoma","display_name":"primary open-angle glaucoma","score":0.9120000004768372}],"concepts":[{"id":"https://openalex.org/C31467283","wikidata":"https://www.wikidata.org/wiki/Q912147","display_name":"Genotyping","level":4,"score":0.859592080116272},{"id":"https://openalex.org/C43563269","wikidata":"https://www.wikidata.org/wiki/Q424709","display_name":"Methylenetetrahydrofolate reductase","level":4,"score":0.6030877232551575},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5290053486824036},{"id":"https://openalex.org/C2778527774","wikidata":"https://www.wikidata.org/wiki/Q159701","display_name":"Glaucoma","level":2,"score":0.48481789231300354},{"id":"https://openalex.org/C149737253","wikidata":"https://www.wikidata.org/wiki/Q3240252","display_name":"Polymorphism (computer science)","level":4,"score":0.484447717666626},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.47775378823280334},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.47695696353912354},{"id":"https://openalex.org/C57089818","wikidata":"https://www.wikidata.org/wiki/Q424728","display_name":"Apolipoprotein E","level":3,"score":0.45003435015678406},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37070003151893616},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3543957471847534},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.2987372577190399},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2125784158706665},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20074614882469177},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.06341546773910522},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000594","descriptor_name":"Amino Acid Oxidoreductases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000594","descriptor_name":"Amino Acid Oxidoreductases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001057","descriptor_name":"Apolipoproteins E","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005902","descriptor_name":"Glaucoma, Open-Angle","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D005902","descriptor_name":"Glaucoma, Open-Angle","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006115","descriptor_name":"Greece","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009691","descriptor_name":"Nucleic Acid Denaturation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017889","descriptor_name":"Exfoliation Syndrome","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D017889","descriptor_name":"Exfoliation Syndrome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D042965","descriptor_name":"Methylenetetrahydrofolate Reductase (NADPH2)","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D060005","descriptor_name":"Genotyping Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":5,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:3654845","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3654845/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3654845/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Vis","raw_type":"Text"},{"id":"pmh:oai:europepmc.org:2654060","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3654845","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:23687437","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23687437","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular vision","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:publications/63a8ebe0-7e3e-40d6-8029-0aed20f41181","doi":null,"is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3654845","pdf_url":null,"source":{"id":"https://openalex.org/S4306401731","display_name":"VBN Forskningsportal (Aalborg Universitet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I891191580","host_organization_name":"Aalborg University","host_organization_lineage":["https://openalex.org/I891191580"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Chiras, D, Tzika, K, Kokotas, H, Oliveira, S C, Grigoriadou, M, Kastania, A, Dima, K, Stefaniotou, M, Aspiotis, M, Petersen, M B, Kroupis, C & Kitsos, G 2013, 'Development of novel LOXL1 genotyping method and evaluation of LOXL1, APOE and MTHFR polymorphisms in exfoliation syndrome/glaucoma in a Greek population', Molecular Vision, vol. 19, pp. 1006-16. < http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654845/ >","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:183460740","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23687437","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3654845","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3654845/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3654845/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Vis","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320331527","display_name":"University of Ioannina","ror":"https://ror.org/01qg3j183"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W183460740.pdf","grobid_xml":"https://content.openalex.org/works/W183460740.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W39932614","https://openalex.org/W115218216","https://openalex.org/W174975285","https://openalex.org/W304188134","https://openalex.org/W1548716865","https://openalex.org/W1594944593","https://openalex.org/W1780762990","https://openalex.org/W1965952143","https://openalex.org/W1973308444","https://openalex.org/W1974149934","https://openalex.org/W1978016941","https://openalex.org/W1980705215","https://openalex.org/W1980852716","https://openalex.org/W1983253520","https://openalex.org/W1984621406","https://openalex.org/W1985564676","https://openalex.org/W1999837902","https://openalex.org/W2039351064","https://openalex.org/W2046438960","https://openalex.org/W2060447792","https://openalex.org/W2060803759","https://openalex.org/W2063891822","https://openalex.org/W2073589898","https://openalex.org/W2077283035","https://openalex.org/W2081287065","https://openalex.org/W2081393706","https://openalex.org/W2087484885","https://openalex.org/W2097450082","https://openalex.org/W2101995519","https://openalex.org/W2103382626","https://openalex.org/W2107031757","https://openalex.org/W2107568852","https://openalex.org/W2110247026","https://openalex.org/W2118094114","https://openalex.org/W2127080160","https://openalex.org/W2127623692","https://openalex.org/W2128036779","https://openalex.org/W2129559771","https://openalex.org/W2132209169","https://openalex.org/W2132848405","https://openalex.org/W2136795277","https://openalex.org/W2153648772","https://openalex.org/W2157862480","https://openalex.org/W2160859576","https://openalex.org/W2165475353","https://openalex.org/W2165715420","https://openalex.org/W2320447672","https://openalex.org/W2320976765","https://openalex.org/W2418481157"],"related_works":["https://openalex.org/W1594944593","https://openalex.org/W7099772586","https://openalex.org/W1510077959","https://openalex.org/W2418481157","https://openalex.org/W2125416537","https://openalex.org/W3158734929","https://openalex.org/W7098994311","https://openalex.org/W1509345209","https://openalex.org/W2132209169","https://openalex.org/W2051234872"],"abstract_inverted_index":{"PURPOSE:":[0],"In":[1,19],"the":[2,33,116,129,144,150,154,159,197,237,248,260,267,278],"Greek":[3,204],"population":[4,221,284],"of":[5,37,102,128,173,208,247,280,285],"Epirus,":[6],"exfoliation":[7,11],"syndrome":[8],"(XFS)":[9],"and":[10,41,46,82,86,105,111,119,146,158,188,210,234,264,269],"glaucoma":[12,80],"(XFG)":[13],"occur":[14],"at":[15],"a":[16,24],"high":[17],"prevalence.":[18],"this":[20,203,220],"study,":[21],"we":[22],"validate":[23],"novel":[25,100,179],"lysyl":[26],"oxidase-like":[27],"1":[28],"(LOXL1)":[29],"genotyping":[30,89,181],"method,":[31],"investigate":[32],"previously":[34],"reported":[35],"association":[36,193,207,238,261],"LOXL1":[38,117,180,198,250,263],"with":[39,69,73,77,96,152,156,170,200,212,242,255],"XFS/XFG,":[40,265],"evaluate":[42],"apolipoprotein":[43],"E":[44],"(APOE)":[45],"methylenetetrahydrofolate":[47],"reductase":[48],"(MTHFR)":[49],"polymorphisms":[50,121,148,271],"as":[51],"genetic":[52],"risk":[53,172,275],"factors":[54,276],"for":[55,143,196,235,277],"both":[56],"conditions":[57],"in":[58,175,202,219,282],"our":[59,176,283],"population.":[60,177,205],"METHODS:":[61],"Blood":[62],"samples":[63],"were":[64,141],"collected":[65],"from":[66,92,287],"82":[67],"patients":[68,72,76,151,155,286],"XFG,":[70,157],"69":[71],"XFS,":[74,153],"52":[75],"primary":[78],"open-angle":[79],"(POAG),":[81],"107":[83],"controls.":[84],"APOE":[85,145,163,268],"MTHFR":[87,147,270],"677C>T":[88],"was":[90,109,183,194,239,252],"performed":[91],"extracted":[93],"genomic":[94],"DNA":[95],"established":[97],"methods.":[98],"A":[99,190],"methodology":[101],"real-time":[103],"PCR":[104],"melting":[106],"curve":[107],"analysis":[108],"developed":[110],"validated":[112],"to":[113,167,185,215,231],"accurately":[114],"genotype":[115],"G153D":[118,213],"R141L":[120],"by":[122],"using":[123],"two":[124,249],"different":[125],"fluorescent":[126],"channels":[127],"LightCycler":[130],"instrument":[131],"(Roche)":[132],"examining":[133],"each":[134],"SNP":[135],"separately.":[136],"RESULTS:":[137],"No":[138],"significant":[139,192,274],"differences":[140],"observed":[142],"between":[149,262],"control":[160],"subjects.":[161],"The":[162,206],"\u03b52":[164],"allele":[165],"appears":[166],"be":[168,216],"associated":[169,254],"elevated":[171],"POAG":[174],"Our":[178],"method":[182],"easy":[184],"perform,":[186],"fast,":[187],"accurate.":[189],"statistically":[191],"found":[195],"gene":[199],"XFS/XFG":[201,281],"XFS":[209],"XFG":[211,243],"appeared":[214],"less":[217],"powerful":[218],"(XFS:":[222],"odds":[223],"ratio":[224],"[OR]=2.162,":[225],"p=0.039,":[226],"XFG:":[227],"OR=2.794,":[228],"p=0.002)":[229],"compared":[230],"other":[232],"populations,":[233],"R141L,":[236],"proven":[240],"only":[241],"(OR=3.592,":[244],"p<0.001).":[245],"Neither":[246],"SNPs":[251],"significantly":[253],"POAG.":[256],"CONCLUSIONS:":[257],"We":[258],"confirmed":[259],"but":[266],"are":[272],"not":[273],"development":[279],"Epirus":[288],"(Greece).":[289]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}