{"id":"https://openalex.org/W1833924236","doi":null,"title":"Las vastatinas, inhibidoras de la bios\u00edntesis del colesterol: eficacia y toxicidad","display_name":"Las vastatinas, inhibidoras de la bios\u00edntesis del colesterol: eficacia y toxicidad","publication_year":2001,"publication_date":"2001-01-01","ids":{"openalex":"https://openalex.org/W1833924236","mag":"1833924236"},"language":"es","primary_location":{"id":"mag:1833924236","doi":null,"is_oa":false,"landing_page_url":"https://www.medigraphic.com/pdfs/facmed/un-2001/un011d.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Revista de la Facultad de Medicina","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068942297","display_name":"J.C. Asenjo-Barr\u00f3n","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8961855","display_name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/01tmp8f25","country_code":"MX","type":"education","lineage":["https://openalex.org/I8961855"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Juan Carlos Asenjo Barr\u00f3n","raw_affiliation_strings":["Universidad Nacional Aut\u00f3noma de M\u00ebxico, Facultad de Medicina, M\u00e9xico, Distrito Federal, M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidad Nacional Aut\u00f3noma de M\u00ebxico, Facultad de Medicina, M\u00e9xico, Distrito Federal, M\u00e9xico","institution_ids":["https://openalex.org/I8961855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070429829","display_name":"Juan C. D\u00edaz Zagoya","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Juan C. D\u00edaz Zagoya","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065223978","display_name":"Marco Antonio Ju\u00e1rez-Oropeza","orcid":"https://orcid.org/0000-0003-1647-2267","observed_orcids":["https://orcid.org/0000-0003-1647-2267"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marco Antonio Ju\u00e1rez Oropeza","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048181871","display_name":"Rodrigo Miranda Zamora","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rodrigo Miranda Zamora","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5040168141","display_name":"Miguel \u00c1ngel Piedras Huerta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8961855","display_name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/01tmp8f25","country_code":"MX","type":"education","lineage":["https://openalex.org/I8961855"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Miguel \u00c1ngel Piedras Huerta","raw_affiliation_strings":["Universidad Nacional Aut\u00f3noma de M\u00ebxico, Facultad de Medicina, M\u00e9xico, Distrito Federal, M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidad Nacional Aut\u00f3noma de M\u00ebxico, Facultad de Medicina, M\u00e9xico, Distrito Federal, M\u00e9xico","institution_ids":["https://openalex.org/I8961855"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"44","issue":"001","first_page":"12","last_page":"17"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.5961999893188477,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.5961999893188477,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.3082999885082245,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.05270000174641609,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/statins","display_name":"statins","score":0.972000002861023},{"id":"https://openalex.org/keywords/cholesterol-synthesis","display_name":"cholesterol biosynthesis","score":0.8740000128746033},{"id":"https://openalex.org/keywords/mevalonate","display_name":"mevalonate","score":0.7360000014305115},{"id":"https://openalex.org/keywords/lovastatin","display_name":"lovastatin","score":0.8069999814033508},{"id":"https://openalex.org/keywords/simvastatin","display_name":"simvastatin","score":0.9929999709129333},{"id":"https://openalex.org/keywords/pravastatin","display_name":"pravastatin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/atorvastatin","display_name":"atorvastatin","score":0.8420000076293945},{"id":"https://openalex.org/keywords/rofecoxib","display_name":"rofecoxib","score":0.656000018119812},{"id":"https://openalex.org/keywords/drug-toxicity","display_name":"drug toxicity","score":0.3700000047683716},{"id":"https://openalex.org/keywords/drug-interactions","display_name":"drug interactions","score":0.48899999260902405},{"id":"https://openalex.org/keywords/hypercholesterolemia","display_name":"hypercholesterolemia","score":0.7609999775886536},{"id":"https://openalex.org/keywords/ldl-cholesterol","display_name":"LDL cholesterol","score":0.44600000977516174},{"id":"https://openalex.org/keywords/mevalonate-pathway","display_name":"mevalonate pathway","score":0.38999998569488525},{"id":"https://openalex.org/keywords/hmg-coa","display_name":"HMG-CoA","score":0.5770000219345093}],"concepts":[{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5322335362434387},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5271914601325989},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.4966471791267395},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12707030773162842}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:1833924236","doi":null,"is_oa":false,"landing_page_url":"https://www.medigraphic.com/pdfs/facmed/un-2001/un011d.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Revista de la Facultad de Medicina","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1562982017","https://openalex.org/W1964390696","https://openalex.org/W1965534366","https://openalex.org/W1978211049","https://openalex.org/W2002249795","https://openalex.org/W2016271864","https://openalex.org/W2020364703","https://openalex.org/W2031963160","https://openalex.org/W2034686245","https://openalex.org/W2046028995","https://openalex.org/W2046100367","https://openalex.org/W2056402221","https://openalex.org/W2057077200","https://openalex.org/W2059813089","https://openalex.org/W2076234573","https://openalex.org/W2088928036","https://openalex.org/W2092642063","https://openalex.org/W2095190789","https://openalex.org/W2114126984","https://openalex.org/W2148463229","https://openalex.org/W2267587045"],"related_works":["https://openalex.org/W2077672507","https://openalex.org/W1996484938","https://openalex.org/W4235781447","https://openalex.org/W4302044475","https://openalex.org/W206865469","https://openalex.org/W2934760560","https://openalex.org/W2114253024","https://openalex.org/W1576305158","https://openalex.org/W2043176967","https://openalex.org/W4232760675"],"abstract_inverted_index":{"En":[0,60,76,170,234],"1964,":[1],"Siperstien":[2],"presento":[3,282],"la":[4,19,43,64,73,93,104,129,144,154,175,202,292],"primera":[5],"evidencia":[6],"directa":[7],"de":[8,21,27,40,42,54,57,66,68,79,95,97,101,106,135,139,153,167,181,183,186,199,201,226,241,250,255,261,265,294,298],"que":[9,70,147,174],"el":[10,37,113,122,197],"colesterol":[11,182,266],"dietario":[12],"deprime":[13],"su":[14,89],"produccion":[15],"endogena":[16],"al":[17,290],"inhibir":[18,72],"incorporacion":[20,94],"acetato":[22,28],"a":[23,29,103,133,244],"mevalonato":[24],"pero":[25,99],"no":[26,100,108],"3-hydroxi-3-metilglutaril-CoA":[30],"(HMG-CoA)":[31],"y":[32,192,208,210,231,277],"es":[33,148],"entonces":[34],"esta":[35],"reductasa":[36],"sitio":[38],"principal":[39],"control":[41],"colesterogenesis.":[44],"Ademas,":[45],"dicha":[46],"enzima,":[47],"se":[48,142,172,211,236,258],"localiza":[49],"en":[50,88,137,190,204,239,270],"las":[51,55,184,272],"membranas":[52],"microsomales":[53],"celulas":[56],"multiples":[58],"tejidos.":[59],"1971,":[61],"Endo":[62],"inicio":[63],"busqueda":[65],"metabolitos":[67],"microorganismos":[69],"pudieran":[71],"HMG-CoA":[74,130,155],"reductasa.":[75,131,156],"un":[77,150],"periodo":[78],"aproximadamente":[80],"dos":[81,256],"anos,":[82],"analizo":[83],"seis":[84],"mil":[85],"cepas":[86,138],"microbiologicas":[87],"capacidad":[90],"para":[91],"bloquear":[92],"radiactividad":[96],"acetato,":[98],"mevalonato,":[102],"fraccion":[105],"lipidos":[107],"saponificables,":[109],"dando":[110],"como":[111],"resultado":[112],"aislamiento":[114],"del":[115,118],"antibiotico":[116],"citrina,":[117],"hongo":[119],"Pythium":[120],"ultimum,":[121],"primer":[123],"compuesto":[124],"con":[125,247],"efecto":[126],"inhibitorio":[127],"sobre":[128],"Posteriormente,":[132],"finales":[134],"1973,":[136],"Penicillium":[140,168],"citrinum,":[141],"aislo":[143],"melavastatina":[145],"(MVT),":[146],"tambien":[149,220],"potente":[151],"inhibidor":[152],"El":[157],"mismo":[158],"compuesto,":[159],"denominado":[160],"compactina,":[161],"fue":[162],"aislado":[163],"anos":[164,206,300],"mas":[165],"tarde":[166],"brevicompactum.":[169],"1980":[171],"demostro":[173],"MVT":[176,203,238],"disminuye":[177],"notablemente":[178],"los":[179,205,262,299,302],"niveles":[180,263],"lipoproteinas":[185],"baja":[187],"densidad":[188],"(LDL-C),":[189],"animales":[191],"humanos.":[193],"Este":[194],"descubrimiento":[195],"estimulo":[196],"desarrollo":[198],"analogos":[200],"ochenta":[207],"noventa,":[209],"han":[212],"identificado":[213],"tres":[214],"farmacos":[215],"mas:":[216],"lovastatina":[217],"(LVT":[218],"llamada":[219],"mevinolina":[221],"o":[222],"monacolina":[223],"k),":[224],"aislada":[225],"Aspergillus":[227],"terreus,":[228],"simvastatina":[229],"(SVT)":[230],"pravastatina":[232],"(PVT).":[233],"1976,":[235],"administro":[237],"dosis":[240],"500":[242],"mg/dia":[243],"una":[245],"paciente":[246],"hipercolesterolemia":[248],"familiar":[249],"tipo":[251],"homocigoto":[252],"y,":[253],"despues":[254],"semanas,":[257],"observo":[259],"disminucion":[260],"plasmaticos":[264],"total":[267],"(CT),":[268],"elevandose":[269],"cambio":[271],"enzimas":[273],"creatina":[274],"fosfocinasa":[275],"(CPK)":[276],"alanina":[278],"aminotransferasa":[279],"(ALT).":[280],"Se":[281],"ademas":[283],"debilidad":[284],"muscular.":[285],"Estos":[286],"efectos":[287],"adversos":[288],"desaparecieron":[289],"suspenderse":[291],"administracion":[293],"MVT.":[295],"A":[296],"mediados":[297],"80":[301],"estuMonografia":[303]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}