{"id":"https://openalex.org/W183391693","doi":"https://doi.org/10.1007/s11596-009-0308-9","title":"Effects of tetrazanbigen on the protein expression in human hepatocellular carcinoma cell line QGY-7701","display_name":"Effects of tetrazanbigen on the protein expression in human hepatocellular carcinoma cell line QGY-7701","publication_year":2009,"publication_date":"2009-06-01","ids":{"openalex":"https://openalex.org/W183391693","doi":"https://doi.org/10.1007/s11596-009-0308-9","mag":"183391693","pmid":"https://pubmed.ncbi.nlm.nih.gov/19513611"},"language":"en","primary_location":{"id":"doi:10.1007/s11596-009-0308-9","doi":"https://doi.org/10.1007/s11596-009-0308-9","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11596-009-0308-9","pdf_url":null,"source":{"id":"https://openalex.org/S4210175609","display_name":"Journal of Huazhong University of Science and Technology [Medical Sciences]","issn_l":"1672-0733","issn":["1672-0733","0510-9752","1993-1352"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1"],"host_organization":"https://openalex.org/P4310311954","host_organization_name":"Huazhong University of Science and Technology","host_organization_lineage":["https://openalex.org/P4310311954"],"host_organization_lineage_names":["Huazhong University of Science and Technology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Huazhong University of Science and Technology [Medical Sciences]","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101960113","display_name":"Yonghua Yuan","orcid":"https://orcid.org/0000-0003-0184-9447","observed_orcids":["https://orcid.org/0000-0003-0184-9447"]},"institutions":[{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yonghua Yuan","raw_affiliation_strings":["Department of Medicinal Chemistry, Research Laboratory of Pharmaceutical Chemistry and Biomaterials, Chongqing Engineering Research Center of Drugs, School of Pharmacy, Chongqing, China. yonghuayuancq@163.com","Department of Medicinal Chemistry, Research Laboratory of Pharmaceutical Chemistry and Biomaterials, Chongqing Engineering Research Center of Drugs, School of Pharmacy, Chongqing, China","Pharmacy of Children\u2019s Hospital, Chongqing Medical University, Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, Research Laboratory of Pharmaceutical Chemistry and Biomaterials, Chongqing Engineering Research Center of Drugs, School of Pharmacy, Chongqing, China. yonghuayuancq@163.com","institution_ids":[]},{"raw_affiliation_string":"Department of Medicinal Chemistry, Research Laboratory of Pharmaceutical Chemistry and Biomaterials, Chongqing Engineering Research Center of Drugs, School of Pharmacy, Chongqing, China","institution_ids":[]},{"raw_affiliation_string":"Pharmacy of Children\u2019s Hospital, Chongqing Medical University, Chongqing, China","institution_ids":["https://openalex.org/I87780372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100318082","display_name":"Wei Li","orcid":"https://orcid.org/0000-0001-9931-5990","observed_orcids":["https://orcid.org/0000-0001-9931-5990"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wei Li","raw_affiliation_strings":["Department of Medicinal Chemistry, Research Laboratory of Pharmaceutical Chemistry and Biomaterials, Chongqing Engineering Research Center of Drugs, School of Pharmacy, Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, Research Laboratory of Pharmaceutical Chemistry and Biomaterials, Chongqing Engineering Research Center of Drugs, School of Pharmacy, Chongqing, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091230191","display_name":"Longjiang Li","orcid":"https://orcid.org/0000-0003-1446-0692","observed_orcids":["https://orcid.org/0000-0003-1446-0692"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Longjiang Li","raw_affiliation_strings":["Department of Medicinal Chemistry, Research Laboratory of Pharmaceutical Chemistry and Biomaterials, Chongqing Engineering Research Center of Drugs, School of Pharmacy, Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, Research Laboratory of Pharmaceutical Chemistry and Biomaterials, Chongqing Engineering Research Center of Drugs, School of Pharmacy, Chongqing, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038268415","display_name":"Xiaolan Yang","orcid":"https://orcid.org/0000-0001-9320-1036","observed_orcids":["https://orcid.org/0000-0001-9320-1036"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaolan Yang","raw_affiliation_strings":["Department of Medicinal Chemistry, Research Laboratory of Pharmaceutical Chemistry and Biomaterials, Chongqing Engineering Research Center of Drugs, School of Pharmacy, Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, Research Laboratory of Pharmaceutical Chemistry and Biomaterials, Chongqing Engineering Research Center of Drugs, School of Pharmacy, Chongqing, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112594659","display_name":"Rong Gu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rong Gu","raw_affiliation_strings":["Pharmacy of Children\u2019s Hospital, Chongqing Medical University, Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacy of Children\u2019s Hospital, Chongqing Medical University, Chongqing, China","institution_ids":["https://openalex.org/I87780372"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Huabo Liu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Huabo Liu","raw_affiliation_strings":["Department of Medicinal Chemistry, Research Laboratory of Pharmaceutical Chemistry and Biomaterials, Chongqing Engineering Research Center of Drugs, School of Pharmacy, Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, Research Laboratory of Pharmaceutical Chemistry and Biomaterials, Chongqing Engineering Research Center of Drugs, School of Pharmacy, Chongqing, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110366835","display_name":"Kaishun Huang","orcid":"https://orcid.org/0009-0009-1963-1850","observed_orcids":["https://orcid.org/0009-0009-1963-1850"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kaishun Huang","raw_affiliation_strings":["Department of Medicinal Chemistry, Research Laboratory of Pharmaceutical Chemistry and Biomaterials, Chongqing Engineering Research Center of Drugs, School of Pharmacy, Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, Research Laboratory of Pharmaceutical Chemistry and Biomaterials, Chongqing Engineering Research Center of Drugs, School of Pharmacy, Chongqing, China","institution_ids":[]}]},{"author_position":"last","author":{"id":null,"display_name":"Yu Yu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yu Yu","raw_affiliation_strings":["Department of Medicinal Chemistry, Research Laboratory of Pharmaceutical Chemistry and Biomaterials, Chongqing Engineering Research Center of Drugs, School of Pharmacy, Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, Research Laboratory of Pharmaceutical Chemistry and Biomaterials, Chongqing Engineering Research Center of Drugs, School of Pharmacy, Chongqing, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5101960113"],"corresponding_institution_ids":["https://openalex.org/I87780372"],"apc_list":null,"apc_paid":null,"fwci":0.2092,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.54990824,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"29","issue":"3","first_page":"304","last_page":"308"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.972000002861023},{"id":"https://openalex.org/keywords/differentially-expressed-proteins","display_name":"differentially expressed proteins","score":0.7289999723434448},{"id":"https://openalex.org/keywords/lipid-droplet-accumulation","display_name":"lipid droplet accumulation","score":0.7149999737739563},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.9139999747276306},{"id":"https://openalex.org/keywords/srebp-1","display_name":"SREBP1","score":0.8450000286102295},{"id":"https://openalex.org/keywords/peroxiredoxin-1","display_name":"peroxiredoxin 1","score":0.8320000171661377},{"id":"https://openalex.org/keywords/heat-shock-protein-90-alpha","display_name":"heat shock protein 90 alpha","score":0.8569999933242798},{"id":"https://openalex.org/keywords/anticancer-mechanism","display_name":"anticancer mechanism","score":0.6970000267028809}],"concepts":[{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.7570998668670654},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5262899994850159},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4634850323200226},{"id":"https://openalex.org/C6856738","wikidata":"https://www.wikidata.org/wiki/Q331672","display_name":"Protein expression","level":3,"score":0.4122907519340515},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.36498379707336426},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.33012691140174866},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.31518036127090454},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2481284737586975},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11481255292892456},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09579905867576599}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001391","descriptor_name":"Azo Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006067","descriptor_name":"Gonanes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1007/s11596-009-0308-9","doi":"https://doi.org/10.1007/s11596-009-0308-9","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11596-009-0308-9","pdf_url":null,"source":{"id":"https://openalex.org/S4210175609","display_name":"Journal of Huazhong University of Science and Technology [Medical Sciences]","issn_l":"1672-0733","issn":["1672-0733","0510-9752","1993-1352"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1"],"host_organization":"https://openalex.org/P4310311954","host_organization_name":"Huazhong University of Science and Technology","host_organization_lineage":["https://openalex.org/P4310311954"],"host_organization_lineage_names":["Huazhong University of Science and Technology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Huazhong University of Science and Technology [Medical Sciences]","raw_type":"journal-article"},{"id":"pmid:19513611","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19513611","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban","raw_type":"Journal Article"},{"id":"mag:3139789405","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/QK/85740A/200903/31424254.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306544964","display_name":"\u534e\u4e2d\u79d1\u6280\u5927\u5b66\u5b66\u62a5\uff1a\u533b\u5b66\u82f1\u5fb7\u6587\u7248","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u534e\u4e2d\u79d1\u6280\u5927\u5b66\u5b66\u62a5\uff1a\u533b\u5b66\u82f1\u5fb7\u6587\u7248","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1963530863","https://openalex.org/W1964313477","https://openalex.org/W1982950140","https://openalex.org/W1987499643","https://openalex.org/W1989518640","https://openalex.org/W2038009322","https://openalex.org/W2050924665","https://openalex.org/W2051793134","https://openalex.org/W2054279321","https://openalex.org/W2054849024","https://openalex.org/W2059920050","https://openalex.org/W2071124826","https://openalex.org/W2082416572","https://openalex.org/W2086453930","https://openalex.org/W2087815224","https://openalex.org/W2123392242","https://openalex.org/W2155282053","https://openalex.org/W2380478065","https://openalex.org/W2380927587","https://openalex.org/W2410412913","https://openalex.org/W7055125043"],"related_works":["https://openalex.org/W3115712616","https://openalex.org/W2380478065","https://openalex.org/W2099756343","https://openalex.org/W2410412913","https://openalex.org/W2121201567","https://openalex.org/W1972461002","https://openalex.org/W2593188734","https://openalex.org/W2375619116","https://openalex.org/W2189072013","https://openalex.org/W2172276655"],"abstract_inverted_index":null,"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
