{"id":"https://openalex.org/W1833519829","doi":"https://doi.org/10.1128/jvi.65.8.4424-4431.1991","title":"Absence of asparagine-linked oligosaccharides from glycoprotein D of herpes simplex virus type 1 results in a structurally altered but biologically active protein","display_name":"Absence of asparagine-linked oligosaccharides from glycoprotein D of herpes simplex virus type 1 results in a structurally altered but biologically active protein","publication_year":1991,"publication_date":"1991-08-01","ids":{"openalex":"https://openalex.org/W1833519829","doi":"https://doi.org/10.1128/jvi.65.8.4424-4431.1991","mag":"1833519829","pmid":"https://pubmed.ncbi.nlm.nih.gov/1649338","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/248882"},"language":"en","primary_location":{"id":"doi:10.1128/jvi.65.8.4424-4431.1991","doi":"https://doi.org/10.1128/jvi.65.8.4424-4431.1991","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.65.8.4424-4431.1991","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/248882","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078380245","display_name":"Donald L. Sodora","orcid":"https://orcid.org/0000-0002-8927-052X","observed_orcids":["https://orcid.org/0000-0002-8927-052X"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D L Sodora","raw_affiliation_strings":["Department of Microbiology, School of Dental Medicine, University of Pennsylvania, Philadelphia 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, School of Dental Medicine, University of Pennsylvania, Philadelphia 19104","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013855641","display_name":"Gary H. Cohen","orcid":"https://orcid.org/0000-0002-8581-8068","observed_orcids":["https://orcid.org/0000-0002-8581-8068"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G H Cohen","raw_affiliation_strings":["Department of Microbiology, School of Dental Medicine, University of Pennsylvania, Philadelphia 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, School of Dental Medicine, University of Pennsylvania, Philadelphia 19104","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033973201","display_name":"Martin I. Muggeridge","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M I Muggeridge","raw_affiliation_strings":["Department of Microbiology, School of Dental Medicine, University of Pennsylvania, Philadelphia 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, School of Dental Medicine, University of Pennsylvania, Philadelphia 19104","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052732110","display_name":"R.J. Eisenberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R J Eisenberg","raw_affiliation_strings":["Department of Microbiology, School of Dental Medicine, University of Pennsylvania, Philadelphia 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, School of Dental Medicine, University of Pennsylvania, Philadelphia 19104","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":null,"apc_paid":null,"fwci":1.3221,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.79173062,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"65","issue":"8","first_page":"4424","last_page":"4431"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.5996000170707703,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.5996000170707703,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.3767000138759613,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.004999999888241291,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/herpes-simplex-virus-type-1","display_name":"herpes simplex virus type 1","score":0.9760000109672546},{"id":"https://openalex.org/keywords/glycoprotein-d","display_name":"glycoprotein D","score":0.9940000176429749},{"id":"https://openalex.org/keywords/asparagine-linked-oligosaccharides","display_name":"asparagine-linked oligosaccharides","score":0.9610000252723694},{"id":"https://openalex.org/keywords/n-glycosylation","display_name":"N-glycosylation","score":0.8650000095367432},{"id":"https://openalex.org/keywords/glycosylation-site-mutants","display_name":"glycosylation site mutants","score":0.6209999918937683},{"id":"https://openalex.org/keywords/protein-conformation","display_name":"protein conformation","score":0.9269999861717224},{"id":"https://openalex.org/keywords/monoclonal-antibody-binding","display_name":"monoclonal antibody binding","score":0.9129999876022339},{"id":"https://openalex.org/keywords/tunicamycin","display_name":"tunicamycin","score":0.746999979019165},{"id":"https://openalex.org/keywords/trypsin-sensitivity","display_name":"trypsin sensitivity","score":0.7400000095367432},{"id":"https://openalex.org/keywords/complementation","display_name":"complementation","score":0.5139999985694885},{"id":"https://openalex.org/keywords/virus-infectivity","display_name":"viral infectivity","score":0.7229999899864197},{"id":"https://openalex.org/keywords/glycoprotein-structure","display_name":"glycoprotein structure","score":0.4779999852180481}],"concepts":[{"id":"https://openalex.org/C2775895851","wikidata":"https://www.wikidata.org/wiki/Q185906","display_name":"Asparagine","level":3,"score":0.7439555525779724},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7326609492301941},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6168427467346191},{"id":"https://openalex.org/C103408237","wikidata":"https://www.wikidata.org/wiki/Q2642668","display_name":"Site-directed mutagenesis","level":4,"score":0.544988214969635},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.5066247582435608},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.4889763593673706},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.46651092171669006},{"id":"https://openalex.org/C2780340462","wikidata":"https://www.wikidata.org/wiki/Q127450","display_name":"Trypsin","level":3,"score":0.4354928433895111},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.4289627969264984},{"id":"https://openalex.org/C2775880066","wikidata":"https://www.wikidata.org/wiki/Q186521","display_name":"Threonine","level":4,"score":0.41874751448631287},{"id":"https://openalex.org/C2776414213","wikidata":"https://www.wikidata.org/wiki/Q183290","display_name":"Serine","level":3,"score":0.3229775130748749},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.16015774011611938},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000956","descriptor_name":"Antigens, Viral","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D001216","descriptor_name":"Asparagine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005816","descriptor_name":"Genetic Complementation Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006031","descriptor_name":"Glycosylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006358","descriptor_name":"Hot Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009844","descriptor_name":"Oligosaccharides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010450","descriptor_name":"Endopeptidases","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014709","descriptor_name":"Vero Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014759","descriptor_name":"Viral Envelope Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014759","descriptor_name":"Viral Envelope Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014759","descriptor_name":"Viral Envelope Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018139","descriptor_name":"Simplexvirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1128/jvi.65.8.4424-4431.1991","doi":"https://doi.org/10.1128/jvi.65.8.4424-4431.1991","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.65.8.4424-4431.1991","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:248882","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/248882","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"},{"id":"pmid:1649338","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1649338","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of virology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.911.612","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.911.612","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jvi.asm.org/content/65/8/4424.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:248882","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/248882","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4043000042438507}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2903832878","display_name":"RESEARCH CENTER IN ORAL BIOLOGY","funder_award_id":"5p50de008239-10","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G366734104","display_name":null,"funder_award_id":"GM-07225","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3986120241","display_name":null,"funder_award_id":"AI18289","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G43797528","display_name":null,"funder_award_id":"DE 08239","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":59,"referenced_works":["https://openalex.org/W128768011","https://openalex.org/W1495765538","https://openalex.org/W1497784734","https://openalex.org/W1512493838","https://openalex.org/W1514552728","https://openalex.org/W1515529788","https://openalex.org/W1530359565","https://openalex.org/W1573745764","https://openalex.org/W1594305617","https://openalex.org/W1604652649","https://openalex.org/W1637878324","https://openalex.org/W1695142101","https://openalex.org/W1770233073","https://openalex.org/W1800374187","https://openalex.org/W1817004310","https://openalex.org/W1825833979","https://openalex.org/W1844703465","https://openalex.org/W1861344368","https://openalex.org/W1894845554","https://openalex.org/W1908212256","https://openalex.org/W1929764420","https://openalex.org/W1950165186","https://openalex.org/W1975514230","https://openalex.org/W1981619459","https://openalex.org/W1982012608","https://openalex.org/W1982371597","https://openalex.org/W1985090349","https://openalex.org/W1990935602","https://openalex.org/W2002079223","https://openalex.org/W2017592191","https://openalex.org/W2018940865","https://openalex.org/W2036931150","https://openalex.org/W2042341439","https://openalex.org/W2042785697","https://openalex.org/W2044264939","https://openalex.org/W2071722818","https://openalex.org/W2084884863","https://openalex.org/W2086900257","https://openalex.org/W2089341748","https://openalex.org/W2096555292","https://openalex.org/W2108504270","https://openalex.org/W2111817213","https://openalex.org/W2117116136","https://openalex.org/W2131175107","https://openalex.org/W2131949423","https://openalex.org/W2138270253","https://openalex.org/W2144079090","https://openalex.org/W2144206181","https://openalex.org/W2145047493","https://openalex.org/W2149818029","https://openalex.org/W2155489185","https://openalex.org/W2163504590","https://openalex.org/W2165960738","https://openalex.org/W2168890635","https://openalex.org/W2169183716","https://openalex.org/W2170607332","https://openalex.org/W2442393790","https://openalex.org/W2888511473","https://openalex.org/W4206701382"],"related_works":["https://openalex.org/W7028993020","https://openalex.org/W2169183716","https://openalex.org/W1604652649","https://openalex.org/W7095542452","https://openalex.org/W126582219","https://openalex.org/W2131949423","https://openalex.org/W1542886234","https://openalex.org/W7062237888","https://openalex.org/W1529453182","https://openalex.org/W2076044906"],"abstract_inverted_index":{"Glycoprotein":[0],"D":[1],"(gD)":[2],"of":[3,14,56,69,102,136,142,148,153,208,226,257],"herpes":[4],"simplex":[5],"virus":[6,228],"contains":[7],"three":[8,47,130],"utilized":[9],"sites":[10,48],"(Asn-X-Ser/Thr)":[11],"for":[12,262],"addition":[13,34],"asparagine-linked":[15],"carbohydrates":[16],"(N-CHO).":[17],"Previously,":[18],"we":[19,75],"used":[20],"oligonucleotide-directed":[21],"mutagenesis":[22],"to":[23,29,108,140,155,160,180,197,202,215,264],"alter":[24],"serine":[25],"or":[26,159,184],"threonine":[27],"residues":[28],"alanine":[30],"at":[31,61,80,111,164,241],"each":[32,221],"N-CHO":[33,131,237,242,259],"site.":[35],"Studies":[36],"with":[37,170],"monoclonal":[38],"antibodies":[39],"showed":[40],"that":[41,89,141,235],"a":[42,122,227],"mutant":[43,222],"protein":[44,158,193],"lacking":[45,229],"all":[46,129],"(now":[49],"designated":[50],"AAA)":[51],"was":[52,138,167,194],"structurally":[53],"altered":[54,163],"because":[55],"the":[57,67,70,93,100,115,146,156,191,209,224,236,258,267],"amino":[58,94,239],"acid":[59,95],"change":[60,96],"residue":[62],"96":[63],"as":[64,66],"well":[65],"absence":[68],"N-CHO.":[71],"In":[72,189],"this":[73],"study,":[74],"constructed":[76,121],"additional":[77],"single":[78,161],"mutations":[79],"site":[81,112,165,243],"1":[82,113,166,244],"(residues":[83],"94":[84,107],"and":[85,87,174,238],"96)":[86],"found":[88],"in":[90,145,219,249,266],"most":[91],"cases,":[92],"itself":[97],"adversely":[98],"affected":[99],"conformation":[101,135],"gD.":[103,119],"However,":[104,151],"changing":[105],"asparagine":[106],"glutamine":[109],"(Q)":[110],"had":[114],"least":[116],"effect":[117],"on":[118],"We":[120,233],"second":[123],"triple":[124],"mutant,":[125],"QAA,":[126],"which":[127],"lacked":[128],"signals.":[132],"The":[133],"antigenic":[134],"QAA":[137,175],"similar":[139],"gD":[143,173,230,253,263],"produced":[144],"presence":[147],"tunicamycin":[149],"(TM-gD).":[150],"binding":[152],"MAbs":[154],"AAA":[157,192,210],"mutants":[162],"reduced":[168],"compared":[169],"TM-gD.":[171],"Wild-type":[172],"proteins":[176],"were":[177],"equally":[178],"susceptible":[179],"digestion":[181],"by":[182],"trypsin":[183,198],"Staphylococcus":[185],"aureus":[186],"V8":[187],"protease.":[188],"contrast,":[190],"more":[195],"sensitive":[196,201],"but":[199,255],"less":[200],"V8,":[203],"again":[204],"suggesting":[205],"conformational":[206],"alterations":[207],"protein.":[211],"Despite":[212],"what":[213],"appeared":[214],"be":[216],"large":[217],"changes":[218],"structure,":[220,254],"complemented":[223],"infectivity":[225],"(F-gD":[231],"beta).":[232],"conclude":[234],"acids":[240],"play":[245],"an":[246],"important":[247],"role":[248],"forming":[250],"and/or":[251],"maintaining":[252],"none":[256],"are":[260],"required":[261],"function":[265],"complementation":[268],"assay.":[269]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
