{"id":"https://openalex.org/W1833486259","doi":null,"title":"Expression of glucose transporters in human pancreatic tumors compared with increased FDG accumulation in PET study.","display_name":"Expression of glucose transporters in human pancreatic tumors compared with increased FDG accumulation in PET study.","publication_year":1997,"publication_date":"1997-09-01","ids":{"openalex":"https://openalex.org/W1833486259","mag":"1833486259","pmid":"https://pubmed.ncbi.nlm.nih.gov/9293783"},"language":"en","primary_location":{"id":"pmid:9293783","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9293783","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067101373","display_name":"Tatsuya Higashi","orcid":"https://orcid.org/0000-0002-8338-4737","observed_orcids":["https://orcid.org/0000-0002-8338-4737"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T Higashi","raw_affiliation_strings":["Department of Nuclear Medicine, Kyoto University Faculty of Medicine, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine, Kyoto University Faculty of Medicine, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025671725","display_name":"Nobuharu Tamaki","orcid":"https://orcid.org/0000-0003-4634-6616","observed_orcids":["https://orcid.org/0000-0003-4634-6616"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Tamaki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"T Honda","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Honda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011217263","display_name":"Tatsuo Torizuka","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Torizuka","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"T Kimura","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Kimura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040991264","display_name":"Tetsuro Inokuma","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Inokuma","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077611996","display_name":"Gakuji Ohshio","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Ohshio","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112565285","display_name":"Ryo Hosotani","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Hosotani","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111644084","display_name":"M Imamura","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Imamura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5112147348","display_name":"Junko Konishi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Konishi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.84,"has_fulltext":false,"cited_by_count":152,"citation_normalized_percentile":{"value":0.85758668,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"38","issue":"9","first_page":"1337","last_page":"44"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.7904999852180481,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.7904999852180481,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.049300000071525574,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.044199999421834946,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glucose-transporters","display_name":"glucose transporters","score":0.9350000023841858},{"id":"https://openalex.org/keywords/glut1","display_name":"GLUT1","score":0.9760000109672546},{"id":"https://openalex.org/keywords/glut2","display_name":"GLUT2","score":0.8709999918937683},{"id":"https://openalex.org/keywords/glut3","display_name":"GLUT3","score":0.9950000047683716},{"id":"https://openalex.org/keywords/glut4","display_name":"GLUT4","score":1.0},{"id":"https://openalex.org/keywords/glut5","display_name":"GLUT5","score":1.0},{"id":"https://openalex.org/keywords/pancreatic-tumors","display_name":"pancreatic tumors","score":0.8489999771118164},{"id":"https://openalex.org/keywords/fdg-uptake","display_name":"FDG uptake","score":0.8849999904632568},{"id":"https://openalex.org/keywords/fdg-pet","display_name":"FDG-PET","score":0.9419999718666077},{"id":"https://openalex.org/keywords/standardized-uptake-value","display_name":"standardized uptake value","score":0.6740000247955322},{"id":"https://openalex.org/keywords/tumor-glucose-metabolism","display_name":"tumor glucose metabolism","score":0.628000020980835},{"id":"https://openalex.org/keywords/benign-pancreatic-tumors","display_name":"benign pancreatic tumors","score":0.6309999823570251},{"id":"https://openalex.org/keywords/sensitivity-and-specificity","display_name":"sensitivity and specificity","score":0.7820000052452087}],"concepts":[{"id":"https://openalex.org/C161573976","wikidata":"https://www.wikidata.org/wiki/Q420277","display_name":"Glucose transporter","level":3,"score":0.8447651863098145},{"id":"https://openalex.org/C2777286243","wikidata":"https://www.wikidata.org/wiki/Q5591926","display_name":"Grading (engineering)","level":2,"score":0.7638599872589111},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.7470398545265198},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6071901321411133},{"id":"https://openalex.org/C2777866211","wikidata":"https://www.wikidata.org/wiki/Q5572349","display_name":"Glucose uptake","level":3,"score":0.49539458751678467},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.46815088391304016},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.4378505051136017},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4367036819458008},{"id":"https://openalex.org/C3019822344","wikidata":"https://www.wikidata.org/wiki/Q1541222","display_name":"Tumor grade","level":3,"score":0.42140719294548035},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4208948016166687},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3115960359573364},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21874889731407166},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11261960864067078},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.10566198825836182},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003847","descriptor_name":"Deoxyglucose","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D003847","descriptor_name":"Deoxyglucose","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005462","descriptor_name":"Fluorine Radioisotopes","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009004","descriptor_name":"Monosaccharide Transport Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014055","descriptor_name":"Tomography, Emission-Computed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D019275","descriptor_name":"Radiopharmaceuticals","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D019788","descriptor_name":"Fluorodeoxyglucose F18","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:9293783","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9293783","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","raw_type":"Comparative Study"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.543.1881","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.543.1881","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jnm.snmjournals.org/content/38/9/1337.full.pdf","raw_type":"text"},{"id":"mag:1833486259","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9293783","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W19918496","https://openalex.org/W1560780443","https://openalex.org/W1834156980","https://openalex.org/W1877096643","https://openalex.org/W1890344985","https://openalex.org/W1964015820","https://openalex.org/W1965504530","https://openalex.org/W1970996670","https://openalex.org/W2008307864","https://openalex.org/W2017811372","https://openalex.org/W2020790836","https://openalex.org/W2029290770","https://openalex.org/W2033475956","https://openalex.org/W2070129086","https://openalex.org/W2073389023","https://openalex.org/W2074783201","https://openalex.org/W2076962597","https://openalex.org/W2082370935","https://openalex.org/W2084918576","https://openalex.org/W2091355364","https://openalex.org/W2091764247","https://openalex.org/W2096343524","https://openalex.org/W2138812230","https://openalex.org/W2172189429","https://openalex.org/W2328838310","https://openalex.org/W2334576825","https://openalex.org/W2389337278","https://openalex.org/W2399309626","https://openalex.org/W2511620365"],"related_works":["https://openalex.org/W7096658813","https://openalex.org/W2401976742","https://openalex.org/W1773759946","https://openalex.org/W2309435427","https://openalex.org/W606496733","https://openalex.org/W7097245407","https://openalex.org/W2403065879","https://openalex.org/W2100518141","https://openalex.org/W2231669190","https://openalex.org/W2182658641"],"abstract_inverted_index":{"UNLABELLED:":[0],"Although":[1],"overexpression":[2],"of":[3,16,65,68,73,90,135,165,175,228,280],"GLUT-1":[4,136,181,198,234,263],"glucose":[5,17,30,137,171,271],"transporter":[6],"has":[7,264],"already":[8],"been":[9],"reported":[10],"in":[11,38,233,252,268,282,285],"human":[12],"cancers,":[13],"the":[14,26,133,146,163,253,269,277],"mechanism":[15],"entry":[18],"into":[19],"pancreatic":[20,48,288],"cancers":[21],"remains":[22],"unknown.":[23],"To":[24],"evaluate":[25],"relationship":[27],"between":[28,224],"GLUT":[29,84,229,256],"transporters":[31],"and":[32,53,103,112,139,155,169,187,215,226,273],"FDG":[33,58,281],"uptake,":[34],"FDG-PET":[35],"was":[36,75,86],"performed":[37],"34":[39],"preoperative":[40],"patients":[41,286],"(mean":[42],"age,":[43],"60.9":[44],"yr)":[45],"with":[46,70,287],"suspected":[47],"tumors,":[49,210],"including":[50],"28":[51],"malignant":[52,121,158,209,270],"6":[54],"benign":[55,177,191],"tumors.":[56],"METHODS:":[57],"uptake":[59,80,279],"at":[60],"50":[61],"min":[62],"after":[63,96],"injection":[64],"185":[66],"MBq":[67],"[18F]FDG":[69],">5":[71],"hr":[72],"fasting":[74],"semiquantitatively":[76],"analyzed":[77],"as":[78],"standardized":[79],"values":[81],"(SUVs).":[82],"The":[83],"expression":[85,134,164],"studied":[87],"by":[88,114,124],"immunohistochemistry":[89],"paraffin":[91],"sections":[92],"from":[93],"these":[94],"tumors":[95,122,129,159,178],"operation":[97],"using":[98],"anti-GLUT-1,":[99],"-2,":[100],"-3,":[101,167,185,213],"-4":[102,168,186,214],"-5":[104,170,216],"antibodies":[105],"to":[106,276],"obtain":[107],"immunohistochemical":[108],"grading":[109,227],"(\"strong,\"":[110],"\"weak\"":[111],"\"negative\")":[113],"three":[115],"experienced":[116],"physicians.":[117],"RESULTS:":[118],"Of":[119],"26":[120],"proved":[123],"histological":[125],"examination,":[126],"23":[127],"(88%)":[128],"were":[130,160,231],"positive":[131,161,194],"for":[132,162,207],"transporter,":[138],"17":[140],"(61%)":[141],"showed":[142,179,193,199],"strong":[143,180],"expression.":[144,182,196],"On":[145],"other":[147],"hand,":[148],"13":[149,156],"(46%),":[150],"0":[151],"(0%),":[152],"9":[153],"(36%)":[154],"(46%)":[157],"GLUT-2,":[166,184,212],"transporters,":[172],"respectively.":[173],"Three":[174],"six":[176],"Concerning":[183],"-5,":[188],"only":[189],"one":[190],"tumor":[192],"GLUT-5":[195],"Thus,":[197],"relatively":[200],"high":[201],"sensitivity":[202],"but":[203,220,250],"low":[204],"specificity":[205],"(50%)":[206],"detecting":[208],"whereas":[211],"had":[217],"lower":[218],"sensitivities":[219],"higher":[221],"specificities.":[222],"Correlations":[223],"SUVs":[225],"immunoreactivity":[230],"significant":[232,266],"(strong,":[235],"4.49":[236],"+/-":[237,241,245],"2.95;":[238],"weak,":[239],"3.42":[240],"1.21;":[242],"negative,":[243],"2.52":[244],"0.84)":[246],"(p":[247],"<":[248],"0.05)":[249],"not":[251],"remaining":[254],"four":[255],"transporters.":[257],"CONCLUSION:":[258],"These":[259],"data":[260],"indicate":[261],"that":[262],"a":[265],"role":[267],"metabolism":[272],"may":[274],"contribute":[275],"increased":[278],"PET":[283],"imaging":[284],"tumor.":[289]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":12}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}