{"id":"https://openalex.org/W1833416738","doi":null,"title":"Metabolism of the HIV-1 reverse transcriptase inhibitor delavirdine in mice.","display_name":"Metabolism of the HIV-1 reverse transcriptase inhibitor delavirdine in mice.","publication_year":1997,"publication_date":"1997-07-01","ids":{"openalex":"https://openalex.org/W1833416738","mag":"1833416738","pmid":"https://pubmed.ncbi.nlm.nih.gov/9224777"},"language":"en","primary_location":{"id":"pmid:9224777","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9224777","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug metabolism and disposition: the biological fate of chemicals","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"M Chang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Chang","raw_affiliation_strings":["Drug Metabolism Research, Pharmacia & Upjohn, Inc., Kalamazoo, MI 49007, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Metabolism Research, Pharmacia & Upjohn, Inc., Kalamazoo, MI 49007, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005186415","display_name":"Virendra K. Sood","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V K Sood","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063242902","display_name":"G J Wilson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G J Wilson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109554156","display_name":"D A Kloosterman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D A Kloosterman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046241262","display_name":"Phillip E. Sanders","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P E Sanders","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043008881","display_name":"Michael J. Hauer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M J Hauer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002167965","display_name":"Wei Zhang","orcid":"https://orcid.org/0000-0001-6937-5562","observed_orcids":["https://orcid.org/0000-0001-6937-5562"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5032134000","display_name":"Daniel G. Branstetter","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D G Branstetter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4164,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.81383599,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"25","issue":"7","first_page":"828","last_page":"39"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.7588000297546387,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.7588000297546387,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.23389999568462372,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/delavirdine","display_name":"delavirdine","score":0.9919999837875366},{"id":"https://openalex.org/keywords/hiv-1-reverse-transcriptase-inhibitors","display_name":"HIV-1 reverse transcriptase inhibitors","score":0.8980000019073486},{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.9769999980926514},{"id":"https://openalex.org/keywords/amide-cleavage","display_name":"amide bond cleavage","score":0.996999979019165},{"id":"https://openalex.org/keywords/pyridine-ring-cleavage","display_name":"pyridine ring cleavage","score":0.9210000038146973},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.7580000162124634},{"id":"https://openalex.org/keywords/nonlinear-pharmacokinetics","display_name":"nonlinear pharmacokinetics","score":0.8569999933242798},{"id":"https://openalex.org/keywords/blood-brain-barrier-penetration","display_name":"blood-brain barrier penetration","score":0.8679999709129333},{"id":"https://openalex.org/keywords/brain-distribution","display_name":"brain distribution","score":0.4749999940395355},{"id":"https://openalex.org/keywords/excretion","display_name":"excretion","score":0.6129999756813049},{"id":"https://openalex.org/keywords/repeated-dosing","display_name":"repeated dosing","score":0.5040000081062317}],"concepts":[{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.5953949093818665},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5695636868476868},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.4990229606628418},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3886493146419525},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3441588282585144},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2963220477104187},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29478922486305237}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001711","descriptor_name":"Biotransformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005243","descriptor_name":"Feces","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006868","descriptor_name":"Hydrolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D013056","descriptor_name":"Spectrophotometry, Ultraviolet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D018894","descriptor_name":"Reverse Transcriptase Inhibitors","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D020008","descriptor_name":"Delavirdine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:9224777","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9224777","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug metabolism and disposition: the biological fate of chemicals","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.912.1723","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.912.1723","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://dmd.aspetjournals.org/content/25/7/828.full.pdf","raw_type":"text"},{"id":"mag:1833416738","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9224777","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1971413009","https://openalex.org/W1979161571","https://openalex.org/W2001967406","https://openalex.org/W2006959383","https://openalex.org/W2010944339","https://openalex.org/W2028143521","https://openalex.org/W2032026161","https://openalex.org/W2034209707","https://openalex.org/W2046134251","https://openalex.org/W2053506445","https://openalex.org/W2062388675","https://openalex.org/W2072409481","https://openalex.org/W2074495023","https://openalex.org/W2086020611","https://openalex.org/W2086462809","https://openalex.org/W2091774457","https://openalex.org/W2102973576","https://openalex.org/W2127439444","https://openalex.org/W2129048881","https://openalex.org/W2146723818","https://openalex.org/W2164625231","https://openalex.org/W2171727029","https://openalex.org/W2180476901","https://openalex.org/W2325115797","https://openalex.org/W2333399282","https://openalex.org/W2336036809","https://openalex.org/W2418339929","https://openalex.org/W2921073505"],"related_works":["https://openalex.org/W2171727029","https://openalex.org/W2146723818","https://openalex.org/W2278215877","https://openalex.org/W1834558831","https://openalex.org/W2471678155","https://openalex.org/W1862796809","https://openalex.org/W3159574890","https://openalex.org/W2789289526","https://openalex.org/W2087707746","https://openalex.org/W1561327252"],"abstract_inverted_index":{"Delavirdine":[0,132],"mesylate":[1,39],"(U-90152T)":[2],"is":[3],"a":[4,110],"highly":[5],"specific":[6],"nonnucleoside":[7],"HIV-1":[8],"reverse":[9],"transcriptase":[10],"inhibitor":[11],"currently":[12],"under":[13],"development":[14],"for":[15],"the":[16,78,137,166,178,182,204,214,229],"treatment":[17],"of":[18,27,37,43,51,77,89,163,181,216],"AIDS.":[19],"The":[20,161],"excretion,":[21],"disposition,":[22],"brain":[23,151],"penetration,":[24],"and":[25,48,59,83,91,104,120,170,185,194,199,235],"metabolism":[26,123,162],"delavirdine":[28,90,101,126,164,217,220],"were":[29,55,118,203],"investigated":[30],"in":[31,81,85,97,113,150,159,165],"CD-1":[32],"mice":[33],"after":[34,236],"oral":[35],"administration":[36],"[14C]delavirdine":[38],"at":[40,152,177,208,232],"single":[41],"doses":[42,50,211,234],"10":[44],"and/or":[45,192],"250":[46],"mg/kg":[47],"multiple":[49,237],"200":[52],"mg/kg/day.":[53],"Studies":[54],"conducted":[56],"with":[57,75],"14C-carboxamide":[58],"2-14C-pyridine":[60],"labels,":[61],"as":[62,64,188,213],"well":[63],"13C3-labeled":[65],"drug":[66,210],"to":[67,124,155,218],"facilitate":[68],"metabolite":[69,94,143],"identification.":[70],"Excretion":[71],"was":[72,102,127,168],"dose":[73],"dependent":[74],"57-70%":[76],"radioactivity":[79],"eliminated":[80],"feces":[82],"25-36%":[84],"urine.":[86],"Pharmacokinetic":[87],"analyses":[88],"its":[92,116,122,141],"N-desisopropyl":[93],"(desalkyl":[95],"delavirdine)":[96],"plasma":[98],"showed":[99],"that":[100,107,115,121],"absorbed":[103],"metabolized":[105],"rapidly,":[106],"it":[108],"constituted":[109],"minor":[111],"component":[112],"circulation,":[114],"pharmacokinetics":[117],"nonlinear,":[119],"desalkyl":[125,219],"capacity":[128],"limited":[129],"or":[130,223],"inhibitable.":[131],"did":[133],"not":[134],"significantly":[135],"cross":[136],"blood-brain":[138],"barrier;":[139],"however,":[140],"N-isopropylpyridinepiperazine":[142],"arising":[144],"from":[145],"amide":[146,172,200,225],"bond":[147,173,201,226],"cleavage-was":[148],"present":[149],"levels":[153],"2-":[154],"3-fold":[156],"higher":[157,233],"than":[158],"plasma.":[160],"mouse":[167],"extensive":[169],"involved":[171],"cleavage,":[174],"N-desalkylation,":[175],"hydroxylation":[176],"C-6'":[179],"position":[180],"pyridine":[183,186],"ring,":[184],"ring-cleavage":[187],"determined":[189],"by":[190],"MS":[191],"1H":[193],"13C":[195],"NMR":[196],"spectroscopies.":[197],"N-desalkylation":[198],"cleavage":[202,227],"primary":[205],"metabolic":[206],"pathways":[207],"low":[209],"and,":[212],"biotransformation":[215],"reached":[221],"saturation":[222],"inhibition,":[224],"became":[228],"predominant":[230],"pathway":[231],"doses.":[238]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}