{"id":"https://openalex.org/W1832918544","doi":"https://doi.org/10.1016/s0026-895x(25)09876-1","title":"Determination and characterization of a cannabinoid receptor in rat brain.","display_name":"Determination and characterization of a cannabinoid receptor in rat brain.","publication_year":1988,"publication_date":"1988-11-01","ids":{"openalex":"https://openalex.org/W1832918544","doi":"https://doi.org/10.1016/s0026-895x(25)09876-1","mag":"1832918544","pmid":"https://pubmed.ncbi.nlm.nih.gov/2848184"},"language":"en","primary_location":{"id":"doi:10.1016/s0026-895x(25)09876-1","doi":"https://doi.org/10.1016/s0026-895x(25)09876-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0026-895x(25)09876-1","pdf_url":null,"source":{"id":"https://openalex.org/S62949411","display_name":"Molecular Pharmacology","issn_l":"0026-895X","issn":["0026-895X","1521-0111"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069581646","display_name":"William A. Devane","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47838141","display_name":"Saint Louis University","ror":"https://ror.org/01p7jjy08","country_code":"US","type":"education","lineage":["https://openalex.org/I47838141"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W A Devane","raw_affiliation_strings":["Department of Pharmacology, St. Louis University Medical School, Missouri 63104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, St. Louis University Medical School, Missouri 63104","institution_ids":["https://openalex.org/I47838141"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067003591","display_name":"F A Dysarz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F A Dysarz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028187830","display_name":"M R Johnson","orcid":"https://orcid.org/0000-0003-0846-7978","observed_orcids":["https://orcid.org/0000-0003-0846-7978"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M R Johnson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110665894","display_name":"Lawrence S. Melvin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L S Melvin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5015356306","display_name":"A\u00adllyn C. Howlett","orcid":"https://orcid.org/0000-0002-2810-0164","observed_orcids":["https://orcid.org/0000-0002-2810-0164"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A C Howlett","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3600,"currency":"USD","value_usd":3600},"apc_paid":null,"fwci":15.1245,"has_fulltext":false,"cited_by_count":2465,"citation_normalized_percentile":{"value":0.99420626,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"34","issue":"5","first_page":"605","last_page":"613"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cannabinoid-receptors","display_name":"cannabinoid receptors","score":0.9110000133514404},{"id":"https://openalex.org/keywords/cp-55-940","display_name":"CP55,940","score":0.8840000033378601},{"id":"https://openalex.org/keywords/rat-brain","display_name":"rat brain","score":0.5889999866485596},{"id":"https://openalex.org/keywords/synaptosomes","display_name":"synaptosomes","score":0.9819999933242798},{"id":"https://openalex.org/keywords/delta9-tetrahydrocannabinol","display_name":"delta-9-tetrahydrocannabinol","score":0.7900000214576721},{"id":"https://openalex.org/keywords/g-protein-coupling","display_name":"G protein coupling","score":0.5759999752044678},{"id":"https://openalex.org/keywords/allosteric-regulation","display_name":"allosteric regulation","score":0.8550000190734863},{"id":"https://openalex.org/keywords/guanylylimidodiphosphate","display_name":"guanylylimidodiphosphate","score":0.8579999804496765},{"id":"https://openalex.org/keywords/binding-kinetics","display_name":"binding kinetics","score":0.5460000038146973},{"id":"https://openalex.org/keywords/receptor-selectivity","display_name":"receptor selectivity","score":0.3490000069141388},{"id":"https://openalex.org/keywords/cannabidiol","display_name":"cannabidiol","score":0.5950000286102295},{"id":"https://openalex.org/keywords/cannabigerol","display_name":"cannabigerol","score":0.9620000123977661},{"id":"https://openalex.org/keywords/delta9-thc","display_name":"\u03949-THC","score":0.5609999895095825},{"id":"https://openalex.org/keywords/cannabinoid-analgesia","display_name":"cannabinoid analgesia","score":0.44600000977516174}],"concepts":[{"id":"https://openalex.org/C118716","wikidata":"https://www.wikidata.org/wiki/Q5514725","display_name":"GTP'","level":3,"score":0.6766351461410522},{"id":"https://openalex.org/C166014724","wikidata":"https://www.wikidata.org/wiki/Q337217","display_name":"Cooperativity","level":2,"score":0.6685935258865356},{"id":"https://openalex.org/C166342909","wikidata":"https://www.wikidata.org/wiki/Q845326","display_name":"Allosteric regulation","level":3,"score":0.650972306728363},{"id":"https://openalex.org/C74998103","wikidata":"https://www.wikidata.org/wiki/Q898254","display_name":"Dissociation constant","level":3,"score":0.6493851542472839},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6344641447067261},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.5954539775848389},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.5921892523765564},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.5850421190261841},{"id":"https://openalex.org/C2910065304","wikidata":"https://www.wikidata.org/wiki/Q422936","display_name":"Cannabinoid Receptor Agonists","level":5,"score":0.528876781463623},{"id":"https://openalex.org/C2780871563","wikidata":"https://www.wikidata.org/wiki/Q422936","display_name":"Cannabinoid","level":3,"score":0.5279126763343811},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4947170913219452},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.4849105477333069},{"id":"https://openalex.org/C187250156","wikidata":"https://www.wikidata.org/wiki/Q2902610","display_name":"Cooperative binding","level":3,"score":0.47469180822372437},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.45520973205566406},{"id":"https://openalex.org/C80631254","wikidata":"https://www.wikidata.org/wiki/Q407438","display_name":"G protein","level":3,"score":0.4185541570186615},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3630099892616272},{"id":"https://openalex.org/C148001335","wikidata":"https://www.wikidata.org/wiki/Q421237","display_name":"Cannabinoid receptor","level":4,"score":0.29585379362106323},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.28881311416625977},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16988679766654968},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.11453735828399658}],"mesh":[{"descriptor_ui":"D000494","descriptor_name":"Allosteric Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001923","descriptor_name":"Brain Chemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003511","descriptor_name":"Cyclohexanols","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006165","descriptor_name":"Guanylyl Imidodiphosphate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008274","descriptor_name":"Magnesium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011955","descriptor_name":"Receptors, Drug","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D011955","descriptor_name":"Receptors, Drug","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012964","descriptor_name":"Sodium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013759","descriptor_name":"Dronabinol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D043882","descriptor_name":"Receptors, Cannabinoid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1016/s0026-895x(25)09876-1","doi":"https://doi.org/10.1016/s0026-895x(25)09876-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0026-895x(25)09876-1","pdf_url":null,"source":{"id":"https://openalex.org/S62949411","display_name":"Molecular Pharmacology","issn_l":"0026-895X","issn":["0026-895X","1521-0111"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Pharmacology","raw_type":"journal-article"},{"id":"pmid:2848184","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2848184","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.572.7935","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.572.7935","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://depts.washington.edu/stellalb/images/Devane Mol Pharm.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.918.8113","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.918.8113","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://molpharm.aspetjournals.org/content/34/5/605.full.pdf","raw_type":"text"},{"id":"mag:1832918544","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2848184","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5558004975","display_name":"GRADUATE TRAINING IN NEUROPHARMACOLOGY","funder_award_id":"T32NS007254","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G8370930516","display_name":"ADENYLATE CYCLASE REGULATION IN NEUROBLASTOMA CELLS","funder_award_id":"K04NS000868","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G8844757424","display_name":"Cannabinoid Receptors in Neuronal Cells and Brain","funder_award_id":"R01DA003690","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"}],"funders":[{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W200391947","https://openalex.org/W1511301017","https://openalex.org/W1521164056","https://openalex.org/W1548579074","https://openalex.org/W1781506262","https://openalex.org/W1803077191","https://openalex.org/W1855443240","https://openalex.org/W1862689510","https://openalex.org/W1892183859","https://openalex.org/W1892639411","https://openalex.org/W1961696944","https://openalex.org/W1965361408","https://openalex.org/W1975540427","https://openalex.org/W1985225359","https://openalex.org/W2000990574","https://openalex.org/W2001084464","https://openalex.org/W2014664792","https://openalex.org/W2043813981","https://openalex.org/W2052346438","https://openalex.org/W2057877784","https://openalex.org/W2061170792","https://openalex.org/W2069019047","https://openalex.org/W2082063337","https://openalex.org/W2084652891","https://openalex.org/W2128635872","https://openalex.org/W2247706632","https://openalex.org/W2261451494","https://openalex.org/W2402987118","https://openalex.org/W2413006285","https://openalex.org/W2525840605"],"related_works":["https://openalex.org/W7099025765","https://openalex.org/W1836729582","https://openalex.org/W2417741841","https://openalex.org/W331446370","https://openalex.org/W2002935274","https://openalex.org/W2031823540","https://openalex.org/W2254129415","https://openalex.org/W2029181309","https://openalex.org/W2060781840","https://openalex.org/W2133433899"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":34},{"year":2025,"cited_by_count":61},{"year":2024,"cited_by_count":62},{"year":2023,"cited_by_count":76},{"year":2022,"cited_by_count":69},{"year":2021,"cited_by_count":81},{"year":2020,"cited_by_count":110},{"year":2019,"cited_by_count":80},{"year":2018,"cited_by_count":100},{"year":2017,"cited_by_count":79},{"year":2016,"cited_by_count":98},{"year":2015,"cited_by_count":87},{"year":2014,"cited_by_count":89},{"year":2013,"cited_by_count":89},{"year":2012,"cited_by_count":86}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
