{"id":"https://openalex.org/W1831738245","doi":"https://doi.org/10.1523/jneurosci.18-19-07953.1998","title":"Brain-Derived Neurotrophic Factor and Basic Fibroblast Growth Factor Downregulate NMDA Receptor Function in Cerebellar Granule Cells","display_name":"Brain-Derived Neurotrophic Factor and Basic Fibroblast Growth Factor Downregulate NMDA Receptor Function in Cerebellar Granule Cells","publication_year":1998,"publication_date":"1998-10-01","ids":{"openalex":"https://openalex.org/W1831738245","doi":"https://doi.org/10.1523/jneurosci.18-19-07953.1998","mag":"1831738245","pmid":"https://pubmed.ncbi.nlm.nih.gov/9742162","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6792992"},"language":"en","primary_location":{"id":"doi:10.1523/jneurosci.18-19-07953.1998","doi":"https://doi.org/10.1523/jneurosci.18-19-07953.1998","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.18-19-07953.1998","pdf_url":"https://www.jneurosci.org/content/jneuro/18/19/7953.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.jneurosci.org/content/jneuro/18/19/7953.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079757385","display_name":"Cinzia Brandoli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cinzia Brandoli","raw_affiliation_strings":["Department of Cell Biology, Division of Neurobiology, Georgetown University, School of Medicine, Washington, DC 20007, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Division of Neurobiology, Georgetown University, School of Medicine, Washington, DC 20007, and","institution_ids":["https://openalex.org/I184565670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042203237","display_name":"Angela Sanna","orcid":"https://orcid.org/0000-0001-6390-3811","observed_orcids":["https://orcid.org/0000-0001-6390-3811"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Angela Sanna","raw_affiliation_strings":["Department of Cell Biology, Division of Neurobiology, Georgetown University, School of Medicine, Washington, DC 20007, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Division of Neurobiology, Georgetown University, School of Medicine, Washington, DC 20007, and","institution_ids":["https://openalex.org/I184565670"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Maria A. De Bernardi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria A. De Bernardi","raw_affiliation_strings":["Department of Biology, Johns Hopkins University, Baltimore, Maryland 21218"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Johns Hopkins University, Baltimore, Maryland 21218","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025648351","display_name":"Paolo Follesa","orcid":"https://orcid.org/0000-0003-4857-476X","observed_orcids":["https://orcid.org/0000-0003-4857-476X"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paolo Follesa","raw_affiliation_strings":["Department of Cell Biology, Division of Neurobiology, Georgetown University, School of Medicine, Washington, DC 20007, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Division of Neurobiology, Georgetown University, School of Medicine, Washington, DC 20007, and","institution_ids":["https://openalex.org/I184565670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071284946","display_name":"Gary Brooker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gary Brooker","raw_affiliation_strings":["Department of Biology, Johns Hopkins University, Baltimore, Maryland 21218"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Johns Hopkins University, Baltimore, Maryland 21218","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086700125","display_name":"Italo Mocchetti","orcid":"https://orcid.org/0000-0002-5010-636X","observed_orcids":["https://orcid.org/0000-0002-5010-636X"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Italo Mocchetti","raw_affiliation_strings":["Department of Cell Biology, Division of Neurobiology, Georgetown University, School of Medicine, Washington, DC 20007, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Division of Neurobiology, Georgetown University, School of Medicine, Washington, DC 20007, and","institution_ids":["https://openalex.org/I184565670"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.1802,"has_fulltext":true,"cited_by_count":131,"citation_normalized_percentile":{"value":0.92652685,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"18","issue":"19","first_page":"7953","last_page":"7961"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.875,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.875,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.10350000113248825,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13047","display_name":"Pharmacological Receptor Mechanisms and Effects","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brain-derived-neurotrophic-factor","display_name":"brain-derived neurotrophic factor","score":0.9909999966621399},{"id":"https://openalex.org/keywords/basic-fibroblast-growth-factor","display_name":"basic fibroblast growth factor","score":0.9980000257492065},{"id":"https://openalex.org/keywords/nmda-receptor","display_name":"NMDA receptor","score":0.9629999995231628},{"id":"https://openalex.org/keywords/cerebellar-granule-cells","display_name":"cerebellar granule cells","score":0.9100000262260437},{"id":"https://openalex.org/keywords/excitotoxicity","display_name":"excitotoxicity","score":0.9679999947547913},{"id":"https://openalex.org/keywords/nmda-receptor-subunit-expression","display_name":"NMDA receptor subunit expression","score":0.7559999823570251},{"id":"https://openalex.org/keywords/nr2a","display_name":"NR2A","score":0.9819999933242798},{"id":"https://openalex.org/keywords/nr2c","display_name":"NR2C","score":1.0},{"id":"https://openalex.org/keywords/intracellular-calcium","display_name":"intracellular calcium","score":0.8579999804496765},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8159999847412109},{"id":"https://openalex.org/keywords/trophic-factors","display_name":"trophic factors","score":0.8199999928474426},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.6380000114440918}],"concepts":[{"id":"https://openalex.org/C67018056","wikidata":"https://www.wikidata.org/wiki/Q414896","display_name":"NMDA receptor","level":3,"score":0.8852646946907043},{"id":"https://openalex.org/C2781012912","wikidata":"https://www.wikidata.org/wiki/Q901117","display_name":"Excitotoxicity","level":4,"score":0.8497107625007629},{"id":"https://openalex.org/C160539049","wikidata":"https://www.wikidata.org/wiki/Q3064187","display_name":"Neurotrophic factors","level":3,"score":0.7081049680709839},{"id":"https://openalex.org/C2778790584","wikidata":"https://www.wikidata.org/wiki/Q123045","display_name":"Brain-derived neurotrophic factor","level":4,"score":0.649410605430603},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.5282201766967773},{"id":"https://openalex.org/C2778888523","wikidata":"https://www.wikidata.org/wiki/Q1777753","display_name":"Granule cell","level":4,"score":0.5125231742858887},{"id":"https://openalex.org/C97124661","wikidata":"https://www.wikidata.org/wiki/Q14897782","display_name":"Tropomyosin receptor kinase B","level":4,"score":0.50152587890625},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4895661771297455},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.45949628949165344},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.44746196269989014},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4424407482147217},{"id":"https://openalex.org/C2779652256","wikidata":"https://www.wikidata.org/wiki/Q130983","display_name":"Cerebellum","level":2,"score":0.44208860397338867},{"id":"https://openalex.org/C2780376555","wikidata":"https://www.wikidata.org/wiki/Q5991156","display_name":"Ifenprodil","level":4,"score":0.42308858036994934},{"id":"https://openalex.org/C92020748","wikidata":"https://www.wikidata.org/wiki/Q420457","display_name":"Neurotrophin","level":3,"score":0.4183773398399353},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37979838252067566},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3167600631713867},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.18939250707626343},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11058533191680908},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C2776464000","wikidata":"https://www.wikidata.org/wiki/Q545787","display_name":"Dentate gyrus","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002531","descriptor_name":"Cerebellum","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016194","descriptor_name":"Receptors, N-Methyl-D-Aspartate","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016194","descriptor_name":"Receptors, N-Methyl-D-Aspartate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016202","descriptor_name":"N-Methylaspartate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016222","descriptor_name":"Fibroblast Growth Factor 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016222","descriptor_name":"Fibroblast Growth Factor 2","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018690","descriptor_name":"Excitatory Amino Acid Agonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019208","descriptor_name":"Brain-Derived Neurotrophic Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019208","descriptor_name":"Brain-Derived Neurotrophic Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1523/jneurosci.18-19-07953.1998","doi":"https://doi.org/10.1523/jneurosci.18-19-07953.1998","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.18-19-07953.1998","pdf_url":"https://www.jneurosci.org/content/jneuro/18/19/7953.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},{"id":"pmid:9742162","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9742162","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of neuroscience : the official journal of the Society for Neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6792992","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6792992/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neurosci","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.319.3010","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.319.3010","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.jneurosci.org/content/18/19/7953.full.pdf","raw_type":"text"},{"id":"pmh:oai:iris.unica.it:11584/1560","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11584/1560","pdf_url":null,"source":{"id":"https://openalex.org/S4377196293","display_name":"UNICA IRIS Institutional Research Information System (University of Cagliari)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I172446870","host_organization_name":"University of Cagliari","host_organization_lineage":["https://openalex.org/I172446870"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1523/jneurosci.18-19-07953.1998","doi":"https://doi.org/10.1523/jneurosci.18-19-07953.1998","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.18-19-07953.1998","pdf_url":"https://www.jneurosci.org/content/jneuro/18/19/7953.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1966589399","display_name":"PHARMACOLOGICAL REGULATION OF NGF BIOSYNTHESIS","funder_award_id":"K04NS001675","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G8027807439","display_name":null,"funder_award_id":"HL 48940","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8914565220","display_name":"NEUROTROPHIC FACTORS IN SPINAL CORD TRAUMA","funder_award_id":"R01NS032671","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1831738245.pdf","grobid_xml":"https://content.openalex.org/works/W1831738245.grobid-xml"},"referenced_works_count":64,"referenced_works":["https://openalex.org/W1500403088","https://openalex.org/W1503746610","https://openalex.org/W1509167648","https://openalex.org/W1572972152","https://openalex.org/W1594111906","https://openalex.org/W1634891144","https://openalex.org/W1846750166","https://openalex.org/W1934555453","https://openalex.org/W1956227640","https://openalex.org/W1964610381","https://openalex.org/W1967475748","https://openalex.org/W1975944686","https://openalex.org/W1977087802","https://openalex.org/W1979603689","https://openalex.org/W1990625157","https://openalex.org/W1993657331","https://openalex.org/W1996024251","https://openalex.org/W1998164097","https://openalex.org/W1999514206","https://openalex.org/W2007449350","https://openalex.org/W2010926499","https://openalex.org/W2012762150","https://openalex.org/W2014203854","https://openalex.org/W2016293448","https://openalex.org/W2016575029","https://openalex.org/W2020622065","https://openalex.org/W2024014699","https://openalex.org/W2026371537","https://openalex.org/W2029603067","https://openalex.org/W2029947381","https://openalex.org/W2033027472","https://openalex.org/W2035842921","https://openalex.org/W2042550512","https://openalex.org/W2043027376","https://openalex.org/W2051395367","https://openalex.org/W2053913017","https://openalex.org/W2053980736","https://openalex.org/W2054698601","https://openalex.org/W2058117427","https://openalex.org/W2059334396","https://openalex.org/W2063435429","https://openalex.org/W2063964698","https://openalex.org/W2065169750","https://openalex.org/W2068331749","https://openalex.org/W2068669272","https://openalex.org/W2072406125","https://openalex.org/W2073334350","https://openalex.org/W2075068097","https://openalex.org/W2082249282","https://openalex.org/W2082739481","https://openalex.org/W2088449548","https://openalex.org/W2091758977","https://openalex.org/W2095285097","https://openalex.org/W2106228778","https://openalex.org/W2106963863","https://openalex.org/W2129108032","https://openalex.org/W2141260882","https://openalex.org/W2145817021","https://openalex.org/W2152549690","https://openalex.org/W2157423347","https://openalex.org/W2162900032","https://openalex.org/W2265450818","https://openalex.org/W2282636056","https://openalex.org/W6695513031"],"related_works":["https://openalex.org/W7097954131","https://openalex.org/W2072406125","https://openalex.org/W2029972861","https://openalex.org/W1634891144","https://openalex.org/W2019683276","https://openalex.org/W1979603689","https://openalex.org/W73166752","https://openalex.org/W1967475748","https://openalex.org/W2008811778","https://openalex.org/W2054882546"],"abstract_inverted_index":{"Evidence":[0],"has":[1],"accumulated":[2],"to":[3,31,98,138,187,213,217],"suggest":[4,221],"that":[5,182,195,222],"the":[6,49,59,63,100,103,126,146,149,160,174,205,235],"NMDA":[7,83,87,105,134,206,236,243],"glutamate":[8],"receptor":[9,88,106,135,244],"subtype":[10],"plays":[11],"an":[12],"important":[13],"role":[14],"in":[15,27,125,154],"neuronal":[16,33,218],"degeneration":[17],"evoked":[18],"by":[19,85,164,233],"hypoxia,":[20],"ischemia,":[21],"or":[22,115],"trauma.":[23],"Cerebellar":[24],"granule":[25,74,229],"cells":[26,230],"culture":[28],"are":[29],"vulnerable":[30],"NMDA-induced":[32],"excitotoxicity.":[34],"In":[35],"these":[36,67,196],"cells,":[37,75],"brain-derived":[38],"neurotrophic":[39],"factor":[40,46],"(BDNF)":[41],"and":[42,80,92,111,119,130,151,156,171,190,224],"basic":[43],"fibroblast":[44],"growth":[45],"(FGF2)":[47],"prevent":[48,82],"excitotoxic":[50],"effect":[51,147],"of":[52,66,102,128,148,204,242],"NMDA.":[53],"However,":[54],"little":[55],"is":[56,211],"known":[57],"about":[58],"molecular":[60],"mechanisms":[61],"underlying":[62],"protective":[64],"properties":[65],"trophic":[68,197],"factors.":[69],"Using":[70],"cultured":[71],"rat":[72],"cerebellar":[73,228],"we":[76,144,220],"investigated":[77],"whether":[78],"BDNF":[79,114,120,170,223],"FGF2":[81,116,118,172,225],"toxicity":[84],"downregulating":[86],"function.":[89],"Western":[90],"blot":[91],"RNase":[93],"protection":[94],"analyses":[95],"were":[96],"used":[97],"determine":[99],"expression":[101,127],"various":[104],"subunits":[107],"(NR1,":[108],"NR2A,":[109],"NR2B,":[110],"NR2C)":[112],"after":[113],"treatment.":[117],"elicited":[121],"a":[122,179,201,240],"time-dependent":[123],"decrease":[124,188],"NR2A":[129,155,189],"NR2C":[131,157,191],"subunits.":[132],"Because":[133,208],"activation":[136],"leads":[137],"increased":[139],"intracellular":[140],"Ca2+":[141,162],"concentration":[142],"([Ca2+]i),":[143],"studied":[145],"BDNF-":[150],"FGF2-induced":[152],"reduction":[153],"synthesis":[158],"on":[159],"NMDA-evoked":[161],"responses":[163],"single-cell":[165],"fura-2":[166],"fluorescence":[167],"ratio":[168],"imaging.":[169],"reduced":[173],"NMDA-mediated":[175],"[Ca2+]i":[176,210],"increase":[177],"with":[178,184],"time":[180],"dependency":[181],"correlates":[183],"their":[185],"ability":[186],"subunit":[192,245],"expression,":[193],"suggesting":[194],"factors":[198],"also":[199],"induce":[200],"functional":[202],"downregulation":[203,241],"receptor.":[207],"sustained":[209],"believed":[212],"be":[214],"causally":[215],"related":[216],"injury,":[219],"may":[226],"protect":[227],"against":[231],"excitotoxicity":[232],"altering":[234],"receptor-Ca2+":[237],"signaling":[238],"via":[239],"expression.":[246]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
