{"id":"https://openalex.org/W1831732289","doi":"https://doi.org/10.4049/jimmunol.176.5.3037","title":"Clonal Competition Inhibits the Proliferation and Differentiation of Adoptively Transferred TCR Transgenic CD4 T Cells in Response to Infection","display_name":"Clonal Competition Inhibits the Proliferation and Differentiation of Adoptively Transferred TCR Transgenic CD4 T Cells in Response to Infection","publication_year":2006,"publication_date":"2006-03-01","ids":{"openalex":"https://openalex.org/W1831732289","doi":"https://doi.org/10.4049/jimmunol.176.5.3037","mag":"1831732289","pmid":"https://pubmed.ncbi.nlm.nih.gov/16493062"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.176.5.3037","doi":"https://doi.org/10.4049/jimmunol.176.5.3037","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.176.5.3037","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/176/5/3037/1215210/3037.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://journals.aai.org/jimmunol/article-pdf/176/5/3037/1215210/3037.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042447717","display_name":"Kathryn E. Foulds","orcid":"https://orcid.org/0000-0003-4418-6495","observed_orcids":["https://orcid.org/0000-0003-4418-6495"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathryn E Foulds","raw_affiliation_strings":["Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058321884","display_name":"Hao Shen","orcid":"https://orcid.org/0000-0002-5003-4992","observed_orcids":["https://orcid.org/0000-0002-5003-4992"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hao Shen","raw_affiliation_strings":["Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":3.1537,"has_fulltext":true,"cited_by_count":63,"citation_normalized_percentile":{"value":0.91963029,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"176","issue":"5","first_page":"3037","last_page":"3043"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clonal-competition","display_name":"clonal competition","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.902999997138977},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.9950000047683716},{"id":"https://openalex.org/keywords/t-cell-proliferation","display_name":"T cell proliferation","score":0.8730000257492065},{"id":"https://openalex.org/keywords/t-cell-differentiation","display_name":"T cell differentiation","score":0.9940000176429749},{"id":"https://openalex.org/keywords/tcr-transgenic-t-cells","display_name":"TCR transgenic T cells","score":0.921999990940094},{"id":"https://openalex.org/keywords/adoptive-transfer","display_name":"adoptive transfer","score":0.9100000262260437},{"id":"https://openalex.org/keywords/bacterial-infection","display_name":"bacterial infection","score":0.8769999742507935},{"id":"https://openalex.org/keywords/precursor-frequency","display_name":"precursor frequency","score":0.8149999976158142},{"id":"https://openalex.org/keywords/t-cell-heterogeneity","display_name":"T cell heterogeneity","score":0.5809999704360962},{"id":"https://openalex.org/keywords/effector-t-cells","display_name":"effector T cells","score":0.5740000009536743}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6260775327682495},{"id":"https://openalex.org/C129374314","wikidata":"https://www.wikidata.org/wiki/Q909381","display_name":"Interleukin 21","level":4,"score":0.5850657224655151},{"id":"https://openalex.org/C90375314","wikidata":"https://www.wikidata.org/wiki/Q3537484","display_name":"Adoptive cell transfer","level":4,"score":0.5827635526657104},{"id":"https://openalex.org/C956191","wikidata":"https://www.wikidata.org/wiki/Q930144","display_name":"Polyclonal antibodies","level":3,"score":0.5763228535652161},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.5673341751098633},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.5106900334358215},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5023739337921143},{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.48706725239753723},{"id":"https://openalex.org/C139563560","wikidata":"https://www.wikidata.org/wiki/Q224930","display_name":"Natural killer T cell","level":4,"score":0.48171764612197876},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.45351096987724304},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.4485003352165222},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.44269391894340515},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.4295494854450226},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.3379446268081665},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.28130537271499634},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.16895198822021484},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.10367926955223083},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.09219026565551758},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06680798530578613},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002999","descriptor_name":"Clone Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018791","descriptor_name":"CD4 Lymphocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019264","descriptor_name":"Adoptive Transfer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.4049/jimmunol.176.5.3037","doi":"https://doi.org/10.4049/jimmunol.176.5.3037","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.176.5.3037","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/176/5/3037/1215210/3037.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:16493062","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16493062","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Comparative Study"}],"best_oa_location":{"id":"doi:10.4049/jimmunol.176.5.3037","doi":"https://doi.org/10.4049/jimmunol.176.5.3037","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.176.5.3037","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/176/5/3037/1215210/3037.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4500390075","display_name":null,"funder_award_id":"AI 45025","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6514533724","display_name":"Cellular Immune Surveillance of Intracellular bacteria","funder_award_id":"R01AI045025","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1831732289.pdf","grobid_xml":"https://content.openalex.org/works/W1831732289.grobid-xml"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W127959263","https://openalex.org/W1482928030","https://openalex.org/W1487003048","https://openalex.org/W1507800008","https://openalex.org/W1508314971","https://openalex.org/W1517571699","https://openalex.org/W1557947969","https://openalex.org/W1594421029","https://openalex.org/W1603918837","https://openalex.org/W1610017743","https://openalex.org/W1654634869","https://openalex.org/W1664407784","https://openalex.org/W1905725226","https://openalex.org/W1931750338","https://openalex.org/W1944811313","https://openalex.org/W1953252508","https://openalex.org/W1959677146","https://openalex.org/W1965786965","https://openalex.org/W1972511495","https://openalex.org/W1981027928","https://openalex.org/W1995835059","https://openalex.org/W1996483176","https://openalex.org/W2004028083","https://openalex.org/W2010436799","https://openalex.org/W2013602773","https://openalex.org/W2018590888","https://openalex.org/W2019337269","https://openalex.org/W2025484368","https://openalex.org/W2038991030","https://openalex.org/W2039848934","https://openalex.org/W2041218370","https://openalex.org/W2042250320","https://openalex.org/W2045008512","https://openalex.org/W2050278093","https://openalex.org/W2054678965","https://openalex.org/W2055495862","https://openalex.org/W2058634008","https://openalex.org/W2064656497","https://openalex.org/W2067701958","https://openalex.org/W2071969437","https://openalex.org/W2072318191","https://openalex.org/W2073391461","https://openalex.org/W2077884399","https://openalex.org/W2086472401","https://openalex.org/W2090481553","https://openalex.org/W2091301099","https://openalex.org/W2093084650","https://openalex.org/W2097398162","https://openalex.org/W2099241614","https://openalex.org/W2100817889","https://openalex.org/W2106860822","https://openalex.org/W2106871637","https://openalex.org/W2108909957","https://openalex.org/W2110459643","https://openalex.org/W2124190967","https://openalex.org/W2125188213","https://openalex.org/W2137639957","https://openalex.org/W2143212200","https://openalex.org/W2146926721","https://openalex.org/W2153268818","https://openalex.org/W2164832071","https://openalex.org/W2410977543"],"related_works":["https://openalex.org/W65820918","https://openalex.org/W1931750338","https://openalex.org/W2041658172","https://openalex.org/W1953252508","https://openalex.org/W2057649717","https://openalex.org/W2117075293","https://openalex.org/W6969373790","https://openalex.org/W1976455260","https://openalex.org/W2133074450","https://openalex.org/W1974636379"],"abstract_inverted_index":{"CD4":[0,18,51,81,91,104,127,147,159],"and":[1,10,33,43,52,66,71,156],"CD8":[2,39,53,73],"T":[3,19,40,54,68,74,82,92,105,118,128,148,160],"cells":[4,20,27,41,75,83,106,129,149,161],"have":[5],"been":[6],"shown":[7],"to":[8,12,45,109],"proliferate":[9],"differentiate":[11,44],"different":[13],"extents":[14],"following":[15,162],"antigenic":[16],"stimulation.":[17],"form":[21],"a":[22,112],"heterogenous":[23],"pool":[24],"of":[25,31,63,101,116,125,134,144,154,158],"effector":[26],"in":[28,87],"various":[29],"stages":[30],"division":[32,86],"differentiation,":[34],"while":[35],"nearly":[36],"all":[37],"responding":[38],"divide":[42],"the":[46,98,132,141,152],"same":[47],"extent.":[48],"We":[49],"examined":[50],"cell":[55],"responses":[56],"during":[57],"bacterial":[58],"infection":[59],"by":[60,111],"adoptive":[61,142],"transfer":[62,143],"CFSE-labeled":[64],"monoclonal":[65,80,103],"polyclonal":[67,72,90],"cells.":[69,93,119,136],"Monoclonal":[70],"both":[76],"divided":[77],"extensively,":[78],"whereas":[79],"underwent":[84],"limited":[85,99],"comparison":[88],"with":[89],"Titration":[94],"studies":[95],"revealed":[96],"that":[97,140],"proliferation":[100,155],"transferred":[102],"was":[107],"due":[108],"inhibition":[110],"high":[113,122],"precursor":[114,123],"frequency":[115,124],"clonal":[117,126],"This":[120],"unusually":[121],"also":[130],"inhibited":[131],"differentiation":[133,157],"these":[135],"These":[137],"results":[138],"suggest":[139],"TCR":[145],"transgenic":[146],"significantly":[150],"underestimates":[151],"extent":[153],"infection.":[163]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}