{"id":"https://openalex.org/W182946511","doi":null,"title":"Emerging targets for diabetes","display_name":"Emerging targets for diabetes","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W182946511","mag":"182946511"},"language":"en","primary_location":{"id":"mag:182946511","doi":null,"is_oa":false,"landing_page_url":"http://www.iisc.ernet.in/currsci/jan252005/241.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Current Science","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009922162","display_name":"Rakesh Kumar Vats","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rakesh Kumar Vats","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000298191","display_name":"Vivek Kumar","orcid":"https://orcid.org/0000-0003-0983-6253","observed_orcids":["https://orcid.org/0000-0003-0983-6253"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vivek Kumar","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0983-6253","affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Abhishek Kothari","orcid":"https://orcid.org/0000-0003-0196-7021","observed_orcids":["https://orcid.org/0000-0003-0196-7021"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Abhishek Kothari","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0196-7021","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025020193","display_name":"Alka Mital","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alka Mital","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5081131660","display_name":"Uma Ramachandran","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152674","display_name":"National Institute of Pharmaceutical Education and Research","ror":"https://ror.org/0418yqg16","country_code":"IN","type":"government","lineage":["https://openalex.org/I4210152674"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Uma Ramachandran","raw_affiliation_strings":["National Institute of Pharmaceutical Education and Research, Mohali"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Pharmaceutical Education and Research, Mohali","institution_ids":["https://openalex.org/I4210152674"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.413,"has_fulltext":false,"cited_by_count":60,"citation_normalized_percentile":{"value":0.51269022,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"88","issue":"2","first_page":"241","last_page":"249"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.5795999765396118,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.5795999765396118,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.17579999566078186,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.11320000141859055,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9980000257492065},{"id":"https://openalex.org/keywords/ppar-agonists","display_name":"PPAR agonists","score":0.7860000133514404},{"id":"https://openalex.org/keywords/ptp1b","display_name":"PTP1B","score":0.921999990940094},{"id":"https://openalex.org/keywords/glycogen-synthase-kinase-3","display_name":"glycogen synthase kinase-3","score":0.996999979019165},{"id":"https://openalex.org/keywords/gsk-3-inhibitors","display_name":"GSK-3 inhibitors","score":0.9980000257492065},{"id":"https://openalex.org/keywords/insulin-signaling","display_name":"insulin signaling","score":0.8199999928474426},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.6600000262260437},{"id":"https://openalex.org/keywords/small-molecule-inhibitors","display_name":"small molecule inhibitors","score":0.574999988079071},{"id":"https://openalex.org/keywords/peptide-inhibitors","display_name":"peptide inhibitors","score":0.503000020980835}],"concepts":[{"id":"https://openalex.org/C182996813","wikidata":"https://www.wikidata.org/wiki/Q910847","display_name":"GSK-3","level":3,"score":0.6920480132102966},{"id":"https://openalex.org/C187345961","wikidata":"https://www.wikidata.org/wiki/Q419629","display_name":"Peroxisome proliferator-activated receptor","level":3,"score":0.48374199867248535},{"id":"https://openalex.org/C112446052","wikidata":"https://www.wikidata.org/wiki/Q422579","display_name":"Insulin receptor","level":4,"score":0.4746949076652527},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.47028234601020813},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45799973607063293},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.4570091664791107},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4536612927913666},{"id":"https://openalex.org/C192118531","wikidata":"https://www.wikidata.org/wiki/Q86360001","display_name":"Glycogen synthase","level":3,"score":0.44312405586242676},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.4353247284889221},{"id":"https://openalex.org/C161624437","wikidata":"https://www.wikidata.org/wiki/Q1988322","display_name":"Small molecule","level":2,"score":0.4346909523010254},{"id":"https://openalex.org/C178666793","wikidata":"https://www.wikidata.org/wiki/Q422476","display_name":"Phosphatase","level":3,"score":0.4221900701522827},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4011438190937042},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3967919945716858},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3813599646091461},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3774647116661072},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.37340492010116577},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2693588435649872},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.22296753525733948},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.21495845913887024},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2041204273700714},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.1936570703983307}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:182946511","doi":null,"is_oa":false,"landing_page_url":"http://www.iisc.ernet.in/currsci/jan252005/241.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Current Science","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":59,"referenced_works":["https://openalex.org/W36311596","https://openalex.org/W47751326","https://openalex.org/W1595616331","https://openalex.org/W1964378600","https://openalex.org/W1964631519","https://openalex.org/W1968855624","https://openalex.org/W1976842203","https://openalex.org/W1983435458","https://openalex.org/W1987653445","https://openalex.org/W1994299107","https://openalex.org/W1999956087","https://openalex.org/W2005319662","https://openalex.org/W2013948951","https://openalex.org/W2017592134","https://openalex.org/W2018194304","https://openalex.org/W2025143050","https://openalex.org/W2031975777","https://openalex.org/W2037783340","https://openalex.org/W2038084705","https://openalex.org/W2039386983","https://openalex.org/W2046820708","https://openalex.org/W2048080194","https://openalex.org/W2050456578","https://openalex.org/W2053674933","https://openalex.org/W2054851762","https://openalex.org/W2058138221","https://openalex.org/W2058157372","https://openalex.org/W2061469716","https://openalex.org/W2064913654","https://openalex.org/W2066593112","https://openalex.org/W2071154296","https://openalex.org/W2074743601","https://openalex.org/W2077857391","https://openalex.org/W2087197447","https://openalex.org/W2089172994","https://openalex.org/W2093167749","https://openalex.org/W2096835691","https://openalex.org/W2098017074","https://openalex.org/W2109479865","https://openalex.org/W2112414398","https://openalex.org/W2113613169","https://openalex.org/W2122608005","https://openalex.org/W2124867155","https://openalex.org/W2125904354","https://openalex.org/W2130357785","https://openalex.org/W2143287170","https://openalex.org/W2148165059","https://openalex.org/W2174349368","https://openalex.org/W2174384846","https://openalex.org/W2174769933","https://openalex.org/W2177916499","https://openalex.org/W2178382797","https://openalex.org/W2179133849","https://openalex.org/W2226825713","https://openalex.org/W2337454357","https://openalex.org/W2589061009","https://openalex.org/W2949871577","https://openalex.org/W3146039437","https://openalex.org/W4381572606"],"related_works":["https://openalex.org/W7169715143","https://openalex.org/W1738841762","https://openalex.org/W2914307176","https://openalex.org/W6907822806","https://openalex.org/W1968265981","https://openalex.org/W3189647023","https://openalex.org/W2054022064","https://openalex.org/W4384926822","https://openalex.org/W2469324777","https://openalex.org/W2387037334"],"abstract_inverted_index":{"The":[0,65,130],"worldwide":[1],"epidemic":[2],"of":[3,21,33,53,67,76,87,132,174],"type":[4],"2":[5],"diabetes":[6],"(NIDDM)":[7],"has":[8,48,145,160],"been":[9,146,161],"stimulating":[10],"the":[11,19,31,40,51,63,74,84,96,156,172],"search":[12],"for":[13,18,126,171],"new":[14],"concepts":[15],"and":[16,42,55,80,116,182],"targets":[17,125],"treatment":[20],"this":[22,128],"incurable":[23],"disease.":[24,64,129],"Most":[25],"current":[26],"therapies":[27],"were":[28],"developed":[29],"in":[30,46,73,155],"absence":[32],"defined":[34],"molecular":[35],"targets.":[36],"Increasing":[37],"knowledge":[38],"on":[39,180],"biochemical":[41],"cellular":[43],"alterations":[44],"occurring":[45],"NIDDM":[47],"led":[49],"to":[50,61,83,101,105],"development":[52,173],"novel":[54],"potentially":[56],"more":[57],"effective":[58],"therapeutic":[59],"approaches":[60],"treat":[62],"role":[66,154],"peroxisome":[68],"proliferator":[69],"activated":[70],"receptors":[71],"(PPARs)":[72],"regulation":[75],"lipid":[77],"metabolism,":[78],"insulin":[79,157],"triglycerides":[81],"leads":[82],"rational":[85],"design":[86],"several":[88],"PPAR":[89],"agonists.":[90],"However,":[91],"many":[92],"promising":[93],"molecules,":[94],"especially":[95],"dual-acting":[97],"PPAR\u03b3/\u03b1,":[98],"are":[99],"yet":[100],"be":[102],"approved":[103],"due":[104],"safety":[106],"issues.":[107],"Meanwhile,":[108],"two":[109],"targets,":[110],"protein":[111],"tyrosine":[112],"phosphatase":[113],"1B":[114],"(PTP-1B)":[115],"glycogen":[117],"synthase":[118],"kinase-3":[119],"(GSK-3),":[120],"have":[121],"emerged":[122],"as":[123,137,139,167],"validated":[124],"treating":[127],"activity":[131],"various":[133,165],"non-peptidic":[134],"small":[135,140],"molecules":[136],"well":[138],"peptides":[141],"like":[142],"PTP-1B":[143,181],"inhibitors":[144,184],"studied.":[147],"Likewise,":[148],"GSK-3,":[149],"which":[150],"plays":[151],"a":[152,168],"key":[153],"signalling":[158],"pathway,":[159],"intensely":[162],"studied":[163,185],"by":[164],"companies":[166],"potential":[169],"target":[170],"antidiabetic":[175],"therapies.":[176],"This":[177],"review":[178],"focuses":[179],"GSK-3":[183],"until":[186],"now.":[187]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}
