{"id":"https://openalex.org/W182910259","doi":null,"title":"Efficacy, tolerability and safety of nebivolol in patients with hypertension and diabetes: a post-marketing surveillance study.","display_name":"Efficacy, tolerability and safety of nebivolol in patients with hypertension and diabetes: a post-marketing surveillance study.","publication_year":2010,"publication_date":"2010-09-01","ids":{"openalex":"https://openalex.org/W182910259","mag":"182910259","pmid":"https://pubmed.ncbi.nlm.nih.gov/21061833"},"language":"en","primary_location":{"id":"pmid:21061833","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21061833","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European review for medical and pharmacological sciences","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113565004","display_name":"Luc M. Van Bortel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32597200","display_name":"Ghent University","ror":"https://ror.org/00cv9y106","country_code":"BE","type":"education","lineage":["https://openalex.org/I32597200"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"L M Van Bortel","raw_affiliation_strings":["Clinical Pharmacology, Heymans Institute of Pharmacology, Ghent University, Gent, Belgium. luc.vanbortel@UGent.be"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Pharmacology, Heymans Institute of Pharmacology, Ghent University, Gent, Belgium. luc.vanbortel@UGent.be","institution_ids":["https://openalex.org/I32597200"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5113565004"],"corresponding_institution_ids":["https://openalex.org/I32597200"],"apc_list":null,"apc_paid":null,"fwci":0.2141,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.60069132,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"14","issue":"9","first_page":"749","last_page":"58"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13381","display_name":"Heart rate and cardiovascular health","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nebivolol","display_name":"nebivolol","score":1.0},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.9419999718666077},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.9959999918937683},{"id":"https://openalex.org/keywords/beta-blockers","display_name":"beta-blockers","score":0.9129999876022339},{"id":"https://openalex.org/keywords/blood-pressure-reduction","display_name":"blood pressure reduction","score":0.8529999852180481},{"id":"https://openalex.org/keywords/blood-glucose","display_name":"blood glucose","score":0.8550000190734863},{"id":"https://openalex.org/keywords/ldl-cholesterol","display_name":"LDL cholesterol","score":0.7990000247955322},{"id":"https://openalex.org/keywords/hdl-ldl-ratio","display_name":"HDL/LDL ratio","score":0.6349999904632568},{"id":"https://openalex.org/keywords/lipid-profile","display_name":"lipid profile","score":0.6010000109672546},{"id":"https://openalex.org/keywords/tolerability","display_name":"tolerability","score":0.7390000224113464},{"id":"https://openalex.org/keywords/safety","display_name":"safety","score":0.4869999885559082},{"id":"https://openalex.org/keywords/post-marketing-surveillance","display_name":"post-marketing surveillance","score":0.7509999871253967}],"concepts":[{"id":"https://openalex.org/C2777537511","wikidata":"https://www.wikidata.org/wiki/Q418130","display_name":"Nebivolol","level":3,"score":0.9477693438529968},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9135422110557556},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.8650685548782349},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.7326764464378357},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6762646436691284},{"id":"https://openalex.org/C197636746","wikidata":"https://www.wikidata.org/wiki/Q7234359","display_name":"Postmarketing surveillance","level":3,"score":0.6521977186203003},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.6519917249679565},{"id":"https://openalex.org/C2779384505","wikidata":"https://www.wikidata.org/wiki/Q17007513","display_name":"Concomitant","level":2,"score":0.4780595600605011},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.4245266318321228},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.38774579763412476},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.17582464218139648}],"mesh":[{"descriptor_ui":"D000068577","descriptor_name":"Nebivolol","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001578","descriptor_name":"Benzopyrans","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D001578","descriptor_name":"Benzopyrans","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D004983","descriptor_name":"Ethanolamines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D004983","descriptor_name":"Ethanolamines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009426","descriptor_name":"Netherlands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011358","descriptor_name":"Product Surveillance, Postmarketing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014280","descriptor_name":"Triglycerides","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055118","descriptor_name":"Medication Adherence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:21061833","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21061833","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European review for medical and pharmacological sciences","raw_type":"Journal Article"},{"id":"pmh:oai:archive.ugent.be:1167051","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1854/LU-1167051","pdf_url":null,"source":{"id":"https://openalex.org/S4306400478","display_name":"Ghent University Academic Bibliography (Ghent University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I32597200","host_organization_name":"Ghent University","host_organization_lineage":["https://openalex.org/I32597200"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 1128-3602","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W43415297","https://openalex.org/W1967904861","https://openalex.org/W1972110417","https://openalex.org/W1977607782","https://openalex.org/W1978372333","https://openalex.org/W1983425312","https://openalex.org/W1984366579","https://openalex.org/W1988716175","https://openalex.org/W1996667713","https://openalex.org/W2043930879","https://openalex.org/W2055454607","https://openalex.org/W2061971390","https://openalex.org/W2065593854","https://openalex.org/W2069357664","https://openalex.org/W2077461050","https://openalex.org/W2081593917","https://openalex.org/W2083575326","https://openalex.org/W2084881649","https://openalex.org/W2085380381","https://openalex.org/W2087839793","https://openalex.org/W2110121427","https://openalex.org/W2112609544","https://openalex.org/W2114333967","https://openalex.org/W2115013092","https://openalex.org/W2116717490","https://openalex.org/W2121042882","https://openalex.org/W2145775279","https://openalex.org/W2146903578","https://openalex.org/W2313326603","https://openalex.org/W2561675035"],"related_works":["https://openalex.org/W1984366579","https://openalex.org/W2402408323","https://openalex.org/W196041042","https://openalex.org/W2039860067","https://openalex.org/W2612934266","https://openalex.org/W4289173065","https://openalex.org/W2026224288","https://openalex.org/W2417926804","https://openalex.org/W6990616047","https://openalex.org/W2736118933"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1,85],"OBJECTIVES:":[2],"Hypertension":[3],"is":[4,15,44],"a":[5,45,160,273],"widely":[6],"prevalent":[7],"condition":[8],"of":[9,23,41,76,130,137,184,188,193],"elevated":[10],"blood":[11,166,209,278],"pressure":[12,167],"(BP)":[13,168],"and":[14,74,98,105,144,169,241,265,280,284],"the":[16,21,71],"leading":[17],"risk":[18,31],"factor":[19],"for":[20,124,177,186],"development":[22],"cardiovascular":[24],"disease":[25],"(CVD).":[26],"Many":[27],"patients":[28,59,80,88,132,138,150,290],"have":[29],"additional":[30],"factors":[32],"such":[33],"as":[34],"diabetes":[35],"mellitus":[36],"(DM)":[37],"or":[38,196,202],"previous":[39,199],"history":[40],"CVD.":[42],"Nebivolol":[43,155,268],"third-generation":[46],"beta":[47],"(beta)-blockers":[48],"which":[49],"has":[50],"been":[51],"shown":[52],"not":[53],"to":[54,67,120,198],"influence":[55],"metabolic":[56],"parameters":[57],"in":[58,78,109,114,163,208,223,262,288],"with":[60,81,89,141,146,153,159,272,291],"DM.":[61,83,154,293],"This":[62],"postmarketing":[63],"surveillance":[64],"study":[65],"aimed":[66],"collect":[68],"information":[69],"on":[70],"efficacy,":[72],"safety":[73],"tolerability":[75],"nebivolol":[77,122,189],"hypertensive":[79,289],"concomitant":[82,292],"PATIENTS":[84],"METHODS:":[86],"Hypertensive":[87],"DM":[90],"followed":[91],"by":[92],"52":[93],"cardiologists,":[94],"internal":[95],"medicine":[96],"specialists":[97],"general":[99],"practitioners,":[100],"between":[101],"24":[102],"August":[103],"2003":[104],"9":[106],"January":[107],"2007":[108],"The":[110],"Netherlands":[111],"were":[112,118,133,139,151,181,252,260],"included":[113],"this":[115],"study.":[116],"Physicians":[117],"asked":[119],"survey":[121],"treatment":[123,269],"6":[125],"months.":[126,256],"RESULTS:":[127],"A":[128,205],"total":[129,224],"510":[131],"enrolled.":[134],"Overall,":[135],"93.3%":[136],"diagnosed":[140],"essential":[142],"hypertension":[143],"6.7%":[145],"secondary":[147],"hypertension.":[148],"All":[149],"co-diagnosed":[152],"therapy":[156],"was":[157,211,270,285],"associated":[158,271],"significant":[161,206,258],"reduction":[162],"both":[164],"systolic":[165],"diastolic":[170],"BP":[171],"versus":[172],"baseline":[173],"(p":[174],"<":[175],"0.001":[176],"both).":[178],"These":[179],"reductions":[180,222],"seen":[182,212,261],"regardless":[183],"reason":[185],"initiation":[187],"(i.e.":[190],"first":[191],"diagnosis":[192],"hypertension,":[194],"resistance":[195],"intolerance":[197],"antihypertensive":[200],"medication,":[201],"other":[203],"reasons).":[204],"improvement":[207],"glucose":[210,279],"at":[213,254],"4":[214],"months":[215],"(-0.6":[216],"mmol/L;":[217,227,237],"p":[218,228,238,249],"=":[219,229,239,250],"0.021).":[220],"Significant":[221],"cholesterol":[225,235,246,264,282],"(-1.45":[226],"0.006),":[230],"low":[231],"density":[232,243],"lipoprotein":[233,244],"(LDL)":[234],"(-1.32":[236],"0.003)":[240],"LDL/high":[242],"(HDL)":[245],"ratio":[247],"(-0.77;":[248],"0.011)":[251],"observed":[253],"2":[255],"No":[257],"changes":[259],"HDL":[263],"triglycerides.":[266],"CONCLUSION:":[267],"significantly":[274],"reduced":[275],"BP,":[276],"improved":[277],"LDL":[281],"levels":[283],"well":[286],"tolerated":[287]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}