{"id":"https://openalex.org/W1828580903","doi":"https://doi.org/10.1002/mds.25486","title":"Parkin disease and the Lewy body conundrum","display_name":"Parkin disease and the Lewy body conundrum","publication_year":2013,"publication_date":"2013-05-07","ids":{"openalex":"https://openalex.org/W1828580903","doi":"https://doi.org/10.1002/mds.25486","mag":"1828580903","pmid":"https://pubmed.ncbi.nlm.nih.gov/23653422","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3739929"},"language":"en","primary_location":{"id":"doi:10.1002/mds.25486","doi":"https://doi.org/10.1002/mds.25486","is_oa":true,"landing_page_url":"https://doi.org/10.1002/mds.25486","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/mds.25486","source":{"id":"https://openalex.org/S163027424","display_name":"Movement Disorders","issn_l":"0885-3185","issn":["0885-3185","1531-8257"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Movement Disorders","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/mds.25486","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058501876","display_name":"Karen A. Doherty","orcid":"https://orcid.org/0000-0001-6486-9774","observed_orcids":["https://orcid.org/0000-0001-6486-9774"]},"institutions":[{"id":"https://openalex.org/I4405260083","display_name":"UCL Queen Square Institute of Neurology","ror":"https://ror.org/0370htr03","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4405260083","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Karen M. Doherty","raw_affiliation_strings":["Reta Lila Weston Institute of Neurological Studies and Research Laboratories Departments of Molecular Neuroscience and Clinical Neuroscience University College London Institute of Neurology London United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reta Lila Weston Institute of Neurological Studies and Research Laboratories Departments of Molecular Neuroscience and Clinical Neuroscience University College London Institute of Neurology London United Kingdom","institution_ids":["https://openalex.org/I4405260083","https://openalex.org/I45129253"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020514779","display_name":"John Hardy","orcid":"https://orcid.org/0000-0002-3122-0423","observed_orcids":["https://orcid.org/0000-0002-3122-0423"]},"institutions":[{"id":"https://openalex.org/I4405260083","display_name":"UCL Queen Square Institute of Neurology","ror":"https://ror.org/0370htr03","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4405260083","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"John Hardy","raw_affiliation_strings":["Reta Lila Weston Institute of Neurological Studies and Research Laboratories Departments of Molecular Neuroscience and Clinical Neuroscience University College London Institute of Neurology London United Kingdom","University College London Institute of Neurology Reta Lila Weston Institute of Neurological Studies and Research Laboratories Departments of Molecular Neuroscience and Clinical Neuroscience London United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reta Lila Weston Institute of Neurological Studies and Research Laboratories Departments of Molecular Neuroscience and Clinical Neuroscience University College London Institute of Neurology London United Kingdom","institution_ids":["https://openalex.org/I4405260083","https://openalex.org/I45129253"]},{"raw_affiliation_string":"University College London Institute of Neurology Reta Lila Weston Institute of Neurological Studies and Research Laboratories Departments of Molecular Neuroscience and Clinical Neuroscience London United Kingdom","institution_ids":["https://openalex.org/I4405260083","https://openalex.org/I45129253"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4480,"currency":"USD","value_usd":4480},"apc_paid":{"value":4480,"currency":"USD","value_usd":4480},"fwci":0.9739,"has_fulltext":true,"cited_by_count":42,"citation_normalized_percentile":{"value":0.74826065,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"28","issue":"6","first_page":"702","last_page":"704"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Deep Brain Stimulation and Movement Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lrrk2-mutations","display_name":"LRRK2 mutations","score":0.781000018119812},{"id":"https://openalex.org/keywords/alpha-synuclein","display_name":"alpha-synuclein","score":0.8009999990463257},{"id":"https://openalex.org/keywords/lewy-bodies","display_name":"Lewy bodies","score":0.9980000257492065},{"id":"https://openalex.org/keywords/monogenic-parkinson-s-disease","display_name":"monogenic Parkinson's disease","score":0.9100000262260437},{"id":"https://openalex.org/keywords/tau-inclusions","display_name":"tau inclusions","score":0.7839999794960022},{"id":"https://openalex.org/keywords/tdp-43-inclusions","display_name":"TDP-43 inclusions","score":0.9049999713897705},{"id":"https://openalex.org/keywords/pink1","display_name":"PINK1","score":0.8870000243186951},{"id":"https://openalex.org/keywords/park6","display_name":"PARK6","score":0.4790000021457672},{"id":"https://openalex.org/keywords/compound-heterozygosity","display_name":"compound heterozygosity","score":0.6169999837875366}],"concepts":[{"id":"https://openalex.org/C2777668072","wikidata":"https://www.wikidata.org/wiki/Q2472777","display_name":"Parkin","level":4,"score":0.8931078910827637},{"id":"https://openalex.org/C2776477761","wikidata":"https://www.wikidata.org/wiki/Q945930","display_name":"Progressive supranuclear palsy","level":3,"score":0.7363286018371582},{"id":"https://openalex.org/C2779097696","wikidata":"https://www.wikidata.org/wiki/Q1822234","display_name":"Lewy body","level":4,"score":0.575274646282196},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5647600889205933},{"id":"https://openalex.org/C2780938664","wikidata":"https://www.wikidata.org/wiki/Q753278","display_name":"Substantia nigra","level":4,"score":0.5550668835639954},{"id":"https://openalex.org/C2776804853","wikidata":"https://www.wikidata.org/wiki/Q18045837","display_name":"PINK1","level":5,"score":0.541720449924469},{"id":"https://openalex.org/C2776939681","wikidata":"https://www.wikidata.org/wiki/Q18579","display_name":"Frontotemporal lobar degeneration","level":5,"score":0.4787527918815613},{"id":"https://openalex.org/C2777682930","wikidata":"https://www.wikidata.org/wiki/Q1531490","display_name":"Gliosis","level":2,"score":0.466374933719635},{"id":"https://openalex.org/C2776936178","wikidata":"https://www.wikidata.org/wiki/Q1755684","display_name":"Corticobasal degeneration","level":4,"score":0.46542805433273315},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.44450992345809937},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37604451179504395},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3640925884246826},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.346948504447937},{"id":"https://openalex.org/C2778641062","wikidata":"https://www.wikidata.org/wiki/Q18592","display_name":"Frontotemporal dementia","level":4,"score":0.3240012228488922},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.24737629294395447},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.16568788886070251}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D016631","descriptor_name":"Lewy Bodies","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1002/mds.25486","doi":"https://doi.org/10.1002/mds.25486","is_oa":true,"landing_page_url":"https://doi.org/10.1002/mds.25486","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/mds.25486","source":{"id":"https://openalex.org/S163027424","display_name":"Movement Disorders","issn_l":"0885-3185","issn":["0885-3185","1531-8257"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Movement Disorders","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2733431","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3739929","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3739929","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3739929","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mov Disord","raw_type":"Text"},{"id":"pmid:23653422","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23653422","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Movement disorders : official journal of the Movement Disorder Society","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.889.901","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.889.901","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://europepmc.org/backend/ptpmcrender.fcgi?accid%3DPMC3739929%26blobtype%3Dpdf","raw_type":"text"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1393793","doi":null,"is_oa":false,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/1393793/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Movement Disorders , 28 (6) pp. 702-704. (2013)","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1002/mds.25486","doi":"https://doi.org/10.1002/mds.25486","is_oa":true,"landing_page_url":"https://doi.org/10.1002/mds.25486","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/mds.25486","source":{"id":"https://openalex.org/S163027424","display_name":"Movement Disorders","issn_l":"0885-3185","issn":["0885-3185","1531-8257"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Movement Disorders","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3221442283","display_name":"A systematic investigation into the pathogenesis and course of Parkinson's syndrome","funder_award_id":"MC_G1000735","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G8921296992","display_name":"A systematic investigation into the pathogenesis and course of Parkinson's syndrome.","funder_award_id":"089698","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1828580903.pdf","grobid_xml":"https://content.openalex.org/works/W1828580903.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1964364573","https://openalex.org/W1965398181","https://openalex.org/W1971740953","https://openalex.org/W1979486721","https://openalex.org/W1980449640","https://openalex.org/W1987572257","https://openalex.org/W1988457275","https://openalex.org/W1998502756","https://openalex.org/W2005331929","https://openalex.org/W2009270310","https://openalex.org/W2011339216","https://openalex.org/W2023886834","https://openalex.org/W2023992844","https://openalex.org/W2030857589","https://openalex.org/W2036980243","https://openalex.org/W2051157328","https://openalex.org/W2070849668","https://openalex.org/W2073449985","https://openalex.org/W2082535345","https://openalex.org/W2092462980","https://openalex.org/W2095202142","https://openalex.org/W2099708534","https://openalex.org/W2099760974","https://openalex.org/W2109040303","https://openalex.org/W2111542278","https://openalex.org/W2115524420","https://openalex.org/W2133865158","https://openalex.org/W2414246859","https://openalex.org/W2473580629"],"related_works":["https://openalex.org/W1982407233","https://openalex.org/W4411429375","https://openalex.org/W1992632425","https://openalex.org/W2418291081","https://openalex.org/W2057668962","https://openalex.org/W2103306563","https://openalex.org/W2033987066","https://openalex.org/W2004918356","https://openalex.org/W1747975408","https://openalex.org/W2165990404"],"abstract_inverted_index":{"A":[0],"clear":[1],"pathologic":[2],"hallmark":[3],"like":[4],"that":[5],"identified":[6],"in":[7,14,32,48],"sporadic":[8],"Parkinson\u2019s":[9],"disease":[10],"(PD)":[11],"is":[12,39],"lacking":[13],"many":[15],"of":[16,20,35,54,79],"the":[17,33,55],"monogenic":[18],"causes":[19],"PD.":[21],"In":[22],"leucine-rich":[23],"repeat":[24],"kinase":[25,89],"2":[26],"(LRRK2)":[27],"mutations":[28],"(PARK8),":[29],"alpha-synu-clein":[30],"pathology":[31],"form":[34],"Lewy":[36],"bodies":[37],"(LBs)":[38],"frequently,":[40],"but":[41],"not":[42],"consistently,":[43],"observed.":[44],"Other":[45],"path-ologies":[46],"reported":[47],"LRRK2":[49],"cases":[50],"include":[51],"tau":[52],"inclu-sions":[53],"Alzheimer,":[56],"progressive":[57],"supranuclear":[58],"palsy,":[59],"and":[60,65,84,107],"frontotemporal":[61],"lobar":[62],"degeneration":[63],"types,":[64],"TAR":[66],"DNA-binding":[67],"protein":[68],"43":[69],"(TDP-43)":[70],"inclusions.1":[71],"There":[72],"has":[73],"been":[74],"only":[75],"a":[76,80,109],"single":[77],"report":[78],"compound":[81],"heterozygous,":[82],"phosphatase":[83],"tensin":[85],"homolog":[86],"(PTEN)-induced,":[87],"putative":[88],"1":[90],"(PINK1;":[91],"PARK6)":[92],"patient":[93,98],"coming":[94],"to":[95],"autopsy.2":[96],"That":[97],"presented":[99],"with":[100],"asymmetrical":[101],"rigidity":[102],"at":[103],"age":[104],"31":[105],"years":[106],"had":[108]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":3},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}