{"id":"https://openalex.org/W1828368784","doi":null,"title":"Citrate induces apoptotic cell death: a promising way to treat gastric carcinoma?","display_name":"Citrate induces apoptotic cell death: a promising way to treat gastric carcinoma?","publication_year":2011,"publication_date":"2011-03-01","ids":{"openalex":"https://openalex.org/W1828368784","mag":"1828368784","pmid":"https://pubmed.ncbi.nlm.nih.gov/21498699"},"language":"en","primary_location":{"id":"pmid:21498699","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21498699","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069183847","display_name":"Yunfei Lu","orcid":"https://orcid.org/0000-0002-3755-5806","observed_orcids":["https://orcid.org/0000-0002-3755-5806"]},"institutions":[{"id":"https://openalex.org/I4210114068","display_name":"Centre Hospitalier Universitaire de Caen Normandie","ror":"https://ror.org/027arzy69","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210114068"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Yunfei Lu","raw_affiliation_strings":["Department of Thoracic Surgery, CHU de Caen, Avenue de la C\u00f4te de Nacre, 14000 Caen, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Surgery, CHU de Caen, Avenue de la C\u00f4te de Nacre, 14000 Caen, France","institution_ids":["https://openalex.org/I4210114068"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100376213","display_name":"Xiaodong Zhang","orcid":"https://orcid.org/0000-0003-3260-870X","observed_orcids":["https://orcid.org/0000-0003-3260-870X","https://orcid.org/0000-0002-6891-9019"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaodong Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Haitian Zhang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Haitian Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004685062","display_name":"Jiao Xia Lan","orcid":"https://orcid.org/0000-0002-0802-6753","observed_orcids":["https://orcid.org/0000-0002-0802-6753"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jiao Lan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003054860","display_name":"Guangwu Huang","orcid":"https://orcid.org/0000-0002-7376-5691","observed_orcids":["https://orcid.org/0000-0002-7376-5691"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guangwu Huang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063608934","display_name":"Emilie Varin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Emilie Varin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029902285","display_name":"Hubert Lincet","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hubert Lincet","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058425515","display_name":"Laurent Poulain","orcid":"https://orcid.org/0000-0003-2241-3466","observed_orcids":["https://orcid.org/0000-0003-2241-3466"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Laurent Poulain","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5078550481","display_name":"Philippe Icard","orcid":"https://orcid.org/0000-0002-5613-0934","observed_orcids":["https://orcid.org/0000-0002-5613-0934"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Philippe Icard","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.5824,"has_fulltext":false,"cited_by_count":77,"citation_normalized_percentile":{"value":0.82367254,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"31","issue":"3","first_page":"797","last_page":"805"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9643999934196472,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9643999934196472,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.017500000074505806,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.005799999926239252,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/citrate","display_name":"citrate","score":1.0},{"id":"https://openalex.org/keywords/gastric-cancer","display_name":"gastric cancer","score":0.9959999918937683},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.968999981880188},{"id":"https://openalex.org/keywords/mitochondrial-apoptosis","display_name":"mitochondrial apoptosis","score":0.8140000104904175},{"id":"https://openalex.org/keywords/mcl-1","display_name":"Mcl-1","score":0.9570000171661377},{"id":"https://openalex.org/keywords/phosphofructokinase-inhibition","display_name":"phosphofructokinase inhibition","score":0.906000018119812},{"id":"https://openalex.org/keywords/glycolysis-inhibition","display_name":"glycolysis inhibition","score":0.8360000252723694},{"id":"https://openalex.org/keywords/warburg-effect","display_name":"Warburg effect","score":0.871999979019165},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.7990000247955322},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.7559999823570251}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6446459889411926},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5908048152923584},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5899454951286316},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.5743483901023865},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.5567910075187683},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5077093839645386},{"id":"https://openalex.org/C88634738","wikidata":"https://www.wikidata.org/wiki/Q24769543","display_name":"Annexin","level":3,"score":0.5016889572143555},{"id":"https://openalex.org/C109156525","wikidata":"https://www.wikidata.org/wiki/Q56770304","display_name":"Warburg effect","level":4,"score":0.45772111415863037},{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.4490427076816559},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22724032402038574},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.07240849733352661},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06619209051132202}],"mesh":[{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019343","descriptor_name":"Citric Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D019343","descriptor_name":"Citric Acid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048430","descriptor_name":"Cell Shape","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D053144","descriptor_name":"Cell Nucleus Shape","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:21498699","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21498699","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-05418478v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-05418478","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Anticancer Research, 2011, 31 (3), pp.797-805","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:1828368784","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21498699","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W80011325","https://openalex.org/W1506369629","https://openalex.org/W1595308056","https://openalex.org/W1964015820","https://openalex.org/W1969134768","https://openalex.org/W1970468997","https://openalex.org/W1985011732","https://openalex.org/W1986568749","https://openalex.org/W1990802782","https://openalex.org/W1991429659","https://openalex.org/W1997055993","https://openalex.org/W2001389093","https://openalex.org/W2003765708","https://openalex.org/W2027612083","https://openalex.org/W2038745273","https://openalex.org/W2053120671","https://openalex.org/W2054490551","https://openalex.org/W2060137763","https://openalex.org/W2068031883","https://openalex.org/W2072451938","https://openalex.org/W2086546138","https://openalex.org/W2087906318","https://openalex.org/W2090632954","https://openalex.org/W2094912923","https://openalex.org/W2097259163","https://openalex.org/W2098714079","https://openalex.org/W2099445744","https://openalex.org/W2103490418","https://openalex.org/W2106787323","https://openalex.org/W2107497146","https://openalex.org/W2113559991","https://openalex.org/W2121905914","https://openalex.org/W2132955042","https://openalex.org/W2135325091","https://openalex.org/W2141074414","https://openalex.org/W2144575277","https://openalex.org/W2144954025","https://openalex.org/W2145572948","https://openalex.org/W2147321863","https://openalex.org/W2152720583","https://openalex.org/W2158608557","https://openalex.org/W2161128788","https://openalex.org/W2163471981","https://openalex.org/W2166467949","https://openalex.org/W2324601854"],"related_works":["https://openalex.org/W2072299794","https://openalex.org/W2757583396","https://openalex.org/W2346456510","https://openalex.org/W2212719824","https://openalex.org/W3137690728","https://openalex.org/W2765315650","https://openalex.org/W2924303645","https://openalex.org/W2521748409","https://openalex.org/W3009419837","https://openalex.org/W2730966137"],"abstract_inverted_index":{"UNLABELLED:":[0],"Gastric":[1],"carcinoma":[2,73],"is":[3,10],"frequent,":[4],"particularly":[5],"in":[6,120,132,147],"China,":[7],"and":[8,81,102,135,170],"therapy":[9],"often":[11],"inefficient.":[12],"Because":[13],"cancer":[14,159],"cells":[15],"are":[16],"partly":[17],"or":[18],"mainly":[19],"dependent":[20],"on":[21,69],"glycolysis":[22,45],"to":[23,31,89,110,113,162,171],"generate":[24],"adenosine":[25],"triphosphate":[26],"ATP":[27],"(Warburg":[28],"effect)":[29],"and/or":[30,52],"produce":[32],"precursors":[33],"(of":[34],"lipid,":[35],"nucleotides,":[36],"etc.)":[37],"for":[38],"building":[39],"new":[40],"cells,":[41],"any":[42],"inhibition":[43],"of":[44,59,116,142,166,168],"may":[46,53],"slow":[47],"down":[48],"the":[49,117,129,140,143,177],"cell":[50,74,118,122,125,174],"proliferation":[51],"kill":[54],"cells.":[55],"The":[56],"antitumor":[57],"effect":[58],"citrate,":[60],"an":[61,163],"anti-glycolytic":[62],"agent":[63],"inhibiting":[64],"phosphofructokinase":[65],"(PFK)":[66],"was":[67,96],"tested":[68],"two":[70,157],"human":[71],"gastric":[72,158],"lines.":[75,149],"MATERIALS":[76],"AND":[77],"METHODS:":[78],"Cell":[79],"viability":[80],"morphology":[82],"were":[83],"assessed":[84,97],"after":[85],"24-72":[86],"h":[87],"exposure":[88,109],"citrate":[90,111],"(5,":[91],"10,":[92],"220":[93],"mM).":[94],"Apoptosis":[95],"by":[98],"annexin":[99],"V-FITC/PI":[100],"staining":[101],"Western":[103],"immunobloting.":[104],"RESULTS:":[105],"A":[106],"3-day":[107],"continuous":[108],"led":[112],"near":[114],"destruction":[115],"population":[119],"both":[121,148],"lines,":[123,160],"apoptotic":[124,173],"death":[126,175],"occurred":[127],"through":[128],"mitochondrial":[130,178],"pathway":[131],"a":[133],"dose-":[134],"time-dependent":[136],"manner,":[137],"associated":[138],"with":[139],"reduction":[141],"anti-apoptotic":[144],"Mcl-1":[145,169],"protein":[146],"CONCLUSION:":[150],"Citrate":[151],"demonstrates":[152],"strong":[153],"cytotoxic":[154],"activity":[155],"against":[156],"leading":[161],"early":[164],"diminution":[165],"expression":[167],"massive":[172],"involving":[176],"pathway.":[179]},"counts_by_year":[{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
