{"id":"https://openalex.org/W1828091636","doi":"https://doi.org/10.1371/journal.pone.0140324","title":"Acidosis-Induced Dysfunction of Cortical GABAergic Neurons through Astrocyte-Related Excitotoxicity","display_name":"Acidosis-Induced Dysfunction of Cortical GABAergic Neurons through Astrocyte-Related Excitotoxicity","publication_year":2015,"publication_date":"2015-10-16","ids":{"openalex":"https://openalex.org/W1828091636","doi":"https://doi.org/10.1371/journal.pone.0140324","mag":"1828091636","pmid":"https://pubmed.ncbi.nlm.nih.gov/26474076","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4608795"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0140324","doi":"https://doi.org/10.1371/journal.pone.0140324","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0140324","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0140324&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0140324&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081575206","display_name":"Li Ting Huang","orcid":"https://orcid.org/0000-0003-1432-2054","observed_orcids":["https://orcid.org/0000-0003-1432-2054"]},"institutions":[{"id":"https://openalex.org/I169351748","display_name":"Bengbu Medical College","ror":"https://ror.org/01f8qvj05","country_code":"CN","type":"education","lineage":["https://openalex.org/I169351748"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Huang","raw_affiliation_strings":["Department of Pathophysiology, Bengbu Medical College, Bengbu Anhui, China 233000"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathophysiology, Bengbu Medical College, Bengbu Anhui, China 233000","institution_ids":["https://openalex.org/I169351748"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100329356","display_name":"Shidi Zhao","orcid":"https://orcid.org/0009-0005-2481-1347","observed_orcids":["https://orcid.org/0009-0005-2481-1347"]},"institutions":[{"id":"https://openalex.org/I169351748","display_name":"Bengbu Medical College","ror":"https://ror.org/01f8qvj05","country_code":"CN","type":"education","lineage":["https://openalex.org/I169351748"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shidi Zhao","raw_affiliation_strings":["Department of Pathophysiology, Bengbu Medical College, Bengbu Anhui, China 233000"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathophysiology, Bengbu Medical College, Bengbu Anhui, China 233000","institution_ids":["https://openalex.org/I169351748"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100673138","display_name":"Wei L\u00fc","orcid":"https://orcid.org/0000-0001-6668-8432","observed_orcids":["https://orcid.org/0000-0001-6668-8432"]},"institutions":[{"id":"https://openalex.org/I108688024","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65","country_code":"CN","type":"education","lineage":["https://openalex.org/I108688024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Lu","raw_affiliation_strings":["Collaborative Innovation Center for Neurodegenerative Disorders in Shandong, Qingdao University, Medical College, 38 Dengzhou, Shandong China 266021"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Collaborative Innovation Center for Neurodegenerative Disorders in Shandong, Qingdao University, Medical College, 38 Dengzhou, Shandong China 266021","institution_ids":["https://openalex.org/I108688024"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109298675","display_name":"Sudong Guan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169351748","display_name":"Bengbu Medical College","ror":"https://ror.org/01f8qvj05","country_code":"CN","type":"education","lineage":["https://openalex.org/I169351748"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Sudong Guan","raw_affiliation_strings":["Department of Pathophysiology, Bengbu Medical College, Bengbu Anhui, China 233000"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathophysiology, Bengbu Medical College, Bengbu Anhui, China 233000","institution_ids":["https://openalex.org/I169351748"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103011855","display_name":"Yan Zhu","orcid":"https://orcid.org/0000-0002-9858-9129","observed_orcids":["https://orcid.org/0000-0002-9858-9129"]},"institutions":[{"id":"https://openalex.org/I169351748","display_name":"Bengbu Medical College","ror":"https://ror.org/01f8qvj05","country_code":"CN","type":"education","lineage":["https://openalex.org/I169351748"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Zhu","raw_affiliation_strings":["Department of Pathophysiology, Bengbu Medical College, Bengbu Anhui, China 233000"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathophysiology, Bengbu Medical College, Bengbu Anhui, China 233000","institution_ids":["https://openalex.org/I169351748"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100394107","display_name":"Jinhui Wang","orcid":"https://orcid.org/0000-0001-8340-717X","observed_orcids":["https://orcid.org/0000-0001-8340-717X"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210112540","display_name":"Institute of Biophysics","ror":"https://ror.org/01tyv8576","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112540"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jin-Hui Wang","raw_affiliation_strings":["\u00a7Institute of Biophysics, Chinese Academy of Sciences, Beijing, China 100101"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u00a7Institute of Biophysics, Chinese Academy of Sciences, Beijing, China 100101","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210112540"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5100394107"],"corresponding_institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210112540"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":1.9586,"has_fulltext":true,"cited_by_count":32,"citation_normalized_percentile":{"value":0.84390278,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"10","issue":"10","first_page":"e0140324","last_page":"e0140324"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acidosis","display_name":"acidosis","score":0.9470000267028809},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.9010000228881836},{"id":"https://openalex.org/keywords/excitotoxicity","display_name":"excitotoxicity","score":0.9549999833106995},{"id":"https://openalex.org/keywords/extracellular-acidosis","display_name":"extracellular acidosis","score":0.722000002861023},{"id":"https://openalex.org/keywords/intracellular-acidification","display_name":"intracellular acidification","score":0.9200000166893005},{"id":"https://openalex.org/keywords/glutamate-transporters","display_name":"glutamate transporters","score":0.7990000247955322},{"id":"https://openalex.org/keywords/excitatory-synaptic-transmission","display_name":"excitatory synaptic transmission","score":0.8159999847412109},{"id":"https://openalex.org/keywords/nmda-receptor","display_name":"NMDA receptor","score":0.890999972820282},{"id":"https://openalex.org/keywords/ampa-receptors","display_name":"AMPA receptors","score":0.996999979019165},{"id":"https://openalex.org/keywords/neuronal-dysfunction","display_name":"neuronal dysfunction","score":0.5059999823570251},{"id":"https://openalex.org/keywords/neuronal-glial-interactions","display_name":"neuron-glia interactions","score":0.6460000276565552}],"concepts":[{"id":"https://openalex.org/C2779177108","wikidata":"https://www.wikidata.org/wiki/Q18356742","display_name":"GABAergic","level":3,"score":0.8378427028656006},{"id":"https://openalex.org/C2781012912","wikidata":"https://www.wikidata.org/wiki/Q901117","display_name":"Excitotoxicity","level":4,"score":0.7789744138717651},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.674164891242981},{"id":"https://openalex.org/C2777542381","wikidata":"https://www.wikidata.org/wiki/Q502961","display_name":"Astrocyte","level":3,"score":0.6595462560653687},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.6255837678909302},{"id":"https://openalex.org/C2778553927","wikidata":"https://www.wikidata.org/wiki/Q185089","display_name":"Acidosis","level":2,"score":0.5314095616340637},{"id":"https://openalex.org/C2778794669","wikidata":"https://www.wikidata.org/wiki/Q43054","display_name":"Neuron","level":2,"score":0.487191379070282},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4614485800266266},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.45978668332099915},{"id":"https://openalex.org/C112592302","wikidata":"https://www.wikidata.org/wiki/Q1207387","display_name":"Excitatory postsynaptic potential","level":3,"score":0.43709221482276917},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3685115575790405},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.23075485229492188},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.19932806491851807},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.1598653495311737},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12219548225402832},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.12141889333724976},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.10469326376914978}],"mesh":[{"descriptor_ui":"D000138","descriptor_name":"Acidosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000138","descriptor_name":"Acidosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000138","descriptor_name":"Acidosis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001928","descriptor_name":"Brain Diseases, Metabolic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001928","descriptor_name":"Brain Diseases, Metabolic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001928","descriptor_name":"Brain Diseases, Metabolic","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016194","descriptor_name":"Receptors, N-Methyl-D-Aspartate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018091","descriptor_name":"Receptors, AMPA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059330","descriptor_name":"GABAergic Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D059330","descriptor_name":"GABAergic Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0140324","doi":"https://doi.org/10.1371/journal.pone.0140324","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0140324","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0140324&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3594631","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4608795","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4608795","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4608795","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:26474076","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26474076","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.807.4820","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.807.4820","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/e3/9e/pone.0140324.PMC4608795.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:b44e3354ce00488eb1fbfa3d128ab9a5","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/b44e3354ce00488eb1fbfa3d128ab9a5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 10, Iss 10, p e0140324 (2015)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0140324","doi":"https://doi.org/10.1371/journal.pone.0140324","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0140324","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0140324&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2581887346","display_name":null,"funder_award_id":"2013CB531304","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G4838041253","display_name":null,"funder_award_id":"81471123","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G7482993141","display_name":null,"funder_award_id":"2013CB531304 and 2011CB504405","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G8937529219","display_name":null,"funder_award_id":"2011CB504405","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"}],"funders":[{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1828091636.pdf","grobid_xml":"https://content.openalex.org/works/W1828091636.grobid-xml"},"referenced_works_count":73,"referenced_works":["https://openalex.org/W21888672","https://openalex.org/W53655940","https://openalex.org/W170942893","https://openalex.org/W1456309294","https://openalex.org/W1509783207","https://openalex.org/W1746647265","https://openalex.org/W1803201338","https://openalex.org/W1833987967","https://openalex.org/W1951770395","https://openalex.org/W1963612963","https://openalex.org/W1966846060","https://openalex.org/W1969330887","https://openalex.org/W1972643176","https://openalex.org/W1973049742","https://openalex.org/W1974667969","https://openalex.org/W1975067337","https://openalex.org/W1975111111","https://openalex.org/W1978916589","https://openalex.org/W1979250220","https://openalex.org/W1981134260","https://openalex.org/W1983604345","https://openalex.org/W1983836947","https://openalex.org/W1985722883","https://openalex.org/W1991935813","https://openalex.org/W1992321658","https://openalex.org/W1992767102","https://openalex.org/W1997989561","https://openalex.org/W1999205439","https://openalex.org/W2000269220","https://openalex.org/W2001725826","https://openalex.org/W2002660891","https://openalex.org/W2007393557","https://openalex.org/W2008027377","https://openalex.org/W2009882594","https://openalex.org/W2012298075","https://openalex.org/W2013367089","https://openalex.org/W2021525475","https://openalex.org/W2022924617","https://openalex.org/W2025743751","https://openalex.org/W2046080285","https://openalex.org/W2060589548","https://openalex.org/W2062450961","https://openalex.org/W2069057737","https://openalex.org/W2075448078","https://openalex.org/W2078803304","https://openalex.org/W2080203024","https://openalex.org/W2087847776","https://openalex.org/W2088081549","https://openalex.org/W2091463635","https://openalex.org/W2094525659","https://openalex.org/W2099468526","https://openalex.org/W2099967068","https://openalex.org/W2105315909","https://openalex.org/W2112927743","https://openalex.org/W2114008977","https://openalex.org/W2116447221","https://openalex.org/W2117088742","https://openalex.org/W2117224626","https://openalex.org/W2119811163","https://openalex.org/W2134733089","https://openalex.org/W2135477843","https://openalex.org/W2147372806","https://openalex.org/W2155760865","https://openalex.org/W2158299803","https://openalex.org/W2163204327","https://openalex.org/W2167596663","https://openalex.org/W2171647806","https://openalex.org/W2328242134","https://openalex.org/W2405398885","https://openalex.org/W2971304254","https://openalex.org/W3000989334","https://openalex.org/W4242120132","https://openalex.org/W4245792346"],"related_works":["https://openalex.org/W7096235526","https://openalex.org/W2343691154","https://openalex.org/W3026031845","https://openalex.org/W2002660891","https://openalex.org/W2082996793","https://openalex.org/W1987209784","https://openalex.org/W2033275198","https://openalex.org/W2094358812","https://openalex.org/W1988340856","https://openalex.org/W2094525659"],"abstract_inverted_index":{"BACKGROUND:":[0],"Acidosis":[1],"impairs":[2],"cognitions":[3],"and":[4,21,40,66,95,107,120,143],"behaviors":[5],"presumably":[6],"by":[7,87,97,181],"acidification-induced":[8],"changes":[9,189],"in":[10,54,68,76,83,92,127,163,184],"neuronal":[11],"metabolism.":[12],"Cortical":[13],"GABAergic":[14,31,56,64,85,111,150,165,179],"neurons":[15,41,94,180],"are":[16],"vulnerable":[17],"to":[18,25,47,174,186],"pathological":[19],"factors":[20],"their":[22,116,187],"injury":[23,33,162],"leads":[24,173],"brain":[26],"dysfunction.":[27],"How":[28],"acidosis":[29,129,135,172],"induces":[30],"neuron":[32,57,86],"remains":[34],"elusive.":[35],"As":[36],"the":[37,49,52,81,102,141,149,153,164,175],"glia":[38],"cells":[39,65],"interact":[42],"each":[43],"other,":[44],"we":[45,79,113],"intend":[46],"examine":[48],"role":[50],"of":[51,104,155,177],"astrocytes":[53,67,96,142],"acidosis-induced":[55,77,161],"injury.":[58],"RESULTS:":[59],"Experiments":[60],"were":[61],"done":[62],"at":[63],"mouse":[69],"cortical":[70,178],"slices.":[71],"To":[72],"identify":[73],"astrocytic":[74],"involvement":[75],"impairment,":[78],"induced":[80],"acidification":[82,106,109],"single":[84],"infusing":[88],"proton":[89,99],"intracellularly":[90],"or":[91],"both":[93],"using":[98],"extracellularly.":[100],"Compared":[101],"effects":[103],"intracellular":[105,131],"extracellular":[108,128,134,160],"on":[110,140,148],"neurons,":[112],"found":[114],"that":[115,171],"active":[117],"intrinsic":[118],"properties":[119],"synaptic":[121,146],"outputs":[122],"appeared":[123],"more":[124],"severely":[125],"impaired":[126],"than":[130],"acidosis.":[132],"Meanwhile,":[133],"deteriorated":[136],"glutamate":[137,156],"transporter":[138],"currents":[139],"upregulated":[144],"excitatory":[145],"transmission":[147],"neurons.":[151,166],"Moreover,":[152],"antagonists":[154],"NMDA-/AMPA-receptors":[157],"partially":[158],"reverse":[159],"CONCLUSION:":[167],"Our":[168],"studies":[169],"suggest":[170],"dysfunction":[176],"astrocyte-mediated":[182],"excitotoxicity,":[183],"addition":[185],"metabolic":[188],"as":[190],"indicated":[191],"previously.":[192]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
