{"id":"https://openalex.org/W1827306188","doi":null,"title":"Pharmacokinetics and cytoprotective evaluation of Caffeic Acid Phenethyl Amide and fluorinated derivatives against oxidative stress","display_name":"Pharmacokinetics and cytoprotective evaluation of Caffeic Acid Phenethyl Amide and fluorinated derivatives against oxidative stress","publication_year":2012,"publication_date":"2012-12-01","ids":{"openalex":"https://openalex.org/W1827306188","mag":"1827306188"},"language":"en","primary_location":{"id":"pmh:oai:repositories.lib.utexas.edu:2152/19620","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2152/19620","pdf_url":"http://hdl.handle.net/2152/19620","source":{"id":"https://openalex.org/S4306400568","display_name":"Texas ScholarWorks (Texas Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210102904","host_organization_name":"Texas Digital Library","host_organization_lineage":["https://openalex.org/I4210102904"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/2152/19620","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027052380","display_name":"John Yang","orcid":"https://orcid.org/0000-0002-2995-9341","observed_orcids":["https://orcid.org/0000-0002-2995-9341"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"John Yang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2995-9341","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5027052380"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11386","display_name":"Bee Products Chemical Analysis","score":0.5586000084877014,"subfield":{"id":"https://openalex.org/subfields/1109","display_name":"Insect Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11386","display_name":"Bee Products Chemical Analysis","score":0.5586000084877014,"subfield":{"id":"https://openalex.org/subfields/1109","display_name":"Insect Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13013","display_name":"Free Radicals and Antioxidants","score":0.16200000047683716,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.0771000012755394,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/caffeic-acid-phenethyl-ester","display_name":"caffeic acid phenethyl ester","score":0.9079999923706055},{"id":"https://openalex.org/keywords/propolis","display_name":"propolis","score":0.6759999990463257},{"id":"https://openalex.org/keywords/ischemia-reperfusion-injury","display_name":"ischemia-reperfusion injury","score":0.8180000185966492},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9179999828338623},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9670000076293945},{"id":"https://openalex.org/keywords/heme-oxygenase-1","display_name":"heme oxygenase-1","score":0.8220000267028809},{"id":"https://openalex.org/keywords/cytoprotection","display_name":"cytoprotection","score":0.8849999904632568},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.7440000176429749},{"id":"https://openalex.org/keywords/plasma-stability","display_name":"plasma stability","score":0.9380000233650208},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8899999856948853},{"id":"https://openalex.org/keywords/elimination-half-life","display_name":"elimination half-life","score":0.9419999718666077},{"id":"https://openalex.org/keywords/fluorinated-derivatives","display_name":"fluorinated derivatives","score":0.6370000243186951},{"id":"https://openalex.org/keywords/antioxidants","display_name":"antioxidants","score":0.32499998807907104}],"concepts":[{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.7596790790557861},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.7454736828804016},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6461371183395386},{"id":"https://openalex.org/C2778224086","wikidata":"https://www.wikidata.org/wiki/Q414116","display_name":"Caffeic acid","level":3,"score":0.602056086063385},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.49692919850349426},{"id":"https://openalex.org/C2776992468","wikidata":"https://www.wikidata.org/wiki/Q15410860","display_name":"Caffeic acid phenethyl ester","level":4,"score":0.4923185110092163},{"id":"https://openalex.org/C2778439535","wikidata":"https://www.wikidata.org/wiki/Q188777","display_name":"Amide","level":2,"score":0.4894484579563141},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3839690387248993},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.36009714007377625},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.26173412799835205}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:repositories.lib.utexas.edu:2152/19620","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2152/19620","pdf_url":"http://hdl.handle.net/2152/19620","source":{"id":"https://openalex.org/S4306400568","display_name":"Texas ScholarWorks (Texas Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210102904","host_organization_name":"Texas Digital Library","host_organization_lineage":["https://openalex.org/I4210102904"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":null},{"id":"mag:1827306188","doi":null,"is_oa":false,"landing_page_url":"https://repositories.lib.utexas.edu/bitstream/2152/19620/1/yang_dissertation_201291.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:repositories.lib.utexas.edu:2152/19620","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2152/19620","pdf_url":"http://hdl.handle.net/2152/19620","source":{"id":"https://openalex.org/S4306400568","display_name":"Texas ScholarWorks (Texas Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210102904","host_organization_name":"Texas Digital Library","host_organization_lineage":["https://openalex.org/I4210102904"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":null},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1827306188.pdf","grobid_xml":"https://content.openalex.org/works/W1827306188.grobid-xml"},"referenced_works_count":144,"referenced_works":["https://openalex.org/W294459378","https://openalex.org/W336450767","https://openalex.org/W608979747","https://openalex.org/W1211777005","https://openalex.org/W1482877205","https://openalex.org/W1488137278","https://openalex.org/W1500754345","https://openalex.org/W1539606768","https://openalex.org/W1848232804","https://openalex.org/W1853939159","https://openalex.org/W1925799544","https://openalex.org/W1933543714","https://openalex.org/W1938199221","https://openalex.org/W1953423403","https://openalex.org/W1964212038","https://openalex.org/W1964319813","https://openalex.org/W1965610383","https://openalex.org/W1966025347","https://openalex.org/W1966582616","https://openalex.org/W1967493112","https://openalex.org/W1969410811","https://openalex.org/W1976960656","https://openalex.org/W1977364904","https://openalex.org/W1979322807","https://openalex.org/W1980387354","https://openalex.org/W1981169658","https://openalex.org/W1983704825","https://openalex.org/W1984658117","https://openalex.org/W1986832068","https://openalex.org/W1987448495","https://openalex.org/W1987519385","https://openalex.org/W1988449390","https://openalex.org/W1988813908","https://openalex.org/W1988986871","https://openalex.org/W1989267501","https://openalex.org/W1990141059","https://openalex.org/W1990793253","https://openalex.org/W1990989620","https://openalex.org/W1991089895","https://openalex.org/W1993189898","https://openalex.org/W2002786275","https://openalex.org/W2003074357","https://openalex.org/W2003259342","https://openalex.org/W2004283080","https://openalex.org/W2005090916","https://openalex.org/W2006100779","https://openalex.org/W2006210140","https://openalex.org/W2007348887","https://openalex.org/W2010381370","https://openalex.org/W2011937509","https://openalex.org/W2016119011","https://openalex.org/W2017978959","https://openalex.org/W2020178087","https://openalex.org/W2021624588","https://openalex.org/W2024560631","https://openalex.org/W2027953218","https://openalex.org/W2029704497","https://openalex.org/W2031836453","https://openalex.org/W2032662949","https://openalex.org/W2033043158","https://openalex.org/W2034683799","https://openalex.org/W2035088045","https://openalex.org/W2035622300","https://openalex.org/W2042924893","https://openalex.org/W2043505804","https://openalex.org/W2044503008","https://openalex.org/W2044837419","https://openalex.org/W2045023739","https://openalex.org/W2045558912","https://openalex.org/W2046336522","https://openalex.org/W2048730287","https://openalex.org/W2052179261","https://openalex.org/W2052206602","https://openalex.org/W2053344641","https://openalex.org/W2060320036","https://openalex.org/W2060860593","https://openalex.org/W2062145087","https://openalex.org/W2063702713","https://openalex.org/W2068486450","https://openalex.org/W2069704785","https://openalex.org/W2072232906","https://openalex.org/W2075736059","https://openalex.org/W2076706063","https://openalex.org/W2080913298","https://openalex.org/W2081120437","https://openalex.org/W2083668480","https://openalex.org/W2084790338","https://openalex.org/W2085125278","https://openalex.org/W2090109532","https://openalex.org/W2090746201","https://openalex.org/W2094127775","https://openalex.org/W2094783740","https://openalex.org/W2100799723","https://openalex.org/W2101333224","https://openalex.org/W2102610804","https://openalex.org/W2103894155","https://openalex.org/W2105043010","https://openalex.org/W2107824899","https://openalex.org/W2107886181","https://openalex.org/W2110455877","https://openalex.org/W2110565948","https://openalex.org/W2112334970","https://openalex.org/W2112765981","https://openalex.org/W2113398581","https://openalex.org/W2114279453","https://openalex.org/W2114893973","https://openalex.org/W2117752737","https://openalex.org/W2117934439","https://openalex.org/W2122028337","https://openalex.org/W2123011696","https://openalex.org/W2124634540","https://openalex.org/W2129609456","https://openalex.org/W2130271956","https://openalex.org/W2130866079","https://openalex.org/W2137179625","https://openalex.org/W2139967865","https://openalex.org/W2140220135","https://openalex.org/W2146800979","https://openalex.org/W2147616820","https://openalex.org/W2150843985","https://openalex.org/W2151802710","https://openalex.org/W2152919855","https://openalex.org/W2157488207","https://openalex.org/W2159611626","https://openalex.org/W2159976029","https://openalex.org/W2162853795","https://openalex.org/W2163820544","https://openalex.org/W2165070991","https://openalex.org/W2166127265","https://openalex.org/W2168948937","https://openalex.org/W2172249877","https://openalex.org/W2302639653","https://openalex.org/W2308310630","https://openalex.org/W2327239378","https://openalex.org/W2335300675","https://openalex.org/W2335390365","https://openalex.org/W2373814643","https://openalex.org/W2401476466","https://openalex.org/W2405159145","https://openalex.org/W2416845680","https://openalex.org/W2421586627","https://openalex.org/W2462285506","https://openalex.org/W2797663228","https://openalex.org/W4406054934"],"related_works":["https://openalex.org/W2052179261","https://openalex.org/W1980387354","https://openalex.org/W3144496399","https://openalex.org/W1573236285","https://openalex.org/W2323500065","https://openalex.org/W1771384872","https://openalex.org/W2379356883","https://openalex.org/W2563787225","https://openalex.org/W2990279411","https://openalex.org/W2300445976"],"abstract_inverted_index":{"Ischemic":[0],"injury":[1,58,77,94],"occurs":[2],"when":[3],"the":[4,16,39,49,66,96,110,194,218,227,231,286],"flow":[5,45],"of":[6,15,26,32,38,43,48,76,98,112,133,149,170,198,207,220,230,273,283,309],"blood":[7,44],"is":[8,78,84,178,184],"reduced":[9],"or":[10,104],"blocked":[11,50],"to":[12,62,91,129,145,240,247,257,292,301],"an":[13,156],"area":[14],"body":[17],"and":[18,35,46,83,140,183],"can":[19,54,101,105],"cause":[20],"significant":[21,168,268],"tissue":[22],"damage":[23],"by":[24],"generation":[25],"reactive":[27],"oxygen":[28],"species":[29],"(ROS),":[30],"activation":[31],"apoptotic":[33],"pathways":[34,108],"through":[36],"induction":[37],"inflammatory":[40],"response.":[41],"Restoration":[42],"reperfusion":[47],"site,":[51],"while":[52,225],"essential,":[53],"generate":[55],"a":[56,85,120,131,147,163,205,258],"second":[57],"that":[59,100,158,236],"itself":[60],"needs":[61],"be":[63,293],"controlled.":[64],"Together":[65],"two":[67],"injuries":[68],"are":[69],"termed":[70],"ischemia/reperfusion":[71],"(I/R)":[72],"injury.":[73],"This":[74,190],"type":[75],"frequently":[79],"encountered":[80],"in":[81,124,138,162,175,181,200,238,270,313,318,321],"medicine":[82],"major":[86],"medical":[87],"problem.":[88],"Therapeutic":[89],"strategies":[90],"combat":[92],"I/R":[93],"include":[95],"introduction":[97],"compounds":[99],"scavenge":[102],"ROS":[103,137,256],"induce":[106,146],"metabolic":[107],"with":[109,217],"effect":[111],"inhibiting":[113],"apoptosis.":[114],"Caffeic":[115,212],"Acid":[116,213],"Phenethyl":[117,214],"Ester":[118],"(CAPE),":[119],"polyphenolic":[121],"compound":[122],"found":[123,235],"propolis,":[125],"has":[126,141,159],"been":[127,143,160],"shown":[128,144],"protect":[130,248],"variety":[132,148],"cells":[134,171,253],"types":[135],"against":[136,172,255],"vitro":[139],"also":[142,185,290],"genes":[150],"including":[151,211],"hemeoxygenase":[152],"1":[153],"(HMOX-1)":[154],",":[155],"enzyme":[157],"implicated":[161],"cytoprotective":[164,196,228],"pathway.":[165],"Despite":[166],"showing":[167],"cytoprotection":[169,320],"oxidant":[173],"stress":[174],"vitro,":[176],"CAPE":[177,199,208,276,297,312],"readily":[179],"hydrolyzed":[180],"plasma":[182,271],"quickly":[186],"removed":[187],"from":[188,285],"circulation.":[189],"result":[191,317],"may":[192,315],"explain":[193],"limited":[195],"effects":[197,229],"vivo.":[201,322],"We":[202,234],"have":[203,266],"synthesized":[204],"series":[206],"amide":[209,243],"derivatives,":[210,244],"Amide":[215],"(CAPA),":[216],"aim":[219],"improving":[221],"CAPE\u2019s":[222],"stability":[223,272],"properties":[224],"maintaining":[226],"parent":[232],"compound.":[233],"CAPA,":[237],"addition":[239],"2":[241],"other":[242],"were":[245],"able":[246],"human":[249],"umbilical":[250],"vein":[251],"endothelial":[252],"(HUVEC)":[254],"similar":[259],"degree":[260],"as":[261],"CAPE.":[262],"In":[263],"addition,":[264],"we":[265],"observed":[267],"improvement":[269],"CAPA":[274,284,310],"over":[275,296,311],"at":[277],"multiple":[278],"temperatures.":[279],"The":[280,305],"elimination":[281],"half-life":[282],"systemic":[287],"circulation":[288,314],"was":[289],"seen":[291],"significantly":[294],"improved":[295],"following":[298],"intravenous":[299],"administration":[300],"male":[302],"Sprague-Dawley":[303],"rats.":[304],"longer":[306],"residence":[307],"time":[308],"potentially":[316],"greater":[319]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2016-06-24T00:00:00"}