{"id":"https://openalex.org/W1827246","doi":null,"title":"The Leiden Early Arthritis Clinic.","display_name":"The Leiden Early Arthritis Clinic.","publication_year":2003,"publication_date":"2003-09-01","ids":{"openalex":"https://openalex.org/W1827246","mag":"1827246","pmid":"https://pubmed.ncbi.nlm.nih.gov/14969059"},"language":"en","primary_location":{"id":"pmid:14969059","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14969059","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental rheumatology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109148075","display_name":"Jill van Aken","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"J van Aken","raw_affiliation_strings":["Leiden University Medical Center, Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leiden University Medical Center, Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084747160","display_name":"Jolanda H. M. van Bilsen","orcid":"https://orcid.org/0000-0003-3439-5445","observed_orcids":["https://orcid.org/0000-0003-3439-5445"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J H van Bilsen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109502579","display_name":"Cornelia F Allaart","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C F Allaart","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052842332","display_name":"Tom W. J. Huizinga","orcid":"https://orcid.org/0000-0001-7033-7520","observed_orcids":["https://orcid.org/0000-0001-7033-7520"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T W Huizinga","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5113906978","display_name":"Ferdinand C Breedveld","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F C Breedveld","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.2334,"has_fulltext":false,"cited_by_count":145,"citation_normalized_percentile":{"value":0.9589468,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"21","issue":"5 Suppl 31","first_page":"S100","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11616","display_name":"Autoimmune and Inflammatory Disorders Research","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/early-arthritis-clinic","display_name":"early arthritis clinic","score":0.949999988079071},{"id":"https://openalex.org/keywords/early-rheumatoid-arthritis","display_name":"early rheumatoid arthritis","score":0.9729999899864197},{"id":"https://openalex.org/keywords/inflammatory-arthritis","display_name":"inflammatory arthritis","score":0.9509999752044678},{"id":"https://openalex.org/keywords/early-detection-and-treatment","display_name":"early detection and treatment","score":0.5130000114440918},{"id":"https://openalex.org/keywords/medical-databases","display_name":"medical databases","score":0.5770000219345093},{"id":"https://openalex.org/keywords/cellular-immunology","display_name":"cellular immunology","score":0.8659999966621399},{"id":"https://openalex.org/keywords/genetic-risk-factors","display_name":"genetic risk factors","score":0.9589999914169312},{"id":"https://openalex.org/keywords/environmental-risk-factors","display_name":"environmental risk factors","score":0.996999979019165}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9540796279907227},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.7139162421226501},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.6917656660079956},{"id":"https://openalex.org/C198451711","wikidata":"https://www.wikidata.org/wiki/Q327657","display_name":"Rheumatology","level":2,"score":0.6046202778816223},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.538469672203064},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.47841745615005493},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4747729003429413},{"id":"https://openalex.org/C2776821229","wikidata":"https://www.wikidata.org/wiki/Q16965166","display_name":"Inflammatory arthritis","level":3,"score":0.42206376791000366},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3390014171600342}],"mesh":[{"descriptor_ui":"D000554","descriptor_name":"Ambulatory Care Facilities","qualifier_ui":"Q000458","qualifier_name":"organization & administration","is_major_topic":true},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009426","descriptor_name":"Netherlands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012017","descriptor_name":"Referral and Consultation","qualifier_ui":"Q000458","qualifier_name":"organization & administration","is_major_topic":true},{"descriptor_ui":"D012219","descriptor_name":"Rheumatology","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D012219","descriptor_name":"Rheumatology","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017063","descriptor_name":"Outcome Assessment, Health Care","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018501","descriptor_name":"Antirheumatic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D026741","descriptor_name":"Physical Therapy Modalities","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:14969059","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14969059","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental rheumatology","raw_type":"Journal Article"},{"id":"mag:1827246","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14969059","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W72649437","https://openalex.org/W1963603430","https://openalex.org/W1978051126","https://openalex.org/W1978054709","https://openalex.org/W1985776841","https://openalex.org/W1995779842","https://openalex.org/W1997743661","https://openalex.org/W2001487805","https://openalex.org/W2013573826","https://openalex.org/W2022941966","https://openalex.org/W2023126747","https://openalex.org/W2024146240","https://openalex.org/W2043343045","https://openalex.org/W2065518321","https://openalex.org/W2066089598","https://openalex.org/W2089475073","https://openalex.org/W2091943129","https://openalex.org/W2107883387","https://openalex.org/W2136042500","https://openalex.org/W2157684375","https://openalex.org/W2165814934","https://openalex.org/W2337699004","https://openalex.org/W2417047264"],"related_works":["https://openalex.org/W2115854466","https://openalex.org/W2304096864","https://openalex.org/W2468446962","https://openalex.org/W2909891047","https://openalex.org/W176108987","https://openalex.org/W7027955076","https://openalex.org/W7046748911","https://openalex.org/W2915396222","https://openalex.org/W1978091951","https://openalex.org/W3197661844"],"abstract_inverted_index":{"In":[0],"1993":[1],"a":[2,137],"special":[3],"Early":[4],"Arthritis":[5],"Clinic":[6],"(EAC)":[7],"was":[8],"established":[9],"at":[10],"the":[11,16,31,74,77,127,143,146,174,189],"Department":[12],"of":[13,15,42,58,130,176],"Rheumatology":[14],"Leiden":[17,190],"University":[18],"Medical":[19],"Center":[20],"in":[21,30,73,105,123,170,188],"order":[22,124],"to":[23,94,125,180],"detect":[24],"and":[25,53,60,65,68,88,109,116,119,161,164],"treat":[26],"inflammatory":[27,131],"disorders":[28],"early":[29,35],"disease":[32,187],"state,":[33],"especially":[34],"rheumatoid":[36,103],"arthritis.":[37,132],"Patients":[38],"with":[39,99],"confirmed":[40],"arthritis":[41],"recent":[43],"onset":[44],"(less":[45],"than":[46],"2":[47],"years)":[48],"were":[49,71],"included":[50],"by":[51],"rheumatologists":[52],"trained":[54],"research":[55,96,183],"nurses.":[56],"Parameters":[57],"first":[59],"follow-up":[61],"visits":[62],"(3,":[63],"6":[64],"9":[66],"months":[67],"yearly)":[69],"that":[70,182],"entered":[72],"EAC-database":[75],"include":[76],"medical":[78],"history,":[79],"physical-diagnostic":[80],"examination,":[81],"laboratory":[82],"tests,":[83],"questionnaires,":[84],"radiographic":[85],"joint":[86],"scores":[87],"diagnosis.":[89],"This":[90],"database":[91],"enables":[92],"us":[93],"conduct":[95],"on":[97,102,139,185],"arthritis,":[98,104],"an":[100,177],"emphasis":[101],"many":[106],"ways.":[107],"Physicians":[108],"basic":[110],"scientists":[111],"have":[112,152],"studied":[113],"cellular":[114],"immunology":[115],"genetic,":[117],"environmental":[118],"clinical":[120,159],"risk":[121],"factors":[122],"determine":[126],"pathophysiologic":[128],"mechanisms":[129],"The":[133],"present":[134],"article":[135],"is":[136],"review":[138],"reports":[140,151],"published":[141],"from":[142],"EAC.":[144],"Over":[145],"past":[147],"ten":[148],"years,":[149],"these":[150],"been":[153],"highly":[154],"relevant":[155],"for":[156],"both":[157],"daily":[158],"practice":[160],"research.":[162],"Present":[163],"planned":[165],"future":[166],"studies,":[167],"as":[168],"described":[169],"this":[171,186],"article,":[172],"reconfirm":[173],"importance":[175],"EAC":[178,191],"framework":[179],"ensure":[181],"continues":[184],"area.":[192]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}