{"id":"https://openalex.org/W1826314859","doi":"https://doi.org/10.4049/jimmunol.158.6.2932","title":"Exogenous CD40 ligand induces a pulmonary inflammation response","display_name":"Exogenous CD40 ligand induces a pulmonary inflammation response","publication_year":1997,"publication_date":"1997-03-01","ids":{"openalex":"https://openalex.org/W1826314859","doi":"https://doi.org/10.4049/jimmunol.158.6.2932","mag":"1826314859","pmid":"https://pubmed.ncbi.nlm.nih.gov/9058832"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.158.6.2932","doi":"https://doi.org/10.4049/jimmunol.158.6.2932","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.158.6.2932","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"J A Wiley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125275712","display_name":"Trudeau Institute","ror":"https://ror.org/04r83e717","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I125275712"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J A Wiley","raw_affiliation_strings":["Trudeau Institute Inc. , Saranac Lake, NY 12983,","Trudeau Institute Inc., Saranac Lake, NY 12983, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Trudeau Institute Inc. , Saranac Lake, NY 12983,","institution_ids":["https://openalex.org/I125275712"]},{"raw_affiliation_string":"Trudeau Institute Inc., Saranac Lake, NY 12983, USA","institution_ids":["https://openalex.org/I125275712"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048379219","display_name":"Raif S. Geha","orcid":"https://orcid.org/0000-0002-6019-3751","observed_orcids":["https://orcid.org/0000-0002-6019-3751"]},"institutions":[{"id":"https://openalex.org/I125275712","display_name":"Trudeau Institute","ror":"https://ror.org/04r83e717","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I125275712"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R Geha","raw_affiliation_strings":["Trudeau Institute Inc. , Saranac Lake, NY 12983,","Trudeau Institute Inc., Saranac Lake, NY 12983, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Trudeau Institute Inc. , Saranac Lake, NY 12983,","institution_ids":["https://openalex.org/I125275712"]},{"raw_affiliation_string":"Trudeau Institute Inc., Saranac Lake, NY 12983, USA","institution_ids":["https://openalex.org/I125275712"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088118263","display_name":"Allen G. Harmsen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125275712","display_name":"Trudeau Institute","ror":"https://ror.org/04r83e717","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I125275712"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A G Harmsen","raw_affiliation_strings":["Trudeau Institute Inc. , Saranac Lake, NY 12983,","Trudeau Institute Inc., Saranac Lake, NY 12983, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Trudeau Institute Inc. , Saranac Lake, NY 12983,","institution_ids":["https://openalex.org/I125275712"]},{"raw_affiliation_string":"Trudeau Institute Inc., Saranac Lake, NY 12983, USA","institution_ids":["https://openalex.org/I125275712"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I125275712"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":2.0359,"has_fulltext":false,"cited_by_count":54,"citation_normalized_percentile":{"value":0.86188473,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"158","issue":"6","first_page":"2932","last_page":"2938"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.7178000211715698,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.7178000211715698,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.10999999940395355,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":0.020800000056624413,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd40-ligand","display_name":"CD40 ligand","score":0.9739999771118164},{"id":"https://openalex.org/keywords/pulmonary-inflammation","display_name":"lung inflammation","score":0.9309999942779541},{"id":"https://openalex.org/keywords/cd40-ligation","display_name":"CD40 ligation","score":0.800000011920929},{"id":"https://openalex.org/keywords/neutrophil-migration","display_name":"neutrophil migration","score":0.8690000176429749},{"id":"https://openalex.org/keywords/alveolar-macrophages","display_name":"alveolar macrophages","score":0.9919999837875366},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.949999988079071}],"concepts":[{"id":"https://openalex.org/C39347974","wikidata":"https://www.wikidata.org/wiki/Q21135811","display_name":"CD40","level":4,"score":0.7212792634963989},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.7210059762001038},{"id":"https://openalex.org/C182704531","wikidata":"https://www.wikidata.org/wiki/Q1364740","display_name":"Knockout mouse","level":3,"score":0.6519607901573181},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5286189913749695},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.45534050464630127},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.42488616704940796},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3805446922779083},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.34327036142349243},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.321617066860199},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.280892938375473},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.25029847025871277},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.17890110611915588},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.16337311267852783},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15516534447669983},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07865232229232788}],"mesh":[{"descriptor_ui":"D000281","descriptor_name":"Administration, Intranasal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000949","descriptor_name":"Histocompatibility Antigens Class II","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019013","descriptor_name":"CD40 Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D023201","descriptor_name":"CD40 Ligand","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.4049/jimmunol.158.6.2932","doi":"https://doi.org/10.4049/jimmunol.158.6.2932","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.158.6.2932","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:9058832","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9058832","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G185566712","display_name":null,"funder_award_id":"HL 55002","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2660399291","display_name":"Reconstitution of Immunity to Pneumocystis in SCID Mice","funder_award_id":"R01HL055002","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1982245851","https://openalex.org/W2042483530","https://openalex.org/W4225555022","https://openalex.org/W2063218763","https://openalex.org/W4361027040","https://openalex.org/W3000566272","https://openalex.org/W81044028","https://openalex.org/W2167969842","https://openalex.org/W4312223455","https://openalex.org/W2361094031"],"abstract_inverted_index":{"Expression":[0],"of":[1,25,31,71,79,103,118,126],"CD40":[2,15,33,54,140],"on":[3],"cells":[4,120],"involved":[5,60],"in":[6,22,51,100,115,121,135,144],"the":[7,23,26,65,69,101,104,122],"inflammatory":[8,27,43,58,119,145],"response":[9,44,59],"has":[10],"lead":[11],"to":[12],"speculation":[13],"that":[14,47,90,94,110,139,148],"ligation":[16,141],"could":[17],"play":[18],"an":[19],"important":[20],"role":[21,114],"establishment":[24],"response.":[28],"Upon":[29],"treatment":[30],"wild-type":[32,80],"mice":[34,84],"with":[35,74,85],"soluble":[36],"CD40L-CD8":[37],"(sCD40L)":[38],"fusion":[39],"protein":[40],"a":[41,113,151],"pulmonary":[42,88,127],"was":[45,48],"induced":[46,87],"not":[49],"observed":[50],"identically":[52],"treated":[53],"knockout":[55,83,106],"mice.":[56,107],"This":[57,108],"polymorphonuclear":[61],"leukocyte":[62],"migration":[63],"into":[64],"alveolar":[66,72],"space":[67],"and":[68,97,147],"accumulation":[70,117],"macrophages":[73,98],"up-regulated":[75],"Ia":[76],"expression.":[77],"Treatment":[78],"or":[81],"IFN-gamma":[82,105,111],"sCD40L":[86,131,149],"responses":[89,146],"were":[91],"similar":[92],"except":[93],"fewer":[95],"neutrophils":[96],"accumulated":[99],"lungs":[102],"suggested":[109],"plays":[112],"sCD40L-induced":[116],"lung.":[123],"The":[124],"induction":[125],"inflammation":[128],"by":[129,137],"exogenous":[130],"supports":[132],"evidence":[133],"derived":[134],"vitro":[136],"others":[138],"can":[142],"result":[143],"is":[150],"potent":[152],"inflammagen.":[153]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
