{"id":"https://openalex.org/W182605585","doi":null,"title":"The effect of lipopolysaccharides on the expression of CD14 and TLR4 in rat Kupffer cells.","display_name":"The effect of lipopolysaccharides on the expression of CD14 and TLR4 in rat Kupffer cells.","publication_year":2003,"publication_date":"2003-05-01","ids":{"openalex":"https://openalex.org/W182605585","mag":"182605585","pmid":"https://pubmed.ncbi.nlm.nih.gov/14599981"},"language":"en","primary_location":{"id":"pmid:14599981","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14599981","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatobiliary & pancreatic diseases international : HBPD INT","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101238479","display_name":"Junming Feng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I151075929","display_name":"Army Medical University","ror":"https://ror.org/05w21nn13","country_code":"CN","type":"education","lineage":["https://openalex.org/I151075929"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun-Ming Feng","raw_affiliation_strings":["Research Institute of Pathology, Southwestern Hospital, Third Military Medical University, Chongqing 400038, China. fjmds@hotmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute of Pathology, Southwestern Hospital, Third Military Medical University, Chongqing 400038, China. fjmds@hotmail.com","institution_ids":["https://openalex.org/I151075929"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031155934","display_name":"Jing-Quan Shi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jing-Quan Shi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5049965359","display_name":"You\u2010Sheng Liu","orcid":"https://orcid.org/0009-0005-1654-2765","observed_orcids":["https://orcid.org/0009-0005-1654-2765"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"You-Sheng Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2076,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.48355077,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"2","issue":"2","first_page":"265","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9900000095367432},{"id":"https://openalex.org/keywords/cd14","display_name":"CD14","score":0.8519999980926514},{"id":"https://openalex.org/keywords/tlr4","display_name":"TLR4","score":0.9980000257492065},{"id":"https://openalex.org/keywords/kupffer-cells","display_name":"Kupffer cells","score":0.9980000257492065},{"id":"https://openalex.org/keywords/toll-like-receptor-expression","display_name":"Toll-like receptor expression","score":0.6079999804496765},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9200000166893005},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.8980000019073486},{"id":"https://openalex.org/keywords/cytokine-production","display_name":"cytokine production","score":0.7540000081062317},{"id":"https://openalex.org/keywords/rat-liver","display_name":"rat liver","score":0.40299999713897705}],"concepts":[{"id":"https://openalex.org/C2776070231","wikidata":"https://www.wikidata.org/wiki/Q14914098","display_name":"TLR4","level":3,"score":0.878893256187439},{"id":"https://openalex.org/C2778513237","wikidata":"https://www.wikidata.org/wiki/Q419553","display_name":"CD14","level":3,"score":0.8346311450004578},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.6089091300964355},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.5694072842597961},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5558705925941467},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.43039047718048096},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4031757712364197},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4004853367805481},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3797626495361328},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.36012813448905945},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.22532424330711365},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21353167295455933}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007728","descriptor_name":"Kupffer Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007728","descriptor_name":"Kupffer Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007728","descriptor_name":"Kupffer Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017077","descriptor_name":"Culture Media, Conditioned","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018950","descriptor_name":"Lipopolysaccharide Receptors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051193","descriptor_name":"Toll-Like Receptors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051197","descriptor_name":"Toll-Like Receptor 4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:14599981","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14599981","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatobiliary & pancreatic diseases international : HBPD INT","raw_type":"Journal Article"},{"id":"mag:182605585","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14599981","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2381520487","https://openalex.org/W2377790417","https://openalex.org/W2348249732","https://openalex.org/W2391261750","https://openalex.org/W2416373678","https://openalex.org/W2379131033","https://openalex.org/W2149065827","https://openalex.org/W2368484625","https://openalex.org/W2165684825","https://openalex.org/W4205422523"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"assess":[2],"the":[3,9,27,41,47,92,110,136,145,154,179],"effect":[4],"of":[5,11,29,43,49,64,95,102,147,156,171],"lipopolysaccharides":[6],"(LPS)":[7],"on":[8],"expression":[10,33,94,159,174],"CD14":[12,30,65,96,103,158,173],"and":[13,31,38,40,59,66,104,144,168],"TLR4":[14,32,67,105],"in":[15,55,68,76,84,106],"rat":[16,22],"Kupffer":[17],"cells":[18],"(KCs).":[19],"METHODS:":[20],"In":[21],"KCs":[23,69,107,114,140],"induced":[24,70,141,162],"by":[25,36,54,71,109,142,163,182],"LPS,":[26],"changes":[28],"were":[34,52,73,124],"measured":[35],"RT-PCR":[37],"immunohistochemistry,":[39],"expressions":[42,63,101,146],"TNF-alphamRNA,":[44],"IL-6mRNA":[45],"or":[46,83,135],"concentrations":[48],"TNF-alpha,":[50],"IL-6":[51],"estimated":[53],"situ":[56],"hybridization,":[57],"radioimmunoassay,":[58],"others.":[60],"RESULTS:":[61],"The":[62,100],"LPS":[72,120,134,143,164],"markedly":[74],"increased":[75],"a":[77,85,130],"dose-dependent":[78],"manner":[79,87],"(10":[80],"mg/L-1":[81],"microg/L)":[82],"time-dependent":[86],"(0.5":[88],"h-24":[89],"h),":[90],"with":[91,178],"peaked":[93],"at":[97],"3-6":[98],"hours.":[99],"stimulated":[108],"active":[111,137],"mediators":[112,138],"from":[113,139],"which":[115],"had":[116],"been":[117],"exposed":[118],"to":[119],"for":[121],"1":[122],"hour":[123],"obviously":[125],"increased.":[126],"CONCLUSIONS:":[127],"There":[128],"is":[129,151],"close":[131],"relationship":[132],"between":[133],"CD14,":[148],"TLR4.":[149],"It":[150],"implied":[152],"that":[153],"increase":[155,170],"TLR4,":[157,172],"may":[160,175],"be":[161,176],"within":[165],"1-3":[166],"hours,":[167],"further":[169],"correlated":[177],"cytokines":[180],"produced":[181],"KCs.":[183]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}