{"id":"https://openalex.org/W1825875625","doi":null,"title":"Etiological involvement of oncogenic human papillomavirus in tonsillar squamous cell carcinomas lacking retinoblastoma cell cycle control.","display_name":"Etiological involvement of oncogenic human papillomavirus in tonsillar squamous cell carcinomas lacking retinoblastoma cell cycle control.","publication_year":1998,"publication_date":"1998-01-01","ids":{"openalex":"https://openalex.org/W1825875625","mag":"1825875625","pmid":"https://pubmed.ncbi.nlm.nih.gov/9426048"},"language":"en","primary_location":{"id":"pmid:9426048","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9426048","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013343878","display_name":"Thomas Andl","orcid":"https://orcid.org/0009-0006-7163-3624","observed_orcids":["https://orcid.org/0009-0006-7163-3624","https://orcid.org/0000-0002-5555-468X"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"T Andl","raw_affiliation_strings":["Molekularbiologisches Labor, Hals-Nasen-Ohren-Klinik, Universit\u00e4t Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molekularbiologisches Labor, Hals-Nasen-Ohren-Klinik, Universit\u00e4t Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070215844","display_name":"Tomas Kahn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Kahn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027078843","display_name":"Andreas Pfuhl","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Pfuhl","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"T Nicola","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Nicola","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033567573","display_name":"Ralf Erber","orcid":"https://orcid.org/0000-0001-9689-2151","observed_orcids":["https://orcid.org/0000-0001-9689-2151"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Erber","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067392519","display_name":"Christian Conradt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Conradt","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112198111","display_name":"Wilhelm Klein","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W Klein","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084470005","display_name":"M. Helbig","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Helbig","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103263275","display_name":"Andreas Dietz","orcid":"https://orcid.org/0000-0001-8254-1676","observed_orcids":["https://orcid.org/0000-0001-8254-1676"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Dietz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061834098","display_name":"H Weidauer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Weidauer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5033323822","display_name":"Francesc Xavier Bosch","orcid":"https://orcid.org/0000-0002-7172-3412","observed_orcids":["https://orcid.org/0000-0002-7172-3412"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F X Bosch","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":13.9031,"has_fulltext":false,"cited_by_count":280,"citation_normalized_percentile":{"value":0.9941358,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"58","issue":"1","first_page":"5","last_page":"13"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.016100000590085983,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-papillomavirus","display_name":"human papillomavirus","score":0.8709999918937683},{"id":"https://openalex.org/keywords/tonsillar-squamous-cell-carcinoma","display_name":"tonsillar squamous cell carcinoma","score":0.9629999995231628},{"id":"https://openalex.org/keywords/retinoblastoma-protein","display_name":"retinoblastoma protein","score":0.9300000071525574},{"id":"https://openalex.org/keywords/prb-inactivation","display_name":"pRb inactivation","score":0.7599999904632568},{"id":"https://openalex.org/keywords/hpv-e7","display_name":"E7 oncoprotein","score":0.8029999732971191},{"id":"https://openalex.org/keywords/cyclin-d1","display_name":"cyclin D1","score":0.847000002861023},{"id":"https://openalex.org/keywords/p16ink4a","display_name":"p16INK4a","score":0.9959999918937683},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.9169999957084656},{"id":"https://openalex.org/keywords/head-and-neck-squamous-cell-carcinoma","display_name":"head and neck squamous cell carcinoma","score":0.9340000152587891},{"id":"https://openalex.org/keywords/tumor-differentiation","display_name":"tumor differentiation","score":0.6549999713897705},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.9459999799728394},{"id":"https://openalex.org/keywords/postoperative-radiotherapy","display_name":"postoperative radiotherapy","score":0.7929999828338623},{"id":"https://openalex.org/keywords/clinical-outcomes","display_name":"clinical outcomes","score":0.5049999952316284}],"concepts":[{"id":"https://openalex.org/C2776062698","wikidata":"https://www.wikidata.org/wiki/Q21111463","display_name":"Retinoblastoma protein","level":4,"score":0.7000109553337097},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6507967710494995},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.5940548181533813},{"id":"https://openalex.org/C2776577112","wikidata":"https://www.wikidata.org/wiki/Q500695","display_name":"Retinoblastoma","level":3,"score":0.580811619758606},{"id":"https://openalex.org/C199835354","wikidata":"https://www.wikidata.org/wiki/Q15311861","display_name":"Cyclin D1","level":4,"score":0.5516416430473328},{"id":"https://openalex.org/C2778264664","wikidata":"https://www.wikidata.org/wiki/Q422445","display_name":"Tumor suppressor gene","level":4,"score":0.5134921669960022},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47836512327194214},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4607241451740265},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4352007508277893},{"id":"https://openalex.org/C195286587","wikidata":"https://www.wikidata.org/wiki/Q424689","display_name":"Gene product","level":4,"score":0.4108276069164276},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3133467137813568},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2988981008529663},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.23549911379814148},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.12382584810256958},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07742652297019958}],"mesh":[{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D002869","descriptor_name":"Chromosome Aberrations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004279","descriptor_name":"DNA, Viral","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014067","descriptor_name":"Tonsillar Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014067","descriptor_name":"Tonsillar Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014067","descriptor_name":"Tonsillar Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014067","descriptor_name":"Tonsillar Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D014067","descriptor_name":"Tonsillar Neoplasms","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016160","descriptor_name":"Retinoblastoma Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016160","descriptor_name":"Retinoblastoma Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016161","descriptor_name":"Genes, Retinoblastoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019938","descriptor_name":"Cyclin D1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019941","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p16","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D027383","descriptor_name":"Papillomaviridae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:9426048","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9426048","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:1825875625","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9426048","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3026542687","https://openalex.org/W2000063139","https://openalex.org/W2132347848","https://openalex.org/W2056023468","https://openalex.org/W1539945172","https://openalex.org/W1919309487","https://openalex.org/W2038444282","https://openalex.org/W2158925744","https://openalex.org/W2083191282","https://openalex.org/W2111207378"],"abstract_inverted_index":{"Two":[0],"hundred":[1],"eight":[2],"primary":[3],"squamous":[4,169],"cell":[5,50,170],"carcinomas":[6,171],"of":[7,20,47,84,111,119,128,144,152,194],"the":[8,18,21,36,45,79,82,85,89,101,149,153,157,173,192,205,217],"head":[9,166],"and":[10,55,147,167,186],"neck":[11,168],"have":[12],"been":[13],"analyzed":[14],"with":[15],"respect":[16],"to":[17,35,61,164],"presence":[19],"retinoblastoma":[22],"tumor":[23],"suppressor":[24],"protein,":[25],"pRb.":[26,48],"Of":[27,196],"these,":[28],"23":[29],"tumors":[30,87,123,146,176,219],"(11%)":[31],"that":[32,216],"preferentially":[33],"localized":[34],"tonsils":[37],"revealed":[38],"complete":[39],"absence":[40],"or":[41,71],"dramatic":[42],"reduction":[43],"in":[44,74,104,109,117,178],"amount":[46],"Other":[49],"cycle":[51],"components,":[52],"cyclin":[53],"D1":[54],"p16INK4A,":[56],"which":[57],"are":[58],"intimately":[59],"related":[60],"pRb":[62,154],"through":[63],"an":[64],"autoregulatory":[65],"loop,":[66],"were":[67,177,188],"also":[68],"dramatically":[69],"decreased":[70],"overexpressed,":[72],"respectively,":[73],"these":[75,105,145,201,209],"pRb-defective":[76,86,113,174,218],"tumors.":[77,106],"On":[78],"other":[80],"hand,":[81],"majority":[83],"contained":[88],"wild-type":[90],"p53":[91],"gene.":[92],"No":[93],"evidence":[94],"was":[95,133,211],"found":[96],"for":[97,139,208],"genetic":[98],"defects":[99],"at":[100,191],"Rb":[102],"locus":[103],"Very":[107],"significantly,":[108],"11":[110],"12":[112],"tonsillar":[114,122,175],"tumors,":[115],"but":[116],"none":[118],"9":[120],"pRb-positive":[121],"(P":[124,183],"<":[125],"10[-7]),":[126],"DNA":[127],"oncogenic":[129],"human":[130,141],"papillomavirus":[131],"types":[132],"identified,":[134],"providing":[135],"a":[136,140],"strong":[137],"indication":[138],"papillomavirus-associated":[142],"etiology":[143],"suggesting":[148],"functional":[150],"inactivation":[151],"protein":[155],"by":[156],"viral":[158],"E7":[159],"gene":[160],"product.":[161],"In":[162],"comparison":[163],"all":[165,189],"studied,":[172],"general":[179],"more":[180],"poorly":[181],"differentiated":[182],"=":[184],"0.0059),":[185],"they":[187],"metastatic":[190],"time":[193],"resection.":[195],"particular":[197],"clinical":[198,206],"interest,":[199],"despite":[200],"adverse":[202],"histopathological":[203],"factors,":[204],"outcome":[207],"patients":[210],"relatively":[212],"favorable,":[213],"strongly":[214],"implying":[215],"responded":[220],"uniformly":[221],"well":[222],"toward":[223],"postoperative":[224],"radiation":[225],"therapy.":[226]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":15},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":19},{"year":2012,"cited_by_count":16}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}