{"id":"https://openalex.org/W1824928531","doi":"https://doi.org/10.1093/genetics/172.4.2025","title":"New Roles for Model Genetic Organisms in Understanding and Treating Human Disease: Report From The 2006 Genetics Society of America Meeting","display_name":"New Roles for Model Genetic Organisms in Understanding and Treating Human Disease: Report From The 2006 Genetics Society of America Meeting","publication_year":2006,"publication_date":"2006-04-01","ids":{"openalex":"https://openalex.org/W1824928531","doi":"https://doi.org/10.1093/genetics/172.4.2025","mag":"1824928531","pmid":"https://pubmed.ncbi.nlm.nih.gov/16636111","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1456383"},"language":"en","primary_location":{"id":"doi:10.1093/genetics/172.4.2025","doi":"https://doi.org/10.1093/genetics/172.4.2025","is_oa":false,"landing_page_url":"https://doi.org/10.1093/genetics/172.4.2025","pdf_url":null,"source":{"id":"https://openalex.org/S65932378","display_name":"Genetics","issn_l":"0016-6731","issn":["0016-6731","1943-2631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1456383","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016264819","display_name":"Allan C. Spradling","orcid":"https://orcid.org/0000-0002-5251-1801","observed_orcids":["https://orcid.org/0000-0002-5251-1801"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I196817621","display_name":"Carnegie Institution for Science","ror":"https://ror.org/04jr01610","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I196817621"]},{"id":"https://openalex.org/I4210117844","display_name":"Department of Embryology","ror":"https://ror.org/03bvtqh46","country_code":"US","type":"facility","lineage":["https://openalex.org/I196817621","https://openalex.org/I4210117844"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Allan Spradling","raw_affiliation_strings":["Department of Embryology/HHMI, Carnegie Institution of Washington, Baltimore, MD 21218, USA. spradling@ciwemb.edu","Department of Embryology/HHMI, Carnegie Institution of Washington, Baltimore, MD 21218, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Embryology/HHMI, Carnegie Institution of Washington, Baltimore, MD 21218, USA. spradling@ciwemb.edu","institution_ids":["https://openalex.org/I196817621","https://openalex.org/I4210117844"]},{"raw_affiliation_string":"Department of Embryology/HHMI, Carnegie Institution of Washington, Baltimore, MD 21218, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I196817621","https://openalex.org/I4210117844"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043643445","display_name":"Barry Ganetsky","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Barry Ganetsky","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088317023","display_name":"Philip Hieter","orcid":"https://orcid.org/0000-0003-3116-7017","observed_orcids":["https://orcid.org/0000-0003-3116-7017"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Phil Hieter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000757668","display_name":"Mark Johnston","orcid":"https://orcid.org/0000-0002-4932-7229","observed_orcids":["https://orcid.org/0000-0002-4932-7229"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark Johnston","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105759334","display_name":"Maynard V. Olson","orcid":"https://orcid.org/0000-0003-3527-9497","observed_orcids":["https://orcid.org/0000-0003-3527-9497"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maynard Olson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034360567","display_name":"Terry L. Orr\u2010Weaver","orcid":"https://orcid.org/0000-0002-7934-111X","observed_orcids":["https://orcid.org/0000-0002-7934-111X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Terry Orr-Weaver","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011985445","display_name":"Janet Rossant","orcid":"https://orcid.org/0000-0002-3731-5466","observed_orcids":["https://orcid.org/0000-0002-3731-5466"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Janet Rossant","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101833057","display_name":"Alejandro S\u00e1nchez","orcid":"https://orcid.org/0000-0003-0947-1071","observed_orcids":["https://orcid.org/0000-0003-0947-1071"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alejandro Sanchez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5074206499","display_name":"R Waterston","orcid":"https://orcid.org/0000-0001-5956-5215","observed_orcids":["https://orcid.org/0000-0001-5956-5215"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert Waterston","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5016264819"],"corresponding_institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I196817621","https://openalex.org/I4210117844"],"apc_list":{"value":4477,"currency":"USD","value_usd":4477},"apc_paid":null,"fwci":9.7669,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.97451078,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"172","issue":"4","first_page":"2025","last_page":"2032"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10778","display_name":"Philosophy and History of Science","score":0.25540000200271606,"subfield":{"id":"https://openalex.org/subfields/1207","display_name":"History and Philosophy of Science"},"field":{"id":"https://openalex.org/fields/12","display_name":"Arts and Humanities"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10778","display_name":"Philosophy and History of Science","score":0.25540000200271606,"subfield":{"id":"https://openalex.org/subfields/1207","display_name":"History and Philosophy of Science"},"field":{"id":"https://openalex.org/fields/12","display_name":"Arts and Humanities"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.1460999995470047,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13656","display_name":"Science, Research, and Medicine","score":0.1354999989271164,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/model-organisms","display_name":"model organisms","score":0.828000009059906},{"id":"https://openalex.org/keywords/human-disease-modeling","display_name":"human disease modeling","score":0.7300000190734863},{"id":"https://openalex.org/keywords/genetic-analysis","display_name":"genetic analysis","score":0.5329999923706055},{"id":"https://openalex.org/keywords/comparative-genomics","display_name":"comparative genomics","score":0.6349999904632568},{"id":"https://openalex.org/keywords/eukaryotic-evolution","display_name":"eukaryotic evolution","score":0.6859999895095825},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.4699999988079071},{"id":"https://openalex.org/keywords/congenital-malformations","display_name":"congenital malformations","score":0.9990000128746033},{"id":"https://openalex.org/keywords/neurological-disorders","display_name":"neurological disorders","score":0.968999981880188},{"id":"https://openalex.org/keywords/reproductive-failure","display_name":"reproductive failure","score":0.9549999833106995},{"id":"https://openalex.org/keywords/malnutrition","display_name":"malnutrition","score":0.8949999809265137},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":1.0},{"id":"https://openalex.org/keywords/gene-environment-interaction","display_name":"gene-environment interaction","score":0.8399999737739563}],"concepts":[{"id":"https://openalex.org/C19843653","wikidata":"https://www.wikidata.org/wiki/Q213907","display_name":"Model organism","level":3,"score":0.8279235363006592},{"id":"https://openalex.org/C137858568","wikidata":"https://www.wikidata.org/wiki/Q7239","display_name":"Organism","level":2,"score":0.8197227716445923},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7465758919715881},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5219021439552307},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5090312957763672},{"id":"https://openalex.org/C164614171","wikidata":"https://www.wikidata.org/wiki/Q5204775","display_name":"DECIPHER","level":2,"score":0.5076724290847778},{"id":"https://openalex.org/C2988867146","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Human disease","level":3,"score":0.4634980857372284},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.4376484155654907},{"id":"https://openalex.org/C47042493","wikidata":"https://www.wikidata.org/wiki/Q265799","display_name":"Human genetics","level":3,"score":0.42982080578804016},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.42421725392341614},{"id":"https://openalex.org/C84084929","wikidata":"https://www.wikidata.org/wiki/Q339557","display_name":"Human biology","level":2,"score":0.42342427372932434},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4185163378715515},{"id":"https://openalex.org/C2992519594","wikidata":"https://www.wikidata.org/wiki/Q870433","display_name":"Genetic model","level":3,"score":0.411624014377594},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3907988667488098},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.35284239053726196},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005823","descriptor_name":"Genetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012568","descriptor_name":"Schizosaccharomyces","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023421","descriptor_name":"Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/genetics/172.4.2025","doi":"https://doi.org/10.1093/genetics/172.4.2025","is_oa":false,"landing_page_url":"https://doi.org/10.1093/genetics/172.4.2025","pdf_url":null,"source":{"id":"https://openalex.org/S65932378","display_name":"Genetics","issn_l":"0016-6731","issn":["0016-6731","1943-2631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:1528936","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1456383","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:16636111","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16636111","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:1528936","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1456383","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3907149891","display_name":"MEETING: GENETIC ANALYSIS: MODEL ORGANISMS TO HUMAN BIOLOGY","funder_award_id":"R13GM076942","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W6929910976","https://openalex.org/W2562946922","https://openalex.org/W4298331042","https://openalex.org/W2083471275","https://openalex.org/W2966903367","https://openalex.org/W2144141495","https://openalex.org/W2967531649","https://openalex.org/W1525168321","https://openalex.org/W4231305604","https://openalex.org/W4413028155"],"abstract_inverted_index":{"Fundamental":[0],"biological":[1,136],"knowledge":[2],"and":[3,18,35,40,91,124,173,180,197,213,241,245,265,274],"the":[4,20,26,46,50,72,82,88,102,122,211,226,281],"technology":[5],"to":[6,16,44,67,70,86,131,141,150,155,178,192,208,228,236,242,263,275],"acquire":[7],"it":[8,148],"have":[9,138,225],"been":[10],"immeasurably":[11],"advanced":[12],"by":[13],"past":[14],"efforts":[15],"understand":[17],"manipulate":[19],"genomes":[21],"of":[22,28,49,55,75,79,94,104,126,159,284],"model":[23,47,97,156,184,249],"organisms.":[24],"Has":[25],"utility":[27],"bacteria,":[29],"yeast,":[30],"worms,":[31],"flies,":[32],"mice,":[33],"plants,":[34],"other":[36],"models":[37,224],"now":[38],"peaked":[39],"are":[41],"humans":[42],"poised":[43],"become":[45],"organism":[48,250],"future?":[51],"The":[52,113],"Genetics":[53],"Society":[54],"America":[56],"recently":[57],"convened":[58],"its":[59],"2006":[60],"meeting":[61,83],"entitled":[62],"\"Genetic":[63],"Analysis:":[64],"Model":[65],"Organisms":[66],"Human":[68],"Biology\"":[69],"examine":[71],"future":[73,92],"role":[74],"genetic":[76,239],"research.":[77],"(Because":[78],"time":[80],"limitations,":[81],"was":[84],"unable":[85],"cover":[87],"substantial":[89],"contributions":[90],"potential":[93,103,227],"research":[95,251],"on":[96,280,286],"prokaryotic":[98],"organisms.)":[99],"In":[100],"fact,":[101],"model-organism-based":[105],"studies":[106],"has":[107,116],"grown":[108],"substantially":[109],"in":[110,175,186,257],"recent":[111],"years.":[112],"genomics":[114],"revolution":[115],"revealed":[117],"an":[118],"underlying":[119],"unity":[120],"between":[121,233],"cells":[123],"tissues":[125],"eukaryotic":[127],"organisms":[128,154],"from":[129,271],"yeast":[130],"humans.":[132],"No":[133],"uniquely":[134],"human":[135,160,201,238,267],"mechanisms":[137],"yet":[139],"come":[140],"light.":[142],"This":[143],"common":[144,194],"evolutionary":[145],"heritage":[146],"makes":[147],"possible":[149],"use":[151],"genetically":[152],"tractable":[153],"important":[157],"aspects":[158],"medical":[161,202,277],"disorders":[162],"such":[163],"as":[164],"cancer,":[165],"birth":[166],"defects,":[167],"neurological":[168],"dysfunction,":[169],"reproductive":[170],"failure,":[171],"malnutrition,":[172],"aging":[174],"systems":[176,185,273],"amenable":[177],"rapid":[179],"powerful":[181],"experimentation.":[182],"Applying":[183],"this":[187],"way":[188],"will":[189,205],"allow":[190,206],"us":[191,207],"identify":[193],"genes,":[195],"proteins,":[196],"processes":[198],"that":[199,216],"underlie":[200],"conditions.":[203],"It":[204],"systematically":[209],"decipher":[210],"gene-gene":[212],"gene-environment":[214],"interactions":[215],"influence":[217],"complex":[218],"multigenic":[219],"disorders.":[220],"Above":[221],"all,":[222],"disease":[223,268],"address":[229],"a":[230,276],"growing":[231],"gap":[232],"our":[234],"ability":[235],"collect":[237],"data":[240],"productively":[243],"interpret":[244],"apply":[246],"it.":[247],"If":[248],"is":[252],"supported":[253],"with":[254],"these":[255],"goals":[256],"mind,":[258],"we":[259],"can":[260],"look":[261],"forward":[262],"diagnosing":[264],"treating":[266],"using":[269],"information":[270],"multiple":[272],"science":[278],"built":[279],"unified":[282],"history":[283],"life":[285],"earth.":[287]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":9}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
