{"id":"https://openalex.org/W1824914858","doi":"https://doi.org/10.4049/jimmunol.177.5.3193","title":"Type I IFNs Stimulate Nitric Oxide Production and Resistance to Trypanosoma cruzi Infection","display_name":"Type I IFNs Stimulate Nitric Oxide Production and Resistance to Trypanosoma cruzi Infection","publication_year":2006,"publication_date":"2006-09-01","ids":{"openalex":"https://openalex.org/W1824914858","doi":"https://doi.org/10.4049/jimmunol.177.5.3193","mag":"1824914858","pmid":"https://pubmed.ncbi.nlm.nih.gov/16920958"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.177.5.3193","doi":"https://doi.org/10.4049/jimmunol.177.5.3193","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.177.5.3193","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/177/5/3193/1226085/zim01706003193.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://journals.aai.org/jimmunol/article-pdf/177/5/3193/1226085/zim01706003193.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059413385","display_name":"Vl\u00e1udia Maria Assis Costa","orcid":"https://orcid.org/0000-0002-4386-3055","observed_orcids":["https://orcid.org/0000-0002-4386-3055"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Vlaudia M A Costa","raw_affiliation_strings":["Departamento de Imunologia, Instituto de Cie\u0302ncias Biome\u0301dicas, Universidade de Sa\u0303o Paulo , Sa\u0303o Paulo ,","*Departamento de Imunologia, Instituto de Cie\u0302ncias Biome\u0301dicas, Universidade de Sa\u0303o Paulo, Sa\u0303o Paulo, Brazil;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Imunologia, Instituto de Cie\u0302ncias Biome\u0301dicas, Universidade de Sa\u0303o Paulo , Sa\u0303o Paulo ,","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"*Departamento de Imunologia, Instituto de Cie\u0302ncias Biome\u0301dicas, Universidade de Sa\u0303o Paulo, Sa\u0303o Paulo, Brazil;","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028105808","display_name":"Karen Torres","orcid":"https://orcid.org/0000-0002-2943-4350","observed_orcids":["https://orcid.org/0000-0002-2943-4350"]},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Karen C L Torres","raw_affiliation_strings":["Departamento de Bioqui\u0301mica e Imunologia, Instituto de Cie\u0302ncias Biolo\u0301gicas, Universidade Federal de Minas Gerais , Belo Horizonte ,","\u2020Departamento de Bioqui\u0301mica e Imunologia, Instituto de Cie\u0302ncias Biolo\u0301gicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Bioqui\u0301mica e Imunologia, Instituto de Cie\u0302ncias Biolo\u0301gicas, Universidade Federal de Minas Gerais , Belo Horizonte ,","institution_ids":["https://openalex.org/I110200422"]},{"raw_affiliation_string":"\u2020Departamento de Bioqui\u0301mica e Imunologia, Instituto de Cie\u0302ncias Biolo\u0301gicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil;","institution_ids":["https://openalex.org/I110200422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079764508","display_name":"Ronaldo Zucatelli Mendon\u00e7a","orcid":"https://orcid.org/0000-0001-6661-5110","observed_orcids":["https://orcid.org/0000-0001-6661-5110"]},"institutions":[{"id":"https://openalex.org/I2800423888","display_name":"Instituto Butantan","ror":"https://ror.org/01whwkf30","country_code":"BR","type":"facility","lineage":["https://openalex.org/I2800423888"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ronaldo Z Mendonc\u0327a","raw_affiliation_strings":["Instituto Butantan , Sa\u0303o Paulo ,","\u2021Instituto Butantan, Sa\u0303o Paulo, Brazil; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Butantan , Sa\u0303o Paulo ,","institution_ids":["https://openalex.org/I2800423888"]},{"raw_affiliation_string":"\u2021Instituto Butantan, Sa\u0303o Paulo, Brazil; and","institution_ids":["https://openalex.org/I2800423888"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017775489","display_name":"Ion Gresser","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210092322","display_name":"Centre de Recherche des Cordeliers","ror":"https://ror.org/00dmms154","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I39804081","https://openalex.org/I4210092322"]},{"id":"https://openalex.org/I4405264447","display_name":"Universit\u00e9 Pierre-et-Marie-Curie","ror":"https://ror.org/01yvrd251","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081","https://openalex.org/I4405264447"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Ion Gresser","raw_affiliation_strings":["Centre de Recherches Biomedicales des Cordeliers, Universite\u0301 Pierre et Marie Curie , Paris ,","\u00a7Centre de Recherches Biomedicales des Cordeliers, Universite\u0301 Pierre et Marie Curie, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de Recherches Biomedicales des Cordeliers, Universite\u0301 Pierre et Marie Curie , Paris ,","institution_ids":["https://openalex.org/I4210092322","https://openalex.org/I4405264447"]},{"raw_affiliation_string":"\u00a7Centre de Recherches Biomedicales des Cordeliers, Universite\u0301 Pierre et Marie Curie, Paris, France","institution_ids":["https://openalex.org/I4210092322","https://openalex.org/I4405264447"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017399345","display_name":"Kenneth J. Gollob","orcid":"https://orcid.org/0000-0003-4184-3867","observed_orcids":["https://orcid.org/0000-0003-4184-3867"]},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Kenneth J Gollob","raw_affiliation_strings":["Departamento de Bioqui\u0301mica e Imunologia, Instituto de Cie\u0302ncias Biolo\u0301gicas, Universidade Federal de Minas Gerais , Belo Horizonte ,","\u2020Departamento de Bioqui\u0301mica e Imunologia, Instituto de Cie\u0302ncias Biolo\u0301gicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Bioqui\u0301mica e Imunologia, Instituto de Cie\u0302ncias Biolo\u0301gicas, Universidade Federal de Minas Gerais , Belo Horizonte ,","institution_ids":["https://openalex.org/I110200422"]},{"raw_affiliation_string":"\u2020Departamento de Bioqui\u0301mica e Imunologia, Instituto de Cie\u0302ncias Biolo\u0301gicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil;","institution_ids":["https://openalex.org/I110200422"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005906255","display_name":"Ises A. Abrahamsohn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ises A Abrahamsohn","raw_affiliation_strings":["Departamento de Imunologia, Instituto de Cie\u0302ncias Biome\u0301dicas, Universidade de Sa\u0303o Paulo , Sa\u0303o Paulo ,","*Departamento de Imunologia, Instituto de Cie\u0302ncias Biome\u0301dicas, Universidade de Sa\u0303o Paulo, Sa\u0303o Paulo, Brazil;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Imunologia, Instituto de Cie\u0302ncias Biome\u0301dicas, Universidade de Sa\u0303o Paulo , Sa\u0303o Paulo ,","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"*Departamento de Imunologia, Instituto de Cie\u0302ncias Biome\u0301dicas, Universidade de Sa\u0303o Paulo, Sa\u0303o Paulo, Brazil;","institution_ids":["https://openalex.org/I17974374"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":3.9038,"has_fulltext":true,"cited_by_count":56,"citation_normalized_percentile":{"value":0.92859961,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"177","issue":"5","first_page":"3193","last_page":"3200"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10890","display_name":"Trypanosoma species research and implications","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10890","display_name":"Trypanosoma species research and implications","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-i-interferon","display_name":"type I interferon","score":0.9819999933242798},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.8159999847412109},{"id":"https://openalex.org/keywords/trypanosoma-cruzi","display_name":"Trypanosoma cruzi","score":0.9869999885559082},{"id":"https://openalex.org/keywords/chagas-disease","display_name":"Chagas disease","score":0.9819999933242798},{"id":"https://openalex.org/keywords/ifn-alpha-beta-receptor","display_name":"IFN-alpha/beta receptor","score":0.7820000052452087},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8429999947547913},{"id":"https://openalex.org/keywords/peritoneal-macrophages","display_name":"peritoneal macrophages","score":0.9470000267028809},{"id":"https://openalex.org/keywords/parasitemia","display_name":"parasitemia","score":0.6940000057220459},{"id":"https://openalex.org/keywords/host-resistance","display_name":"host resistance","score":0.34599998593330383},{"id":"https://openalex.org/keywords/strain-differences","display_name":"strain differences","score":0.4970000088214874},{"id":"https://openalex.org/keywords/c57bl-6-mice","display_name":"C57BL/6 mice","score":0.8119999766349792},{"id":"https://openalex.org/keywords/balb-c-mice","display_name":"BALB/c mice","score":0.8799999952316284},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.6129999756813049},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.9760000109672546}],"concepts":[{"id":"https://openalex.org/C2775867548","wikidata":"https://www.wikidata.org/wiki/Q1897162","display_name":"Parasitemia","level":4,"score":0.9505216479301453},{"id":"https://openalex.org/C2777625466","wikidata":"https://www.wikidata.org/wiki/Q150162","display_name":"Trypanosoma cruzi","level":3,"score":0.8455123901367188},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7135269641876221},{"id":"https://openalex.org/C2778536324","wikidata":"https://www.wikidata.org/wiki/Q1030169","display_name":"Peritoneal cavity","level":2,"score":0.5582785606384277},{"id":"https://openalex.org/C2780841837","wikidata":"https://www.wikidata.org/wiki/Q24741149","display_name":"Interferon gamma","level":3,"score":0.5223382711410522},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5080040097236633},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.4850415587425232},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4408930838108063},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4289957284927368},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.40014123916625977},{"id":"https://openalex.org/C71928629","wikidata":"https://www.wikidata.org/wiki/Q804206","display_name":"Parasite hosting","level":2,"score":0.3112473487854004},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.10628396272659302},{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.09811830520629883},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D014349","descriptor_name":"Trypanosoma cruzi","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D014349","descriptor_name":"Trypanosoma cruzi","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014355","descriptor_name":"Chagas Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014355","descriptor_name":"Chagas Disease","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D014355","descriptor_name":"Chagas Disease","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016753","descriptor_name":"Interleukin-10","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016898","descriptor_name":"Interferon-alpha","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D016899","descriptor_name":"Interferon-beta","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D017471","descriptor_name":"Receptors, Interferon","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D017471","descriptor_name":"Receptors, Interferon","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017471","descriptor_name":"Receptors, Interferon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.4049/jimmunol.177.5.3193","doi":"https://doi.org/10.4049/jimmunol.177.5.3193","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.177.5.3193","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/177/5/3193/1226085/zim01706003193.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:16920958","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16920958","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.4049/jimmunol.177.5.3193","doi":"https://doi.org/10.4049/jimmunol.177.5.3193","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.177.5.3193","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/177/5/3193/1226085/zim01706003193.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1824914858.pdf","grobid_xml":"https://content.openalex.org/works/W1824914858.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W1489445152","https://openalex.org/W1489889255","https://openalex.org/W1534729394","https://openalex.org/W1540820582","https://openalex.org/W1564780530","https://openalex.org/W1578257252","https://openalex.org/W1645345532","https://openalex.org/W1883200073","https://openalex.org/W1912760637","https://openalex.org/W1969406774","https://openalex.org/W1971654593","https://openalex.org/W1984553131","https://openalex.org/W1988417835","https://openalex.org/W1989807793","https://openalex.org/W1992067375","https://openalex.org/W1994310347","https://openalex.org/W1995778103","https://openalex.org/W2004829503","https://openalex.org/W2009662910","https://openalex.org/W2013824064","https://openalex.org/W2014715291","https://openalex.org/W2016586610","https://openalex.org/W2018086295","https://openalex.org/W2019202919","https://openalex.org/W2024297051","https://openalex.org/W2031924191","https://openalex.org/W2044633977","https://openalex.org/W2052067612","https://openalex.org/W2053708558","https://openalex.org/W2068489286","https://openalex.org/W2072701951","https://openalex.org/W2080936432","https://openalex.org/W2082354600","https://openalex.org/W2095842810","https://openalex.org/W2099019634","https://openalex.org/W2101520700","https://openalex.org/W2112434543","https://openalex.org/W2130876365","https://openalex.org/W2134522869","https://openalex.org/W2136559515","https://openalex.org/W2139332922","https://openalex.org/W2156305705","https://openalex.org/W2161344955","https://openalex.org/W2163175900","https://openalex.org/W2163212927","https://openalex.org/W2165199797","https://openalex.org/W2165536760","https://openalex.org/W2165643140","https://openalex.org/W2322376302","https://openalex.org/W2410138713","https://openalex.org/W2410922780","https://openalex.org/W4246415763","https://openalex.org/W4301958886","https://openalex.org/W4313331137"],"related_works":["https://openalex.org/W2029818608","https://openalex.org/W2136559515","https://openalex.org/W2112434543","https://openalex.org/W2321988497","https://openalex.org/W2170398222","https://openalex.org/W7099227404","https://openalex.org/W2118335285","https://openalex.org/W2038480224","https://openalex.org/W7100129170","https://openalex.org/W2042985663"],"abstract_inverted_index":{"The":[0],"participation":[1],"of":[2,25,37,100,128,140,144,164,182,209],"type":[3],"I":[4],"IFNs":[5],"(IFN-I)":[6],"in":[7,74,80,91,94,136,153,157,173,187,199,212],"NO":[8,33,38,66,107,165,196],"production":[9,112],"and":[10,34,70,98,169],"resistance":[11],"to":[12,205],"Trypanosoma":[13],"cruzi":[14,201],"infection":[15],"was":[16,42,115,124,171,184],"investigated.":[17],"Adherent":[18],"cells":[19,41,58],"obtained":[20],"from":[21,59,85],"the":[22,29,75,101,119,137,145,154,210],"peritoneal":[23,57,167],"cavity":[24],"mice":[26,63,88,130,174],"infected":[27,87,95],"by":[28,39,45,113,166,178],"i.p.":[30],"route":[31],"produced":[32,64],"IFN-I.":[35],"Synthesis":[36],"these":[40],"partially":[43],"inhibited":[44],"treatment":[46,99],"with":[47,53,103,131,159],"anti-IFN-alphabeta":[48,104],"or":[49,110],"anti-TNF-alpha":[50],"Abs.":[51],"Compared":[52],"susceptible":[54],"BALB/c":[55,96],"mice,":[56,97],"parasite-infected":[60],"resistant":[61,213],"C57BL/6":[62,92,129],"more":[65],"(2-fold),":[67],"IFN-I":[68,77,132,194],"(10-fold),":[69],"TNF-alpha":[71],"(3.5-fold).":[72],"Later":[73],"infection,":[76,202],"levels":[78,135,152],"measured":[79],"spleen":[81],"cell":[82],"(SC)":[83],"cultures":[84,102],"8-day":[86],"were":[89],"greater":[90],"than":[93,186],"Ab":[105],"reduced":[106,133,172],"production.":[108],"IFN-gamma":[109],"IL-10":[111],"SCs":[114,170],"not":[116,125],"different":[117],"between":[118],"two":[120],"mouse":[121],"strains;":[122],"IL-4":[123],"detectable.":[126],"Treatment":[127],"parasitemia":[134,151,211],"acute":[138,155],"phase":[139,156],"infection.":[141],"Mice":[142],"deprived":[143],"IFN-alphabetaR":[146],"gene":[147],"developed":[148],"3-fold":[149],"higher":[150],"comparison":[158],"control":[160,188,208],"129Sv":[161],"mice.":[162,190,214],"Production":[163],"macrophages":[168,183],"that":[175,193],"lacked":[176],"signaling":[177],"IFN-alphabeta,":[179],"whereas":[180],"parasitism":[181],"heavier":[185],"wild-type":[189],"We":[191],"conclude":[192],"costimulate":[195],"synthesis":[197],"early":[198],"T.":[200],"which":[203],"contributes":[204],"a":[206],"better":[207]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}